O10274 (PTP1_NPVOP) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative tyrosine-protein phosphatase 1
Short name=Protein-tyrosine phosphatase 1
EC=3.1.3.48

Gene names

Name:	PTP-1
ORF Names:	ORF10

Organism

Orgyia pseudotsugata multicapsid polyhedrosis virus (OpMNPV) [Complete proteome]

Taxonomic identifier

262177 [NCBI]

Taxonomic lineage

Viruses › dsDNA viruses, no RNA stage › Baculoviridae › Alphabaculovirus

Virus host

Orgyia pseudotsugata (Douglas fir tussock moth) [TaxID: 33414]

Protein attributes

Sequence length	220 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Could be inactive as the active site cysteine is modified to tryptophan.
Catalytic activity	Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.
Sequence similarities	Belongs to the protein-tyrosine phosphatase family. Non-receptor class CDC14 subfamily.

Ontologies

Keywords
Molecular function	Hydrolase Protein phosphatase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	peptidyl-tyrosine dephosphorylation Inferred from electronic annotation. Source: GOC
Molecular_function	protein tyrosine phosphatase activity Inferred from electronic annotation. Source: EC protein tyrosine/serine/threonine phosphatase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 220	220	Putative tyrosine-protein phosphatase 1		PRO_0000094882
Sites
	Site	162	1	Equivalent of active site Cys

Sequences

	Sequence		Length	Mass (Da)
	O10274 [UniParc]. Last modified July 1, 1997. Version 1. Checksum: D3FC093F1953D425	FASTA	220	25,234
	10 20 30 40 50 60 MLTSRRWAVI YTRTSERNCG GAWCTNGVRR RRQVHLPSVR ARAMFPDRWH EYTACGAVIE 70 80 90 100 110 120 GTRLLCFKVP LNAELFEYVT SDEDRWTAAS VLARHSALGA VIDLTNTARY YDGAQMVKMG 130 140 150 160 170 180 LLYKKIRVPG RAVPDDDIVA EFIETVDEFF RRCPTMLVAV HWTHGLNRSG YLVCRYMVER 190 200 210 220 LGVSPTDAIA RFETARGHKI ERTNYLQDLL ARKHVRGQPN

References

[1]	"The sequence of the Orgyia pseudotsugata multinucleocapsid nuclear polyhedrosis virus genome." Ahrens C.H., Russell R.R., Funk C.J., Evans J., Harwood S., Rohrmann G.F. Virology 229:381-399(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	U75930 Genomic DNA. Translation: AAC59009.1.
RefSeq	NP_046166.1. NC_001875.2.
3D structure databases
ProteinModelPortal	O10274.
SMR	O10274. Positions 44-210.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	912096.
Phylogenomic databases
ProtClustDB	CLSP2509865.
Family and domain databases
InterPro	IPR000340. Dual-sp_phosphatase_cat-dom. IPR000387. Tyr/Dual-sp_Pase. [Graphical view]
Pfam	PF00782. DSPc. 1 hit. [Graphical view]
PROSITE	PS00383. TYR_PHOSPHATASE_1. False negative. PS50056. TYR_PHOSPHATASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PTP1_NPVOP

Accession

Primary (citable) accession number: O10274

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	July 1, 1997
Last modified:	April 3, 2013
This is version 57 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program