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O09178

- AMPD3_RAT

UniProt

O09178 - AMPD3_RAT

Protein

AMP deaminase 3

Gene

Ampd3

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 96 (01 Oct 2014)
      Sequence version 2 (01 Nov 1997)
      Previous versions | rss
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    Functioni

    AMP deaminase plays a critical role in energy metabolism.

    Catalytic activityi

    AMP + H2O = IMP + NH3.

    Cofactori

    Binds 1 zinc ion per subunit.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi315 – 3151Zinc; catalyticBy similarity
    Metal bindingi317 – 3171Zinc; catalyticBy similarity
    Binding sitei317 – 3171SubstrateBy similarity
    Metal bindingi584 – 5841Zinc; catalyticBy similarity
    Binding sitei587 – 5871SubstrateBy similarity
    Active sitei606 – 6061Proton acceptorPROSITE-ProRule annotation
    Metal bindingi661 – 6611Zinc; catalyticBy similarity

    GO - Molecular functioni

    1. AMP deaminase activity Source: RGD
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. AMP catabolic process Source: RGD
    2. IMP salvage Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Nucleotide metabolism

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    UniPathwayiUPA00591; UER00663.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    AMP deaminase 3 (EC:3.5.4.6)
    Alternative name(s):
    AMP deaminase isoform E
    Gene namesi
    Name:Ampd3
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi2111. Ampd3.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 765765AMP deaminase 3PRO_0000194412Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei106 – 1061PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiO09178.
    PRIDEiO09178.

    Expressioni

    Tissue specificityi

    Three isoforms are present in mammals: AMP deaminase 1 is the predominant form in skeletal muscle; AMP deaminase 2 predominates in smooth muscle, non-muscle tissue, embryonic muscle and undifferentiated myoblasts; AMP deaminase 3 is found in erythrocytes.

    Gene expression databases

    GenevestigatoriO09178.

    Interactioni

    Subunit structurei

    Homotetramer.By similarity

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000024933.

    Structurei

    3D structure databases

    ProteinModelPortaliO09178.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni386 – 3916Substrate bindingBy similarity
    Regioni662 – 6654Substrate bindingBy similarity

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG1816.
    HOGENOMiHOG000092200.
    HOVERGENiHBG050494.
    InParanoidiO09178.
    KOiK01490.
    PhylomeDBiO09178.

    Family and domain databases

    InterProiIPR006650. A/AMP_deam_AS.
    IPR001365. A/AMP_deaminase_dom.
    IPR006329. AMPD.
    [Graphical view]
    PANTHERiPTHR11359. PTHR11359. 1 hit.
    PfamiPF00962. A_deaminase. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001251. AMP_deaminase_met. 1 hit.
    TIGRFAMsiTIGR01429. AMP_deaminase. 1 hit.
    PROSITEiPS00485. A_DEAMINASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    This entry describes 1 isoform i produced by alternative splicing. Align

    Note: A number of isoforms are produced.

    Isoform 1 (identifier: O09178-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MPRQFPKLNM SDLDEHVRLL AEKVFAKVLR EEDSKDVMSL FTVPKDCPIG    50
    QKEAKERELQ KELAEQKSVE TAKRKKSFKM IRSQSMSLQM PTQDWKGPPS 100
    VSPAMSPTTP LVLGAASKPG LAPYDMPEYQ RATISGDYCA GITMEDYEQA 150
    AKSLAKALMI REKYARLAYH RFPRTTAQYL AHQGESVPLE EGLPDFHPPP 200
    LPQEDPYCLD DAPPNLGYLV RMQGGVLFVY DNQTMLERQE PHSLPYPDLE 250
    TYIVDMSHIL ALITDGPTKT YCHRRLNFLE SKFSLHEMLN EMSEFKELKS 300
    NPHRDFYNVR KVDTHIHAAA CMNQKHLLRF IKYTYQTEPD RTVAEKLGRK 350
    ITLRQVFDSL HMDPYDLTVD SLDVHAGRQT FHGFDKFNSK YNPVGASELR 400
    DLYLKTENYL GGEYFARMVK EVARELEDSK YQYSEPRLSI YGRSPKEWSS 450
    LARWFIQHKV YSPNMRWIIQ VPRIYDIFRS KKLLPSFGKM LENIFLPLFQ 500
    ATINPQDHRE LHLFLKYVTG FDSVDDESKH SDHMFSDKSP SPDLWTSEQN 550
    PPYSYYLYYM YANIMVLNNL RRERGLSTFL FRPHCGEAGS ITHLVSAFLT 600
    ADNISHGLLL KKSPVLQYLY YLAQIPIAMS PLSNNSLFLE YSKNPLREFL 650
    HKGLHVSLST DDPMQFHYTK EALMEEYAIA AQVWKLSTCD LCEIARNSVL 700
    QSGLSHQEKQ KFLGQNYYKE GPEGNDIRKT NVAQIRMAFR YETLCNELSF 750
    LSDAMKSEEI TALAD 765
    Length:765
    Mass (Da):88,483
    Last modified:November 1, 1997 - v2
    Checksum:iF826FA5966221B09
    GO

    Sequence cautioni

    The sequence AAC53348.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U90888 mRNA. Translation: AAC53348.1. Different initiation.
    RefSeqiNP_113732.1. NM_031544.1.
    UniGeneiRn.11106.

    Genome annotation databases

    GeneIDi25095.
    KEGGirno:25095.
    UCSCiRGD:2111. rat. [O09178-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U90888 mRNA. Translation: AAC53348.1 . Different initiation.
    RefSeqi NP_113732.1. NM_031544.1.
    UniGenei Rn.11106.

    3D structure databases

    ProteinModelPortali O09178.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000024933.

    Proteomic databases

    PaxDbi O09178.
    PRIDEi O09178.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 25095.
    KEGGi rno:25095.
    UCSCi RGD:2111. rat. [O09178-1 ]

    Organism-specific databases

    CTDi 272.
    RGDi 2111. Ampd3.

    Phylogenomic databases

    eggNOGi COG1816.
    HOGENOMi HOG000092200.
    HOVERGENi HBG050494.
    InParanoidi O09178.
    KOi K01490.
    PhylomeDBi O09178.

    Enzyme and pathway databases

    UniPathwayi UPA00591 ; UER00663 .

    Miscellaneous databases

    NextBioi 605393.

    Gene expression databases

    Genevestigatori O09178.

    Family and domain databases

    InterProi IPR006650. A/AMP_deam_AS.
    IPR001365. A/AMP_deaminase_dom.
    IPR006329. AMPD.
    [Graphical view ]
    PANTHERi PTHR11359. PTHR11359. 1 hit.
    Pfami PF00962. A_deaminase. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001251. AMP_deaminase_met. 1 hit.
    TIGRFAMsi TIGR01429. AMP_deaminase. 1 hit.
    PROSITEi PS00485. A_DEAMINASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Regulation of rat AMP deaminase 3 (isoform C) by development and skeletal muscle fibre type."
      Mahnke-Zizelman D.K., D'Cunha J., Wojnar J.M., Brogley M.A., Sabina R.L.
      Biochem. J. 326:521-529(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Heart.

    Entry informationi

    Entry nameiAMPD3_RAT
    AccessioniPrimary (citable) accession number: O09178
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1997
    Last modified: October 1, 2014
    This is version 96 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3