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O09112 (DUS8_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 113. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Dual specificity protein phosphatase 8

EC=3.1.3.16
EC=3.1.3.48
Alternative name(s):
Neuronal tyrosine threonine phosphatase 1
Gene names
Name:Dusp8
Synonyms:Nttp1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length663 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

This protein shows both activity toward tyrosine-protein phosphate as well as with serine/threonine-protein phosphate By similarity.

Catalytic activity

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Subcellular location

Cytoplasm. Nucleus Ref.1.

Tissue specificity

Expressed predominantly in brain and lung. Ref.1

Sequence similarities

Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.

Contains 1 rhodanese domain.

Contains 1 tyrosine-protein phosphatase domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 663663Dual specificity protein phosphatase 8
PRO_0000094811

Regions

Domain23 – 138116Rhodanese
Domain162 – 432271Tyrosine-protein phosphatase
Compositional bias311 – 552242Pro-rich
Compositional bias452 – 4598Poly-Arg
Compositional bias555 – 5584Poly-Ser
Compositional bias559 – 57618Poly-Gly
Compositional bias577 – 60024Poly-Ser

Sites

Active site2461Phosphocysteine intermediate By similarity

Sequences

Sequence LengthMass (Da)Tools
O09112 [UniParc].

Last modified July 1, 1997. Version 1.
Checksum: 416F429A12C1FA7C

FASTA66368,847
        10         20         30         40         50         60 
MAGDRLPRKV MDAKKLASLL RGGPGGPLVI DSRSFVEYNS CHVLSSVNIC CSKLVKRRLQ 

        70         80         90        100        110        120 
QGKVTIAELI QPATRSQVDA TEPQDVVVYD QSTRDASVLA ADSFLSILLS KLDGCFDSVA 

       130        140        150        160        170        180 
ILTGGFATFS SCFPGLCEGK PATLPSMSLS QPCLPVPSVG LTRILPHLYL GSQKDVLNKD 

       190        200        210        220        230        240 
LMTQNGISYV LNASNSCPKP DFICESRFMR IPINDNYCEK LLPWLDKSIE FIDKAKLSSC 

       250        260        270        280        290        300 
QVIVHCLAGI SRSATIAIAY IMKTMGMSSD DAYRFVKDRR PSISPNFNFL GQLLEYERSL 

       310        320        330        340        350        360 
KLLAALQTDG PHLGTPEPLM GPAAGIPLPR LPPSTSESAA TGSEAATAAR EGSPSAGGDA 

       370        380        390        400        410        420 
PIPSTAPATS ALQQGLRGLH LSSDRLQDTN RLKRSFSLDI KSAYAPSRRP DFPGPPDPGE 

       430        440        450        460        470        480 
APKLCKLDSP SGGTLGLPSP SPDSPDSVPE CRPRPRRRRP PASSPARSPA HGLGLNFGDT 

       490        500        510        520        530        540 
ARQTPRHGLS ALSAPGLPGP GQPAGPGGWV PPLDSPGTPS PDGPWCFSPE GAQGPGAVFS 

       550        560        570        580        590        600 
AFGRVSAGAP GPGNSSSSGG GGGGGGGGGG GGGGGGSSSS NSSSSSSSSS SSSSSSSSSS 

       610        620        630        640        650        660 
DLRRRDVRTG WPEEPAADAQ FKRRSCQMEF EEGMVEGRAR GEELAALGKQ TSFSGSVEVI 


EVS 

« Hide

References

[1]"A member of the MAP kinase phosphatase gene family in mouse containing a complex trinucleotide repeat in the coding region."
Theodosiou A.M., Rodrigues N.R., Nesbit M.A., Ambrose H.J., Paterson H., McLellan-Arnold E., Boyd Y., Leversha M.A., Owen N., Blake D.J., Ashworth A., Davies K.E.
Hum. Mol. Genet. 5:675-684(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X95518 mRNA. Translation: CAA64772.1.
CCDSCCDS22024.1.
RefSeqNP_032774.1. NM_008748.3.
XP_006508572.1. XM_006508509.1.
UniGeneMm.39725.

3D structure databases

ProteinModelPortalO09112.
SMRO09112. Positions 14-139, 160-309.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteO09112.

Proteomic databases

PRIDEO09112.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000039926; ENSMUSP00000049414; ENSMUSG00000037887.
GeneID18218.
KEGGmmu:18218.
UCSCuc009kmo.2. mouse.

Organism-specific databases

CTD1850.
MGIMGI:106626. Dusp8.

Phylogenomic databases

eggNOGCOG2453.
GeneTreeENSGT00750000117567.
HOVERGENHBG005541.
InParanoidO09112.
KOK04459.
OMADGRHSWH.
OrthoDBEOG747PJD.
TreeFamTF105122.

Gene expression databases

ArrayExpressO09112.
BgeeO09112.
CleanExMM_DUSP8.
GenevestigatorO09112.

Family and domain databases

Gene3D3.40.250.10. 1 hit.
3.90.190.10. 1 hit.
InterProIPR000340. Dual-sp_phosphatase_cat-dom.
IPR020422. Dual-sp_phosphatase_subgr_cat.
IPR024950. DUSP.
IPR008343. MKP.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR001763. Rhodanese-like_dom.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
[Graphical view]
PANTHERPTHR10159. PTHR10159. 1 hit.
PfamPF00782. DSPc. 1 hit.
PF00581. Rhodanese. 1 hit.
[Graphical view]
PRINTSPR01764. MAPKPHPHTASE.
SMARTSM00195. DSPc. 1 hit.
SM00450. RHOD. 1 hit.
[Graphical view]
SUPFAMSSF52799. SSF52799. 1 hit.
SSF52821. SSF52821. 1 hit.
PROSITEPS50206. RHODANESE_3. 1 hit.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio293632.
PROO09112.
SOURCESearch...

Entry information

Entry nameDUS8_MOUSE
AccessionPrimary (citable) accession number: O09112
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: July 1, 1997
Last modified: July 9, 2014
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot