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O09112

- DUS8_MOUSE

UniProt

O09112 - DUS8_MOUSE

Protein

Dual specificity protein phosphatase 8

Gene

Dusp8

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 115 (01 Oct 2014)
      Sequence version 1 (01 Jul 1997)
      Previous versions | rss
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    • Comment

    Functioni

    This protein shows both activity toward tyrosine-protein phosphate as well as with serine/threonine-protein phosphate.By similarity

    Catalytic activityi

    Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation
    [a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei246 – 2461Phosphocysteine intermediatePROSITE-ProRule annotation

    GO - Molecular functioni

    1. MAP kinase tyrosine/serine/threonine phosphatase activity Source: InterPro
    2. protein tyrosine/serine/threonine phosphatase activity Source: RefGenome
    3. protein tyrosine phosphatase activity Source: UniProtKB-EC

    GO - Biological processi

    1. protein dephosphorylation Source: RefGenome

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Dual specificity protein phosphatase 8 (EC:3.1.3.16, EC:3.1.3.48)
    Alternative name(s):
    Neuronal tyrosine threonine phosphatase 1
    Gene namesi
    Name:Dusp8
    Synonyms:Nttp1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 7

    Organism-specific databases

    MGIiMGI:106626. Dusp8.

    Subcellular locationi

    Cytoplasm 1 Publication. Nucleus 1 Publication

    GO - Cellular componenti

    1. cytoplasm Source: RefGenome
    2. nucleus Source: RefGenome

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 663663Dual specificity protein phosphatase 8PRO_0000094811Add
    BLAST

    Proteomic databases

    PRIDEiO09112.

    PTM databases

    PhosphoSiteiO09112.

    Expressioni

    Tissue specificityi

    Expressed predominantly in brain and lung.1 Publication

    Gene expression databases

    ArrayExpressiO09112.
    BgeeiO09112.
    CleanExiMM_DUSP8.
    GenevestigatoriO09112.

    Structurei

    3D structure databases

    ProteinModelPortaliO09112.
    SMRiO09112. Positions 14-139, 160-309.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini23 – 138116RhodanesePROSITE-ProRule annotationAdd
    BLAST
    Domaini162 – 432271Tyrosine-protein phosphataseAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi311 – 552242Pro-richAdd
    BLAST
    Compositional biasi452 – 4598Poly-Arg
    Compositional biasi555 – 5584Poly-Ser
    Compositional biasi559 – 57618Poly-GlyAdd
    BLAST
    Compositional biasi577 – 60024Poly-SerAdd
    BLAST

    Sequence similaritiesi

    Contains 1 rhodanese domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG2453.
    GeneTreeiENSGT00750000117567.
    HOVERGENiHBG005541.
    InParanoidiO09112.
    KOiK04459.
    OMAiDGRHSWH.
    OrthoDBiEOG747PJD.
    TreeFamiTF105122.

    Family and domain databases

    Gene3Di3.40.250.10. 1 hit.
    3.90.190.10. 1 hit.
    InterProiIPR000340. Dual-sp_phosphatase_cat-dom.
    IPR020422. Dual-sp_phosphatase_subgr_cat.
    IPR024950. DUSP.
    IPR008343. MKP.
    IPR029021. Prot-tyrosine_phosphatase-like.
    IPR001763. Rhodanese-like_dom.
    IPR000387. Tyr/Dual-sp_Pase.
    IPR016130. Tyr_Pase_AS.
    [Graphical view]
    PANTHERiPTHR10159. PTHR10159. 1 hit.
    PfamiPF00782. DSPc. 1 hit.
    PF00581. Rhodanese. 1 hit.
    [Graphical view]
    PRINTSiPR01764. MAPKPHPHTASE.
    SMARTiSM00195. DSPc. 1 hit.
    SM00450. RHOD. 1 hit.
    [Graphical view]
    SUPFAMiSSF52799. SSF52799. 1 hit.
    SSF52821. SSF52821. 1 hit.
    PROSITEiPS50206. RHODANESE_3. 1 hit.
    PS00383. TYR_PHOSPHATASE_1. 1 hit.
    PS50056. TYR_PHOSPHATASE_2. 1 hit.
    PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O09112-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAGDRLPRKV MDAKKLASLL RGGPGGPLVI DSRSFVEYNS CHVLSSVNIC    50
    CSKLVKRRLQ QGKVTIAELI QPATRSQVDA TEPQDVVVYD QSTRDASVLA 100
    ADSFLSILLS KLDGCFDSVA ILTGGFATFS SCFPGLCEGK PATLPSMSLS 150
    QPCLPVPSVG LTRILPHLYL GSQKDVLNKD LMTQNGISYV LNASNSCPKP 200
    DFICESRFMR IPINDNYCEK LLPWLDKSIE FIDKAKLSSC QVIVHCLAGI 250
    SRSATIAIAY IMKTMGMSSD DAYRFVKDRR PSISPNFNFL GQLLEYERSL 300
    KLLAALQTDG PHLGTPEPLM GPAAGIPLPR LPPSTSESAA TGSEAATAAR 350
    EGSPSAGGDA PIPSTAPATS ALQQGLRGLH LSSDRLQDTN RLKRSFSLDI 400
    KSAYAPSRRP DFPGPPDPGE APKLCKLDSP SGGTLGLPSP SPDSPDSVPE 450
    CRPRPRRRRP PASSPARSPA HGLGLNFGDT ARQTPRHGLS ALSAPGLPGP 500
    GQPAGPGGWV PPLDSPGTPS PDGPWCFSPE GAQGPGAVFS AFGRVSAGAP 550
    GPGNSSSSGG GGGGGGGGGG GGGGGGSSSS NSSSSSSSSS SSSSSSSSSS 600
    DLRRRDVRTG WPEEPAADAQ FKRRSCQMEF EEGMVEGRAR GEELAALGKQ 650
    TSFSGSVEVI EVS 663
    Length:663
    Mass (Da):68,847
    Last modified:July 1, 1997 - v1
    Checksum:i416F429A12C1FA7C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X95518 mRNA. Translation: CAA64772.1.
    CCDSiCCDS22024.1.
    RefSeqiNP_032774.1. NM_008748.3.
    XP_006508572.1. XM_006508509.1.
    UniGeneiMm.39725.

    Genome annotation databases

    EnsembliENSMUST00000039926; ENSMUSP00000049414; ENSMUSG00000037887.
    GeneIDi18218.
    KEGGimmu:18218.
    UCSCiuc009kmo.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X95518 mRNA. Translation: CAA64772.1 .
    CCDSi CCDS22024.1.
    RefSeqi NP_032774.1. NM_008748.3.
    XP_006508572.1. XM_006508509.1.
    UniGenei Mm.39725.

    3D structure databases

    ProteinModelPortali O09112.
    SMRi O09112. Positions 14-139, 160-309.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei O09112.

    Proteomic databases

    PRIDEi O09112.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000039926 ; ENSMUSP00000049414 ; ENSMUSG00000037887 .
    GeneIDi 18218.
    KEGGi mmu:18218.
    UCSCi uc009kmo.2. mouse.

    Organism-specific databases

    CTDi 1850.
    MGIi MGI:106626. Dusp8.

    Phylogenomic databases

    eggNOGi COG2453.
    GeneTreei ENSGT00750000117567.
    HOVERGENi HBG005541.
    InParanoidi O09112.
    KOi K04459.
    OMAi DGRHSWH.
    OrthoDBi EOG747PJD.
    TreeFami TF105122.

    Miscellaneous databases

    NextBioi 293632.
    PROi O09112.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O09112.
    Bgeei O09112.
    CleanExi MM_DUSP8.
    Genevestigatori O09112.

    Family and domain databases

    Gene3Di 3.40.250.10. 1 hit.
    3.90.190.10. 1 hit.
    InterProi IPR000340. Dual-sp_phosphatase_cat-dom.
    IPR020422. Dual-sp_phosphatase_subgr_cat.
    IPR024950. DUSP.
    IPR008343. MKP.
    IPR029021. Prot-tyrosine_phosphatase-like.
    IPR001763. Rhodanese-like_dom.
    IPR000387. Tyr/Dual-sp_Pase.
    IPR016130. Tyr_Pase_AS.
    [Graphical view ]
    PANTHERi PTHR10159. PTHR10159. 1 hit.
    Pfami PF00782. DSPc. 1 hit.
    PF00581. Rhodanese. 1 hit.
    [Graphical view ]
    PRINTSi PR01764. MAPKPHPHTASE.
    SMARTi SM00195. DSPc. 1 hit.
    SM00450. RHOD. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52799. SSF52799. 1 hit.
    SSF52821. SSF52821. 1 hit.
    PROSITEi PS50206. RHODANESE_3. 1 hit.
    PS00383. TYR_PHOSPHATASE_1. 1 hit.
    PS50056. TYR_PHOSPHATASE_2. 1 hit.
    PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A member of the MAP kinase phosphatase gene family in mouse containing a complex trinucleotide repeat in the coding region."
      Theodosiou A.M., Rodrigues N.R., Nesbit M.A., Ambrose H.J., Paterson H., McLellan-Arnold E., Boyd Y., Leversha M.A., Owen N., Blake D.J., Ashworth A., Davies K.E.
      Hum. Mol. Genet. 5:675-684(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
      Tissue: Brain.

    Entry informationi

    Entry nameiDUS8_MOUSE
    AccessioniPrimary (citable) accession number: O09112
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1999
    Last sequence update: July 1, 1997
    Last modified: October 1, 2014
    This is version 115 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3