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Protein

Neurogenic differentiation factor 4

Gene

Neurod4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probably acts as a transcriptional activator. Mediates neuronal differentiation. Required for the regulation of amacrine cell fate specification in the retina.1 Publication

GO - Molecular functioni

GO - Biological processi

  • amacrine cell differentiation Source: UniProtKB
  • camera-type eye development Source: MGI
  • cell fate commitment Source: MGI
  • glial cell differentiation Source: MGI
  • neuroblast proliferation Source: MGI
  • neuron development Source: MGI
  • neuron migration Source: MGI
  • Notch signaling pathway Source: MGI
  • positive regulation of cell differentiation Source: UniProtKB
  • regulation of transcription, DNA-templated Source: UniProtKB-KW
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionActivator, Developmental protein, DNA-binding
Biological processDifferentiation, Neurogenesis, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Neurogenic differentiation factor 4
Short name:
NeuroD4
Alternative name(s):
Helix-loop-helix protein mATH-3
Short name:
mATH3
Protein atonal homolog 3
Gene namesi
Name:Neurod4
Synonyms:Ath3, Atoh3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:108055 Neurod4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001273911 – 330Neurogenic differentiation factor 4Add BLAST330

Post-translational modificationi

Serine or threonine phosphorylation within the basic region may regulate neurogenic activity.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiO09105
PRIDEiO09105

PTM databases

PhosphoSitePlusiO09105

Expressioni

Tissue specificityi

Expressed in retinal interneurons amacrine cells (at protein level). Expressed in neurons of ventricular zone of the retina at postnatal day 1 (P1). Expressed transiently in amacrine and horizontal cells of the inner nuclear layer (INL) of the retina at P7 until P14.3 Publications

Developmental stagei

Weakly expressed in the neural tube around E8.5. By E9.5, expression is prominent in the ventral brain and spinal cord, and weak expression begins in the retina. At E10.5, highly expressed in the trigeminal and dorsal root ganglions, and the ventral midbrain and hindbrain. At E12.5, expressed in the mantle layer of the brain and spinal cord, trigeminal ganglion, Rathke's pouch, dorsal root ganglion and the ventricular zone of the neural retina. At E16.5, expression becomes restricted to the anterior region, persisting in the diencephalon and neural retina but decreasing in other regions.2 Publications

Gene expression databases

BgeeiENSMUSG00000048015
CleanExiMM_NEUROD4
ExpressionAtlasiO09105 baseline and differential
GenevisibleiO09105 MM

Interactioni

Subunit structurei

Efficient DNA binding requires dimerization with another bHLH protein.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi198239, 1 interactor
STRINGi10090.ENSMUSP00000051379

Structurei

3D structure databases

ProteinModelPortaliO09105
SMRiO09105
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini87 – 139bHLHPROSITE-ProRule annotationAdd BLAST53

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi49 – 65Asp/Glu-rich (acidic)Add BLAST17

Phylogenomic databases

eggNOGiENOG410KD2S Eukaryota
ENOG410Z6FG LUCA
GeneTreeiENSGT00680000099860
HOGENOMiHOG000049256
HOVERGENiHBG000250
InParanoidiO09105
KOiK09079
OMAiYGHMETH
OrthoDBiEOG091G15AI
PhylomeDBiO09105
TreeFamiTF315153

Family and domain databases

CDDicd00083 HLH, 1 hit
Gene3Di4.10.280.10, 1 hit
InterProiView protein in InterPro
IPR011598 bHLH_dom
IPR036638 HLH_DNA-bd_sf
IPR032651 Neurod4
IPR022575 Neurogenic_DUF
IPR016637 TF_bHLH_NeuroD
PANTHERiPTHR19290:SF86 PTHR19290:SF86, 1 hit
PfamiView protein in Pfam
PF00010 HLH, 1 hit
PF12533 Neuro_bHLH, 1 hit
PIRSFiPIRSF015618 bHLH_NeuroD, 1 hit
SMARTiView protein in SMART
SM00353 HLH, 1 hit
SUPFAMiSSF47459 SSF47459, 1 hit
PROSITEiView protein in PROSITE
PS50888 BHLH, 1 hit

Sequencei

Sequence statusi: Complete.

O09105-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKMYMKSKD MVELVNTQSW MDKGLSSQNE MKEQERRPGS YGMLGTLTEE
60 70 80 90 100
HDSIEEDEEE EEDGDKPKRR GPKKKKMTKA RLERFRARRV KANARERTRM
110 120 130 140 150
HGLNDALDNL RRVMPCYSKT QKLSKIETLR LARNYIWALS EVLETGQTLE
160 170 180 190 200
GKGFVEMLCK GLSQPTSNLV AGCLQLGPQS TLLEKHEEKS SICDSTISVH
210 220 230 240 250
SFNYQSPGLP SPPYGHMETH SLHLKPQPFK SLGDSFGSHP PDCSTPPYEG
260 270 280 290 300
PLTPPLSISG NFSLKQDGSP DLEKSYNFMP HYTSASLSSG HVHSTPFQTG
310 320 330
TPRYDVPVDL SYDSYSHHSI GTQLNTIFSD
Length:330
Mass (Da):37,133
Last modified:July 1, 1997 - v1
Checksum:iF8EC228F4EE0FF88
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D85845 mRNA Translation: BAA12880.1
AF036257 Genomic DNA Translation: AAC15969.1
BC054391 mRNA Translation: AAH54391.1
CCDSiCCDS24353.1
RefSeqiNP_001316418.1, NM_001329489.1
NP_001316419.1, NM_001329490.1
NP_031527.1, NM_007501.5
UniGeneiMm.10695

Genome annotation databases

EnsembliENSMUST00000061571; ENSMUSP00000051379; ENSMUSG00000048015
GeneIDi11923
KEGGimmu:11923
UCSCiuc007hri.2 mouse

Similar proteinsi

Entry informationi

Entry nameiNDF4_MOUSE
AccessioniPrimary (citable) accession number: O09105
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: July 1, 1997
Last modified: October 25, 2017
This is version 139 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

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