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Protein

Extracellular superoxide dismutase [Cu-Zn]

Gene

Sod3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Protect the extracellular space from toxic effect of reactive oxygen intermediates by converting superoxide radicals into hydrogen peroxide and oxygen.By similarity

Catalytic activityi

2 superoxide + 2 H+ = O2 + H2O2.

Cofactori

Protein has several cofactor binding sites:
  • Cu cationBy similarityNote: Binds 1 copper ion per subunit.By similarity
  • Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi128Copper; catalyticBy similarity1
Metal bindingi130Copper; catalyticBy similarity1
Metal bindingi145Copper; catalyticBy similarity1
Metal bindingi145Zinc; structuralBy similarity1
Metal bindingi153Zinc; structuralBy similarity1
Metal bindingi156Zinc; structuralBy similarity1
Metal bindingi159Zinc; structuralBy similarity1
Metal bindingi195Copper; catalyticBy similarity1

GO - Molecular functioni

  • copper ion binding Source: GO_Central
  • superoxide dismutase activity Source: MGI
  • zinc ion binding Source: GO_Central

GO - Biological processi

  • response to copper ion Source: Ensembl
  • response to hypoxia Source: MGI
  • response to reactive oxygen species Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Antioxidant, Oxidoreductase

Keywords - Ligandi

Copper, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-MMU-3299685. Detoxification of Reactive Oxygen Species.

Names & Taxonomyi

Protein namesi
Recommended name:
Extracellular superoxide dismutase [Cu-Zn] (EC:1.15.1.1)
Short name:
EC-SOD
Gene namesi
Name:Sod3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:103181. Sod3.

Subcellular locationi

GO - Cellular componenti

  • extracellular exosome Source: MGI
  • extracellular matrix Source: Ensembl
  • extracellular space Source: MGI
  • Golgi lumen Source: Reactome
  • nucleus Source: Ensembl
  • trans-Golgi network Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 15By similarityAdd BLAST15
PropeptideiPRO_000003285616 – 241 Publication9
ChainiPRO_000003285725 – 251Extracellular superoxide dismutase [Cu-Zn]Add BLAST227

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi77 ↔ 222By similarity
Glycosylationi121N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi139 ↔ 221By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiO09164.
PaxDbiO09164.
PeptideAtlasiO09164.
PRIDEiO09164.

PTM databases

iPTMnetiO09164.
PhosphoSitePlusiO09164.
SwissPalmiO09164.
UniCarbKBiO09164.

Expressioni

Gene expression databases

BgeeiENSMUSG00000072941.
CleanExiMM_SOD3.
ExpressionAtlasiO09164. baseline and differential.
GenevisibleiO09164. MM.

Interactioni

Protein-protein interaction databases

BioGridi203389. 1 interactor.
IntActiO09164. 1 interactor.
MINTiMINT-4135206.
STRINGi10090.ENSMUSP00000098768.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DZ2model-A120-228[»]
2DZ3model-A84-228[»]
ProteinModelPortaliO09164.
SMRiO09164.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Cu-Zn superoxide dismutase family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG0441. Eukaryota.
COG2032. LUCA.
GeneTreeiENSGT00530000063226.
HOGENOMiHOG000263447.
HOVERGENiHBG000062.
InParanoidiO09164.
KOiK16627.
OMAiHPRHPGD.
OrthoDBiEOG091G13ID.
PhylomeDBiO09164.
TreeFamiTF105133.

Family and domain databases

CDDicd00305. Cu-Zn_Superoxide_Dismutase. 1 hit.
Gene3Di2.60.40.200. 1 hit.
InterProiIPR024134. SOD_Cu/Zn_/chaperone.
IPR018152. SOD_Cu/Zn_BS.
IPR001424. SOD_Cu_Zn_dom.
[Graphical view]
PANTHERiPTHR10003. PTHR10003. 1 hit.
PfamiPF00080. Sod_Cu. 1 hit.
[Graphical view]
PRINTSiPR00068. CUZNDISMTASE.
SUPFAMiSSF49329. SSF49329. 1 hit.
PROSITEiPS00087. SOD_CU_ZN_1. 1 hit.
PS00332. SOD_CU_ZN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O09164-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLAFLFYGLL LAACGSVTMS NPGESSFDLA DRLDPVEKID RLDLVEKIGD
60 70 80 90 100
THAKVLEIWM ELGRRREVDA AEMHAICRVQ PSATLPPDQP QITGLVLFRQ
110 120 130 140 150
LGPGSRLEAY FSLEGFPAEQ NASNRAIHVH EFGDLSQGCD STGPHYNPME
160 170 180 190 200
VPHPQHPGDF GNFVVRNGQL WRHRVGLTAS LAGPHAILGR SVVVHAGEDD
210 220 230 240 250
LGKGGNQASL QNGNAGRRLA CCVVGTSSSA AWESQTKERK KRRRESECKT

T
Length:251
Mass (Da):27,392
Last modified:July 1, 1997 - v1
Checksum:i9EAF850E458966C4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U38261 mRNA. Translation: AAB51106.1.
D50856 mRNA. Translation: BAA23493.1.
AF223251 Genomic DNA. Translation: AAF27932.1.
CCDSiCCDS19283.1.
RefSeqiNP_035565.1. NM_011435.3.
UniGeneiMm.2407.

Genome annotation databases

EnsembliENSMUST00000101208; ENSMUSP00000098768; ENSMUSG00000072941.
GeneIDi20657.
KEGGimmu:20657.
UCSCiuc008xkl.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U38261 mRNA. Translation: AAB51106.1.
D50856 mRNA. Translation: BAA23493.1.
AF223251 Genomic DNA. Translation: AAF27932.1.
CCDSiCCDS19283.1.
RefSeqiNP_035565.1. NM_011435.3.
UniGeneiMm.2407.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DZ2model-A120-228[»]
2DZ3model-A84-228[»]
ProteinModelPortaliO09164.
SMRiO09164.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi203389. 1 interactor.
IntActiO09164. 1 interactor.
MINTiMINT-4135206.
STRINGi10090.ENSMUSP00000098768.

PTM databases

iPTMnetiO09164.
PhosphoSitePlusiO09164.
SwissPalmiO09164.
UniCarbKBiO09164.

Proteomic databases

EPDiO09164.
PaxDbiO09164.
PeptideAtlasiO09164.
PRIDEiO09164.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000101208; ENSMUSP00000098768; ENSMUSG00000072941.
GeneIDi20657.
KEGGimmu:20657.
UCSCiuc008xkl.1. mouse.

Organism-specific databases

CTDi6649.
MGIiMGI:103181. Sod3.

Phylogenomic databases

eggNOGiKOG0441. Eukaryota.
COG2032. LUCA.
GeneTreeiENSGT00530000063226.
HOGENOMiHOG000263447.
HOVERGENiHBG000062.
InParanoidiO09164.
KOiK16627.
OMAiHPRHPGD.
OrthoDBiEOG091G13ID.
PhylomeDBiO09164.
TreeFamiTF105133.

Enzyme and pathway databases

ReactomeiR-MMU-3299685. Detoxification of Reactive Oxygen Species.

Miscellaneous databases

PROiO09164.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000072941.
CleanExiMM_SOD3.
ExpressionAtlasiO09164. baseline and differential.
GenevisibleiO09164. MM.

Family and domain databases

CDDicd00305. Cu-Zn_Superoxide_Dismutase. 1 hit.
Gene3Di2.60.40.200. 1 hit.
InterProiIPR024134. SOD_Cu/Zn_/chaperone.
IPR018152. SOD_Cu/Zn_BS.
IPR001424. SOD_Cu_Zn_dom.
[Graphical view]
PANTHERiPTHR10003. PTHR10003. 1 hit.
PfamiPF00080. Sod_Cu. 1 hit.
[Graphical view]
PRINTSiPR00068. CUZNDISMTASE.
SUPFAMiSSF49329. SSF49329. 1 hit.
PROSITEiPS00087. SOD_CU_ZN_1. 1 hit.
PS00332. SOD_CU_ZN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSODE_MOUSE
AccessioniPrimary (citable) accession number: O09164
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 1, 1997
Last modified: November 2, 2016
This is version 147 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.