Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

O09100

- GATA2_MOUSE

UniProt

O09100 - GATA2_MOUSE

Protein

Endothelial transcription factor GATA-2

Gene

Gata2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 108 (01 Oct 2014)
      Sequence version 2 (27 May 2002)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Transcriptional activator which regulates endothelin-1 gene expression in endothelial cells. Binds to the consensus sequence 5'-AGATAG-3'.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri295 – 31925GATA-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri349 – 37325GATA-type 2PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. chromatin binding Source: MGI
    2. DNA binding Source: MGI
    3. enhancer sequence-specific DNA binding Source: MGI
    4. protein binding Source: BHF-UCL
    5. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: MGI
    6. RNA polymerase II distal enhancer sequence-specific DNA binding Source: MGI
    7. zinc ion binding Source: InterPro

    GO - Biological processi

    1. cell differentiation Source: MGI
    2. cell differentiation in hindbrain Source: MGI
    3. cell fate determination Source: MGI
    4. cell maturation Source: MGI
    5. central nervous system neuron development Source: MGI
    6. commitment of neuronal cell to specific neuron type in forebrain Source: MGI
    7. definitive hemopoiesis Source: MGI
    8. embryonic placenta development Source: MGI
    9. eosinophil fate commitment Source: Ensembl
    10. GABAergic neuron differentiation Source: MGI
    11. homeostasis of number of cells within a tissue Source: MGI
    12. inner ear morphogenesis Source: MGI
    13. negative regulation of fat cell differentiation Source: MGI
    14. negative regulation of fat cell proliferation Source: Ensembl
    15. negative regulation of macrophage differentiation Source: MGI
    16. negative regulation of myeloid cell differentiation Source: MGI
    17. negative regulation of neural precursor cell proliferation Source: MGI
    18. negative regulation of Notch signaling pathway Source: Ensembl
    19. negative regulation of transcription from RNA polymerase II promoter Source: MGI
    20. neuron differentiation Source: MGI
    21. neuron fate commitment Source: MGI
    22. phagocytosis Source: UniProtKB-KW
    23. pituitary gland development Source: MGI
    24. positive regulation of angiogenesis Source: MGI
    25. positive regulation of erythrocyte differentiation Source: MGI
    26. positive regulation of megakaryocyte differentiation Source: MGI
    27. positive regulation of phagocytosis Source: UniProtKB
    28. positive regulation of transcription from RNA polymerase II promoter Source: MGI
    29. regulation of forebrain neuron differentiation Source: MGI
    30. regulation of histone acetylation Source: MGI
    31. semicircular canal development Source: MGI
    32. somatic stem cell maintenance Source: MGI
    33. urogenital system development Source: MGI
    34. ventral spinal cord interneuron differentiation Source: MGI

    Keywords - Molecular functioni

    Activator

    Keywords - Biological processi

    Phagocytosis, Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Enzyme and pathway databases

    ReactomeiREACT_198649. Factors involved in megakaryocyte development and platelet production.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Endothelial transcription factor GATA-2
    Alternative name(s):
    GATA-binding protein 2
    Gene namesi
    Name:Gata2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 6

    Organism-specific databases

    MGIiMGI:95662. Gata2.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: MGI
    2. protein complex Source: MGI

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 480480Endothelial transcription factor GATA-2PRO_0000083404Add
    BLAST

    Proteomic databases

    PRIDEiO09100.

    PTM databases

    PhosphoSiteiO09100.

    Expressioni

    Gene expression databases

    ArrayExpressiO09100.
    BgeeiO09100.
    CleanExiMM_GATA2.
    GenevestigatoriO09100.

    Interactioni

    Subunit structurei

    Interacts with BRD3.1 Publication

    Protein-protein interaction databases

    BioGridi199839. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliO09100.
    SMRiO09100. Positions 293-397.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Contains 2 GATA-type zinc fingers.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri295 – 31925GATA-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri349 – 37325GATA-type 2PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5641.
    HOGENOMiHOG000047701.
    HOVERGENiHBG051705.
    InParanoidiO09100.
    KOiK17894.
    OMAiNKKGAEC.
    OrthoDBiEOG7CCBRF.
    PhylomeDBiO09100.
    TreeFamiTF315391.

    Family and domain databases

    Gene3Di3.30.50.10. 2 hits.
    InterProiIPR029522. GATA-2.
    IPR016374. TF_GATA-1/2/3.
    IPR000679. Znf_GATA.
    IPR013088. Znf_NHR/GATA.
    [Graphical view]
    PANTHERiPTHR10071:SF149. PTHR10071:SF149. 1 hit.
    PfamiPF00320. GATA. 2 hits.
    [Graphical view]
    PIRSFiPIRSF003027. TF_GATA-1/2/3. 1 hit.
    PRINTSiPR00619. GATAZNFINGER.
    SMARTiSM00401. ZnF_GATA. 2 hits.
    [Graphical view]
    PROSITEiPS00344. GATA_ZN_FINGER_1. 2 hits.
    PS50114. GATA_ZN_FINGER_2. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O09100-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEVAPEQPRW MAHPAVLNAQ HPDSHHPGLA HNYMEPAQLL PPDEVDVFFN    50
    HLDSQGNPYY ANPAHARARV SYSPAHARLT GGQMCRPHLL HSPGLPWLDG 100
    GKAALSAAAA HHHSPWTVSP FSKTPLHPSA AGAPGGPLSV YPGAAGGSGG 150
    GSGSSVASLT PTAAHSGSHL FGFPPTPPKE VSPDPSTTGA ASPASSSAGG 200
    SVARGEDKDG VKYQVSLSES MKMEGGSPLR PGLATMGTQP ATHHPIPTYP 250
    SYVPAAAHDY GSSLFHPGGF LGGPASSFTP KQRSKARSCS EGRECVNCGA 300
    TATPLWRRDG TGHYLCNACG LYHKMNGQNR PLIKPKRRLS AARRAGTCCA 350
    NCQTTTTTLW RRNANGDPVC NACGLYYKLH NVNRPLTMKK EGIQTRNRKM 400
    SSKSKKSKKG AECFEELSKC MQEKSPPFSA AALAGHMAPV GHLPPFSHSG 450
    HILPTPTPIH PSSSLSFGHP HPSSMVTAMG 480
    Length:480
    Mass (Da):50,468
    Last modified:May 27, 2002 - v2
    Checksum:i7E0DCE9B53F49C8A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB000096 mRNA. Translation: BAA19053.2.
    CCDSiCCDS20333.1.
    RefSeqiNP_032116.4. NM_008090.5.
    XP_006505602.1. XM_006505539.1.
    UniGeneiMm.491156.

    Genome annotation databases

    EnsembliENSMUST00000015197; ENSMUSP00000015197; ENSMUSG00000015053.
    ENSMUST00000170089; ENSMUSP00000128198; ENSMUSG00000015053.
    GeneIDi14461.
    KEGGimmu:14461.
    UCSCiuc009cvc.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB000096 mRNA. Translation: BAA19053.2 .
    CCDSi CCDS20333.1.
    RefSeqi NP_032116.4. NM_008090.5.
    XP_006505602.1. XM_006505539.1.
    UniGenei Mm.491156.

    3D structure databases

    ProteinModelPortali O09100.
    SMRi O09100. Positions 293-397.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 199839. 1 interaction.

    PTM databases

    PhosphoSitei O09100.

    Proteomic databases

    PRIDEi O09100.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000015197 ; ENSMUSP00000015197 ; ENSMUSG00000015053 .
    ENSMUST00000170089 ; ENSMUSP00000128198 ; ENSMUSG00000015053 .
    GeneIDi 14461.
    KEGGi mmu:14461.
    UCSCi uc009cvc.2. mouse.

    Organism-specific databases

    CTDi 2624.
    MGIi MGI:95662. Gata2.

    Phylogenomic databases

    eggNOGi COG5641.
    HOGENOMi HOG000047701.
    HOVERGENi HBG051705.
    InParanoidi O09100.
    KOi K17894.
    OMAi NKKGAEC.
    OrthoDBi EOG7CCBRF.
    PhylomeDBi O09100.
    TreeFami TF315391.

    Enzyme and pathway databases

    Reactomei REACT_198649. Factors involved in megakaryocyte development and platelet production.

    Miscellaneous databases

    NextBioi 286096.
    PROi O09100.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O09100.
    Bgeei O09100.
    CleanExi MM_GATA2.
    Genevestigatori O09100.

    Family and domain databases

    Gene3Di 3.30.50.10. 2 hits.
    InterProi IPR029522. GATA-2.
    IPR016374. TF_GATA-1/2/3.
    IPR000679. Znf_GATA.
    IPR013088. Znf_NHR/GATA.
    [Graphical view ]
    PANTHERi PTHR10071:SF149. PTHR10071:SF149. 1 hit.
    Pfami PF00320. GATA. 2 hits.
    [Graphical view ]
    PIRSFi PIRSF003027. TF_GATA-1/2/3. 1 hit.
    PRINTSi PR00619. GATAZNFINGER.
    SMARTi SM00401. ZnF_GATA. 2 hits.
    [Graphical view ]
    PROSITEi PS00344. GATA_ZN_FINGER_1. 2 hits.
    PS50114. GATA_ZN_FINGER_2. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Suwabe N., Minegishi N., Yamamoto M.
      Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Liver.
    2. "Alternative promoters regulate transcription of the mouse GATA-2 gene."
      Minegishi N., Ohta J., Suwabe N., Nakauchi H., Ishihara H., Hayashi N., Yamamoto M.
      J. Biol. Chem. 273:3625-3634(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENOMIC ORGANIZATION.
    3. "Bromodomain protein Brd3 associates with acetylated GATA1 to promote its chromatin occupancy at erythroid target genes."
      Lamonica J.M., Deng W., Kadauke S., Campbell A.E., Gamsjaeger R., Wang H., Cheng Y., Billin A.N., Hardison R.C., Mackay J.P., Blobel G.A.
      Proc. Natl. Acad. Sci. U.S.A. 108:E159-E168(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH BRD3.

    Entry informationi

    Entry nameiGATA2_MOUSE
    AccessioniPrimary (citable) accession number: O09100
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: May 27, 2002
    Last modified: October 1, 2014
    This is version 108 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3