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O09118

- NET1_MOUSE

UniProt

O09118 - NET1_MOUSE

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Protein
Netrin-1
Gene
Ntn1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Netrins control guidance of CNS commissural axons and peripheral motor axons. Its association with either DCC or some UNC5 receptors will lead to axon attraction or repulsion, respectively. It also serve as a survival factor via its association with its receptors which prevent the initiation of apoptosis. Involved in colorectal tumorigenesis by regulating apoptosis By similarity.2 Publications

GO - Molecular functioni

  1. protein binding Source: UniProtKB
Complete GO annotation...

GO - Biological processi

  1. anterior/posterior axon guidance Source: MGI
  2. apoptotic process Source: UniProtKB-KW
  3. axon guidance Source: MGI
  4. axonogenesis Source: MGI
  5. establishment of nucleus localization Source: MGI
  6. inner ear morphogenesis Source: MGI
  7. mammary gland development Source: MGI
  8. mammary gland duct morphogenesis Source: MGI
  9. negative regulation of axon extension Source: MGI
  10. neuron migration Source: MGI
  11. positive regulation of axon extension Source: MGI
  12. positive regulation of cell proliferation Source: MGI
  13. regulation of cell migration Source: MGI
  14. single organismal cell-cell adhesion Source: MGI
Complete GO annotation...

Keywords - Biological processi

Apoptosis

Names & Taxonomyi

Protein namesi
Recommended name:
Netrin-1
Gene namesi
Name:Ntn1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:105088. Ntn1.

Subcellular locationi

Secretedextracellular spaceextracellular matrix 1 Publication

GO - Cellular componenti

  1. basement membrane Source: MGI
  2. cell periphery Source: MGI
  3. cytoplasm Source: MGI
  4. extracellular region Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424 Reviewed prediction
Add
BLAST
Chaini25 – 604580Netrin-1
PRO_0000017083Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi95 – 951N-linked (GlcNAc...) Reviewed prediction
Glycosylationi116 – 1161N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi119 ↔ 152 By similarity
Glycosylationi131 – 1311N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi285 ↔ 294 By similarity
Disulfide bondi287 ↔ 304 By similarity
Disulfide bondi306 ↔ 315 By similarity
Disulfide bondi318 ↔ 338 By similarity
Disulfide bondi341 ↔ 350 By similarity
Disulfide bondi343 ↔ 368 By similarity
Disulfide bondi371 ↔ 380 By similarity
Disulfide bondi383 ↔ 401 By similarity
Disulfide bondi404 ↔ 416 By similarity
Disulfide bondi406 ↔ 423 By similarity
Glycosylationi417 – 4171N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi425 ↔ 434 By similarity
Disulfide bondi437 ↔ 451 By similarity
Disulfide bondi472 ↔ 544 By similarity
Disulfide bondi491 ↔ 601 By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiO09118.

PTM databases

PhosphoSiteiO09118.

Expressioni

Tissue specificityi

In the embryo, widely expressed in the developing nervous system and in mesodermal tissues.1 Publication

Gene expression databases

ArrayExpressiO09118.
BgeeiO09118.
CleanExiMM_NTN1.
GenevestigatoriO09118.

Interactioni

Subunit structurei

Binds to its receptors; DCC, UNC5A, UNC5B, UNC5C and probably UNC5D By similarity. Binds to its receptor; DSCAM.1 Publication

Protein-protein interaction databases

IntActiO09118. 2 interactions.
STRINGi10090.ENSMUSP00000021284.

Structurei

3D structure databases

ProteinModelPortaliO09118.
SMRiO09118. Positions 41-446.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini47 – 284238Laminin N-terminal
Add
BLAST
Domaini285 – 34056Laminin EGF-like 1
Add
BLAST
Domaini341 – 40363Laminin EGF-like 2
Add
BLAST
Domaini404 – 45350Laminin EGF-like 3
Add
BLAST
Domaini472 – 601130NTR
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi530 – 5323Cell attachment site Reviewed prediction

Sequence similaritiesi

Contains 1 NTR domain.

Keywords - Domaini

Laminin EGF-like domain, Repeat, Signal

Phylogenomic databases

eggNOGiNOG244580.
GeneTreeiENSGT00750000117313.
HOGENOMiHOG000286017.
HOVERGENiHBG006464.
InParanoidiB1ARR0.
KOiK06843.
OMAiDSYYYAV.
OrthoDBiEOG7SR4KJ.
TreeFamiTF352481.

Family and domain databases

Gene3Di2.60.120.260. 1 hit.
InterProiIPR013032. EGF-like_CS.
IPR002049. EGF_laminin.
IPR008979. Galactose-bd-like.
IPR008211. Laminin_N.
IPR001134. Netrin_domain.
IPR018933. Netrin_module_non-TIMP.
IPR008993. TIMP-like_OB-fold.
[Graphical view]
PfamiPF00053. Laminin_EGF. 3 hits.
PF00055. Laminin_N. 1 hit.
PF01759. NTR. 1 hit.
[Graphical view]
SMARTiSM00643. C345C. 1 hit.
SM00180. EGF_Lam. 3 hits.
SM00136. LamNT. 1 hit.
[Graphical view]
SUPFAMiSSF49785. SSF49785. 1 hit.
SSF50242. SSF50242. 1 hit.
PROSITEiPS00022. EGF_1. 2 hits.
PS01248. EGF_LAM_1. 3 hits.
PS50027. EGF_LAM_2. 3 hits.
PS51117. LAMININ_NTER. 1 hit.
PS50189. NTR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O09118-1 [UniParc]FASTAAdd to Basket

« Hide

MMRAVWEALA ALAAVACLVG AVRGGPGLSM FAGQAAQPDP CSDENGHPRR    50
CIPDFVNAAF GKDVRVSSTC GRPPARYCVV SERGEERLRS CHLCNSSDPK 100
KAHPPAFLTD LNNPHNLTCW QSENYLQFPH NVTLTLSLGK KFEVTYVSLQ 150
FCSPRPESMA IYKSMDYGRT WVPFQFYSTQ CRKMYNRPHR APITKQNEQE 200
AVCTDSHTDM RPLSGGLIAF STLDGRPSAH DFDNSPVLQD WVTATDIRVA 250
FSRLHTFGDE NEDDSELARD SYYYAVSDLQ VGGRCKCNGH AARCVRDRDD 300
SLVCDCRHNT AGPECDRCKP FHYDRPWQRA TAREANECVA CNCNLHARRC 350
RFNMELYKLS GRKSGGVCLN CRHNTAGRHC HYCKEGFYRD MGKPITHRKA 400
CKACDCHPVG AAGKTCNQTT GQCPCKDGVT GITCNRCAKG YQQSRSPIAP 450
CIKIPVAPPT TAASSVEEPE DCDSYCKASK GKLKMNMKKY CRKDYAVQIH 500
ILKADKAGDW WKFTVNIISV YKQGTSRIRR GDQSLWIRSR DIACKCPKIK 550
PLKKYLLLGN AEDSPDQSGI VADKSSLVIQ WRDTWARRLR KFQQREKKGK 600
CKKA 604
Length:604
Mass (Da):67,810
Last modified:July 27, 2011 - v3
Checksum:i135120DB6F0482F3
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti24 – 241Missing in AAC52971. 1 Publication
Sequence conflicti88 – 881L → V in AAC52971. 1 Publication
Sequence conflicti88 – 881L → V in AAD28602. 1 Publication
Sequence conflicti466 – 4661V → A in AAD28602. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U65418 mRNA. Translation: AAC52971.1.
AF128865 mRNA. Translation: AAD28602.1.
AL669842, AL606831, AL662894 Genomic DNA. Translation: CAI24775.1.
AL606831, AL662894, AL669842 Genomic DNA. Translation: CAI25691.1.
AL662894, AL606831, AL669842 Genomic DNA. Translation: CAI25793.1.
CH466601 Genomic DNA. Translation: EDL10446.1.
BC141294 mRNA. Translation: AAI41295.1.
U23505 mRNA. Translation: AAA87938.1.
CCDSiCCDS24864.1.
RefSeqiNP_032770.2. NM_008744.2.
UniGeneiMm.39095.

Genome annotation databases

EnsembliENSMUST00000021284; ENSMUSP00000021284; ENSMUSG00000020902.
ENSMUST00000108674; ENSMUSP00000104314; ENSMUSG00000020902.
GeneIDi18208.
KEGGimmu:18208.
UCSCiuc007jnm.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U65418 mRNA. Translation: AAC52971.1 .
AF128865 mRNA. Translation: AAD28602.1 .
AL669842 , AL606831 , AL662894 Genomic DNA. Translation: CAI24775.1 .
AL606831 , AL662894 , AL669842 Genomic DNA. Translation: CAI25691.1 .
AL662894 , AL606831 , AL669842 Genomic DNA. Translation: CAI25793.1 .
CH466601 Genomic DNA. Translation: EDL10446.1 .
BC141294 mRNA. Translation: AAI41295.1 .
U23505 mRNA. Translation: AAA87938.1 .
CCDSi CCDS24864.1.
RefSeqi NP_032770.2. NM_008744.2.
UniGenei Mm.39095.

3D structure databases

ProteinModelPortali O09118.
SMRi O09118. Positions 41-446.
ModBasei Search...

Protein-protein interaction databases

IntActi O09118. 2 interactions.
STRINGi 10090.ENSMUSP00000021284.

PTM databases

PhosphoSitei O09118.

Proteomic databases

PRIDEi O09118.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000021284 ; ENSMUSP00000021284 ; ENSMUSG00000020902 .
ENSMUST00000108674 ; ENSMUSP00000104314 ; ENSMUSG00000020902 .
GeneIDi 18208.
KEGGi mmu:18208.
UCSCi uc007jnm.1. mouse.

Organism-specific databases

CTDi 9423.
MGIi MGI:105088. Ntn1.

Phylogenomic databases

eggNOGi NOG244580.
GeneTreei ENSGT00750000117313.
HOGENOMi HOG000286017.
HOVERGENi HBG006464.
InParanoidi B1ARR0.
KOi K06843.
OMAi DSYYYAV.
OrthoDBi EOG7SR4KJ.
TreeFami TF352481.

Miscellaneous databases

NextBioi 293590.
PROi O09118.
SOURCEi Search...

Gene expression databases

ArrayExpressi O09118.
Bgeei O09118.
CleanExi MM_NTN1.
Genevestigatori O09118.

Family and domain databases

Gene3Di 2.60.120.260. 1 hit.
InterProi IPR013032. EGF-like_CS.
IPR002049. EGF_laminin.
IPR008979. Galactose-bd-like.
IPR008211. Laminin_N.
IPR001134. Netrin_domain.
IPR018933. Netrin_module_non-TIMP.
IPR008993. TIMP-like_OB-fold.
[Graphical view ]
Pfami PF00053. Laminin_EGF. 3 hits.
PF00055. Laminin_N. 1 hit.
PF01759. NTR. 1 hit.
[Graphical view ]
SMARTi SM00643. C345C. 1 hit.
SM00180. EGF_Lam. 3 hits.
SM00136. LamNT. 1 hit.
[Graphical view ]
SUPFAMi SSF49785. SSF49785. 1 hit.
SSF50242. SSF50242. 1 hit.
PROSITEi PS00022. EGF_1. 2 hits.
PS01248. EGF_LAM_1. 3 hits.
PS50027. EGF_LAM_2. 3 hits.
PS51117. LAMININ_NTER. 1 hit.
PS50189. NTR. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Netrin-1 is required for commissural axon guidance in the developing vertebrate nervous system."
    Serafini T., Colamarino S.A., Leonardo E.D., Wang H., Beddington R., Skarnes W.C., Tessier-Lavigne M.
    Cell 87:1001-1014(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
    Tissue: Embryonic brain.
  2. "Divergent properties of mouse netrins."
    Pueschel A.W.
    Mech. Dev. 83:65-75(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  4. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  6. "Capturing genes encoding membrane and secreted proteins important for mouse development."
    Skarnes W.C., Moss J.E., Hurtley S.M., Beddington R.S.
    Proc. Natl. Acad. Sci. U.S.A. 92:6592-6596(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 352-398, SUBCELLULAR LOCATION.
  7. "DSCAM is a netrin receptor that collaborates with DCC in mediating turning responses to netrin-1."
    Ly A., Nikolaev A., Suresh G., Zheng Y., Tessier-Lavigne M., Stein E.
    Cell 133:1241-1254(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH DSCAM.

Entry informationi

Entry nameiNET1_MOUSE
AccessioniPrimary (citable) accession number: O09118
Secondary accession number(s): B1ARR0, Q60832, Q9QY50
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 15, 2002
Last sequence update: July 27, 2011
Last modified: September 3, 2014
This is version 129 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi