Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Glutathione S-transferase omega-1

Gene

Gsto1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Exhibits glutathione-dependent thiol transferase and dehydroascorbate reductase activities. Has S-(phenacyl)glutathione reductase activity. Has also glutathione S-transferase activity. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA) and dimethylarsonic acid.By similarity

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.By similarity
2 glutathione + dehydroascorbate = glutathione disulfide + ascorbate.By similarity
Methylarsonate + 2 glutathione = methylarsonite + glutathione disulfide + H2O.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei32NucleophileBy similarity1
Binding sitei59GlutathioneBy similarity1
Binding sitei72Glutathione; via amide nitrogen and carbonyl oxygenBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase, Transferase

Enzyme and pathway databases

ReactomeiR-MMU-156581. Methylation.
R-MMU-156590. Glutathione conjugation.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione S-transferase omega-1 (EC:2.5.1.18By similarity)
Short name:
GSTO-1
Alternative name(s):
Glutathione S-transferase omega 1-1
Short name:
GSTO 1-1
Glutathione-dependent dehydroascorbate reductase (EC:1.8.5.1By similarity)
Monomethylarsonic acid reductase (EC:1.20.4.2By similarity)
Short name:
MMA(V) reductase
S-(Phenacyl)glutathione reductase
Short name:
SPG-R
p28
Gene namesi
Name:Gsto1
Synonyms:Gstx, Gtsttl
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:1342273. Gsto1.

Subcellular locationi

  • Cytoplasmcytosol By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001858852 – 240Glutathione S-transferase omega-1Add BLAST239

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Modified residuei57N6-acetyllysineBy similarity1
Modified residuei129PhosphoserineCombined sources1
Modified residuei152N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiO09131.
MaxQBiO09131.
PaxDbiO09131.
PeptideAtlasiO09131.
PRIDEiO09131.

2D gel databases

REPRODUCTION-2DPAGEIPI00114285.

PTM databases

iPTMnetiO09131.
PhosphoSitePlusiO09131.
SwissPalmiO09131.

Expressioni

Gene expression databases

BgeeiENSMUSG00000025068.
CleanExiMM_GSTO1.
GenevisibleiO09131. MM.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

BioGridi200104. 1 interactor.
IntActiO09131. 3 interactors.
MINTiMINT-1868625.
STRINGi10090.ENSMUSP00000026050.

Structurei

3D structure databases

ProteinModelPortaliO09131.
SMRiO09131.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini22 – 101GST N-terminalAdd BLAST80
Domaini106 – 227GST C-terminalAdd BLAST122

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni85 – 86Glutathione bindingBy similarity2

Sequence similaritiesi

Belongs to the GST superfamily. Omega family.Curated
Contains 1 GST C-terminal domain.Curated
Contains 1 GST N-terminal domain.Curated

Phylogenomic databases

eggNOGiKOG0406. Eukaryota.
ENOG410XSIX. LUCA.
GeneTreeiENSGT00390000005479.
HOGENOMiHOG000006560.
HOVERGENiHBG051853.
InParanoidiO09131.
KOiK00799.
OMAiIESLVIC.
OrthoDBiEOG091G0IEA.
PhylomeDBiO09131.
TreeFamiTF105325.

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR005442. GST_omega.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF00043. GST_C. 1 hit.
PF13417. GST_N_3. 1 hit.
[Graphical view]
PRINTSiPR01625. GSTRNSFRASEO.
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O09131-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGESSRSLG KGSAPPGPVP EGQIRVYSMR FCPFAQRTLM VLKAKGIRHE
60 70 80 90 100
VININLKNKP EWFFEKNPLG LVPVLENSQG HLVTESVITC EYLDEAYPEK
110 120 130 140 150
KLFPDDPYKK ARQKMTLESF SKVPPLIASF VRSKRKEDSP NLREALENEF
160 170 180 190 200
KKLEEGMDNY KSFLGGDSPS MVDYLTWPWF QRLEALELKE CLAHTPKLKL
210 220 230 240
WMAAMQQDPV ASSHKIDAKT YREYLNLYLQ DSPEACDYGL
Length:240
Mass (Da):27,498
Last modified:January 1, 1998 - v2
Checksum:i17FEB52DB4BBE506
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U80819 mRNA. Translation: AAB70110.1.
AK027922 mRNA. Translation: BAC25667.1.
AK146834 mRNA. Translation: BAE27469.1.
AK168383 mRNA. Translation: BAE40311.1.
BC085165 mRNA. Translation: AAH85165.1.
CCDSiCCDS29893.1.
RefSeqiNP_034492.1. NM_010362.3.
UniGeneiMm.378931.

Genome annotation databases

EnsembliENSMUST00000026050; ENSMUSP00000026050; ENSMUSG00000025068.
GeneIDi14873.
KEGGimmu:14873.
UCSCiuc008hvq.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U80819 mRNA. Translation: AAB70110.1.
AK027922 mRNA. Translation: BAC25667.1.
AK146834 mRNA. Translation: BAE27469.1.
AK168383 mRNA. Translation: BAE40311.1.
BC085165 mRNA. Translation: AAH85165.1.
CCDSiCCDS29893.1.
RefSeqiNP_034492.1. NM_010362.3.
UniGeneiMm.378931.

3D structure databases

ProteinModelPortaliO09131.
SMRiO09131.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi200104. 1 interactor.
IntActiO09131. 3 interactors.
MINTiMINT-1868625.
STRINGi10090.ENSMUSP00000026050.

PTM databases

iPTMnetiO09131.
PhosphoSitePlusiO09131.
SwissPalmiO09131.

2D gel databases

REPRODUCTION-2DPAGEIPI00114285.

Proteomic databases

EPDiO09131.
MaxQBiO09131.
PaxDbiO09131.
PeptideAtlasiO09131.
PRIDEiO09131.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000026050; ENSMUSP00000026050; ENSMUSG00000025068.
GeneIDi14873.
KEGGimmu:14873.
UCSCiuc008hvq.1. mouse.

Organism-specific databases

CTDi9446.
MGIiMGI:1342273. Gsto1.

Phylogenomic databases

eggNOGiKOG0406. Eukaryota.
ENOG410XSIX. LUCA.
GeneTreeiENSGT00390000005479.
HOGENOMiHOG000006560.
HOVERGENiHBG051853.
InParanoidiO09131.
KOiK00799.
OMAiIESLVIC.
OrthoDBiEOG091G0IEA.
PhylomeDBiO09131.
TreeFamiTF105325.

Enzyme and pathway databases

ReactomeiR-MMU-156581. Methylation.
R-MMU-156590. Glutathione conjugation.

Miscellaneous databases

PROiO09131.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000025068.
CleanExiMM_GSTO1.
GenevisibleiO09131. MM.

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR005442. GST_omega.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF00043. GST_C. 1 hit.
PF13417. GST_N_3. 1 hit.
[Graphical view]
PRINTSiPR01625. GSTRNSFRASEO.
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGSTO1_MOUSE
AccessioniPrimary (citable) accession number: O09131
Secondary accession number(s): Q3TH87
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: January 1, 1998
Last modified: November 2, 2016
This is version 143 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.