O09800 (GN_HHV11) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Glycoprotein N
Short name=gN

Alternative name(s):
Protein UL49.5
Protein UL49A

Gene names

Name:	gN
ORF Names:	UL49.5, UL49A

Organism

Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) [Reference proteome]

Taxonomic identifier

10299 [NCBI]

Taxonomic lineage

Viruses › dsDNA viruses, no RNA stage › Herpesvirales › Herpesviridae › Alphaherpesvirinae › Simplexvirus › Human herpesvirus 1

Virus host

Homo sapiens (Human) [TaxID: 9606]

Protein attributes

Sequence length	91 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Envelope glycoprotein necessary for proper maturation of gM. May be involved in virus assembly By similarity.
Subunit structure	Interacts with gM By similarity. The gM-gN heterodimer forms the gCII complex By similarity.
Subcellular location	Virion membrane; Single-pass type I membrane protein By similarity. Host membrane; Single-pass type I membrane protein By similarity. Host Golgi apparatus membrane; Single-pass membrane protein By similarity Ref.3.
Sequence similarities	Belongs to the simplexvirus glycoprotein N family.

Ontologies

Keywords
Cellular component	Host Golgi apparatus Host membrane Membrane Viral envelope protein Virion
Domain	Signal Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	host cell Golgi membrane Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW viral envelope Inferred from electronic annotation. Source: UniProtKB-KW virion membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 23	23	Potential
	Chain	24 – 91	68	Glycoprotein N		PRO_0000116098
Regions
	Topological domain	24 – 55	32	Virion surface Potential
	Transmembrane	56 – 76	21	Helical; Potential
	Topological domain	77 – 91	15	Intravirion Potential

Sequences

	Sequence		Length	Mass (Da)
	O09800 [UniParc]. Last modified July 1, 1997. Version 1. Checksum: 8CF33C769092BB5F	FASTA	91	9,202
	10 20 30 40 50 60 MGPPRRVCRA GLLFVLLVAL AAGDAGPRGE PPGEEGGRDG IGGARCETQN TGQMSAPGAL 70 80 90 VPFYVGMASM GVCIIAHVCQ ICQRLLAAGH A

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The complete DNA sequence of the long unique region in the genome of herpes simplex virus type 1." McGeoch D.J., Dalrymple M.A., Davison A.J., Dolan A., Frame M.C., McNab D., Perry L.J., Scott J.E., Taylor P. J. Gen. Virol. 69:1531-1574(1988) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"Herpes simplex virus type 1 bacterial artificial chromosome." Cunningham C., Davison A.J. Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 17 syn+.
[3]	"Comprehensive characterization of extracellular herpes simplex virus type 1 virions." Loret S., Guay G., Lippe R. J. Virol. 82:8605-8618(2008) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION. Strain: F.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X14112 Genomic DNA. Translation: CAA32300.1. FJ593289 Genomic DNA. Translation: ACM62273.1.
RefSeq	NP_044652.1. NC_001806.1.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2703419.
Phylogenomic databases
ProtClustDB	CLSP2510168.
Family and domain databases
InterPro	IPR017376. Herpes_UL49A. [Graphical view]
PIRSF	PIRSF038075. Herpes_UL49A_env. 1 hit.
ProtoNet	Search...

Entry information

Entry name

GN_HHV11

Accession

Primary (citable) accession number: O09800
Secondary accession number(s): B9VQH8

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 2, 2004
Last sequence update:	July 1, 1997
Last modified:	May 1, 2013
This is version 45 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program