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O09131

- GSTO1_MOUSE

UniProt

O09131 - GSTO1_MOUSE

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Protein

Glutathione S-transferase omega-1

Gene

Gsto1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Exhibits glutathione-dependent thiol transferase and dehydroascorbate reductase activities. Has S-(phenacyl)glutathione reductase activity. Has also glutathione S-transferase activity. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA) and dimethylarsonic acid (By similarity).By similarity

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.
2 glutathione + dehydroascorbate = glutathione disulfide + ascorbate.
Methylarsonate + 2 glutathione = methylarsonite + glutathione disulfide + H2O.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei32 – 321NucleophileBy similarity
Binding sitei59 – 591GlutathioneBy similarity
Binding sitei72 – 721Glutathione; via amide nitrogen and carbonyl oxygenBy similarity

GO - Molecular functioni

  1. glutathione dehydrogenase (ascorbate) activity Source: UniProtKB
  2. glutathione transferase activity Source: UniProtKB
  3. methylarsonate reductase activity Source: UniProtKB-EC
  4. oxidoreductase activity Source: UniProtKB

GO - Biological processi

  1. cellular response to arsenic-containing substance Source: UniProtKB
  2. L-ascorbic acid metabolic process Source: UniProtKB
  3. negative regulation of ryanodine-sensitive calcium-release channel activity Source: Ensembl
  4. positive regulation of ryanodine-sensitive calcium-release channel activity Source: Ensembl
  5. regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum Source: Ensembl
  6. xenobiotic catabolic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase, Transferase

Enzyme and pathway databases

ReactomeiREACT_215316. Glutathione conjugation.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione S-transferase omega-1 (EC:2.5.1.18)
Short name:
GSTO-1
Alternative name(s):
Glutathione S-transferase omega 1-1
Short name:
GSTO 1-1
Glutathione-dependent dehydroascorbate reductase (EC:1.8.5.1)
Monomethylarsonic acid reductase (EC:1.20.4.2)
Short name:
MMA(V) reductase
S-(Phenacyl)glutathione reductase
Short name:
SPG-R
p28
Gene namesi
Name:Gsto1
Synonyms:Gstx, Gtsttl
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 19

Organism-specific databases

MGIiMGI:1342273. Gsto1.

Subcellular locationi

Cytoplasmcytosol By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. extracellular vesicular exosome Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 240239Glutathione S-transferase omega-1PRO_0000185885Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserineBy similarity
Modified residuei57 – 571N6-acetyllysineBy similarity
Modified residuei152 – 1521N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiO09131.
PaxDbiO09131.
PRIDEiO09131.

2D gel databases

REPRODUCTION-2DPAGEIPI00114285.

PTM databases

PhosphoSiteiO09131.

Expressioni

Gene expression databases

BgeeiO09131.
CleanExiMM_GSTO1.
GenevestigatoriO09131.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

IntActiO09131. 2 interactions.
MINTiMINT-1868625.
STRINGi10090.ENSMUSP00000026050.

Structurei

3D structure databases

ProteinModelPortaliO09131.
SMRiO09131. Positions 3-240.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini22 – 10180GST N-terminalAdd
BLAST
Domaini106 – 227122GST C-terminalAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni85 – 862Glutathione bindingBy similarity

Sequence similaritiesi

Belongs to the GST superfamily. Omega family.Curated
Contains 1 GST C-terminal domain.Curated
Contains 1 GST N-terminal domain.Curated

Phylogenomic databases

eggNOGiCOG0625.
GeneTreeiENSGT00390000005479.
HOGENOMiHOG000006560.
HOVERGENiHBG051853.
InParanoidiO09131.
KOiK00799.
OMAiAYANEMP.
OrthoDBiEOG71CFNG.
PhylomeDBiO09131.
TreeFamiTF105325.

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR005442. GST_omega.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF00043. GST_C. 1 hit.
PF13417. GST_N_3. 1 hit.
[Graphical view]
PRINTSiPR01625. GSTRNSFRASEO.
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O09131-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSGESSRSLG KGSAPPGPVP EGQIRVYSMR FCPFAQRTLM VLKAKGIRHE
60 70 80 90 100
VININLKNKP EWFFEKNPLG LVPVLENSQG HLVTESVITC EYLDEAYPEK
110 120 130 140 150
KLFPDDPYKK ARQKMTLESF SKVPPLIASF VRSKRKEDSP NLREALENEF
160 170 180 190 200
KKLEEGMDNY KSFLGGDSPS MVDYLTWPWF QRLEALELKE CLAHTPKLKL
210 220 230 240
WMAAMQQDPV ASSHKIDAKT YREYLNLYLQ DSPEACDYGL
Length:240
Mass (Da):27,498
Last modified:January 1, 1998 - v2
Checksum:i17FEB52DB4BBE506
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U80819 mRNA. Translation: AAB70110.1.
AK027922 mRNA. Translation: BAC25667.1.
AK146834 mRNA. Translation: BAE27469.1.
AK168383 mRNA. Translation: BAE40311.1.
BC085165 mRNA. Translation: AAH85165.1.
CCDSiCCDS29893.1.
RefSeqiNP_034492.1. NM_010362.2.
UniGeneiMm.378931.

Genome annotation databases

EnsembliENSMUST00000026050; ENSMUSP00000026050; ENSMUSG00000025068.
GeneIDi14873.
KEGGimmu:14873.
UCSCiuc008hvq.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U80819 mRNA. Translation: AAB70110.1 .
AK027922 mRNA. Translation: BAC25667.1 .
AK146834 mRNA. Translation: BAE27469.1 .
AK168383 mRNA. Translation: BAE40311.1 .
BC085165 mRNA. Translation: AAH85165.1 .
CCDSi CCDS29893.1.
RefSeqi NP_034492.1. NM_010362.2.
UniGenei Mm.378931.

3D structure databases

ProteinModelPortali O09131.
SMRi O09131. Positions 3-240.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi O09131. 2 interactions.
MINTi MINT-1868625.
STRINGi 10090.ENSMUSP00000026050.

PTM databases

PhosphoSitei O09131.

2D gel databases

REPRODUCTION-2DPAGE IPI00114285.

Proteomic databases

MaxQBi O09131.
PaxDbi O09131.
PRIDEi O09131.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000026050 ; ENSMUSP00000026050 ; ENSMUSG00000025068 .
GeneIDi 14873.
KEGGi mmu:14873.
UCSCi uc008hvq.1. mouse.

Organism-specific databases

CTDi 9446.
MGIi MGI:1342273. Gsto1.

Phylogenomic databases

eggNOGi COG0625.
GeneTreei ENSGT00390000005479.
HOGENOMi HOG000006560.
HOVERGENi HBG051853.
InParanoidi O09131.
KOi K00799.
OMAi AYANEMP.
OrthoDBi EOG71CFNG.
PhylomeDBi O09131.
TreeFami TF105325.

Enzyme and pathway databases

Reactomei REACT_215316. Glutathione conjugation.

Miscellaneous databases

NextBioi 287145.
PROi O09131.
SOURCEi Search...

Gene expression databases

Bgeei O09131.
CleanExi MM_GSTO1.
Genevestigatori O09131.

Family and domain databases

Gene3Di 1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProi IPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR005442. GST_omega.
IPR012336. Thioredoxin-like_fold.
[Graphical view ]
Pfami PF00043. GST_C. 1 hit.
PF13417. GST_N_3. 1 hit.
[Graphical view ]
PRINTSi PR01625. GSTRNSFRASEO.
SUPFAMi SSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEi PS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The cloning and characterization of a new stress response protein. A mammalian member of a family of theta class glutathione s-transferase-like proteins."
    Kodym R., Calkins P., Story M.D.
    J. Biol. Chem. 274:5131-5137(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Amnion.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Brain.

Entry informationi

Entry nameiGSTO1_MOUSE
AccessioniPrimary (citable) accession number: O09131
Secondary accession number(s): Q3TH87
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: January 1, 1998
Last modified: October 29, 2014
This is version 123 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3