Chorion-specific transcription factor GCMb

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O09102 (GCM2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 86. History...

Clusters with 100%, 90%, 50% identity |

Documents (2) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Chorion-specific transcription factor GCMb
Short name=mGCMb

Alternative name(s):
GCM motif protein 2
Glial cells missing homolog 2

Gene names

Name:	Gcm2
Synonyms:	Gcmb

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	504 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Probable transcriptional regulator.
Subcellular location	Nucleus By similarity.
Sequence similarities	Contains 1 GCM DNA-binding domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Ligand	DNA-binding Metal-binding Zinc
Molecular function	Developmental protein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell differentiation Inferred from mutant phenotype PubMed 17382312. Source: MGI cellular calcium ion homeostasis Inferred from sequence or structural similarity PubMed 9928992. Source: UniProtKB cellular phosphate ion homeostasis Inferred from sequence or structural similarity PubMed 9928992. Source: UniProtKB cellular response to organic substance Inferred from direct assay PubMed 20484821. Source: MGI negative regulation of apoptotic process Inferred from mutant phenotype PubMed 17382312. Source: MGI parathyroid gland development Inferred from sequence or structural similarity PubMed 9928992. Source: UniProtKB transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nucleus Inferred from direct assay PubMed 14573516 Ref.2. Source: MGI
Molecular_function	metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW sequence-specific DNA binding Inferred from sequence or structural similarity PubMed 9928992. Source: UniProtKB sequence-specific DNA binding transcription factor activity Traceable author statement PubMed 10910362. Source: MGI
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 504

504

Chorion-specific transcription factor GCMb

PRO_0000126651

Regions

DNA binding

19 – 174

156

GCM

Sites

Metal binding

Zinc 1 By similarity

Metal binding

Zinc 2 By similarity

Metal binding

Zinc 2 By similarity

Metal binding

118

Zinc 2 By similarity

Metal binding

121

Zinc 2 By similarity

Metal binding

130

Zinc 1 By similarity

Metal binding

157

Zinc 1 By similarity

Metal binding

159

Zinc 1 By similarity

Experimental info

Sequence conflict

159

H → R in BAA13649. Ref.1

Sequence conflict

191

E → G in AAC64782. Ref.2

Sequence conflict

241

H → Y in AAC64782. Ref.2

Sequence conflict

297

V → E in AAC64782. Ref.2

Sequence conflict

357

S → L in AAC64782. Ref.2

Sequence conflict

376

T → S in AAC64782. Ref.2

Sequence conflict

400

S → G in AAC64782. Ref.2

Sequence conflict

436

Q → R in BAA13649. Ref.1

Sequence conflict

438

A → V in AAC64782. Ref.2

Sequence conflict

501

N → D in BAA13649. Ref.1

Sequences

Sequence

Length

Mass (Da)

Tools

O09102 [UniParc].

Last modified July 25, 2003. Version 2.
Checksum: 2EBC3CFD8A120425
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FASTA

504

56,039

        10         20         30         40         50         60 
MPADSTQDED AVLSYGMKLT WDINDPQMPQ EPTHFDHFRE WPDGYVRFIY SSQEKKAQRH 

        70         80         90        100        110        120 
LSGWAMRNTN NHNGHILKKS CLGVVVCARA CALKDGSHLQ LRPAICDKAR LKQQKKACPN 

       130        140        150        160        170        180 
CHSPLELVPC RGHSGYPVTN FWRLDGNAIF FQAKGVHDHP RPESKSETEG RRSALKRQMA 

       190        200        210        220        230        240 
SFYQPQKRRS EEPEARSTQD IRGHLNSTAA LEPTELFDMT ADTSFPIPGQ PSPSFPNSDV 

       250        260        270        280        290        300 
HRVTCDLPTF QGDIILPFQK YPNPSIYFPG PPWGYELASS GVTGSSPYST LYKDSSVVPD 

       310        320        330        340        350        360 
DPDWIPLNSL QYNVSSYGSY ERTLDFTARY HSWKPTHGKP SLEEKVDCEQ CQAVPTSPYY 

       370        380        390        400        410        420 
NLELPCRYLP VPAAGTQALQ TVITTTVAYQ AYQHPALKHS DSMQEVSSLA SCTYASENLP 

       430        440        450        460        470        480 
MPIYPPALDP QEGVIQAASP SGRAPLKVPG DCQAPRPTLD FPQEADPSGT DGADVWDVCL 

       490        500 
SGVGSVMGYL DRTGQPFSFD NEDF

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The gcm-motif: a novel DNA binding motif conserved in Drosophila and mammals." Akiyama Y., Hosoya T., Poole A.M., Hotta Y. Proc. Natl. Acad. Sci. U.S.A. 93:14912-14916(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Brain.
[2]	"Isolation and characterization of mammalian homologs of the Drosophila gene glial cells missing." Kim J., Jones B.W., Zock C., Chen Z., Wang H., Goodman C.S., Anderson D.J. Proc. Natl. Acad. Sci. U.S.A. 95:12364-12369(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA]. Strain: 129/SvEv and C57BL/6.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	D88611 mRNA. Translation: BAA13649.1. AF081556 mRNA. Translation: AAC64782.1. AF081558 Genomic DNA. Translation: AAC64784.1. BC110631 mRNA. Translation: AAI10632.1. BC110632 mRNA. Translation: AAI10633.1.
IPI	IPI00114229.
RefSeq	NP_032130.2. NM_008104.2.
UniGene	Mm.1399.
3D structure databases
ProteinModelPortal	O09102.
SMR	O09102. Positions 19-173.
ModBase	Search...
PTM databases
PhosphoSite	O09102.
Proteomic databases
PRIDE	O09102.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000021791; ENSMUSP00000021791; ENSMUSG00000021362.
GeneID	107889.
KEGG	mmu:107889.
UCSC	uc007qey.1. mouse.
Organism-specific databases
CTD	9247.
MGI	MGI:1861438. Gcm2.
Phylogenomic databases
eggNOG	NOG74196.
GeneTree	ENSGT00390000006777.
HOGENOM	HOG000112702.
HOVERGEN	HBG039461.
InParanoid	Q2TB03.
OrthoDB	EOG4K0QNN.
Gene expression databases
Bgee	O09102.
CleanEx	MM_GCM2.
Genevestigator	O09102.
GermOnline	ENSMUSG00000021362. Mus musculus.
Family and domain databases
InterPro	IPR003902. Tscrpt_reg_GCM_motif. [Graphical view]
PANTHER	PTHR12414. PTHR12414. 1 hit.
Pfam	PF03615. GCM. 1 hit. [Graphical view]
ProDom	PD014393. GCM_motif. 1 hit. [Graphical view] [Entries sharing at least one domain]
SUPFAM	SSF90073. GCM_motif. 1 hit.
PROSITE	PS50807. GCM. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	359649.
SOURCE	Search...

Entry information

Entry name

GCM2_MOUSE

Accession

Primary (citable) accession number: O09102
Secondary accession number(s): Q2TB03, Q9QWX7, Q9Z289

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 25, 2003
Last sequence update:	July 25, 2003
Last modified:	April 3, 2013
This is version 86 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Sites

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents