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O09158

- CP3AP_MOUSE

UniProt

O09158 - CP3AP_MOUSE

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Protein

Cytochrome P450 3A25

Gene

Cyp3a25

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Catalytic activityi

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi442 – 4421Iron (heme axial ligand)By similarity

GO - Molecular functioni

  1. aromatase activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_216259. Miscellaneous substrates.
REACT_237136. Aflatoxin activation and detoxification.
REACT_245291. Xenobiotics.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 3A25 (EC:1.14.14.1)
Alternative name(s):
CYPIIIA25
Gene namesi
Name:Cyp3a25
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 5

Organism-specific databases

MGIiMGI:1930638. Cyp3a25.

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB-KW
  2. membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 503503Cytochrome P450 3A25PRO_0000051805Add
BLAST

Proteomic databases

MaxQBiO09158.
PaxDbiO09158.
PRIDEiO09158.

PTM databases

PhosphoSiteiO09158.

Expressioni

Inductioni

P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.

Gene expression databases

BgeeiO09158.
ExpressionAtlasiO09158. baseline and differential.
GenevestigatoriO09158.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000065585.

Structurei

3D structure databases

ProteinModelPortaliO09158.
SMRiO09158. Positions 28-497.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

eggNOGiCOG2124.
GeneTreeiENSGT00760000118816.
HOGENOMiHOG000039127.
HOVERGENiHBG108567.
InParanoidiO09158.
KOiK07424.
OMAiFMKKAIT.
PhylomeDBiO09158.
TreeFamiTF105087.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR008072. Cyt_P450_E_CYP3A.
IPR002402. Cyt_P450_E_grp-II.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00464. EP450II.
PR01689. EP450IICYP3A.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O09158-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MELIPNLSIE TWVLLVTSLV LFYIYGTYSH GLFKKLGIPG PKPLPLLGTI
60 70 80 90 100
FNYYDGMWKF DEDCYKKYGK IWGFYEGPQP ILAIMDPEII KIVLVKECYS
110 120 130 140 150
VFTNRRFFGP VGFMKKAITI SEDEEWKRLR TLLSPTFTSG KLKEMFPIMR
160 170 180 190 200
QYGDILVRNL RREEEKGEPI SMKDIFGAYS MDVITGTSFG VNVDSLNNPQ
210 220 230 240 250
DPFVQKAKKI LKFKIFDPFL LSIILFPFLT PIYEMLNFSI FPRDSMNFFK
260 270 280 290 300
KFVKRMKKER LASNQKNRVD FLQLMMNTQN SKGQESQKAL SDLEMAAQAV
310 320 330 340 350
IFIFGGYDAT STSISLIMYE LATHPDVQKK LQDEIDRTLP NKAPVTYDAL
360 370 380 390 400
MDMEYLDMVV NESLRLYPIA IRLERVSKKD VEINGVFIPK GTVVMIPIYP
410 420 430 440 450
LHRNPEYWPE PQEFCPERFS KENKGNIDPY IYMPFGNGPR NCIGMRFALI
460 470 480 490 500
SIKLAVIGVL QNFTVQPCEE TQIPLKISRE PIFQPEKPII LKVVSRDKPR

TGS
Length:503
Mass (Da):58,122
Last modified:July 1, 1997 - v1
Checksum:i9EE9EAF1746595C8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y11995 mRNA. Translation: CAA72720.1.
BC028855 mRNA. Translation: AAH28855.1.
CCDSiCCDS19866.1.
RefSeqiNP_062766.2. NM_019792.2.
UniGeneiMm.301900.
Mm.384461.

Genome annotation databases

EnsembliENSMUST00000068317; ENSMUSP00000065585; ENSMUSG00000029630.
GeneIDi56388.
KEGGimmu:56388.
UCSCiuc009amz.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y11995 mRNA. Translation: CAA72720.1 .
BC028855 mRNA. Translation: AAH28855.1 .
CCDSi CCDS19866.1.
RefSeqi NP_062766.2. NM_019792.2.
UniGenei Mm.301900.
Mm.384461.

3D structure databases

ProteinModelPortali O09158.
SMRi O09158. Positions 28-497.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000065585.

PTM databases

PhosphoSitei O09158.

Proteomic databases

MaxQBi O09158.
PaxDbi O09158.
PRIDEi O09158.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000068317 ; ENSMUSP00000065585 ; ENSMUSG00000029630 .
GeneIDi 56388.
KEGGi mmu:56388.
UCSCi uc009amz.2. mouse.

Organism-specific databases

CTDi 56388.
MGIi MGI:1930638. Cyp3a25.

Phylogenomic databases

eggNOGi COG2124.
GeneTreei ENSGT00760000118816.
HOGENOMi HOG000039127.
HOVERGENi HBG108567.
InParanoidi O09158.
KOi K07424.
OMAi FMKKAIT.
PhylomeDBi O09158.
TreeFami TF105087.

Enzyme and pathway databases

Reactomei REACT_216259. Miscellaneous substrates.
REACT_237136. Aflatoxin activation and detoxification.
REACT_245291. Xenobiotics.

Miscellaneous databases

NextBioi 312480.
PROi O09158.
SOURCEi Search...

Gene expression databases

Bgeei O09158.
ExpressionAtlasi O09158. baseline and differential.
Genevestigatori O09158.

Family and domain databases

Gene3Di 1.10.630.10. 1 hit.
InterProi IPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR008072. Cyt_P450_E_CYP3A.
IPR002402. Cyt_P450_E_grp-II.
[Graphical view ]
Pfami PF00067. p450. 1 hit.
[Graphical view ]
PRINTSi PR00464. EP450II.
PR01689. EP450IICYP3A.
PR00385. P450.
SUPFAMi SSF48264. SSF48264. 1 hit.
PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Mahnke A., Roos P., Hanstein W.G.
    Submitted (MAR-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Liver.

Entry informationi

Entry nameiCP3AP_MOUSE
AccessioniPrimary (citable) accession number: O09158
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: July 1, 1997
Last modified: November 26, 2014
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3