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O09102 (GCM2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 92. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Chorion-specific transcription factor GCMb

Short name=mGCMb
Alternative name(s):
GCM motif protein 2
Glial cells missing homolog 2
Gene names
Name:Gcm2
Synonyms:Gcmb
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length504 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Probable transcriptional regulator.

Subcellular location

Nucleus By similarity.

Sequence similarities

Contains 1 GCM DNA-binding domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 504504Chorion-specific transcription factor GCMb
PRO_0000126651

Regions

DNA binding19 – 174156GCM

Sites

Metal binding811Zinc 1 By similarity
Metal binding871Zinc 2 By similarity
Metal binding911Zinc 2 By similarity
Metal binding1181Zinc 2 By similarity
Metal binding1211Zinc 2 By similarity
Metal binding1301Zinc 1 By similarity
Metal binding1571Zinc 1 By similarity
Metal binding1591Zinc 1 By similarity

Experimental info

Sequence conflict1591H → R in BAA13649. Ref.1
Sequence conflict1911E → G in AAC64782. Ref.2
Sequence conflict2411H → Y in AAC64782. Ref.2
Sequence conflict2971V → E in AAC64782. Ref.2
Sequence conflict3571S → L in AAC64782. Ref.2
Sequence conflict3761T → S in AAC64782. Ref.2
Sequence conflict4001S → G in AAC64782. Ref.2
Sequence conflict4361Q → R in BAA13649. Ref.1
Sequence conflict4381A → V in AAC64782. Ref.2
Sequence conflict5011N → D in BAA13649. Ref.1

Sequences

Sequence LengthMass (Da)Tools
O09102 [UniParc].

Last modified July 25, 2003. Version 2.
Checksum: 2EBC3CFD8A120425

FASTA50456,039
        10         20         30         40         50         60 
MPADSTQDED AVLSYGMKLT WDINDPQMPQ EPTHFDHFRE WPDGYVRFIY SSQEKKAQRH 

        70         80         90        100        110        120 
LSGWAMRNTN NHNGHILKKS CLGVVVCARA CALKDGSHLQ LRPAICDKAR LKQQKKACPN 

       130        140        150        160        170        180 
CHSPLELVPC RGHSGYPVTN FWRLDGNAIF FQAKGVHDHP RPESKSETEG RRSALKRQMA 

       190        200        210        220        230        240 
SFYQPQKRRS EEPEARSTQD IRGHLNSTAA LEPTELFDMT ADTSFPIPGQ PSPSFPNSDV 

       250        260        270        280        290        300 
HRVTCDLPTF QGDIILPFQK YPNPSIYFPG PPWGYELASS GVTGSSPYST LYKDSSVVPD 

       310        320        330        340        350        360 
DPDWIPLNSL QYNVSSYGSY ERTLDFTARY HSWKPTHGKP SLEEKVDCEQ CQAVPTSPYY 

       370        380        390        400        410        420 
NLELPCRYLP VPAAGTQALQ TVITTTVAYQ AYQHPALKHS DSMQEVSSLA SCTYASENLP 

       430        440        450        460        470        480 
MPIYPPALDP QEGVIQAASP SGRAPLKVPG DCQAPRPTLD FPQEADPSGT DGADVWDVCL 

       490        500 
SGVGSVMGYL DRTGQPFSFD NEDF 

« Hide

References

« Hide 'large scale' references
[1]"The gcm-motif: a novel DNA binding motif conserved in Drosophila and mammals."
Akiyama Y., Hosoya T., Poole A.M., Hotta Y.
Proc. Natl. Acad. Sci. U.S.A. 93:14912-14916(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Brain.
[2]"Isolation and characterization of mammalian homologs of the Drosophila gene glial cells missing."
Kim J., Jones B.W., Zock C., Chen Z., Wang H., Goodman C.S., Anderson D.J.
Proc. Natl. Acad. Sci. U.S.A. 95:12364-12369(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
Strain: 129/SvEv and C57BL/6.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D88611 mRNA. Translation: BAA13649.1.
AF081556 mRNA. Translation: AAC64782.1.
AF081558 Genomic DNA. Translation: AAC64784.1.
BC110631 mRNA. Translation: AAI10632.1.
BC110632 mRNA. Translation: AAI10633.1.
RefSeqNP_032130.2. NM_008104.2.
UniGeneMm.1399.

3D structure databases

ProteinModelPortalO09102.
SMRO09102. Positions 19-173.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteO09102.

Proteomic databases

PRIDEO09102.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000021791; ENSMUSP00000021791; ENSMUSG00000021362.
GeneID107889.
KEGGmmu:107889.
UCSCuc007qey.1. mouse.

Organism-specific databases

CTD9247.
MGIMGI:1861438. Gcm2.

Phylogenomic databases

eggNOGNOG74196.
GeneTreeENSGT00390000006777.
HOGENOMHOG000112702.
HOVERGENHBG039461.
InParanoidQ2TB03.
OrthoDBEOG7M3J08.
PhylomeDBO09102.
TreeFamTF324146.

Gene expression databases

BgeeO09102.
CleanExMM_GCM2.
GenevestigatorO09102.

Family and domain databases

InterProIPR003902. Tscrpt_reg_GCM_motif.
[Graphical view]
PANTHERPTHR12414. PTHR12414. 1 hit.
PfamPF03615. GCM. 1 hit.
[Graphical view]
ProDomPD014393. GCM_motif. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMSSF90073. SSF90073. 1 hit.
PROSITEPS50807. GCM. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio359649.
PROO09102.
SOURCESearch...

Entry information

Entry nameGCM2_MOUSE
AccessionPrimary (citable) accession number: O09102
Secondary accession number(s): Q2TB03, Q9QWX7, Q9Z289
Entry history
Integrated into UniProtKB/Swiss-Prot: July 25, 2003
Last sequence update: July 25, 2003
Last modified: April 16, 2014
This is version 92 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot