Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

O09102

- GCM2_MOUSE

UniProt

O09102 - GCM2_MOUSE

Protein

Chorion-specific transcription factor GCMb

Gene

Gcm2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 96 (01 Oct 2014)
      Sequence version 2 (25 Jul 2003)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Probable transcriptional regulator.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi81 – 811Zinc 1PROSITE-ProRule annotation
    Metal bindingi87 – 871Zinc 2PROSITE-ProRule annotation
    Metal bindingi91 – 911Zinc 2PROSITE-ProRule annotation
    Metal bindingi118 – 1181Zinc 2PROSITE-ProRule annotation
    Metal bindingi121 – 1211Zinc 2PROSITE-ProRule annotation
    Metal bindingi130 – 1301Zinc 1PROSITE-ProRule annotation
    Metal bindingi157 – 1571Zinc 1PROSITE-ProRule annotation
    Metal bindingi159 – 1591Zinc 1PROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi19 – 174156GCMPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: MGI
    2. metal ion binding Source: UniProtKB-KW
    3. sequence-specific DNA binding Source: UniProtKB
    4. sequence-specific DNA binding transcription factor activity Source: MGI

    GO - Biological processi

    1. cell differentiation Source: MGI
    2. cellular calcium ion homeostasis Source: UniProtKB
    3. cellular phosphate ion homeostasis Source: UniProtKB
    4. cellular response to organic substance Source: MGI
    5. negative regulation of apoptotic process Source: MGI
    6. parathyroid gland development Source: UniProtKB
    7. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Chorion-specific transcription factor GCMb
    Short name:
    mGCMb
    Alternative name(s):
    GCM motif protein 2
    Glial cells missing homolog 2
    Gene namesi
    Name:Gcm2
    Synonyms:Gcmb
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 13

    Organism-specific databases

    MGIiMGI:1861438. Gcm2.

    Subcellular locationi

    Nucleus PROSITE-ProRule annotation

    GO - Cellular componenti

    1. nucleus Source: MGI

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 504504Chorion-specific transcription factor GCMbPRO_0000126651Add
    BLAST

    Proteomic databases

    PRIDEiO09102.

    PTM databases

    PhosphoSiteiO09102.

    Expressioni

    Gene expression databases

    BgeeiO09102.
    CleanExiMM_GCM2.
    GenevestigatoriO09102.

    Structurei

    3D structure databases

    ProteinModelPortaliO09102.
    SMRiO09102. Positions 19-173.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Contains 1 GCM DNA-binding domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG74196.
    GeneTreeiENSGT00390000006777.
    HOGENOMiHOG000112702.
    HOVERGENiHBG039461.
    InParanoidiQ2TB03.
    OrthoDBiEOG7M3J08.
    PhylomeDBiO09102.
    TreeFamiTF324146.

    Family and domain databases

    InterProiIPR003902. Tscrpt_reg_GCM.
    [Graphical view]
    PfamiPF03615. GCM. 1 hit.
    [Graphical view]
    ProDomiPD014393. GCM_motif. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    SUPFAMiSSF90073. SSF90073. 1 hit.
    PROSITEiPS50807. GCM. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O09102-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPADSTQDED AVLSYGMKLT WDINDPQMPQ EPTHFDHFRE WPDGYVRFIY    50
    SSQEKKAQRH LSGWAMRNTN NHNGHILKKS CLGVVVCARA CALKDGSHLQ 100
    LRPAICDKAR LKQQKKACPN CHSPLELVPC RGHSGYPVTN FWRLDGNAIF 150
    FQAKGVHDHP RPESKSETEG RRSALKRQMA SFYQPQKRRS EEPEARSTQD 200
    IRGHLNSTAA LEPTELFDMT ADTSFPIPGQ PSPSFPNSDV HRVTCDLPTF 250
    QGDIILPFQK YPNPSIYFPG PPWGYELASS GVTGSSPYST LYKDSSVVPD 300
    DPDWIPLNSL QYNVSSYGSY ERTLDFTARY HSWKPTHGKP SLEEKVDCEQ 350
    CQAVPTSPYY NLELPCRYLP VPAAGTQALQ TVITTTVAYQ AYQHPALKHS 400
    DSMQEVSSLA SCTYASENLP MPIYPPALDP QEGVIQAASP SGRAPLKVPG 450
    DCQAPRPTLD FPQEADPSGT DGADVWDVCL SGVGSVMGYL DRTGQPFSFD 500
    NEDF 504
    Length:504
    Mass (Da):56,039
    Last modified:July 25, 2003 - v2
    Checksum:i2EBC3CFD8A120425
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti159 – 1591H → R in BAA13649. (PubMed:8962155)Curated
    Sequence conflicti191 – 1911E → G in AAC64782. (PubMed:9770492)Curated
    Sequence conflicti241 – 2411H → Y in AAC64782. (PubMed:9770492)Curated
    Sequence conflicti297 – 2971V → E in AAC64782. (PubMed:9770492)Curated
    Sequence conflicti357 – 3571S → L in AAC64782. (PubMed:9770492)Curated
    Sequence conflicti376 – 3761T → S in AAC64782. (PubMed:9770492)Curated
    Sequence conflicti400 – 4001S → G in AAC64782. (PubMed:9770492)Curated
    Sequence conflicti436 – 4361Q → R in BAA13649. (PubMed:8962155)Curated
    Sequence conflicti438 – 4381A → V in AAC64782. (PubMed:9770492)Curated
    Sequence conflicti501 – 5011N → D in BAA13649. (PubMed:8962155)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D88611 mRNA. Translation: BAA13649.1.
    AF081556 mRNA. Translation: AAC64782.1.
    AF081558 Genomic DNA. Translation: AAC64784.1.
    BC110631 mRNA. Translation: AAI10632.1.
    BC110632 mRNA. Translation: AAI10633.1.
    CCDSiCCDS26472.1.
    RefSeqiNP_032130.2. NM_008104.2.
    UniGeneiMm.1399.

    Genome annotation databases

    EnsembliENSMUST00000021791; ENSMUSP00000021791; ENSMUSG00000021362.
    GeneIDi107889.
    KEGGimmu:107889.
    UCSCiuc007qey.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D88611 mRNA. Translation: BAA13649.1 .
    AF081556 mRNA. Translation: AAC64782.1 .
    AF081558 Genomic DNA. Translation: AAC64784.1 .
    BC110631 mRNA. Translation: AAI10632.1 .
    BC110632 mRNA. Translation: AAI10633.1 .
    CCDSi CCDS26472.1.
    RefSeqi NP_032130.2. NM_008104.2.
    UniGenei Mm.1399.

    3D structure databases

    ProteinModelPortali O09102.
    SMRi O09102. Positions 19-173.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei O09102.

    Proteomic databases

    PRIDEi O09102.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000021791 ; ENSMUSP00000021791 ; ENSMUSG00000021362 .
    GeneIDi 107889.
    KEGGi mmu:107889.
    UCSCi uc007qey.1. mouse.

    Organism-specific databases

    CTDi 9247.
    MGIi MGI:1861438. Gcm2.

    Phylogenomic databases

    eggNOGi NOG74196.
    GeneTreei ENSGT00390000006777.
    HOGENOMi HOG000112702.
    HOVERGENi HBG039461.
    InParanoidi Q2TB03.
    OrthoDBi EOG7M3J08.
    PhylomeDBi O09102.
    TreeFami TF324146.

    Miscellaneous databases

    NextBioi 359649.
    PROi O09102.
    SOURCEi Search...

    Gene expression databases

    Bgeei O09102.
    CleanExi MM_GCM2.
    Genevestigatori O09102.

    Family and domain databases

    InterProi IPR003902. Tscrpt_reg_GCM.
    [Graphical view ]
    Pfami PF03615. GCM. 1 hit.
    [Graphical view ]
    ProDomi PD014393. GCM_motif. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    SUPFAMi SSF90073. SSF90073. 1 hit.
    PROSITEi PS50807. GCM. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The gcm-motif: a novel DNA binding motif conserved in Drosophila and mammals."
      Akiyama Y., Hosoya T., Poole A.M., Hotta Y.
      Proc. Natl. Acad. Sci. U.S.A. 93:14912-14916(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Brain.
    2. "Isolation and characterization of mammalian homologs of the Drosophila gene glial cells missing."
      Kim J., Jones B.W., Zock C., Chen Z., Wang H., Goodman C.S., Anderson D.J.
      Proc. Natl. Acad. Sci. U.S.A. 95:12364-12369(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
      Strain: 129/SvEv and C57BL/6.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

    Entry informationi

    Entry nameiGCM2_MOUSE
    AccessioniPrimary (citable) accession number: O09102
    Secondary accession number(s): Q2TB03, Q9QWX7, Q9Z289
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 25, 2003
    Last sequence update: July 25, 2003
    Last modified: October 1, 2014
    This is version 96 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3