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Protein

Endothelial transcription factor GATA-2

Gene

Gata2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transcriptional activator which regulates endothelin-1 gene expression in endothelial cells. Binds to the consensus sequence 5'-AGATAG-3'.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri295 – 31925GATA-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri349 – 37325GATA-type 2PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

  • cell differentiation Source: MGI
  • cell differentiation in hindbrain Source: MGI
  • cell fate determination Source: MGI
  • cell maturation Source: MGI
  • central nervous system neuron development Source: MGI
  • commitment of neuronal cell to specific neuron type in forebrain Source: MGI
  • definitive hemopoiesis Source: MGI
  • embryonic placenta development Source: MGI
  • eosinophil fate commitment Source: MGI
  • GABAergic neuron differentiation Source: MGI
  • homeostasis of number of cells within a tissue Source: MGI
  • inner ear morphogenesis Source: MGI
  • mast cell degranulation Source: Ensembl
  • negative regulation of fat cell differentiation Source: MGI
  • negative regulation of fat cell proliferation Source: MGI
  • negative regulation of macrophage differentiation Source: MGI
  • negative regulation of myeloid cell differentiation Source: MGI
  • negative regulation of neural precursor cell proliferation Source: MGI
  • negative regulation of Notch signaling pathway Source: MGI
  • negative regulation of transcription from RNA polymerase II promoter Source: MGI
  • neuron differentiation Source: MGI
  • neuron fate commitment Source: MGI
  • neuron migration Source: Ensembl
  • phagocytosis Source: UniProtKB-KW
  • pituitary gland development Source: MGI
  • positive regulation of angiogenesis Source: MGI
  • positive regulation of cytosolic calcium ion concentration Source: Ensembl
  • positive regulation of erythrocyte differentiation Source: MGI
  • positive regulation of megakaryocyte differentiation Source: MGI
  • positive regulation of neuron differentiation Source: Ensembl
  • positive regulation of phagocytosis Source: UniProtKB
  • positive regulation of phagocytosis, engulfment Source: Ensembl
  • positive regulation of transcription from RNA polymerase II promoter Source: MGI
  • regulation of forebrain neuron differentiation Source: MGI
  • regulation of histone acetylation Source: MGI
  • response to lipid Source: Ensembl
  • semicircular canal development Source: MGI
  • somatic stem cell maintenance Source: MGI
  • transcription, DNA-templated Source: MGI
  • transcription from RNA polymerase II promoter Source: GOC
  • urogenital system development Source: MGI
  • ventral spinal cord interneuron differentiation Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Phagocytosis, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_280010. Factors involved in megakaryocyte development and platelet production.

Names & Taxonomyi

Protein namesi
Recommended name:
Endothelial transcription factor GATA-2
Alternative name(s):
GATA-binding protein 2
Gene namesi
Name:Gata2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:95662. Gata2.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: GOC
  • mast cell granule Source: Ensembl
  • nucleoplasm Source: MGI
  • nucleus Source: MGI
  • protein complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 480480Endothelial transcription factor GATA-2PRO_0000083404Add
BLAST

Proteomic databases

PRIDEiO09100.

PTM databases

PhosphoSiteiO09100.

Expressioni

Gene expression databases

BgeeiO09100.
CleanExiMM_GATA2.
ExpressionAtlasiO09100. baseline and differential.
GenevisibleiO09100. MM.

Interactioni

Subunit structurei

Interacts with BRD3. Interacts with AR and CCAR1 (By similarity).By similarity1 Publication

Protein-protein interaction databases

BioGridi199839. 2 interactions.
STRINGi10090.ENSMUSP00000015197.

Structurei

3D structure databases

ProteinModelPortaliO09100.
SMRiO09100. Positions 293-397.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 2 GATA-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri295 – 31925GATA-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri349 – 37325GATA-type 2PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5641.
GeneTreeiENSGT00760000119221.
HOGENOMiHOG000047701.
HOVERGENiHBG051705.
InParanoidiO09100.
KOiK17894.
OMAiNKKGAEC.
OrthoDBiEOG7CCBRF.
PhylomeDBiO09100.
TreeFamiTF315391.

Family and domain databases

Gene3Di3.30.50.10. 2 hits.
InterProiIPR029522. GATA-2.
IPR016374. TF_GATA-2/3.
IPR000679. Znf_GATA.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PANTHERiPTHR10071:SF149. PTHR10071:SF149. 1 hit.
PfamiPF00320. GATA. 2 hits.
[Graphical view]
PIRSFiPIRSF003027. TF_GATA-1/2/3. 1 hit.
PRINTSiPR00619. GATAZNFINGER.
SMARTiSM00401. ZnF_GATA. 2 hits.
[Graphical view]
PROSITEiPS00344. GATA_ZN_FINGER_1. 2 hits.
PS50114. GATA_ZN_FINGER_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O09100-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEVAPEQPRW MAHPAVLNAQ HPDSHHPGLA HNYMEPAQLL PPDEVDVFFN
60 70 80 90 100
HLDSQGNPYY ANPAHARARV SYSPAHARLT GGQMCRPHLL HSPGLPWLDG
110 120 130 140 150
GKAALSAAAA HHHSPWTVSP FSKTPLHPSA AGAPGGPLSV YPGAAGGSGG
160 170 180 190 200
GSGSSVASLT PTAAHSGSHL FGFPPTPPKE VSPDPSTTGA ASPASSSAGG
210 220 230 240 250
SVARGEDKDG VKYQVSLSES MKMEGGSPLR PGLATMGTQP ATHHPIPTYP
260 270 280 290 300
SYVPAAAHDY GSSLFHPGGF LGGPASSFTP KQRSKARSCS EGRECVNCGA
310 320 330 340 350
TATPLWRRDG TGHYLCNACG LYHKMNGQNR PLIKPKRRLS AARRAGTCCA
360 370 380 390 400
NCQTTTTTLW RRNANGDPVC NACGLYYKLH NVNRPLTMKK EGIQTRNRKM
410 420 430 440 450
SSKSKKSKKG AECFEELSKC MQEKSPPFSA AALAGHMAPV GHLPPFSHSG
460 470 480
HILPTPTPIH PSSSLSFGHP HPSSMVTAMG
Length:480
Mass (Da):50,468
Last modified:May 27, 2002 - v2
Checksum:i7E0DCE9B53F49C8A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB000096 mRNA. Translation: BAA19053.2.
CCDSiCCDS20333.1.
RefSeqiNP_032116.4. NM_008090.5.
XP_006505602.1. XM_006505539.2.
UniGeneiMm.491156.

Genome annotation databases

EnsembliENSMUST00000015197; ENSMUSP00000015197; ENSMUSG00000015053.
ENSMUST00000170089; ENSMUSP00000128198; ENSMUSG00000015053.
GeneIDi14461.
KEGGimmu:14461.
UCSCiuc009cvc.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB000096 mRNA. Translation: BAA19053.2.
CCDSiCCDS20333.1.
RefSeqiNP_032116.4. NM_008090.5.
XP_006505602.1. XM_006505539.2.
UniGeneiMm.491156.

3D structure databases

ProteinModelPortaliO09100.
SMRiO09100. Positions 293-397.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi199839. 2 interactions.
STRINGi10090.ENSMUSP00000015197.

PTM databases

PhosphoSiteiO09100.

Proteomic databases

PRIDEiO09100.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000015197; ENSMUSP00000015197; ENSMUSG00000015053.
ENSMUST00000170089; ENSMUSP00000128198; ENSMUSG00000015053.
GeneIDi14461.
KEGGimmu:14461.
UCSCiuc009cvc.2. mouse.

Organism-specific databases

CTDi2624.
MGIiMGI:95662. Gata2.

Phylogenomic databases

eggNOGiCOG5641.
GeneTreeiENSGT00760000119221.
HOGENOMiHOG000047701.
HOVERGENiHBG051705.
InParanoidiO09100.
KOiK17894.
OMAiNKKGAEC.
OrthoDBiEOG7CCBRF.
PhylomeDBiO09100.
TreeFamiTF315391.

Enzyme and pathway databases

ReactomeiREACT_280010. Factors involved in megakaryocyte development and platelet production.

Miscellaneous databases

NextBioi286096.
PROiO09100.
SOURCEiSearch...

Gene expression databases

BgeeiO09100.
CleanExiMM_GATA2.
ExpressionAtlasiO09100. baseline and differential.
GenevisibleiO09100. MM.

Family and domain databases

Gene3Di3.30.50.10. 2 hits.
InterProiIPR029522. GATA-2.
IPR016374. TF_GATA-2/3.
IPR000679. Znf_GATA.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PANTHERiPTHR10071:SF149. PTHR10071:SF149. 1 hit.
PfamiPF00320. GATA. 2 hits.
[Graphical view]
PIRSFiPIRSF003027. TF_GATA-1/2/3. 1 hit.
PRINTSiPR00619. GATAZNFINGER.
SMARTiSM00401. ZnF_GATA. 2 hits.
[Graphical view]
PROSITEiPS00344. GATA_ZN_FINGER_1. 2 hits.
PS50114. GATA_ZN_FINGER_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Suwabe N., Minegishi N., Yamamoto M.
    Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver.
  2. "Alternative promoters regulate transcription of the mouse GATA-2 gene."
    Minegishi N., Ohta J., Suwabe N., Nakauchi H., Ishihara H., Hayashi N., Yamamoto M.
    J. Biol. Chem. 273:3625-3634(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENOMIC ORGANIZATION.
  3. "Bromodomain protein Brd3 associates with acetylated GATA1 to promote its chromatin occupancy at erythroid target genes."
    Lamonica J.M., Deng W., Kadauke S., Campbell A.E., Gamsjaeger R., Wang H., Cheng Y., Billin A.N., Hardison R.C., Mackay J.P., Blobel G.A.
    Proc. Natl. Acad. Sci. U.S.A. 108:E159-E168(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH BRD3.

Entry informationi

Entry nameiGATA2_MOUSE
AccessioniPrimary (citable) accession number: O09100
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 27, 2002
Last modified: July 22, 2015
This is version 115 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.