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Protein

Myelin and lymphocyte protein

Gene

Mal

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Could be an important component in vesicular trafficking cycling between the Golgi complex and the apical plasma membrane. Plays a role in the maintenance of the myelin sheath and in axon-glia and glia-glia interactions.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Myelin and lymphocyte protein
Alternative name(s):
T-lymphocyte maturation-associated protein
Gene namesi
Name:Mal
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:892970. Mal.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2424CytoplasmicSequence analysisAdd
BLAST
Transmembranei25 – 4622HelicalSequence analysisAdd
BLAST
Topological domaini47 – 537ExtracellularSequence analysis
Transmembranei54 – 7522HelicalSequence analysisAdd
BLAST
Topological domaini76 – 9217CytoplasmicSequence analysisAdd
BLAST
Transmembranei93 – 11422HelicalSequence analysisAdd
BLAST
Topological domaini115 – 12511ExtracellularSequence analysisAdd
BLAST
Transmembranei126 – 14722HelicalSequence analysisAdd
BLAST
Topological domaini148 – 1536CytoplasmicSequence analysis

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Golgi apparatus, Membrane

Pathology & Biotechi

Disruption phenotypei

Abnormal myelination and optic nerve morphology.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 153153Myelin and lymphocyte proteinPRO_0000156806Add
BLAST

Post-translational modificationi

Lipoprotein.By similarity

Keywords - PTMi

Lipoprotein

Proteomic databases

PaxDbiO09198.

Expressioni

Tissue specificityi

Expressed in the spinal cord, brain, kidney and gastrointestinal tract especially in the stomach and caecum. Highly expressed by myelinating glial cells.1 Publication

Gene expression databases

BgeeiENSMUSG00000027375.
GenevisibleiO09198. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000028854.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini18 – 151134MARVELPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the MAL family.Curated
Contains 1 MARVEL domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4788. Eukaryota.
ENOG4111IAF. LUCA.
GeneTreeiENSGT00730000110762.
HOGENOMiHOG000231752.
HOVERGENiHBG000925.
InParanoidiO09198.
OMAiVPIPLIQ.
OrthoDBiEOG091G0OS1.
PhylomeDBiO09198.
TreeFamiTF316174.

Family and domain databases

InterProiIPR013295. MAL.
IPR008253. Marvel.
[Graphical view]
PfamiPF01284. MARVEL. 1 hit.
[Graphical view]
PRINTSiPR01884. MALPROTEIN.
PROSITEiPS51225. MARVEL. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O09198-1) [UniParc]FASTAAdd to basket
Also known as: A

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAPAAASGGS TLPSGFSVFT TFPDLLFVCE FVFGGLVWIL IASSLVPLPL
60 70 80 90 100
AQGWVMFVSV FCFVATTSLM ILYIIGTHGG ETSWITLDAA YHCVAALFYL
110 120 130 140 150
SASVLEALAT ISMFDGFTYK HYHENIAAVV FAYVVTLIYV VHAVFSLIRW

KSS
Length:153
Mass (Da):16,596
Last modified:July 1, 1997 - v1
Checksum:i5EED415344669B4B
GO
Isoform 2 (identifier: O09198-2) [UniParc]FASTAAdd to basket
Also known as: C

The sequence of this isoform differs from the canonical sequence as follows:
     32-87: Missing.

Show »
Length:97
Mass (Da):10,556
Checksum:i82ADEBB69D494C1E
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei32 – 8756Missing in isoform 2. 1 PublicationVSP_031253Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y07626 mRNA. Translation: CAA68907.1.
Y07627
, Y07628, Y07629, Y07630 Genomic DNA. Translation: CAA68908.1.
Y07812 mRNA. Translation: CAA69143.1.
AK004639 mRNA. Translation: BAB23430.1.
AK019046 mRNA. Translation: BAB31523.1.
AK158653 mRNA. Translation: BAE34599.1.
AK169172 mRNA. Translation: BAE40951.1.
AL731831, AL844204 Genomic DNA. Translation: CAM13438.1.
AL731831, AL844204 Genomic DNA. Translation: CAM13439.1.
AL844204, AL731831 Genomic DNA. Translation: CAM16966.1.
AL844204, AL731831 Genomic DNA. Translation: CAM16967.1.
BC006826 mRNA. Translation: AAH06826.1.
CCDSiCCDS16707.1. [O09198-1]
CCDS50705.1. [O09198-2]
RefSeqiNP_001164658.1. NM_001171187.1. [O09198-2]
NP_034892.1. NM_010762.5. [O09198-1]
UniGeneiMm.39040.

Genome annotation databases

EnsembliENSMUST00000028853; ENSMUSP00000028853; ENSMUSG00000027375. [O09198-2]
ENSMUST00000028854; ENSMUSP00000028854; ENSMUSG00000027375. [O09198-1]
GeneIDi17153.
KEGGimmu:17153.
UCSCiuc008mfv.2. mouse. [O09198-1]
uc008mfw.2. mouse. [O09198-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y07626 mRNA. Translation: CAA68907.1.
Y07627
, Y07628, Y07629, Y07630 Genomic DNA. Translation: CAA68908.1.
Y07812 mRNA. Translation: CAA69143.1.
AK004639 mRNA. Translation: BAB23430.1.
AK019046 mRNA. Translation: BAB31523.1.
AK158653 mRNA. Translation: BAE34599.1.
AK169172 mRNA. Translation: BAE40951.1.
AL731831, AL844204 Genomic DNA. Translation: CAM13438.1.
AL731831, AL844204 Genomic DNA. Translation: CAM13439.1.
AL844204, AL731831 Genomic DNA. Translation: CAM16966.1.
AL844204, AL731831 Genomic DNA. Translation: CAM16967.1.
BC006826 mRNA. Translation: AAH06826.1.
CCDSiCCDS16707.1. [O09198-1]
CCDS50705.1. [O09198-2]
RefSeqiNP_001164658.1. NM_001171187.1. [O09198-2]
NP_034892.1. NM_010762.5. [O09198-1]
UniGeneiMm.39040.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000028854.

Proteomic databases

PaxDbiO09198.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000028853; ENSMUSP00000028853; ENSMUSG00000027375. [O09198-2]
ENSMUST00000028854; ENSMUSP00000028854; ENSMUSG00000027375. [O09198-1]
GeneIDi17153.
KEGGimmu:17153.
UCSCiuc008mfv.2. mouse. [O09198-1]
uc008mfw.2. mouse. [O09198-2]

Organism-specific databases

CTDi4118.
MGIiMGI:892970. Mal.

Phylogenomic databases

eggNOGiKOG4788. Eukaryota.
ENOG4111IAF. LUCA.
GeneTreeiENSGT00730000110762.
HOGENOMiHOG000231752.
HOVERGENiHBG000925.
InParanoidiO09198.
OMAiVPIPLIQ.
OrthoDBiEOG091G0OS1.
PhylomeDBiO09198.
TreeFamiTF316174.

Miscellaneous databases

PROiO09198.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000027375.
GenevisibleiO09198. MM.

Family and domain databases

InterProiIPR013295. MAL.
IPR008253. Marvel.
[Graphical view]
PfamiPF01284. MARVEL. 1 hit.
[Graphical view]
PRINTSiPR01884. MALPROTEIN.
PROSITEiPS51225. MARVEL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMAL_MOUSE
AccessioniPrimary (citable) accession number: O09198
Secondary accession number(s): O08819
, O09109, Q545Q7, Q9D2R2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 1, 1997
Last modified: September 7, 2016
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.