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Protein

Putative tyrosine-protein phosphatase 1

Gene

PTP-1

Organism
Orgyia pseudotsugata multicapsid polyhedrosis virus (OpMNPV)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Could be inactive as the active site cysteine is modified to tryptophan.

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei162 – 1621Equivalent of active site Cys

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Names & Taxonomyi

Protein namesi
Recommended name:
Putative tyrosine-protein phosphatase 1 (EC:3.1.3.48)
Short name:
Protein-tyrosine phosphatase 1
Gene namesi
Name:PTP-1
ORF Names:ORF10
OrganismiOrgyia pseudotsugata multicapsid polyhedrosis virus (OpMNPV)
Taxonomic identifieri262177 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageBaculoviridaeAlphabaculovirus
Virus hostiOrgyia pseudotsugata (Douglas-fir tussock moth) [TaxID: 33414]
ProteomesiUP000009248 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 220220Putative tyrosine-protein phosphatase 1PRO_0000094882Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliO10274.
SMRiO10274. Positions 44-210.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

KOiK14165.

Family and domain databases

Gene3Di3.90.190.10. 1 hit.
InterProiIPR000340. Dual-sp_phosphatase_cat-dom.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
[Graphical view]
PfamiPF00782. DSPc. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.
PROSITEiPS50056. TYR_PHOSPHATASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O10274-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLTSRRWAVI YTRTSERNCG GAWCTNGVRR RRQVHLPSVR ARAMFPDRWH
60 70 80 90 100
EYTACGAVIE GTRLLCFKVP LNAELFEYVT SDEDRWTAAS VLARHSALGA
110 120 130 140 150
VIDLTNTARY YDGAQMVKMG LLYKKIRVPG RAVPDDDIVA EFIETVDEFF
160 170 180 190 200
RRCPTMLVAV HWTHGLNRSG YLVCRYMVER LGVSPTDAIA RFETARGHKI
210 220
ERTNYLQDLL ARKHVRGQPN
Length:220
Mass (Da):25,234
Last modified:July 1, 1997 - v1
Checksum:iD3FC093F1953D425
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U75930 Genomic DNA. Translation: AAC59009.1.
RefSeqiNP_046166.1. NC_001875.2.

Genome annotation databases

GeneIDi912096.
KEGGivg:912096.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U75930 Genomic DNA. Translation: AAC59009.1.
RefSeqiNP_046166.1. NC_001875.2.

3D structure databases

ProteinModelPortaliO10274.
SMRiO10274. Positions 44-210.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi912096.
KEGGivg:912096.

Phylogenomic databases

KOiK14165.

Family and domain databases

Gene3Di3.90.190.10. 1 hit.
InterProiIPR000340. Dual-sp_phosphatase_cat-dom.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
[Graphical view]
PfamiPF00782. DSPc. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.
PROSITEiPS50056. TYR_PHOSPHATASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The sequence of the Orgyia pseudotsugata multinucleocapsid nuclear polyhedrosis virus genome."
    Ahrens C.H., Russell R.R., Funk C.J., Evans J., Harwood S., Rohrmann G.F.
    Virology 229:381-399(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiPTP1_NPVOP
AccessioniPrimary (citable) accession number: O10274
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 1, 1997
Last modified: April 1, 2015
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.