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O09158

- CP3AP_MOUSE

UniProt

O09158 - CP3AP_MOUSE

Protein

Cytochrome P450 3A25

Gene

Cyp3a25

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 120 (01 Oct 2014)
      Sequence version 1 (01 Jul 1997)
      Previous versions | rss
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    Functioni

    Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

    Catalytic activityi

    RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

    Cofactori

    Heme group.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi442 – 4421Iron (heme axial ligand)By similarity

    GO - Molecular functioni

    1. aromatase activity Source: UniProtKB-EC
    2. heme binding Source: InterPro
    3. iron ion binding Source: InterPro

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Enzyme and pathway databases

    ReactomeiREACT_216259. Miscellaneous substrates.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome P450 3A25 (EC:1.14.14.1)
    Alternative name(s):
    CYPIIIA25
    Gene namesi
    Name:Cyp3a25
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 5

    Organism-specific databases

    MGIiMGI:1930638. Cyp3a25.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Microsome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 503503Cytochrome P450 3A25PRO_0000051805Add
    BLAST

    Proteomic databases

    MaxQBiO09158.
    PaxDbiO09158.
    PRIDEiO09158.

    PTM databases

    PhosphoSiteiO09158.

    Expressioni

    Inductioni

    P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.

    Gene expression databases

    BgeeiO09158.
    GenevestigatoriO09158.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000065585.

    Structurei

    3D structure databases

    ProteinModelPortaliO09158.
    SMRiO09158. Positions 28-497.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome P450 family.Curated

    Phylogenomic databases

    eggNOGiCOG2124.
    GeneTreeiENSGT00730000110610.
    HOGENOMiHOG000039127.
    HOVERGENiHBG108567.
    InParanoidiO09158.
    KOiK07424.
    OMAiFMKKAIT.
    PhylomeDBiO09158.
    TreeFamiTF105087.

    Family and domain databases

    Gene3Di1.10.630.10. 1 hit.
    InterProiIPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR008072. Cyt_P450_E_CYP3A.
    IPR002402. Cyt_P450_E_grp-II.
    [Graphical view]
    PfamiPF00067. p450. 1 hit.
    [Graphical view]
    PRINTSiPR00464. EP450II.
    PR01689. EP450IICYP3A.
    PR00385. P450.
    SUPFAMiSSF48264. SSF48264. 1 hit.
    PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O09158-1 [UniParc]FASTAAdd to Basket

    « Hide

    MELIPNLSIE TWVLLVTSLV LFYIYGTYSH GLFKKLGIPG PKPLPLLGTI    50
    FNYYDGMWKF DEDCYKKYGK IWGFYEGPQP ILAIMDPEII KIVLVKECYS 100
    VFTNRRFFGP VGFMKKAITI SEDEEWKRLR TLLSPTFTSG KLKEMFPIMR 150
    QYGDILVRNL RREEEKGEPI SMKDIFGAYS MDVITGTSFG VNVDSLNNPQ 200
    DPFVQKAKKI LKFKIFDPFL LSIILFPFLT PIYEMLNFSI FPRDSMNFFK 250
    KFVKRMKKER LASNQKNRVD FLQLMMNTQN SKGQESQKAL SDLEMAAQAV 300
    IFIFGGYDAT STSISLIMYE LATHPDVQKK LQDEIDRTLP NKAPVTYDAL 350
    MDMEYLDMVV NESLRLYPIA IRLERVSKKD VEINGVFIPK GTVVMIPIYP 400
    LHRNPEYWPE PQEFCPERFS KENKGNIDPY IYMPFGNGPR NCIGMRFALI 450
    SIKLAVIGVL QNFTVQPCEE TQIPLKISRE PIFQPEKPII LKVVSRDKPR 500
    TGS 503
    Length:503
    Mass (Da):58,122
    Last modified:July 1, 1997 - v1
    Checksum:i9EE9EAF1746595C8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y11995 mRNA. Translation: CAA72720.1.
    BC028855 mRNA. Translation: AAH28855.1.
    CCDSiCCDS19866.1.
    RefSeqiNP_062766.2. NM_019792.2.
    UniGeneiMm.301900.
    Mm.384461.

    Genome annotation databases

    EnsembliENSMUST00000068317; ENSMUSP00000065585; ENSMUSG00000029630.
    GeneIDi56388.
    KEGGimmu:56388.
    UCSCiuc009amz.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y11995 mRNA. Translation: CAA72720.1 .
    BC028855 mRNA. Translation: AAH28855.1 .
    CCDSi CCDS19866.1.
    RefSeqi NP_062766.2. NM_019792.2.
    UniGenei Mm.301900.
    Mm.384461.

    3D structure databases

    ProteinModelPortali O09158.
    SMRi O09158. Positions 28-497.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000065585.

    PTM databases

    PhosphoSitei O09158.

    Proteomic databases

    MaxQBi O09158.
    PaxDbi O09158.
    PRIDEi O09158.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000068317 ; ENSMUSP00000065585 ; ENSMUSG00000029630 .
    GeneIDi 56388.
    KEGGi mmu:56388.
    UCSCi uc009amz.2. mouse.

    Organism-specific databases

    CTDi 56388.
    MGIi MGI:1930638. Cyp3a25.

    Phylogenomic databases

    eggNOGi COG2124.
    GeneTreei ENSGT00730000110610.
    HOGENOMi HOG000039127.
    HOVERGENi HBG108567.
    InParanoidi O09158.
    KOi K07424.
    OMAi FMKKAIT.
    PhylomeDBi O09158.
    TreeFami TF105087.

    Enzyme and pathway databases

    Reactomei REACT_216259. Miscellaneous substrates.

    Miscellaneous databases

    NextBioi 312480.
    PROi O09158.
    SOURCEi Search...

    Gene expression databases

    Bgeei O09158.
    Genevestigatori O09158.

    Family and domain databases

    Gene3Di 1.10.630.10. 1 hit.
    InterProi IPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR008072. Cyt_P450_E_CYP3A.
    IPR002402. Cyt_P450_E_grp-II.
    [Graphical view ]
    Pfami PF00067. p450. 1 hit.
    [Graphical view ]
    PRINTSi PR00464. EP450II.
    PR01689. EP450IICYP3A.
    PR00385. P450.
    SUPFAMi SSF48264. SSF48264. 1 hit.
    PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Mahnke A., Roos P., Hanstein W.G.
      Submitted (MAR-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Liver.

    Entry informationi

    Entry nameiCP3AP_MOUSE
    AccessioniPrimary (citable) accession number: O09158
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1999
    Last sequence update: July 1, 1997
    Last modified: October 1, 2014
    This is version 120 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3