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O09158 (CP3AP_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 116. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome P450 3A25

EC=1.14.14.1
Alternative name(s):
CYPIIIA25
Gene names
Name:Cyp3a25
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length503 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Catalytic activity

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactor

Heme group By similarity.

Subcellular location

Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Induction

P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.

Sequence similarities

Belongs to the cytochrome P450 family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 503503Cytochrome P450 3A25
PRO_0000051805

Sites

Metal binding4421Iron (heme axial ligand) By similarity

Sequences

Sequence LengthMass (Da)Tools
O09158 [UniParc].

Last modified July 1, 1997. Version 1.
Checksum: 9EE9EAF1746595C8

FASTA50358,122
        10         20         30         40         50         60 
MELIPNLSIE TWVLLVTSLV LFYIYGTYSH GLFKKLGIPG PKPLPLLGTI FNYYDGMWKF 

        70         80         90        100        110        120 
DEDCYKKYGK IWGFYEGPQP ILAIMDPEII KIVLVKECYS VFTNRRFFGP VGFMKKAITI 

       130        140        150        160        170        180 
SEDEEWKRLR TLLSPTFTSG KLKEMFPIMR QYGDILVRNL RREEEKGEPI SMKDIFGAYS 

       190        200        210        220        230        240 
MDVITGTSFG VNVDSLNNPQ DPFVQKAKKI LKFKIFDPFL LSIILFPFLT PIYEMLNFSI 

       250        260        270        280        290        300 
FPRDSMNFFK KFVKRMKKER LASNQKNRVD FLQLMMNTQN SKGQESQKAL SDLEMAAQAV 

       310        320        330        340        350        360 
IFIFGGYDAT STSISLIMYE LATHPDVQKK LQDEIDRTLP NKAPVTYDAL MDMEYLDMVV 

       370        380        390        400        410        420 
NESLRLYPIA IRLERVSKKD VEINGVFIPK GTVVMIPIYP LHRNPEYWPE PQEFCPERFS 

       430        440        450        460        470        480 
KENKGNIDPY IYMPFGNGPR NCIGMRFALI SIKLAVIGVL QNFTVQPCEE TQIPLKISRE 

       490        500 
PIFQPEKPII LKVVSRDKPR TGS 

« Hide

References

« Hide 'large scale' references
[1]Mahnke A., Roos P., Hanstein W.G.
Submitted (MAR-1997) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N.
Tissue: Liver.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Y11995 mRNA. Translation: CAA72720.1.
BC028855 mRNA. Translation: AAH28855.1.
RefSeqNP_062766.2. NM_019792.2.
UniGeneMm.301900.
Mm.384461.

3D structure databases

ProteinModelPortalO09158.
SMRO09158. Positions 28-497.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000065585.

PTM databases

PhosphoSiteO09158.

Proteomic databases

PaxDbO09158.
PRIDEO09158.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000068317; ENSMUSP00000065585; ENSMUSG00000029630.
GeneID56388.
KEGGmmu:56388.
UCSCuc009amz.2. mouse.

Organism-specific databases

CTD56388.
MGIMGI:1930638. Cyp3a25.

Phylogenomic databases

eggNOGCOG2124.
GeneTreeENSGT00730000110610.
HOGENOMHOG000039127.
HOVERGENHBG108567.
InParanoidO09158.
KOK07424.
OMAFMKKAIT.
PhylomeDBO09158.
TreeFamTF105087.

Gene expression databases

BgeeO09158.
GenevestigatorO09158.

Family and domain databases

Gene3D1.10.630.10. 1 hit.
InterProIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR008072. Cyt_P450_E_CYP3A.
IPR002402. Cyt_P450_E_grp-II.
[Graphical view]
PfamPF00067. p450. 1 hit.
[Graphical view]
PRINTSPR00464. EP450II.
PR01689. EP450IICYP3A.
PR00385. P450.
SUPFAMSSF48264. SSF48264. 1 hit.
PROSITEPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio312480.
PROO09158.
SOURCESearch...

Entry information

Entry nameCP3AP_MOUSE
AccessionPrimary (citable) accession number: O09158
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: July 1, 1997
Last modified: April 16, 2014
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot