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O09164

- SODE_MOUSE

UniProt

O09164 - SODE_MOUSE

Protein

Extracellular superoxide dismutase [Cu-Zn]

Gene

Sod3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 126 (01 Oct 2014)
      Sequence version 1 (01 Jul 1997)
      Previous versions | rss
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    Functioni

    Protect the extracellular space from toxic effect of reactive oxygen intermediates by converting superoxide radicals into hydrogen peroxide and oxygen.By similarity

    Catalytic activityi

    2 superoxide + 2 H+ = O2 + H2O2.

    Cofactori

    Binds 1 copper ion per subunit.By similarity
    Binds 1 zinc ion per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi128 – 1281Copper; catalyticBy similarity
    Metal bindingi130 – 1301Copper; catalyticBy similarity
    Metal bindingi145 – 1451Copper; catalyticBy similarity
    Metal bindingi145 – 1451Zinc; structuralBy similarity
    Metal bindingi153 – 1531Zinc; structuralBy similarity
    Metal bindingi156 – 1561Zinc; structuralBy similarity
    Metal bindingi159 – 1591Zinc; structuralBy similarity
    Metal bindingi195 – 1951Copper; catalyticBy similarity

    GO - Molecular functioni

    1. copper ion binding Source: RefGenome
    2. protein binding Source: MGI
    3. superoxide dismutase activity Source: MGI
    4. zinc ion binding Source: RefGenome

    GO - Biological processi

    1. removal of superoxide radicals Source: RefGenome
    2. response to copper ion Source: Ensembl
    3. response to hypoxia Source: MGI

    Keywords - Molecular functioni

    Antioxidant, Oxidoreductase

    Keywords - Ligandi

    Copper, Metal-binding, Zinc

    Enzyme and pathway databases

    ReactomeiREACT_189141. Detoxification of Reactive Oxygen Species.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Extracellular superoxide dismutase [Cu-Zn] (EC:1.15.1.1)
    Short name:
    EC-SOD
    Gene namesi
    Name:Sod3
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 5

    Organism-specific databases

    MGIiMGI:103181. Sod3.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: RefGenome
    2. extracellular matrix Source: Ensembl
    3. extracellular space Source: MGI
    4. Golgi lumen Source: Reactome
    5. nucleus Source: Ensembl
    6. trans-Golgi network Source: MGI

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1515By similarityAdd
    BLAST
    Propeptidei16 – 2491 PublicationPRO_0000032856
    Chaini25 – 251227Extracellular superoxide dismutase [Cu-Zn]PRO_0000032857Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi77 ↔ 222By similarity
    Glycosylationi121 – 1211N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi139 ↔ 221By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    MaxQBiO09164.
    PaxDbiO09164.
    PRIDEiO09164.

    PTM databases

    PhosphoSiteiO09164.

    Expressioni

    Gene expression databases

    ArrayExpressiO09164.
    BgeeiO09164.
    CleanExiMM_SOD3.
    GenevestigatoriO09164.

    Interactioni

    Protein-protein interaction databases

    BioGridi203389. 1 interaction.
    IntActiO09164. 1 interaction.
    MINTiMINT-4135206.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2DZ2model-A120-228[»]
    2DZ3model-A84-228[»]
    ProteinModelPortaliO09164.
    SMRiO09164. Positions 73-235.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the Cu-Zn superoxide dismutase family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG2032.
    HOGENOMiHOG000263447.
    HOVERGENiHBG000062.
    InParanoidiO09164.
    KOiK16627.
    OMAiHPRHPGD.
    OrthoDBiEOG77HDHG.
    PhylomeDBiO09164.
    TreeFamiTF105133.

    Family and domain databases

    Gene3Di2.60.40.200. 1 hit.
    InterProiIPR018152. SOD_Cu/Zn_BS.
    IPR024141. SOD_Cu/Zn_extracel.
    IPR001424. SOD_Cu_Zn_dom.
    [Graphical view]
    PANTHERiPTHR10003:SF36. PTHR10003:SF36. 1 hit.
    PfamiPF00080. Sod_Cu. 1 hit.
    [Graphical view]
    PRINTSiPR00068. CUZNDISMTASE.
    SUPFAMiSSF49329. SSF49329. 1 hit.
    PROSITEiPS00087. SOD_CU_ZN_1. 1 hit.
    PS00332. SOD_CU_ZN_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O09164-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLAFLFYGLL LAACGSVTMS NPGESSFDLA DRLDPVEKID RLDLVEKIGD    50
    THAKVLEIWM ELGRRREVDA AEMHAICRVQ PSATLPPDQP QITGLVLFRQ 100
    LGPGSRLEAY FSLEGFPAEQ NASNRAIHVH EFGDLSQGCD STGPHYNPME 150
    VPHPQHPGDF GNFVVRNGQL WRHRVGLTAS LAGPHAILGR SVVVHAGEDD 200
    LGKGGNQASL QNGNAGRRLA CCVVGTSSSA AWESQTKERK KRRRESECKT 250
    T 251
    Length:251
    Mass (Da):27,392
    Last modified:July 1, 1997 - v1
    Checksum:i9EAF850E458966C4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U38261 mRNA. Translation: AAB51106.1.
    D50856 mRNA. Translation: BAA23493.1.
    AF223251 Genomic DNA. Translation: AAF27932.1.
    CCDSiCCDS19283.1.
    RefSeqiNP_035565.1. NM_011435.3.
    UniGeneiMm.2407.

    Genome annotation databases

    EnsembliENSMUST00000101208; ENSMUSP00000098768; ENSMUSG00000072941.
    GeneIDi20657.
    KEGGimmu:20657.
    UCSCiuc008xkl.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U38261 mRNA. Translation: AAB51106.1 .
    D50856 mRNA. Translation: BAA23493.1 .
    AF223251 Genomic DNA. Translation: AAF27932.1 .
    CCDSi CCDS19283.1.
    RefSeqi NP_035565.1. NM_011435.3.
    UniGenei Mm.2407.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2DZ2 model - A 120-228 [» ]
    2DZ3 model - A 84-228 [» ]
    ProteinModelPortali O09164.
    SMRi O09164. Positions 73-235.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 203389. 1 interaction.
    IntActi O09164. 1 interaction.
    MINTi MINT-4135206.

    PTM databases

    PhosphoSitei O09164.

    Proteomic databases

    MaxQBi O09164.
    PaxDbi O09164.
    PRIDEi O09164.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000101208 ; ENSMUSP00000098768 ; ENSMUSG00000072941 .
    GeneIDi 20657.
    KEGGi mmu:20657.
    UCSCi uc008xkl.1. mouse.

    Organism-specific databases

    CTDi 6649.
    MGIi MGI:103181. Sod3.

    Phylogenomic databases

    eggNOGi COG2032.
    HOGENOMi HOG000263447.
    HOVERGENi HBG000062.
    InParanoidi O09164.
    KOi K16627.
    OMAi HPRHPGD.
    OrthoDBi EOG77HDHG.
    PhylomeDBi O09164.
    TreeFami TF105133.

    Enzyme and pathway databases

    Reactomei REACT_189141. Detoxification of Reactive Oxygen Species.

    Miscellaneous databases

    NextBioi 299089.
    PROi O09164.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O09164.
    Bgeei O09164.
    CleanExi MM_SOD3.
    Genevestigatori O09164.

    Family and domain databases

    Gene3Di 2.60.40.200. 1 hit.
    InterProi IPR018152. SOD_Cu/Zn_BS.
    IPR024141. SOD_Cu/Zn_extracel.
    IPR001424. SOD_Cu_Zn_dom.
    [Graphical view ]
    PANTHERi PTHR10003:SF36. PTHR10003:SF36. 1 hit.
    Pfami PF00080. Sod_Cu. 1 hit.
    [Graphical view ]
    PRINTSi PR00068. CUZNDISMTASE.
    SUPFAMi SSF49329. SSF49329. 1 hit.
    PROSITEi PS00087. SOD_CU_ZN_1. 1 hit.
    PS00332. SOD_CU_ZN_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Mouse extracellular superoxide dismutase: primary structure, tissue-specific gene expression, chromosomal localization, and lung in situ hybridization."
      Folz R.J., Guan J., Seldin M.F., Oury T.D., Enghild J.J., Crapo J.D.
      Am. J. Respir. Cell Mol. Biol. 17:393-403(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 25-36.
      Strain: C57BL/6 X CBA.
      Tissue: Lung.
    2. "Sequence analysis, tissue expression and chromosomal localization of a mouse secreted superoxide dismutase gene."
      Suh J.-G., Takai S., Yamanishi T., Kikuchi T., Folz R.J., Tanaka K., Oh Y.-S., Wada K.
      Mol. Cells 7:204-207(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: C57BL/6J.
      Tissue: Kidney.
    3. "Murine extracellular superoxide dismutase genomic sequence."
      Siegfried M.R., Schultz D., Harrison D.G., Fukai T.
      Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6.
      Tissue: Liver.

    Entry informationi

    Entry nameiSODE_MOUSE
    AccessioniPrimary (citable) accession number: O09164
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: July 1, 1997
    Last modified: October 1, 2014
    This is version 126 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3