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O09800

- GN_HHV11

UniProt

O09800 - GN_HHV11

Protein

Envelope glycoprotein N

Gene

gN

Organism
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
  1. Functioni

    Envelope glycoprotein necessary for proper maturation of gM. May be involved in virus assembly By similarity.By similarity

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Envelope glycoprotein N
    Alternative name(s):
    Protein UL49.5
    Protein UL49A
    Gene namesi
    Name:gN
    ORF Names:UL49.5, UL49A
    OrganismiHuman herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
    Taxonomic identifieri10299 [NCBI]
    Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeSimplexvirus
    Virus hostiHomo sapiens (Human) [TaxID: 9606]
    ProteomesiUP000009294: Genome

    Subcellular locationi

    GO - Cellular componenti

    1. host cell Golgi membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW
    3. viral envelope Source: UniProtKB-KW
    4. virion membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Host Golgi apparatus, Host membrane, Membrane, Viral envelope protein, Virion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2323Sequence AnalysisAdd
    BLAST
    Chaini24 – 9168Envelope glycoprotein NPRO_0000116098Add
    BLAST

    Interactioni

    Subunit structurei

    Interacts with gM. The gM-gN heterodimer forms the gCII complex.By similarity

    Structurei

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini24 – 5532Virion surfaceSequence AnalysisAdd
    BLAST
    Topological domaini77 – 9115IntravirionSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei56 – 7621HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the simplexvirus glycoprotein N family.Curated

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Family and domain databases

    InterProiIPR017376. Herpes_UL49A.
    [Graphical view]
    PIRSFiPIRSF038075. Herpes_UL49A_env. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O09800-1 [UniParc]FASTAAdd to Basket

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    MGPPRRVCRA GLLFVLLVAL AAGDAGPRGE PPGEEGGRDG IGGARCETQN   50
    TGQMSAPGAL VPFYVGMASM GVCIIAHVCQ ICQRLLAAGH A 91
    Length:91
    Mass (Da):9,202
    Last modified:July 1, 1997 - v1
    Checksum:i8CF33C769092BB5F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X14112 Genomic DNA. Translation: CAA32300.1.
    FJ593289 Genomic DNA. Translation: ACM62273.1.
    RefSeqiNP_044652.1. NC_001806.1.

    Genome annotation databases

    GeneIDi2703419.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X14112 Genomic DNA. Translation: CAA32300.1 .
    FJ593289 Genomic DNA. Translation: ACM62273.1 .
    RefSeqi NP_044652.1. NC_001806.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Chemistry

    ChEMBLi CHEMBL2364696.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 2703419.

    Family and domain databases

    InterProi IPR017376. Herpes_UL49A.
    [Graphical view ]
    PIRSFi PIRSF038075. Herpes_UL49A_env. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The complete DNA sequence of the long unique region in the genome of herpes simplex virus type 1."
      McGeoch D.J., Dalrymple M.A., Davison A.J., Dolan A., Frame M.C., McNab D., Perry L.J., Scott J.E., Taylor P.
      J. Gen. Virol. 69:1531-1574(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. "Herpes simplex virus type 1 bacterial artificial chromosome."
      Cunningham C., Davison A.J.
      Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 17 syn+.
    3. "Comprehensive characterization of extracellular herpes simplex virus type 1 virions."
      Loret S., Guay G., Lippe R.
      J. Virol. 82:8605-8618(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION.
      Strain: F.

    Entry informationi

    Entry nameiGN_HHV11
    AccessioniPrimary (citable) accession number: O09800
    Secondary accession number(s): B9VQH8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 2, 2004
    Last sequence update: July 1, 1997
    Last modified: October 1, 2014
    This is version 51 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3