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O09100 (GATA2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 106. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Endothelial transcription factor GATA-2
Alternative name(s):
GATA-binding protein 2
Gene names
Name:Gata2
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length480 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Transcriptional activator which regulates endothelin-1 gene expression in endothelial cells. Binds to the consensus sequence 5'-AGATAG-3'.

Subunit structure

Interacts with BRD3. Ref.3

Subcellular location

Nucleus.

Sequence similarities

Contains 2 GATA-type zinc fingers.

Ontologies

Keywords
   Biological processPhagocytosis
Transcription
Transcription regulation
   Cellular componentNucleus
   DomainRepeat
Zinc-finger
   LigandDNA-binding
Metal-binding
Zinc
   Molecular functionActivator
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processGABAergic neuron differentiation

Inferred from mutant phenotype PubMed 22991444. Source: MGI

cell differentiation

Inferred from mutant phenotype PubMed 16543408. Source: MGI

cell differentiation in hindbrain

Inferred from mutant phenotype PubMed 10357893. Source: MGI

cell fate determination

Inferred from direct assay PubMed 10367888. Source: MGI

cell maturation

Inferred from mutant phenotype PubMed 16543408. Source: MGI

central nervous system neuron development

Inferred from mutant phenotype PubMed 10357893. Source: MGI

commitment of neuronal cell to specific neuron type in forebrain

Inferred from mutant phenotype PubMed 22991444. Source: MGI

definitive hemopoiesis

Inferred from mutant phenotype PubMed 8078582PubMed 9822612. Source: MGI

embryonic placenta development

Inferred from mutant phenotype PubMed 9043071. Source: MGI

eosinophil fate commitment

Inferred from electronic annotation. Source: Ensembl

homeostasis of number of cells within a tissue

Inferred from mutant phenotype PubMed 15811962. Source: MGI

inner ear morphogenesis

Inferred from mutant phenotype PubMed 20652952. Source: MGI

negative regulation of Notch signaling pathway

Inferred from electronic annotation. Source: Ensembl

negative regulation of fat cell differentiation

Inferred from mutant phenotype PubMed 16082385. Source: MGI

negative regulation of fat cell proliferation

Inferred from electronic annotation. Source: Ensembl

negative regulation of macrophage differentiation

Inferred from direct assay PubMed 16254139. Source: MGI

negative regulation of myeloid cell differentiation

Inferred from mutant phenotype PubMed 16621992. Source: MGI

negative regulation of neural precursor cell proliferation

Inferred from mutant phenotype PubMed 16672344. Source: MGI

negative regulation of transcription from RNA polymerase II promoter

Inferred from direct assay PubMed 16082385. Source: MGI

neuron differentiation

Inferred from mutant phenotype PubMed 14973276. Source: MGI

neuron fate commitment

Inferred from mutant phenotype PubMed 19088086. Source: MGI

phagocytosis

Inferred from electronic annotation. Source: UniProtKB-KW

pituitary gland development

Inferred from mutant phenotype PubMed 16543408. Source: MGI

positive regulation of angiogenesis

Inferred from mutant phenotype PubMed 9043071. Source: MGI

positive regulation of erythrocyte differentiation

Inferred from direct assay PubMed 16254139. Source: MGI

positive regulation of megakaryocyte differentiation

Inferred from direct assay PubMed 16254139. Source: MGI

positive regulation of phagocytosis

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of transcription from RNA polymerase II promoter

Inferred from direct assay PubMed 7720565. Source: MGI

regulation of forebrain neuron differentiation

Inferred from mutant phenotype PubMed 22991444. Source: MGI

regulation of histone acetylation

Inferred from direct assay PubMed 16254139. Source: MGI

semicircular canal development

Inferred from mutant phenotype PubMed 20652952. Source: MGI

somatic stem cell maintenance

Inferred from mutant phenotype PubMed 16082385. Source: MGI

urogenital system development

Inferred from mutant phenotype PubMed 9822612. Source: MGI

ventral spinal cord interneuron differentiation

Inferred from mutant phenotype PubMed 10934027. Source: MGI

   Cellular_componentnucleus

Inferred from direct assay PubMed 9305891. Source: MGI

protein complex

Inferred from direct assay PubMed 19323994. Source: MGI

   Molecular_functionDNA binding

Inferred from direct assay PubMed 10367888PubMed 12023274. Source: MGI

RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription

Inferred from direct assay PubMed 16254139PubMed 7720565PubMed 9305891. Source: MGI

RNA polymerase II distal enhancer sequence-specific DNA binding

Inferred from direct assay PubMed 17962413. Source: MGI

chromatin binding

Inferred from direct assay PubMed 18184866PubMed 18779319. Source: MGI

enhancer sequence-specific DNA binding

Inferred from sequence orthology PubMed 19323994. Source: MGI

protein binding

Inferred from physical interaction PubMed 11724781. Source: BHF-UCL

zinc ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 480480Endothelial transcription factor GATA-2
PRO_0000083404

Regions

Zinc finger295 – 31925GATA-type 1
Zinc finger349 – 37325GATA-type 2

Sequences

Sequence LengthMass (Da)Tools
O09100 [UniParc].

Last modified May 27, 2002. Version 2.
Checksum: 7E0DCE9B53F49C8A

FASTA48050,468
        10         20         30         40         50         60 
MEVAPEQPRW MAHPAVLNAQ HPDSHHPGLA HNYMEPAQLL PPDEVDVFFN HLDSQGNPYY 

        70         80         90        100        110        120 
ANPAHARARV SYSPAHARLT GGQMCRPHLL HSPGLPWLDG GKAALSAAAA HHHSPWTVSP 

       130        140        150        160        170        180 
FSKTPLHPSA AGAPGGPLSV YPGAAGGSGG GSGSSVASLT PTAAHSGSHL FGFPPTPPKE 

       190        200        210        220        230        240 
VSPDPSTTGA ASPASSSAGG SVARGEDKDG VKYQVSLSES MKMEGGSPLR PGLATMGTQP 

       250        260        270        280        290        300 
ATHHPIPTYP SYVPAAAHDY GSSLFHPGGF LGGPASSFTP KQRSKARSCS EGRECVNCGA 

       310        320        330        340        350        360 
TATPLWRRDG TGHYLCNACG LYHKMNGQNR PLIKPKRRLS AARRAGTCCA NCQTTTTTLW 

       370        380        390        400        410        420 
RRNANGDPVC NACGLYYKLH NVNRPLTMKK EGIQTRNRKM SSKSKKSKKG AECFEELSKC 

       430        440        450        460        470        480 
MQEKSPPFSA AALAGHMAPV GHLPPFSHSG HILPTPTPIH PSSSLSFGHP HPSSMVTAMG 

« Hide

References

[1]Suwabe N., Minegishi N., Yamamoto M.
Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Liver.
[2]"Alternative promoters regulate transcription of the mouse GATA-2 gene."
Minegishi N., Ohta J., Suwabe N., Nakauchi H., Ishihara H., Hayashi N., Yamamoto M.
J. Biol. Chem. 273:3625-3634(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOMIC ORGANIZATION.
[3]"Bromodomain protein Brd3 associates with acetylated GATA1 to promote its chromatin occupancy at erythroid target genes."
Lamonica J.M., Deng W., Kadauke S., Campbell A.E., Gamsjaeger R., Wang H., Cheng Y., Billin A.N., Hardison R.C., Mackay J.P., Blobel G.A.
Proc. Natl. Acad. Sci. U.S.A. 108:E159-E168(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH BRD3.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB000096 mRNA. Translation: BAA19053.2.
CCDSCCDS20333.1.
RefSeqNP_032116.4. NM_008090.5.
XP_006505602.1. XM_006505539.1.
UniGeneMm.491156.

3D structure databases

ProteinModelPortalO09100.
SMRO09100. Positions 293-397.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid199839. 1 interaction.

PTM databases

PhosphoSiteO09100.

Proteomic databases

PRIDEO09100.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000015197; ENSMUSP00000015197; ENSMUSG00000015053.
ENSMUST00000170089; ENSMUSP00000128198; ENSMUSG00000015053.
GeneID14461.
KEGGmmu:14461.
UCSCuc009cvc.2. mouse.

Organism-specific databases

CTD2624.
MGIMGI:95662. Gata2.

Phylogenomic databases

eggNOGCOG5641.
HOGENOMHOG000047701.
HOVERGENHBG051705.
InParanoidO09100.
KOK17894.
OMANKKGAEC.
OrthoDBEOG7CCBRF.
PhylomeDBO09100.
TreeFamTF315391.

Gene expression databases

ArrayExpressO09100.
BgeeO09100.
CleanExMM_GATA2.
GenevestigatorO09100.

Family and domain databases

Gene3D3.30.50.10. 2 hits.
InterProIPR016374. TF_GATA-1/2/3.
IPR000679. Znf_GATA.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamPF00320. GATA. 2 hits.
[Graphical view]
PIRSFPIRSF003027. TF_GATA-1/2/3. 1 hit.
PRINTSPR00619. GATAZNFINGER.
SMARTSM00401. ZnF_GATA. 2 hits.
[Graphical view]
PROSITEPS00344. GATA_ZN_FINGER_1. 2 hits.
PS50114. GATA_ZN_FINGER_2. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio286096.
PROO09100.
SOURCESearch...

Entry information

Entry nameGATA2_MOUSE
AccessionPrimary (citable) accession number: O09100
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 27, 2002
Last modified: July 9, 2014
This is version 106 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot