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O09100

- GATA2_MOUSE

UniProt

O09100 - GATA2_MOUSE

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Protein

Endothelial transcription factor GATA-2

Gene

Gata2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Transcriptional activator which regulates endothelin-1 gene expression in endothelial cells. Binds to the consensus sequence 5'-AGATAG-3'.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri295 – 31925GATA-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri349 – 37325GATA-type 2PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. chromatin binding Source: MGI
  2. DNA binding Source: MGI
  3. enhancer sequence-specific DNA binding Source: MGI
  4. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: MGI
  5. RNA polymerase II distal enhancer sequence-specific DNA binding Source: MGI
  6. zinc ion binding Source: InterPro

GO - Biological processi

  1. cell differentiation Source: MGI
  2. cell differentiation in hindbrain Source: MGI
  3. cell fate determination Source: MGI
  4. cell maturation Source: MGI
  5. central nervous system neuron development Source: MGI
  6. commitment of neuronal cell to specific neuron type in forebrain Source: MGI
  7. definitive hemopoiesis Source: MGI
  8. embryonic placenta development Source: MGI
  9. eosinophil fate commitment Source: Ensembl
  10. GABAergic neuron differentiation Source: MGI
  11. homeostasis of number of cells within a tissue Source: MGI
  12. inner ear morphogenesis Source: MGI
  13. negative regulation of fat cell differentiation Source: MGI
  14. negative regulation of fat cell proliferation Source: Ensembl
  15. negative regulation of macrophage differentiation Source: MGI
  16. negative regulation of myeloid cell differentiation Source: MGI
  17. negative regulation of neural precursor cell proliferation Source: MGI
  18. negative regulation of Notch signaling pathway Source: Ensembl
  19. negative regulation of transcription from RNA polymerase II promoter Source: MGI
  20. neuron differentiation Source: MGI
  21. neuron fate commitment Source: MGI
  22. phagocytosis Source: UniProtKB-KW
  23. pituitary gland development Source: MGI
  24. positive regulation of angiogenesis Source: MGI
  25. positive regulation of erythrocyte differentiation Source: MGI
  26. positive regulation of megakaryocyte differentiation Source: MGI
  27. positive regulation of phagocytosis Source: UniProtKB
  28. positive regulation of transcription from RNA polymerase II promoter Source: MGI
  29. regulation of forebrain neuron differentiation Source: MGI
  30. regulation of histone acetylation Source: MGI
  31. semicircular canal development Source: MGI
  32. somatic stem cell maintenance Source: MGI
  33. urogenital system development Source: MGI
  34. ventral spinal cord interneuron differentiation Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Phagocytosis, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_198649. Factors involved in megakaryocyte development and platelet production.

Names & Taxonomyi

Protein namesi
Recommended name:
Endothelial transcription factor GATA-2
Alternative name(s):
GATA-binding protein 2
Gene namesi
Name:Gata2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 6

Organism-specific databases

MGIiMGI:95662. Gata2.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: MGI
  2. protein complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 480480Endothelial transcription factor GATA-2PRO_0000083404Add
BLAST

Proteomic databases

PRIDEiO09100.

PTM databases

PhosphoSiteiO09100.

Expressioni

Gene expression databases

BgeeiO09100.
CleanExiMM_GATA2.
ExpressionAtlasiO09100. baseline and differential.
GenevestigatoriO09100.

Interactioni

Subunit structurei

Interacts with BRD3.1 Publication

Protein-protein interaction databases

BioGridi199839. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliO09100.
SMRiO09100. Positions 293-397.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 2 GATA-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri295 – 31925GATA-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri349 – 37325GATA-type 2PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5641.
HOGENOMiHOG000047701.
HOVERGENiHBG051705.
InParanoidiO09100.
KOiK17894.
OMAiNKKGAEC.
OrthoDBiEOG7CCBRF.
PhylomeDBiO09100.
TreeFamiTF315391.

Family and domain databases

Gene3Di3.30.50.10. 2 hits.
InterProiIPR029522. GATA-2.
IPR016374. TF_GATA-1/2/3.
IPR000679. Znf_GATA.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PANTHERiPTHR10071:SF149. PTHR10071:SF149. 1 hit.
PfamiPF00320. GATA. 2 hits.
[Graphical view]
PIRSFiPIRSF003027. TF_GATA-1/2/3. 1 hit.
PRINTSiPR00619. GATAZNFINGER.
SMARTiSM00401. ZnF_GATA. 2 hits.
[Graphical view]
PROSITEiPS00344. GATA_ZN_FINGER_1. 2 hits.
PS50114. GATA_ZN_FINGER_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O09100-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEVAPEQPRW MAHPAVLNAQ HPDSHHPGLA HNYMEPAQLL PPDEVDVFFN
60 70 80 90 100
HLDSQGNPYY ANPAHARARV SYSPAHARLT GGQMCRPHLL HSPGLPWLDG
110 120 130 140 150
GKAALSAAAA HHHSPWTVSP FSKTPLHPSA AGAPGGPLSV YPGAAGGSGG
160 170 180 190 200
GSGSSVASLT PTAAHSGSHL FGFPPTPPKE VSPDPSTTGA ASPASSSAGG
210 220 230 240 250
SVARGEDKDG VKYQVSLSES MKMEGGSPLR PGLATMGTQP ATHHPIPTYP
260 270 280 290 300
SYVPAAAHDY GSSLFHPGGF LGGPASSFTP KQRSKARSCS EGRECVNCGA
310 320 330 340 350
TATPLWRRDG TGHYLCNACG LYHKMNGQNR PLIKPKRRLS AARRAGTCCA
360 370 380 390 400
NCQTTTTTLW RRNANGDPVC NACGLYYKLH NVNRPLTMKK EGIQTRNRKM
410 420 430 440 450
SSKSKKSKKG AECFEELSKC MQEKSPPFSA AALAGHMAPV GHLPPFSHSG
460 470 480
HILPTPTPIH PSSSLSFGHP HPSSMVTAMG
Length:480
Mass (Da):50,468
Last modified:May 27, 2002 - v2
Checksum:i7E0DCE9B53F49C8A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB000096 mRNA. Translation: BAA19053.2.
CCDSiCCDS20333.1.
RefSeqiNP_032116.4. NM_008090.5.
XP_006505602.1. XM_006505539.1.
UniGeneiMm.491156.

Genome annotation databases

EnsembliENSMUST00000015197; ENSMUSP00000015197; ENSMUSG00000015053.
ENSMUST00000170089; ENSMUSP00000128198; ENSMUSG00000015053.
GeneIDi14461.
KEGGimmu:14461.
UCSCiuc009cvc.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB000096 mRNA. Translation: BAA19053.2 .
CCDSi CCDS20333.1.
RefSeqi NP_032116.4. NM_008090.5.
XP_006505602.1. XM_006505539.1.
UniGenei Mm.491156.

3D structure databases

ProteinModelPortali O09100.
SMRi O09100. Positions 293-397.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 199839. 1 interaction.

PTM databases

PhosphoSitei O09100.

Proteomic databases

PRIDEi O09100.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000015197 ; ENSMUSP00000015197 ; ENSMUSG00000015053 .
ENSMUST00000170089 ; ENSMUSP00000128198 ; ENSMUSG00000015053 .
GeneIDi 14461.
KEGGi mmu:14461.
UCSCi uc009cvc.2. mouse.

Organism-specific databases

CTDi 2624.
MGIi MGI:95662. Gata2.

Phylogenomic databases

eggNOGi COG5641.
HOGENOMi HOG000047701.
HOVERGENi HBG051705.
InParanoidi O09100.
KOi K17894.
OMAi NKKGAEC.
OrthoDBi EOG7CCBRF.
PhylomeDBi O09100.
TreeFami TF315391.

Enzyme and pathway databases

Reactomei REACT_198649. Factors involved in megakaryocyte development and platelet production.

Miscellaneous databases

NextBioi 286096.
PROi O09100.
SOURCEi Search...

Gene expression databases

Bgeei O09100.
CleanExi MM_GATA2.
ExpressionAtlasi O09100. baseline and differential.
Genevestigatori O09100.

Family and domain databases

Gene3Di 3.30.50.10. 2 hits.
InterProi IPR029522. GATA-2.
IPR016374. TF_GATA-1/2/3.
IPR000679. Znf_GATA.
IPR013088. Znf_NHR/GATA.
[Graphical view ]
PANTHERi PTHR10071:SF149. PTHR10071:SF149. 1 hit.
Pfami PF00320. GATA. 2 hits.
[Graphical view ]
PIRSFi PIRSF003027. TF_GATA-1/2/3. 1 hit.
PRINTSi PR00619. GATAZNFINGER.
SMARTi SM00401. ZnF_GATA. 2 hits.
[Graphical view ]
PROSITEi PS00344. GATA_ZN_FINGER_1. 2 hits.
PS50114. GATA_ZN_FINGER_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Suwabe N., Minegishi N., Yamamoto M.
    Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver.
  2. "Alternative promoters regulate transcription of the mouse GATA-2 gene."
    Minegishi N., Ohta J., Suwabe N., Nakauchi H., Ishihara H., Hayashi N., Yamamoto M.
    J. Biol. Chem. 273:3625-3634(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENOMIC ORGANIZATION.
  3. "Bromodomain protein Brd3 associates with acetylated GATA1 to promote its chromatin occupancy at erythroid target genes."
    Lamonica J.M., Deng W., Kadauke S., Campbell A.E., Gamsjaeger R., Wang H., Cheng Y., Billin A.N., Hardison R.C., Mackay J.P., Blobel G.A.
    Proc. Natl. Acad. Sci. U.S.A. 108:E159-E168(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH BRD3.

Entry informationi

Entry nameiGATA2_MOUSE
AccessioniPrimary (citable) accession number: O09100
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 27, 2002
Last modified: October 29, 2014
This is version 109 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3