Reviewed,
UniProtKB/Swiss-Prot O09178 (AMPD3_RAT)
Last modified
October 13, 2009.
Version 63.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: AMP deaminase 3 EC=3.5.4.6 Alternative name(s): AMP deaminase isoform E | ||
| Gene names |
| ||
| Organism | Rattus norvegicus (Rat) | ||
| Taxonomic identifier | 10116 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus |
Protein attributes
| Sequence length | 765 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | AMP deaminase plays a critical role in energy metabolism. |
| Catalytic activity | AMP + H2O = IMP + NH3. |
| Pathway | Purine metabolism; IMP biosynthesis via salvage pathway; IMP from AMP: step 1/1. |
| Subunit structure | Homotetramer By similarity. |
| Tissue specificity | Three isoforms are present in mammals: AMP deaminase 1 is the predominant form in skeletal muscle; AMP deaminase 2 predominates in smooth muscle, non-muscle tissue, embryonic muscle and undifferentiated myoblasts; AMP deaminase 3 is found in erythrocytes By similarity. |
| Sequence similarities | Belongs to the adenosine and AMP deaminases family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Nucleotide metabolism |
| Coding sequence diversity | Alternative splicing |
| Molecular function | Hydrolase |
| Gene Ontology (GO) | |
| Biological process | AMP catabolic process Ref.1 Traceable author statement. Source: RGD purine base metabolic processInferred from electronic annotation. Source: InterPro purine ribonucleoside monophosphate biosynthetic processInferred from electronic annotation. Source: InterPro |
| Molecular function | AMP deaminase activity Ref.1 Inferred from direct assay. Source: RGD |
| Complete GO annotation... | |
Alternative products
| This entry describes 1 isoform produced by alternative splicing. [Select] Note: A number of isoforms are produced. | ||||||
| Isoform 1 (identifier: O09178-1) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||
Molecule processing | |||||||
|---|---|---|---|---|---|---|---|
| Chain | 1 – 765 | 765 | AMP deaminase 3 | PRO_0000194412 | |||
Sequences
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References
| [1] | "Regulation of rat AMP deaminase 3 (isoform C) by development and skeletal muscle fibre type." Mahnke-Zizelman D.K., D'Cunha J., Wojnar J.M., Brogley M.A., Sabina R.L. Biochem. J. 326:521-529(1997) [PubMed: 9291127] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Heart. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| U90888 mRNA. Translation: AAC53348.1. Different initiation. | |
| IPI | IPI00231195. |
| RefSeq | NP_113732.1. |
| UniGene | Rn.11106 |
3D structure databases | |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | O09178. |
Genome annotation databases | |
| Ensembl | ENSRNOT00000024933; ENSRNOP00000024933; ENSRNOG00000018262; Rattus norvegicus. [Genome view] |
| GeneID | 25095. |
| KEGG | rno:25095. |
| UCSC | U90888. rat. |
Organism-specific databases | |
| CTD | 25095. |
| RGD | 2111. Ampd3. |
Phylogenomic databases | |
| HOVERGEN | O09178. |
Enzyme and pathway databases | |
| BRENDA | 3.5.4.6. 248. |
Gene expression databases | |
| ArrayExpress | O09178. |
| Genevestigator | O09178. |
| GermOnline | ENSRNOG00000018262. Rattus norvegicus. |
Family and domain databases | |
| InterPro | IPR006650. A/AMP_deam_AS. IPR001365. A/AMP_deaminase. IPR006329. AMP_deaminase. IPR016297. AMP_deaminase_met. [Graphical view] |
| Pfam | PF00962. A_deaminase. 1 hit. [Graphical view] |
| PIRSF | PIRSF001251. AMP_deaminase_met. 1 hit. |
| TIGRFAMs | TIGR01429. AMP_deaminase. 1 hit. |
| PROSITE | PS00485. A_DEAMINASE. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 605393. |
Entry information
| Entry name | AMPD3_RAT | ||||||||
| Accession | Primary (citable) accession number: O09178 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with


