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Protein

Alpha-methylacyl-CoA racemase

Gene

Amacr

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Racemization of 2-methyl-branched fatty acid CoA esters. Responsible for the conversion of pristanoyl-CoA and C27-bile acyl-CoAs to their (S)-stereoisomers.

Catalytic activityi

(2S)-2-methylacyl-CoA = (2R)-2-methylacyl-CoA.

Pathwayi: bile acid biosynthesis

This protein is involved in the pathway bile acid biosynthesis, which is part of Lipid metabolism.
View all proteins of this organism that are known to be involved in the pathway bile acid biosynthesis and in Lipid metabolism.

Pathwayi: fatty acid metabolism

This protein is involved in the pathway fatty acid metabolism, which is part of Lipid metabolism.
View all proteins of this organism that are known to be involved in the pathway fatty acid metabolism and in Lipid metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei151NucleophileBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase

Enzyme and pathway databases

BRENDAi5.1.99.4 3474
ReactomeiR-MMU-193368 Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
R-MMU-193775 Synthesis of bile acids and bile salts via 24-hydroxycholesterol
R-MMU-389887 Beta-oxidation of pristanoyl-CoA
R-MMU-9033241 Peroxisomal protein import
UniPathwayiUPA00199
UPA00221

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-methylacyl-CoA racemase (EC:5.1.99.4)
Alternative name(s):
2-methylacyl-CoA racemase
Gene namesi
Name:Amacr
Synonyms:Macr1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:1098273 Amacr

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion, Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001947062 – 381Alpha-methylacyl-CoA racemaseAdd BLAST380

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei57N6-acetyllysineCombined sources1
Modified residuei86N6-acetyllysine; alternateCombined sources1
Modified residuei86N6-succinyllysine; alternateCombined sources1
Modified residuei100N6-acetyllysine; alternateCombined sources1
Modified residuei100N6-succinyllysine; alternateCombined sources1
Modified residuei117N6-acetyllysineCombined sources1
Modified residuei267N6-succinyllysineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiO09174
MaxQBiO09174
PaxDbiO09174
PeptideAtlasiO09174
PRIDEiO09174

PTM databases

iPTMnetiO09174
PhosphoSitePlusiO09174

Expressioni

Gene expression databases

BgeeiENSMUSG00000022244
CleanExiMM_AMACR
GenevisibleiO09174 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

IntActiO09174, 5 interactors
MINTiO09174
STRINGi10090.ENSMUSP00000066915

Structurei

3D structure databases

ProteinModelPortaliO09174
SMRiO09174
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi379 – 381Microbody targeting signalBy similarity3

Sequence similaritiesi

Belongs to the CaiB/BaiF CoA-transferase family.Curated

Phylogenomic databases

eggNOGiKOG3957 Eukaryota
COG1804 LUCA
GeneTreeiENSGT00530000063418
HOGENOMiHOG000219744
HOVERGENiHBG060891
InParanoidiO09174
KOiK01796
OMAiYVASWLF
OrthoDBiEOG091G0FPV
TreeFamiTF314188

Family and domain databases

Gene3Di3.40.50.10540, 2 hits
InterProiView protein in InterPro
IPR003673 CoA-Trfase_fam_III
IPR023606 CoA-Trfase_III_dom_sf
PfamiView protein in Pfam
PF02515 CoA_transf_3, 1 hit
SUPFAMiSSF89796 SSF89796, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O09174-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVLRGVRVVE LAGLAPGPFC GMVLADFGAE VVRVNRLGST GENFLARGKR
60 70 80 90 100
SLALDLKRSQ GVTVLRRMCA RADVLLEPFR CGVMEKLQLG PETLLQDNPK
110 120 130 140 150
LIYARLSGFG QSGIFSKVAG HDINYLALSG VLSKIGRSGE NPYPPLNLLA
160 170 180 190 200
DFGGGGLMCT LGIVLALFER TRSGRGQVID SSMVEGTAYL SSFLWKTQPM
210 220 230 240 250
GLWKQPRGQN ILDGGAPFYT TYKTADGEFM AVGAIEPQFY ALLLKGLGLE
260 270 280 290 300
SEELPSQMSS ADWPEMKKKF ADVFAKKTKA EWCQIFDGTD ACVTPVLTFE
310 320 330 340 350
EALHHQHNRE RASFITDGEQ LPSPRPAPLL SRTPAVPSAK RDPSVGEHTV
360 370 380
EVLREYGFSQ EEILQLHSDR IVESDKLKAN L
Length:381
Mass (Da):41,704
Last modified:July 27, 2011 - v4
Checksum:i97FD19F9553FFE99
GO

Sequence cautioni

The sequence AAB72146 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti178V → I in AAB72146 (PubMed:9307041).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK048249 mRNA Translation: BAC33284.1
AK002401 mRNA Translation: BAB22072.2
U89906 mRNA Translation: AAB72146.1 Different initiation.
CCDSiCCDS27381.1
RefSeqiNP_032563.2, NM_008537.4
UniGeneiMm.2787

Genome annotation databases

EnsembliENSMUST00000070877; ENSMUSP00000066915; ENSMUSG00000022244
GeneIDi17117
KEGGimmu:17117
UCSCiuc007vgw.1 mouse

Similar proteinsi

Entry informationi

Entry nameiAMACR_MOUSE
AccessioniPrimary (citable) accession number: O09174
Secondary accession number(s): Q543Q9, Q9DCW6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: July 27, 2011
Last modified: June 20, 2018
This is version 149 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

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