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Protein

Homeobox protein orthopedia

Gene

Otp

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in the specification of hypothalamic neuroendocrine cells. Specifically required for the specification of diencephalic dopaminergic neurons of the A11 group.4 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi104 – 16360HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

  • forebrain neuron differentiation Source: MGI
  • hypothalamus cell differentiation Source: MGI
  • neurohypophysis development Source: MGI
  • positive regulation of neuroblast proliferation Source: MGI
  • regulation of transcription, DNA-templated Source: UniProtKB-KW
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Neurogenesis, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein orthopedia
Gene namesi
Name:Otp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:99835. Otp.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Disruption phenotypei

Death at birth or within the first 2 postnatal days due to defects in neuroendocrine hypothalamus differentiation.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 325325Homeobox protein orthopediaPRO_0000049204Add
BLAST

Proteomic databases

MaxQBiO09113.
PaxDbiO09113.
PRIDEiO09113.

PTM databases

PhosphoSiteiO09113.

Expressioni

Tissue specificityi

Restricted regions of the developing forebrain, hindbrain, and spinal cord.1 Publication

Developmental stagei

First detected at E9.5 in restricted domains of the developing diencephalon and along all the hindbrain and the spinal cord. At E10, found in the medioventral region of the developing spinal cord. At E12.5, expressed in restricted zones in the preoptic, postoptic and dorsoposterior regions. At later stages, in the intermedial region of the lateral horn, in the optic tract, the presumptive stria terminalis, the amygdaloid complex of the lateral horn in the spinal cord.1 Publication

Gene expression databases

BgeeiENSMUSG00000021685.
CleanExiMM_OTP.
GenevisibleiO09113. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000022195.

Structurei

3D structure databases

ProteinModelPortaliO09113.
SMRiO09113. Positions 105-158.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi306 – 31914OARPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi187 – 1948Poly-Ala
Compositional biasi210 – 2134Poly-Ala

Sequence similaritiesi

Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0490. Eukaryota.
ENOG410YIJ3. LUCA.
GeneTreeiENSGT00760000118958.
HOGENOMiHOG000039976.
HOVERGENiHBG001617.
InParanoidiO09113.
OMAiWATAGMP.
OrthoDBiEOG091G1416.
PhylomeDBiO09113.
TreeFamiTF351614.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR000047. HTH_motif.
IPR003654. OAR_dom.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
PF03826. OAR. 1 hit.
[Graphical view]
PRINTSiPR00031. HTHREPRESSR.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS50803. OAR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O09113-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSHADLLDA RLGMKDAAEL LGHREAVKCR LGVGGSDPGG HPGDLAPNSD
60 70 80 90 100
PVEGATLLPG EDITTVGSTP ASLAVSAKDP DKQPGPQGGP NPSQAGQQQG
110 120 130 140 150
QQKQKRHRTR FTPAQLNELE RSFAKTHYPD IFMREELALR IGLTESRVQV
160 170 180 190 200
WFQNRRAKWK KRKKTTNVFR APGTLLPTPG LPQFPSAAAA AAAAMGDSLC
210 220 230 240 250
SFHANDTRWA AAAMPGVSQL PLPPALGRQQ AMAQSLSQCS LAAGPPPNSM
260 270 280 290 300
GLSNSLAGSN GAGLQSHLYQ PAFPGMVPAS LPGPSNVSGS PQLCSSPDSS
310 320
DVWRGTSIAS LRRKALEHTV SMSFT
Length:325
Mass (Da):34,159
Last modified:July 1, 1997 - v1
Checksum:i429E3A91E0A9BA5F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y10413 mRNA. Translation: CAA71439.1.
CCDSiCCDS26695.1.
RefSeqiNP_035151.1. NM_011021.3.
UniGeneiMm.42051.

Genome annotation databases

EnsembliENSMUST00000022195; ENSMUSP00000022195; ENSMUSG00000021685.
GeneIDi18420.
KEGGimmu:18420.
UCSCiuc007rly.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y10413 mRNA. Translation: CAA71439.1.
CCDSiCCDS26695.1.
RefSeqiNP_035151.1. NM_011021.3.
UniGeneiMm.42051.

3D structure databases

ProteinModelPortaliO09113.
SMRiO09113. Positions 105-158.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000022195.

PTM databases

PhosphoSiteiO09113.

Proteomic databases

MaxQBiO09113.
PaxDbiO09113.
PRIDEiO09113.

Protocols and materials databases

DNASUi18420.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000022195; ENSMUSP00000022195; ENSMUSG00000021685.
GeneIDi18420.
KEGGimmu:18420.
UCSCiuc007rly.1. mouse.

Organism-specific databases

CTDi23440.
MGIiMGI:99835. Otp.

Phylogenomic databases

eggNOGiKOG0490. Eukaryota.
ENOG410YIJ3. LUCA.
GeneTreeiENSGT00760000118958.
HOGENOMiHOG000039976.
HOVERGENiHBG001617.
InParanoidiO09113.
OMAiWATAGMP.
OrthoDBiEOG091G1416.
PhylomeDBiO09113.
TreeFamiTF351614.

Miscellaneous databases

PROiO09113.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000021685.
CleanExiMM_OTP.
GenevisibleiO09113. MM.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR000047. HTH_motif.
IPR003654. OAR_dom.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
PF03826. OAR. 1 hit.
[Graphical view]
PRINTSiPR00031. HTHREPRESSR.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS50803. OAR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOTP_MOUSE
AccessioniPrimary (citable) accession number: O09113
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: July 1, 1997
Last modified: September 7, 2016
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.