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Protein

Chorion-specific transcription factor GCMb

Gene

Gcm2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Probable transcriptional regulator.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi81 – 811Zinc 1PROSITE-ProRule annotation
Metal bindingi87 – 871Zinc 2PROSITE-ProRule annotation
Metal bindingi91 – 911Zinc 2PROSITE-ProRule annotation
Metal bindingi118 – 1181Zinc 2PROSITE-ProRule annotation
Metal bindingi121 – 1211Zinc 2PROSITE-ProRule annotation
Metal bindingi130 – 1301Zinc 1PROSITE-ProRule annotation
Metal bindingi157 – 1571Zinc 1PROSITE-ProRule annotation
Metal bindingi159 – 1591Zinc 1PROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi19 – 174156GCMPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: MGI
  2. metal ion binding Source: UniProtKB-KW
  3. sequence-specific DNA binding Source: UniProtKB
  4. sequence-specific DNA binding transcription factor activity Source: MGI

GO - Biological processi

  1. cell differentiation Source: MGI
  2. cellular calcium ion homeostasis Source: UniProtKB
  3. cellular phosphate ion homeostasis Source: UniProtKB
  4. cellular response to organic substance Source: MGI
  5. negative regulation of apoptotic process Source: MGI
  6. parathyroid gland development Source: UniProtKB
  7. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Chorion-specific transcription factor GCMb
Short name:
mGCMb
Alternative name(s):
GCM motif protein 2
Glial cells missing homolog 2
Gene namesi
Name:Gcm2
Synonyms:Gcmb
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 13

Organism-specific databases

MGIiMGI:1861438. Gcm2.

Subcellular locationi

Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

  1. nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 504504Chorion-specific transcription factor GCMbPRO_0000126651Add
BLAST

Proteomic databases

PRIDEiO09102.

PTM databases

PhosphoSiteiO09102.

Expressioni

Gene expression databases

BgeeiO09102.
CleanExiMM_GCM2.
GenevestigatoriO09102.

Structurei

3D structure databases

ProteinModelPortaliO09102.
SMRiO09102. Positions 19-173.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 1 GCM DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG74196.
GeneTreeiENSGT00390000006777.
HOGENOMiHOG000112702.
HOVERGENiHBG039461.
InParanoidiO09102.
OrthoDBiEOG7M3J08.
PhylomeDBiO09102.
TreeFamiTF324146.

Family and domain databases

InterProiIPR003902. Tscrpt_reg_GCM.
[Graphical view]
PfamiPF03615. GCM. 1 hit.
[Graphical view]
ProDomiPD014393. GCM_motif. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF90073. SSF90073. 1 hit.
PROSITEiPS50807. GCM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O09102-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPADSTQDED AVLSYGMKLT WDINDPQMPQ EPTHFDHFRE WPDGYVRFIY
60 70 80 90 100
SSQEKKAQRH LSGWAMRNTN NHNGHILKKS CLGVVVCARA CALKDGSHLQ
110 120 130 140 150
LRPAICDKAR LKQQKKACPN CHSPLELVPC RGHSGYPVTN FWRLDGNAIF
160 170 180 190 200
FQAKGVHDHP RPESKSETEG RRSALKRQMA SFYQPQKRRS EEPEARSTQD
210 220 230 240 250
IRGHLNSTAA LEPTELFDMT ADTSFPIPGQ PSPSFPNSDV HRVTCDLPTF
260 270 280 290 300
QGDIILPFQK YPNPSIYFPG PPWGYELASS GVTGSSPYST LYKDSSVVPD
310 320 330 340 350
DPDWIPLNSL QYNVSSYGSY ERTLDFTARY HSWKPTHGKP SLEEKVDCEQ
360 370 380 390 400
CQAVPTSPYY NLELPCRYLP VPAAGTQALQ TVITTTVAYQ AYQHPALKHS
410 420 430 440 450
DSMQEVSSLA SCTYASENLP MPIYPPALDP QEGVIQAASP SGRAPLKVPG
460 470 480 490 500
DCQAPRPTLD FPQEADPSGT DGADVWDVCL SGVGSVMGYL DRTGQPFSFD

NEDF
Length:504
Mass (Da):56,039
Last modified:July 25, 2003 - v2
Checksum:i2EBC3CFD8A120425
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti159 – 1591H → R in BAA13649. (PubMed:8962155)Curated
Sequence conflicti191 – 1911E → G in AAC64782. (PubMed:9770492)Curated
Sequence conflicti241 – 2411H → Y in AAC64782. (PubMed:9770492)Curated
Sequence conflicti297 – 2971V → E in AAC64782. (PubMed:9770492)Curated
Sequence conflicti357 – 3571S → L in AAC64782. (PubMed:9770492)Curated
Sequence conflicti376 – 3761T → S in AAC64782. (PubMed:9770492)Curated
Sequence conflicti400 – 4001S → G in AAC64782. (PubMed:9770492)Curated
Sequence conflicti436 – 4361Q → R in BAA13649. (PubMed:8962155)Curated
Sequence conflicti438 – 4381A → V in AAC64782. (PubMed:9770492)Curated
Sequence conflicti501 – 5011N → D in BAA13649. (PubMed:8962155)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D88611 mRNA. Translation: BAA13649.1.
AF081556 mRNA. Translation: AAC64782.1.
AF081558 Genomic DNA. Translation: AAC64784.1.
BC110631 mRNA. Translation: AAI10632.1.
BC110632 mRNA. Translation: AAI10633.1.
CCDSiCCDS26472.1.
RefSeqiNP_032130.2. NM_008104.2.
UniGeneiMm.1399.

Genome annotation databases

EnsembliENSMUST00000021791; ENSMUSP00000021791; ENSMUSG00000021362.
GeneIDi107889.
KEGGimmu:107889.
UCSCiuc007qey.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D88611 mRNA. Translation: BAA13649.1.
AF081556 mRNA. Translation: AAC64782.1.
AF081558 Genomic DNA. Translation: AAC64784.1.
BC110631 mRNA. Translation: AAI10632.1.
BC110632 mRNA. Translation: AAI10633.1.
CCDSiCCDS26472.1.
RefSeqiNP_032130.2. NM_008104.2.
UniGeneiMm.1399.

3D structure databases

ProteinModelPortaliO09102.
SMRiO09102. Positions 19-173.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

PhosphoSiteiO09102.

Proteomic databases

PRIDEiO09102.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000021791; ENSMUSP00000021791; ENSMUSG00000021362.
GeneIDi107889.
KEGGimmu:107889.
UCSCiuc007qey.1. mouse.

Organism-specific databases

CTDi9247.
MGIiMGI:1861438. Gcm2.

Phylogenomic databases

eggNOGiNOG74196.
GeneTreeiENSGT00390000006777.
HOGENOMiHOG000112702.
HOVERGENiHBG039461.
InParanoidiO09102.
OrthoDBiEOG7M3J08.
PhylomeDBiO09102.
TreeFamiTF324146.

Miscellaneous databases

NextBioi359649.
PROiO09102.
SOURCEiSearch...

Gene expression databases

BgeeiO09102.
CleanExiMM_GCM2.
GenevestigatoriO09102.

Family and domain databases

InterProiIPR003902. Tscrpt_reg_GCM.
[Graphical view]
PfamiPF03615. GCM. 1 hit.
[Graphical view]
ProDomiPD014393. GCM_motif. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF90073. SSF90073. 1 hit.
PROSITEiPS50807. GCM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The gcm-motif: a novel DNA binding motif conserved in Drosophila and mammals."
    Akiyama Y., Hosoya T., Poole A.M., Hotta Y.
    Proc. Natl. Acad. Sci. U.S.A. 93:14912-14916(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  2. "Isolation and characterization of mammalian homologs of the Drosophila gene glial cells missing."
    Kim J., Jones B.W., Zock C., Chen Z., Wang H., Goodman C.S., Anderson D.J.
    Proc. Natl. Acad. Sci. U.S.A. 95:12364-12369(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
    Strain: 129/SvEv and C57BL/6.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiGCM2_MOUSE
AccessioniPrimary (citable) accession number: O09102
Secondary accession number(s): Q2TB03, Q9QWX7, Q9Z289
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2003
Last sequence update: July 25, 2003
Last modified: January 7, 2015
This is version 98 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.