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Protein

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial

Gene

Ndufb11

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.By similarity

GO - Biological processi

Keywordsi

Biological processElectron transport, Respiratory chain, Transport

Enzyme and pathway databases

ReactomeiR-MMU-611105. Respiratory electron transport.
R-MMU-6799198. Complex I biogenesis.

Names & Taxonomyi

Protein namesi
Recommended name:
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial
Alternative name(s):
Complex I-ESSS
Short name:
CI-ESSS
NADH-ubiquinone oxidoreductase ESSS subunit
Neuronal protein 15.6
Short name:
Np15.6
Short name:
p15.6
Gene namesi
Name:Ndufb11
Synonyms:Np15
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:1349919. Ndufb11.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei87 – 107HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 29MitochondrionBy similarityAdd BLAST29
ChainiPRO_000002005830 – 151NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrialAdd BLAST122

Proteomic databases

EPDiO09111.
MaxQBiO09111.
PaxDbiO09111.
PeptideAtlasiO09111.
PRIDEiO09111.
TopDownProteomicsiO09111.

PTM databases

iPTMnetiO09111.
PhosphoSitePlusiO09111.

Expressioni

Gene expression databases

BgeeiENSMUSG00000031059.
GenevisibleiO09111. MM.

Interactioni

Subunit structurei

Complex I is composed of 45 different subunits.By similarity

Protein-protein interaction databases

BioGridi222383. 2 interactors.
CORUMiO09111.
IntActiO09111. 1 interactor.
STRINGi10090.ENSMUSP00000112320.

Structurei

3D structure databases

SMRiO09111.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I NDUFB11 subunit family.Curated

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4808. Eukaryota.
ENOG41120A5. LUCA.
GeneTreeiENSGT00390000003022.
HOGENOMiHOG000049196.
HOVERGENiHBG004073.
InParanoidiO09111.
KOiK11351.
OMAiYLPDYRM.
OrthoDBiEOG091G0WTH.
PhylomeDBiO09111.
TreeFamiTF314671.

Family and domain databases

InterProiView protein in InterPro
IPR019329. NADH_UbQ_OxRdtase_ESSS_su.
PfamiView protein in Pfam
PF10183. ESSS. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O09111-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAARLLSLYG RCLSAAGAMR GLPAARVRWE SSRAVIAPSG VEKKRQREPT
60 70 80 90 100
MQWQEDPEPE DENVYAKNPD FHGYDSDPVV DVWNMRAVFF FGFSIVLVFG
110 120 130 140 150
TTFVAYVPDY RMQEWARREA ERLVKYREVN GLPIMESNYF DPSKIQLPED

D
Length:151
Mass (Da):17,444
Last modified:June 27, 2003 - v2
Checksum:iABF2C84E326F23A6
GO

Sequence cautioni

The sequence AAH27265 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC25760 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAA69961 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y08702 mRNA. Translation: CAA69961.1. Different initiation.
AK028121 mRNA. Translation: BAC25760.1. Different initiation.
BC027265 mRNA. Translation: AAH27265.1. Different initiation.
CCDSiCCDS53012.1.
RefSeqiNP_062308.2. NM_019435.4.
XP_006527617.1. XM_006527554.1.
UniGeneiMm.30084.

Genome annotation databases

EnsembliENSMUST00000116621; ENSMUSP00000112320; ENSMUSG00000031059.
GeneIDi104130.
KEGGimmu:104130.
UCSCiuc009ste.2. mouse.

Similar proteinsi

Entry informationi

Entry nameiNDUBB_MOUSE
AccessioniPrimary (citable) accession number: O09111
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2003
Last sequence update: June 27, 2003
Last modified: September 27, 2017
This is version 127 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families