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Protein

Calcium-transporting ATPase

Gene
N/A
Organism
Leishmania amazonensis
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.UniRule annotation

Catalytic activityi

ATP + H2O + Ca2+(Side 1) = ADP + phosphate + Ca2+(Side 2).UniRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

HydrolaseUniRule annotationSAAS annotation

Keywords - Biological processi

Calcium transportUniRule annotation, Ion transport, Transport

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotation, Calcium, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Calcium-transporting ATPaseUniRule annotation (EC:3.6.3.8UniRule annotation)
OrganismiLeishmania amazonensisImported
Taxonomic identifieri5659 [NCBI]
Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeLeishmaniinaeLeishmania

Subcellular locationi

  • Membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei79 – 98HelicalUniRule annotationAdd BLAST20
Transmembranei104 – 123HelicalUniRule annotationAdd BLAST20
Transmembranei265 – 289HelicalUniRule annotationAdd BLAST25
Transmembranei841 – 864HelicalUniRule annotationAdd BLAST24
Transmembranei932 – 952HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Structurei

3D structure databases

ProteinModelPortaliO09489.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini22 – 96Cation_ATPase_NInterPro annotationAdd BLAST75

Sequence similaritiesi

Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. [View classification]UniRule annotationSAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotationSAAS annotation

Family and domain databases

Gene3Di1.20.1110.10. 2 hits.
2.70.150.10. 2 hits.
3.40.1110.10. 1 hit.
InterProiIPR006068. ATPase_P-typ_cation-transptr_C.
IPR004014. ATPase_P-typ_cation-transptr_N.
IPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR023298. ATPase_P-typ_TM_dom.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR023214. HAD-like_dom.
IPR005782. P-type_ATPase_IIA.
IPR001757. P_typ_ATPase.
[Graphical view]
PfamiPF00689. Cation_ATPase_C. 1 hit.
PF00690. Cation_ATPase_N. 1 hit.
PF00122. E1-E2_ATPase. 1 hit.
[Graphical view]
SMARTiSM00831. Cation_ATPase_N. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 2 hits.
SSF81660. SSF81660. 1 hit.
TIGRFAMsiTIGR01116. ATPase-IIA1_Ca. 1 hit.
TIGR01494. ATPase_P-type. 2 hits.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O09489-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKLGGHPSR PDHPAVLVLP DDPRSMDGHL ICSLLEVKEA HGLAQDEVDR
60 70 80 90 100
RLHEFGKNGF PTGSSTPFWK LVVGQFEDTL VRILLLAAFV SFCLAVLENN
110 120 130 140 150
VMDLVEPFII LLILTLNAIV GVWQEDRAEK AIDALKTSFL KQLLLFVRVC
160 170 180 190 200
RWQENLVPGD IVEVAVGDRV AADVRLLTLE STTLRVDQSI LNGESVEAMK
210 220 230 240 250
QVESVRGNRE RFPSSMVYRG TAVVYGKARG VVVRTGTSTE MGFIERDVRE
260 270 280 290 300
QEETKTPLQL KLDEFGVLLS GVIGYICLFV FVANLLHWFR THTPTTEESW
310 320 330 340 350
FERYIQPTVH SLKVAVALAV AAIPEGLPAV VTTCLALGAR KMARHNALVR
360 370 380 390 400
DLPSVETLGR CTVICSDKTG TLTTNMMSVS EVVTMEPSGK AHEYCLHDSR
410 420 430 440 450
FNVVAASVSH RGTPAGDVLG NDAALDMVAT IATLCSDASL IFGTRSAEVE
460 470 480 490 500
KVGDATEAAL LVMSEKLYHS AAWNGVDGAR LPADRCRSLK KKLWLKKATL
510 520 530 540 550
EFTRSRKSMS VCCTSTRHSL FVKGAPEEIL KRCTRIMFKD GRISPLTPKM
560 570 580 590 600
VNTVTANIDR MSGTEEALRC IAFAFRPIPD PKQLDLSDPA KFEAIDSHLT
610 620 630 640 650
WGGVFGILDP PRREVADAIA KCRTAGIRVI VITGDKKETA EAVCRRIGLM
660 670 680 690 700
SSEPTKGLSF TGYELDQMTP AQRRAAVSSA VLFSRTDPSH KMQLVNLLQE
710 720 730 740 750
QKLICAMTGD GVNDSPALKK ADIGIAMGSG TEVAKAASKL VLADDNFATV
760 770 780 790 800
VKAVHEGRTI FNNTKQFIRY LISSNIGEVA CVLATDCLAC QKHSADQLLW
810 820 830 840 850
VNLVTDGLPA TACWVQTPPI QTLWNRHRGE ETSPLSTGWL FFRYMVVGVY
860 870 880 890 900
VGLATVAGFV WWFLTNGFTM ADLVSFTTCT DMSNPKCAVL ANPQTARAIA
910 920 930 940 950
LSILVVVEML NALNALSENQ SLVVIRPSTN KWLIAAICSS IALHLTIMYI
960 970 980 990 1000
PFFSRLFGVT PLGVDADVVA TANSWDVLLP TDFTDWKTVL VLSIPVIFLD
1010 1020 1030
ELLKLFSRCS NHHRENHSAE PVVRGLSRIW N
Length:1,031
Mass (Da):113,098
Last modified:July 1, 1997 - v1
Checksum:i07B51CE3C51B142B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U70540 Genomic DNA. Translation: AAC47505.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U70540 Genomic DNA. Translation: AAC47505.1.

3D structure databases

ProteinModelPortaliO09489.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di1.20.1110.10. 2 hits.
2.70.150.10. 2 hits.
3.40.1110.10. 1 hit.
InterProiIPR006068. ATPase_P-typ_cation-transptr_C.
IPR004014. ATPase_P-typ_cation-transptr_N.
IPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR023298. ATPase_P-typ_TM_dom.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR023214. HAD-like_dom.
IPR005782. P-type_ATPase_IIA.
IPR001757. P_typ_ATPase.
[Graphical view]
PfamiPF00689. Cation_ATPase_C. 1 hit.
PF00690. Cation_ATPase_N. 1 hit.
PF00122. E1-E2_ATPase. 1 hit.
[Graphical view]
SMARTiSM00831. Cation_ATPase_N. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 2 hits.
SSF81660. SSF81660. 1 hit.
TIGRFAMsiTIGR01116. ATPase-IIA1_Ca. 1 hit.
TIGR01494. ATPase_P-type. 2 hits.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiO09489_LEIAM
AccessioniPrimary (citable) accession number: O09489
Entry historyi
Integrated into UniProtKB/TrEMBL: July 1, 1997
Last sequence update: July 1, 1997
Last modified: May 11, 2016
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.