Reviewed,
UniProtKB/Swiss-Prot O09173 (HGD_MOUSE)
Last modified
October 13, 2009.
Version 72.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Homogentisate 1,2-dioxygenase EC=1.13.11.5 Alternative name(s): Homogentisic acid oxidase Homogentisate oxygenase Homogentisicase | ||||
| Gene names |
| ||||
| Organism | Mus musculus (Mouse) | ||||
| Taxonomic identifier | 10090 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus |
Protein attributes
| Sequence length | 445 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Catalytic activity | Homogentisate + O2 = 4-maleylacetoacetate. |
| Cofactor | Iron. |
| Pathway | |
| Subunit structure | Homotrimer Probable. |
| Involvement in disease | Defects in Hgd are the cause of alkaptonuria (aku). Aku is an autosomal recessive error of metabolism which is characterized by an increase in the level of homogentisic acid. |
| Sequence similarities | Belongs to the homogentisate dioxygenase family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Phenylalanine catabolism Tyrosine catabolism |
| Ligand | Iron Metal-binding |
| Molecular function | Dioxygenase Oxidoreductase |
| PTM | Acetylation |
| Technical term | Direct protein sequencing |
| Gene Ontology (GO) | |
| Biological process | L-phenylalanine catabolic process Inferred from electronic annotation. Source: UniProtKB-KW oxidation reductionInferred from electronic annotation. Source: UniProtKB-KW tyrosine catabolic processInferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | homogentisate 1,2-dioxygenase activity Inferred from electronic annotation. Source: EC iron ion bindingInferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 445 | 445 | Homogentisate 1,2-dioxygenase | PRO_0000220241 | |||||
Sites | |||||||||
| Metal binding | 335 | 1 | Iron By similarity | ||||||
| Metal binding | 341 | 1 | Iron By similarity | ||||||
| Metal binding | 371 | 1 | Iron By similarity | ||||||
Amino acid modifications | |||||||||
| Modified residue | 98 | 1 | N6-acetyllysine By similarity | ||||||
Sequences
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References
| [1] | "Cloning of the homogentisate 1,2-dioxygenase gene, the key enzyme of alkaptonuria in mouse." Schmidt S.R., Gehrig A., Koehler M.R., Schmid M., Mueller C.R., Kress W. Mamm. Genome 8:168-171(1997) [PubMed: 9069115] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE. Strain: C57BL/6 X CBA. Tissue: Liver. |
| [2] | "Murine liver homogentisate 1,2-dioxygenase. Purification to homogeneity and novel biochemical properties." Schmidt S.R., Muller C.R., Kress W. Eur. J. Biochem. 228:425-430(1995) [PubMed: 7705358] [Abstract] Cited for: CHARACTERIZATION. Tissue: Liver. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| U58988 mRNA. Translation: AAC53224.1. | |
| IPI | IPI00114330. |
| UniGene | Mm.157442 |
3D structure databases | |
| HSSP | HSSP built from PDB template 1EYB based on UniProtKB Q93099. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | O09173. |
Proteomic databases | |
| PRIDE | O09173. |
Genome annotation databases | |
| Ensembl | ENSMUST00000023519; ENSMUSP00000023519; ENSMUSG00000022821; Mus musculus. [Genome view] |
| UCSC | uc007zeg.1. mouse. |
Organism-specific databases | |
| CTD | 15233. |
| MGI | MGI:96078. Hgd. |
Phylogenomic databases | |
| HOGENOM | O09173. |
| HOVERGEN | O09173. |
Enzyme and pathway databases | |
| BRENDA | 1.13.11.5. 244. |
Gene expression databases | |
| ArrayExpress | O09173. |
| Bgee | O09173. |
| CleanEx | MM_HGD. |
| Genevestigator | O09173. |
| GermOnline | ENSMUSG00000022821. Mus musculus. |
Family and domain databases | |
| InterPro | IPR005708. Homogentis_dOase. [Graphical view] |
| PANTHER | PTHR11056. Homogentis_dOase. 1 hit. |
| Pfam | PF04209. HgmA. 1 hit. [Graphical view] |
| TIGRFAMs | TIGR01015. hmgA. 1 hit. |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 287827. |
| SOURCE | Search... |
Entry information
| Entry name | HGD_MOUSE | ||||||||
| Accession | Primary (citable) accession number: O09173 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| MGD cross-references Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot |
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with


