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Protein

Synaptophysin-like protein 1

Gene

Sypl1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Synaptophysin-like protein 1
Alternative name(s):
Pantophysin
Gene namesi
Name:Sypl1
Synonyms:Pphn, Sypl
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:108081. Sypl.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 33CytoplasmicSequence analysisAdd BLAST33
Transmembranei34 – 54HelicalSequence analysisAdd BLAST21
Topological domaini55 – 117VesicularSequence analysisAdd BLAST63
Transmembranei118 – 138HelicalSequence analysisAdd BLAST21
Topological domaini139 – 151CytoplasmicSequence analysisAdd BLAST13
Transmembranei152 – 172HelicalSequence analysisAdd BLAST21
Topological domaini173 – 214VesicularSequence analysisAdd BLAST42
Transmembranei215 – 235HelicalSequence analysisAdd BLAST21
Topological domaini236 – 261CytoplasmicSequence analysisAdd BLAST26

GO - Cellular componenti

  • extracellular exosome Source: MGI
  • integral component of synaptic vesicle membrane Source: GO_Central
  • melanosome Source: UniProtKB-SubCell
  • membrane Source: MGI
  • secretory granule Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001791651 – 261Synaptophysin-like protein 1Add BLAST261

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi70N-linked (GlcNAc...); atypical1 Publication1
Glycosylationi72N-linked (GlcNAc...)2 Publications1
Glycosylationi95N-linked (GlcNAc...)1 Publication1
Glycosylationi214N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiO09117.
PaxDbiO09117.
PeptideAtlasiO09117.
PRIDEiO09117.

PTM databases

iPTMnetiO09117.
PhosphoSitePlusiO09117.

Expressioni

Tissue specificityi

Ubiquitously expressed.1 Publication

Gene expression databases

BgeeiENSMUSG00000020570.
CleanExiMM_SYPL.
ExpressionAtlasiO09117. baseline and differential.
GenevisibleiO09117. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000075990.

Structurei

3D structure databases

ProteinModelPortaliO09117.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini28 – 239MARVELPROSITE-ProRule annotationAdd BLAST212

Sequence similaritiesi

Belongs to the synaptophysin/synaptobrevin family.Curated
Contains 1 MARVEL domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IF9X. Eukaryota.
ENOG4111FYV. LUCA.
GeneTreeiENSGT00390000010039.
HOGENOMiHOG000252913.
HOVERGENiHBG006681.
InParanoidiO09117.
OMAiQHLYRES.
OrthoDBiEOG091G0ZEI.
PhylomeDBiO09117.
TreeFamiTF315804.

Family and domain databases

InterProiIPR008253. Marvel.
IPR001285. Synaptophysin/porin.
[Graphical view]
PANTHERiPTHR10306. PTHR10306. 1 hit.
PfamiPF01284. MARVEL. 1 hit.
[Graphical view]
PRINTSiPR00220. SYNAPTOPHYSN.
PROSITEiPS51225. MARVEL. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O09117-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASKANMVRQ RFSRLSQRMS AFQINLNPLK EPLGFIKILE WFASIFAFAT
60 70 80 90 100
CGGFKGKTEI QVNCPKVGVN KNQTVTATFG YPFRLNQASF HTPPNVSVCD
110 120 130 140 150
VNWEKHVLIG DYSSSAQFYV TFAVFVFLYC IAALLLYVGY TNLYRDSRKL
160 170 180 190 200
PMIDFIVTLV ATFLWLVSSS AWAKALTDIK VATGHRIVEE LEICNPESGV
210 220 230 240 250
SCYFVSVTSM GSLNVSVIFG FLNMILWGGN AWFVYKETSL HSPSNTSASH
260
SQGGGPPTSG M
Length:261
Mass (Da):28,899
Last modified:October 10, 2003 - v2
Checksum:i5140C6B432B9E282
GO
Isoform 2 (identifier: O09117-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-18: Missing.

Show »
Length:243
Mass (Da):26,751
Checksum:i2A25876AA24F7582
GO

Sequence cautioni

The sequence BAC33808 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti97S → N in AAB39891 (PubMed:8707851).Curated1
Sequence conflicti202C → R in BAC35036 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0085581 – 18Missing in isoform 2. 1 PublicationAdd BLAST18

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF081501 Genomic DNA. Translation: AAB39891.1.
AK049545 mRNA. Translation: BAC33803.1.
AK049556 mRNA. Translation: BAC33808.1. Different initiation.
AK052556 mRNA. Translation: BAC35036.1.
BC060971 mRNA. Translation: AAH60971.1.
CCDSiCCDS25872.1. [O09117-1]
CCDS25873.1. [O09117-2]
RefSeqiNP_038663.2. NM_013635.3. [O09117-1]
NP_942003.1. NM_198710.3. [O09117-2]
UniGeneiMm.246304.

Genome annotation databases

EnsembliENSMUST00000020885; ENSMUSP00000020885; ENSMUSG00000020570. [O09117-2]
ENSMUST00000076698; ENSMUSP00000075990; ENSMUSG00000020570. [O09117-1]
GeneIDi19027.
KEGGimmu:19027.
UCSCiuc007nih.2. mouse. [O09117-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF081501 Genomic DNA. Translation: AAB39891.1.
AK049545 mRNA. Translation: BAC33803.1.
AK049556 mRNA. Translation: BAC33808.1. Different initiation.
AK052556 mRNA. Translation: BAC35036.1.
BC060971 mRNA. Translation: AAH60971.1.
CCDSiCCDS25872.1. [O09117-1]
CCDS25873.1. [O09117-2]
RefSeqiNP_038663.2. NM_013635.3. [O09117-1]
NP_942003.1. NM_198710.3. [O09117-2]
UniGeneiMm.246304.

3D structure databases

ProteinModelPortaliO09117.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000075990.

PTM databases

iPTMnetiO09117.
PhosphoSitePlusiO09117.

Proteomic databases

MaxQBiO09117.
PaxDbiO09117.
PeptideAtlasiO09117.
PRIDEiO09117.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000020885; ENSMUSP00000020885; ENSMUSG00000020570. [O09117-2]
ENSMUST00000076698; ENSMUSP00000075990; ENSMUSG00000020570. [O09117-1]
GeneIDi19027.
KEGGimmu:19027.
UCSCiuc007nih.2. mouse. [O09117-1]

Organism-specific databases

CTDi19027.
MGIiMGI:108081. Sypl.

Phylogenomic databases

eggNOGiENOG410IF9X. Eukaryota.
ENOG4111FYV. LUCA.
GeneTreeiENSGT00390000010039.
HOGENOMiHOG000252913.
HOVERGENiHBG006681.
InParanoidiO09117.
OMAiQHLYRES.
OrthoDBiEOG091G0ZEI.
PhylomeDBiO09117.
TreeFamiTF315804.

Miscellaneous databases

PROiO09117.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000020570.
CleanExiMM_SYPL.
ExpressionAtlasiO09117. baseline and differential.
GenevisibleiO09117. MM.

Family and domain databases

InterProiIPR008253. Marvel.
IPR001285. Synaptophysin/porin.
[Graphical view]
PANTHERiPTHR10306. PTHR10306. 1 hit.
PfamiPF01284. MARVEL. 1 hit.
[Graphical view]
PRINTSiPR00220. SYNAPTOPHYSN.
PROSITEiPS51225. MARVEL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSYPL1_MOUSE
AccessioniPrimary (citable) accession number: O09117
Secondary accession number(s): Q8BQI8, Q8BQJ1, Q8C749
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 10, 2003
Last modified: November 2, 2016
This is version 126 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.