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Protein

Envelope glycoprotein N

Gene

gN

Organism
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Envelope glycoprotein necessary for proper maturation of gM. May be involved in virus assembly (By similarity).By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
Envelope glycoprotein N
Alternative name(s):
Protein UL49.5
Protein UL49A
Gene namesi
Name:gN
ORF Names:UL49.5, UL49A
OrganismiHuman herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Taxonomic identifieri10299 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeSimplexvirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000009294 Componenti: Genome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini24 – 5532Virion surfaceSequence analysisAdd
BLAST
Transmembranei56 – 7621HelicalSequence analysisAdd
BLAST
Topological domaini77 – 9115IntravirionSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Host Golgi apparatus, Host membrane, Membrane, Viral envelope protein, Virion

Pathology & Biotechi

Chemistry

ChEMBLiCHEMBL2364696.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence analysisAdd
BLAST
Chaini24 – 9168Envelope glycoprotein NPRO_0000116098Add
BLAST

Interactioni

Subunit structurei

Interacts with gM. The gM-gN heterodimer forms the gCII complex.By similarity

Family & Domainsi

Sequence similaritiesi

Belongs to the simplexvirus glycoprotein N family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Family and domain databases

InterProiIPR017376. Herpes_UL49A.
[Graphical view]
PIRSFiPIRSF038075. Herpes_UL49A_env. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O09800-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGPPRRVCRA GLLFVLLVAL AAGDAGPRGE PPGEEGGRDG IGGARCETQN
60 70 80 90
TGQMSAPGAL VPFYVGMASM GVCIIAHVCQ ICQRLLAAGH A
Length:91
Mass (Da):9,202
Last modified:July 1, 1997 - v1
Checksum:i8CF33C769092BB5F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14112 Genomic DNA. Translation: CAA32300.1.
FJ593289 Genomic DNA. Translation: ACM62273.1.
RefSeqiYP_009137125.1. NC_001806.2.

Genome annotation databases

GeneIDi2703419.
KEGGivg:2703419.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14112 Genomic DNA. Translation: CAA32300.1.
FJ593289 Genomic DNA. Translation: ACM62273.1.
RefSeqiYP_009137125.1. NC_001806.2.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Chemistry

ChEMBLiCHEMBL2364696.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi2703419.
KEGGivg:2703419.

Miscellaneous databases

PROiO09800.

Family and domain databases

InterProiIPR017376. Herpes_UL49A.
[Graphical view]
PIRSFiPIRSF038075. Herpes_UL49A_env. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiGN_HHV11
AccessioniPrimary (citable) accession number: O09800
Secondary accession number(s): B9VQH8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 2, 2004
Last sequence update: July 1, 1997
Last modified: September 7, 2016
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.