O09489 (O09489_LEIAM) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names	Submitted name: Organelle-type Ca2+-ATPase EMBL AAC47505.1
Organism	Leishmania amazonensis EMBL AAC47505.1
Taxonomic identifier	5659 [NCBI]
Taxonomic lineage	Eukaryota › Euglenozoa › Kinetoplastida › Trypanosomatidae › Leishmania

Protein attributes

Sequence length	1031 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Sequence similarities

Belongs to the cation transport ATPase (P-type) family. RuleBase RU000653

Ontologies

Keywords
Biological process	Ion transport SAAS SAAS023300 Transport
Cellular component	Membrane
Domain	Transmembrane Transmembrane helix SAAS SAAS004014
Ligand	ATP-binding SAAS SAAS004014 RuleBase RU000653 Nucleotide-binding
Molecular function	Hydrolase SAAS SAAS004014 RuleBase RU000653
PTM	Phosphoprotein RuleBase RU000653 SAAS SAAS004014
Gene Ontology (GO)
Biological process	ATP biosynthetic process Inferred from electronic annotation. Source: InterPro
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW calcium-transporting ATPase activity Inferred from electronic annotation. Source: InterPro metal ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	O09489 [UniParc]. Last modified July 1, 1997. Version 1. Checksum: 07B51CE3C51B142B	FASTA	1,031	113,098
	10 20 30 40 50 60 MSKLGGHPSR PDHPAVLVLP DDPRSMDGHL ICSLLEVKEA HGLAQDEVDR RLHEFGKNGF 70 80 90 100 110 120 PTGSSTPFWK LVVGQFEDTL VRILLLAAFV SFCLAVLENN VMDLVEPFII LLILTLNAIV 130 140 150 160 170 180 GVWQEDRAEK AIDALKTSFL KQLLLFVRVC RWQENLVPGD IVEVAVGDRV AADVRLLTLE 190 200 210 220 230 240 STTLRVDQSI LNGESVEAMK QVESVRGNRE RFPSSMVYRG TAVVYGKARG VVVRTGTSTE 250 260 270 280 290 300 MGFIERDVRE QEETKTPLQL KLDEFGVLLS GVIGYICLFV FVANLLHWFR THTPTTEESW 310 320 330 340 350 360 FERYIQPTVH SLKVAVALAV AAIPEGLPAV VTTCLALGAR KMARHNALVR DLPSVETLGR 370 380 390 400 410 420 CTVICSDKTG TLTTNMMSVS EVVTMEPSGK AHEYCLHDSR FNVVAASVSH RGTPAGDVLG 430 440 450 460 470 480 NDAALDMVAT IATLCSDASL IFGTRSAEVE KVGDATEAAL LVMSEKLYHS AAWNGVDGAR 490 500 510 520 530 540 LPADRCRSLK KKLWLKKATL EFTRSRKSMS VCCTSTRHSL FVKGAPEEIL KRCTRIMFKD 550 560 570 580 590 600 GRISPLTPKM VNTVTANIDR MSGTEEALRC IAFAFRPIPD PKQLDLSDPA KFEAIDSHLT 610 620 630 640 650 660 WGGVFGILDP PRREVADAIA KCRTAGIRVI VITGDKKETA EAVCRRIGLM SSEPTKGLSF 670 680 690 700 710 720 TGYELDQMTP AQRRAAVSSA VLFSRTDPSH KMQLVNLLQE QKLICAMTGD GVNDSPALKK 730 740 750 760 770 780 ADIGIAMGSG TEVAKAASKL VLADDNFATV VKAVHEGRTI FNNTKQFIRY LISSNIGEVA 790 800 810 820 830 840 CVLATDCLAC QKHSADQLLW VNLVTDGLPA TACWVQTPPI QTLWNRHRGE ETSPLSTGWL 850 860 870 880 890 900 FFRYMVVGVY VGLATVAGFV WWFLTNGFTM ADLVSFTTCT DMSNPKCAVL ANPQTARAIA 910 920 930 940 950 960 LSILVVVEML NALNALSENQ SLVVIRPSTN KWLIAAICSS IALHLTIMYI PFFSRLFGVT 970 980 990 1000 1010 1020 PLGVDADVVA TANSWDVLLP TDFTDWKTVL VLSIPVIFLD ELLKLFSRCS NHHRENHSAE 1030 PVVRGLSRIW N

References

[1]	"Intracellular Ca2+ pool content and signaling and expression of a calcium pump are linked to virulence in Leishmania mexicana amazonesis amastigotes." Lu H.G., Zhong L., Chang K.P., Docampo R. J. Biol. Chem. 272:9464-9473(1997) [PubMed: 9083086] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: RAT/BA/LV78 EMBL AAC47505.1.
[2]	Lu H.-G., Zhong L., Docampo R. Submitted (SEP-1996) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: RAT/BA/LV78 EMBL AAC47505.1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U70540 Genomic DNA. Translation: AAC47505.1.
3D structure databases
HSSP	HSSP built from PDB template 1SU4 based on UniProtKB P04191.
ProteinModelPortal	O09489.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR023306. ATPase_cation_domN. IPR008250. ATPase_P-typ_ATPase-assoc-dom. IPR005782. ATPase_P-typ_Ca-transp. IPR006068. ATPase_P-typ_cation-transptr_C. IPR004014. ATPase_P-typ_cation-transptr_N. IPR023300. ATPase_P-typ_cyto_domA. IPR023299. ATPase_P-typ_cyto_domN. IPR001757. ATPase_P-typ_ion-transptr. IPR018303. ATPase_P-typ_P_site. IPR023298. ATPase_P-typ_TM_dom. IPR005834. Dehalogen-like_hydro. IPR023214. HAD-like_dom. [Graphical view]
Gene3D	G3DSA:2.70.150.10. ATPase_P-typ_cyto_domA. 2 hits. G3DSA:3.40.1110.10. ATPase_P-typ_cyto_domN. 1 hit. G3DSA:1.20.1110.10. ATPase_P-typ_TM_dom. 2 hits.
Pfam	PF00689. Cation_ATPase_C. 1 hit. PF00690. Cation_ATPase_N. 1 hit. PF00122. E1-E2_ATPase. 1 hit. PF00702. Hydrolase. 1 hit. [Graphical view]
PRINTS	PR00119. CATATPASE.
SMART	SM00831. Cation_ATPase_N. 1 hit. [Graphical view]
SUPFAM	SSF81660. ATPase_cation_domN. 1 hit. SSF56784. HAD-like_dom. 1 hit.
TIGRFAMs	TIGR01116. ATPase-IIA1_Ca. 1 hit. TIGR01494. ATPase_P-type. 2 hits.
PROSITE	PS00154. ATPASE_E1_E2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

O09489_LEIAM

Accession

Primary (citable) accession number: O09489

Entry history

Integrated into UniProtKB/TrEMBL:	July 1, 1997
Last sequence update:	July 1, 1997
Last modified:	July 27, 2011
This is version 76 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)