ID   GN_HHV11                Reviewed;          91 AA.
AC   O09800; B9VQH8;
DT   02-FEB-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1997, sequence version 1.
DT   21-SEP-2011, entry version 40.
DE   RecName: Full=Glycoprotein N;
DE            Short=gN;
DE   AltName: Full=Protein UL49.5;
DE   AltName: Full=Protein UL49A;
DE   Flags: Precursor;
GN   Name=gN; ORFNames=UL49.5, UL49A;
OS   Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus
OS   1).
OC   Viruses; dsDNA viruses, no RNA stage; Herpesvirales; Herpesviridae;
OC   Alphaherpesvirinae; Simplexvirus.
OX   NCBI_TaxID=10299;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   MEDLINE=88274327; PubMed=2839594;
RA   McGeoch D.J., Dalrymple M.A., Davison A.J., Dolan A., Frame M.C.,
RA   McNab D., Perry L.J., Scott J.E., Taylor P.;
RT   "The complete DNA sequence of the long unique region in the genome of
RT   herpes simplex virus type 1.";
RL   J. Gen. Virol. 69:1531-1574(1988).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=17 syn+;
RA   Cunningham C., Davison A.J.;
RT   "Herpes simplex virus type 1 bacterial artificial chromosome.";
RL   Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   SUBCELLULAR LOCATION.
RC   STRAIN=F;
RX   PubMed=18596102; DOI=10.1128/JVI.00904-08;
RA   Loret S., Guay G., Lippe R.;
RT   "Comprehensive characterization of extracellular herpes simplex virus
RT   type 1 virions.";
RL   J. Virol. 82:8605-8618(2008).
CC   -!- FUNCTION: Necessary for proper maturation of gM. Putative envelope
CC       protein. May be involved in virus assembly (By similarity).
CC   -!- SUBUNIT: Interacts with gM (By similarity). The gM-gN heterodimer
CC       forms the gCII complex (By similarity).
CC   -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane
CC       protein (By similarity). Host Golgi apparatus membrane; Single-
CC       pass membrane protein (By similarity). Note=Presence in the
CC       extracellular virions remains controvertial.
CC   -!- SIMILARITY: Belongs to the Simplexvirus glycoprotein N family.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; X14112; CAA32300.1; -; Genomic_DNA.
DR   EMBL; FJ593289; ACM62273.1; -; Genomic_DNA.
DR   RefSeq; NP_044652.1; NC_001806.1.
DR   GeneID; 2703419; -.
DR   ProtClustDB; CLSP2510168; -.
DR   GO; GO:0044178; C:host cell Golgi membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR017376; Herpes_UL49A.
DR   PIRSF; PIRSF038075; Herpes_UL49A_env; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Host Golgi apparatus; Host membrane; Membrane;
KW   Reference proteome; Signal; Transmembrane; Transmembrane helix.
FT   SIGNAL        1     23       Potential.
FT   CHAIN        24     91       Glycoprotein N.
FT                                /FTId=PRO_0000116098.
FT   TOPO_DOM     24     55       Extracellular (Potential).
FT   TRANSMEM     56     76       Helical; (Potential).
FT   TOPO_DOM     77     91       Cytoplasmic (Potential).
SQ   SEQUENCE   91 AA;  9202 MW;  8CF33C769092BB5F CRC64;
     MGPPRRVCRA GLLFVLLVAL AAGDAGPRGE PPGEEGGRDG IGGARCETQN TGQMSAPGAL
     VPFYVGMASM GVCIIAHVCQ ICQRLLAAGH A
//