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O09112

- DUS8_MOUSE

UniProt

O09112 - DUS8_MOUSE

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Protein
Dual specificity protein phosphatase 8
Gene
Dusp8, Nttp1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

This protein shows both activity toward tyrosine-protein phosphate as well as with serine/threonine-protein phosphate By similarity.

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.
[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei246 – 2461Phosphocysteine intermediate By similarity

GO - Molecular functioni

  1. MAP kinase tyrosine/serine/threonine phosphatase activity Source: InterPro
  2. protein tyrosine phosphatase activity Source: UniProtKB-EC
  3. protein tyrosine/serine/threonine phosphatase activity Source: RefGenome

GO - Biological processi

  1. protein dephosphorylation Source: RefGenome
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Names & Taxonomyi

Protein namesi
Recommended name:
Dual specificity protein phosphatase 8 (EC:3.1.3.16, EC:3.1.3.48)
Alternative name(s):
Neuronal tyrosine threonine phosphatase 1
Gene namesi
Name:Dusp8
Synonyms:Nttp1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 7

Organism-specific databases

MGIiMGI:106626. Dusp8.

Subcellular locationi

Cytoplasm. Nucleus 1 Publication

GO - Cellular componenti

  1. cytoplasm Source: RefGenome
  2. nucleus Source: RefGenome
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 663663Dual specificity protein phosphatase 8
PRO_0000094811Add
BLAST

Proteomic databases

PRIDEiO09112.

PTM databases

PhosphoSiteiO09112.

Expressioni

Tissue specificityi

Expressed predominantly in brain and lung.1 Publication

Gene expression databases

ArrayExpressiO09112.
BgeeiO09112.
CleanExiMM_DUSP8.
GenevestigatoriO09112.

Structurei

3D structure databases

ProteinModelPortaliO09112.
SMRiO09112. Positions 14-139, 160-309.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini23 – 138116Rhodanese
Add
BLAST
Domaini162 – 432271Tyrosine-protein phosphatase
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi311 – 552242Pro-rich
Add
BLAST
Compositional biasi452 – 4598Poly-Arg
Compositional biasi555 – 5584Poly-Ser
Compositional biasi559 – 57618Poly-Gly
Add
BLAST
Compositional biasi577 – 60024Poly-Ser
Add
BLAST

Sequence similaritiesi

Contains 1 rhodanese domain.

Phylogenomic databases

eggNOGiCOG2453.
GeneTreeiENSGT00750000117567.
HOVERGENiHBG005541.
InParanoidiO09112.
KOiK04459.
OMAiDGRHSWH.
OrthoDBiEOG747PJD.
TreeFamiTF105122.

Family and domain databases

Gene3Di3.40.250.10. 1 hit.
3.90.190.10. 1 hit.
InterProiIPR000340. Dual-sp_phosphatase_cat-dom.
IPR020422. Dual-sp_phosphatase_subgr_cat.
IPR024950. DUSP.
IPR008343. MKP.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR001763. Rhodanese-like_dom.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
[Graphical view]
PANTHERiPTHR10159. PTHR10159. 1 hit.
PfamiPF00782. DSPc. 1 hit.
PF00581. Rhodanese. 1 hit.
[Graphical view]
PRINTSiPR01764. MAPKPHPHTASE.
SMARTiSM00195. DSPc. 1 hit.
SM00450. RHOD. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.
SSF52821. SSF52821. 1 hit.
PROSITEiPS50206. RHODANESE_3. 1 hit.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O09112-1 [UniParc]FASTAAdd to Basket

« Hide

MAGDRLPRKV MDAKKLASLL RGGPGGPLVI DSRSFVEYNS CHVLSSVNIC    50
CSKLVKRRLQ QGKVTIAELI QPATRSQVDA TEPQDVVVYD QSTRDASVLA 100
ADSFLSILLS KLDGCFDSVA ILTGGFATFS SCFPGLCEGK PATLPSMSLS 150
QPCLPVPSVG LTRILPHLYL GSQKDVLNKD LMTQNGISYV LNASNSCPKP 200
DFICESRFMR IPINDNYCEK LLPWLDKSIE FIDKAKLSSC QVIVHCLAGI 250
SRSATIAIAY IMKTMGMSSD DAYRFVKDRR PSISPNFNFL GQLLEYERSL 300
KLLAALQTDG PHLGTPEPLM GPAAGIPLPR LPPSTSESAA TGSEAATAAR 350
EGSPSAGGDA PIPSTAPATS ALQQGLRGLH LSSDRLQDTN RLKRSFSLDI 400
KSAYAPSRRP DFPGPPDPGE APKLCKLDSP SGGTLGLPSP SPDSPDSVPE 450
CRPRPRRRRP PASSPARSPA HGLGLNFGDT ARQTPRHGLS ALSAPGLPGP 500
GQPAGPGGWV PPLDSPGTPS PDGPWCFSPE GAQGPGAVFS AFGRVSAGAP 550
GPGNSSSSGG GGGGGGGGGG GGGGGGSSSS NSSSSSSSSS SSSSSSSSSS 600
DLRRRDVRTG WPEEPAADAQ FKRRSCQMEF EEGMVEGRAR GEELAALGKQ 650
TSFSGSVEVI EVS 663
Length:663
Mass (Da):68,847
Last modified:July 1, 1997 - v1
Checksum:i416F429A12C1FA7C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X95518 mRNA. Translation: CAA64772.1.
CCDSiCCDS22024.1.
RefSeqiNP_032774.1. NM_008748.3.
XP_006508572.1. XM_006508509.1.
UniGeneiMm.39725.

Genome annotation databases

EnsembliENSMUST00000039926; ENSMUSP00000049414; ENSMUSG00000037887.
GeneIDi18218.
KEGGimmu:18218.
UCSCiuc009kmo.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X95518 mRNA. Translation: CAA64772.1 .
CCDSi CCDS22024.1.
RefSeqi NP_032774.1. NM_008748.3.
XP_006508572.1. XM_006508509.1.
UniGenei Mm.39725.

3D structure databases

ProteinModelPortali O09112.
SMRi O09112. Positions 14-139, 160-309.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei O09112.

Proteomic databases

PRIDEi O09112.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000039926 ; ENSMUSP00000049414 ; ENSMUSG00000037887 .
GeneIDi 18218.
KEGGi mmu:18218.
UCSCi uc009kmo.2. mouse.

Organism-specific databases

CTDi 1850.
MGIi MGI:106626. Dusp8.

Phylogenomic databases

eggNOGi COG2453.
GeneTreei ENSGT00750000117567.
HOVERGENi HBG005541.
InParanoidi O09112.
KOi K04459.
OMAi DGRHSWH.
OrthoDBi EOG747PJD.
TreeFami TF105122.

Miscellaneous databases

NextBioi 293632.
PROi O09112.
SOURCEi Search...

Gene expression databases

ArrayExpressi O09112.
Bgeei O09112.
CleanExi MM_DUSP8.
Genevestigatori O09112.

Family and domain databases

Gene3Di 3.40.250.10. 1 hit.
3.90.190.10. 1 hit.
InterProi IPR000340. Dual-sp_phosphatase_cat-dom.
IPR020422. Dual-sp_phosphatase_subgr_cat.
IPR024950. DUSP.
IPR008343. MKP.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR001763. Rhodanese-like_dom.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
[Graphical view ]
PANTHERi PTHR10159. PTHR10159. 1 hit.
Pfami PF00782. DSPc. 1 hit.
PF00581. Rhodanese. 1 hit.
[Graphical view ]
PRINTSi PR01764. MAPKPHPHTASE.
SMARTi SM00195. DSPc. 1 hit.
SM00450. RHOD. 1 hit.
[Graphical view ]
SUPFAMi SSF52799. SSF52799. 1 hit.
SSF52821. SSF52821. 1 hit.
PROSITEi PS50206. RHODANESE_3. 1 hit.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "A member of the MAP kinase phosphatase gene family in mouse containing a complex trinucleotide repeat in the coding region."
    Theodosiou A.M., Rodrigues N.R., Nesbit M.A., Ambrose H.J., Paterson H., McLellan-Arnold E., Boyd Y., Leversha M.A., Owen N., Blake D.J., Ashworth A., Davies K.E.
    Hum. Mol. Genet. 5:675-684(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    Tissue: Brain.

Entry informationi

Entry nameiDUS8_MOUSE
AccessioniPrimary (citable) accession number: O09112
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: July 1, 1997
Last modified: September 3, 2014
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi