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Protein

Endothelial transcription factor GATA-2

Gene

Gata2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcriptional activator which regulates endothelin-1 gene expression in endothelial cells. Binds to the consensus sequence 5'-AGATAG-3'.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri295 – 319GATA-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri349 – 373GATA-type 2PROSITE-ProRule annotationAdd BLAST25

GO - Molecular functioni

GO - Biological processi

  • cell differentiation Source: MGI
  • cell differentiation in hindbrain Source: MGI
  • cell fate determination Source: MGI
  • cell maturation Source: MGI
  • central nervous system neuron development Source: MGI
  • cochlea development Source: Ensembl
  • commitment of neuronal cell to specific neuron type in forebrain Source: MGI
  • definitive hemopoiesis Source: MGI
  • embryonic placenta development Source: MGI
  • eosinophil fate commitment Source: MGI
  • GABAergic neuron differentiation Source: MGI
  • homeostasis of number of cells within a tissue Source: MGI
  • inner ear morphogenesis Source: MGI
  • negative regulation of endothelial cell apoptotic process Source: MGI
  • negative regulation of fat cell differentiation Source: MGI
  • negative regulation of fat cell proliferation Source: MGI
  • negative regulation of macrophage differentiation Source: MGI
  • negative regulation of myeloid cell differentiation Source: MGI
  • negative regulation of neural precursor cell proliferation Source: MGI
  • negative regulation of Notch signaling pathway Source: MGI
  • negative regulation of transcription by RNA polymerase II Source: MGI
  • neuron differentiation Source: MGI
  • neuron fate commitment Source: MGI
  • neuron migration Source: Ensembl
  • phagocytosis Source: UniProtKB-KW
  • pituitary gland development Source: MGI
  • positive regulation of angiogenesis Source: MGI
  • positive regulation of cytosolic calcium ion concentration Source: Ensembl
  • positive regulation of erythrocyte differentiation Source: MGI
  • positive regulation of mast cell degranulation Source: Ensembl
  • positive regulation of megakaryocyte differentiation Source: MGI
  • positive regulation of neuron differentiation Source: Ensembl
  • positive regulation of phagocytosis Source: UniProtKB
  • positive regulation of phagocytosis, engulfment Source: Ensembl
  • positive regulation of transcription by RNA polymerase II Source: MGI
  • regulation of forebrain neuron differentiation Source: MGI
  • regulation of histone acetylation Source: MGI
  • regulation of primitive erythrocyte differentiation Source: MGI
  • response to lipid Source: Ensembl
  • semicircular canal development Source: MGI
  • somatic stem cell population maintenance Source: MGI
  • transcription, DNA-templated Source: MGI
  • urogenital system development Source: MGI
  • ventral spinal cord interneuron differentiation Source: MGI

Keywordsi

Molecular functionActivator, DNA-binding
Biological processPhagocytosis, Transcription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-MMU-8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs
R-MMU-983231 Factors involved in megakaryocyte development and platelet production

Names & Taxonomyi

Protein namesi
Recommended name:
Endothelial transcription factor GATA-2
Alternative name(s):
GATA-binding protein 2
Gene namesi
Name:Gata2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:95662 Gata2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000834041 – 480Endothelial transcription factor GATA-2Add BLAST480

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei73PhosphoserineBy similarity1
Modified residuei86Asymmetric dimethylarginineBy similarity1
Modified residuei192PhosphoserineBy similarity1
Cross-linki389Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiO09100
PRIDEiO09100

PTM databases

iPTMnetiO09100
PhosphoSitePlusiO09100

Expressioni

Gene expression databases

BgeeiENSMUSG00000015053
CleanExiMM_GATA2
ExpressionAtlasiO09100 baseline and differential
GenevisibleiO09100 MM

Interactioni

Subunit structurei

Interacts with BRD3. Interacts with AR and CCAR1 (By similarity).By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi199839, 3 interactors
CORUMiO09100
STRINGi10090.ENSMUSP00000015197

Structurei

3D structure databases

ProteinModelPortaliO09100
SMRiO09100
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri295 – 319GATA-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri349 – 373GATA-type 2PROSITE-ProRule annotationAdd BLAST25

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1601 Eukaryota
COG5641 LUCA
GeneTreeiENSGT00760000119221
HOGENOMiHOG000047701
HOVERGENiHBG051705
InParanoidiO09100
KOiK17894
OMAiPRWMAHH
OrthoDBiEOG091G0AUR
PhylomeDBiO09100
TreeFamiTF315391

Family and domain databases

Gene3Di3.30.50.10, 2 hits
InterProiView protein in InterPro
IPR029522 GATA-2
IPR016374 TF_GATA-2/3
IPR000679 Znf_GATA
IPR013088 Znf_NHR/GATA
PANTHERiPTHR10071:SF149 PTHR10071:SF149, 1 hit
PfamiView protein in Pfam
PF00320 GATA, 2 hits
PIRSFiPIRSF003027 TF_GATA-1/2/3, 1 hit
PRINTSiPR00619 GATAZNFINGER
SMARTiView protein in SMART
SM00401 ZnF_GATA, 2 hits
PROSITEiView protein in PROSITE
PS00344 GATA_ZN_FINGER_1, 2 hits
PS50114 GATA_ZN_FINGER_2, 2 hits

Sequencei

Sequence statusi: Complete.

O09100-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEVAPEQPRW MAHPAVLNAQ HPDSHHPGLA HNYMEPAQLL PPDEVDVFFN
60 70 80 90 100
HLDSQGNPYY ANPAHARARV SYSPAHARLT GGQMCRPHLL HSPGLPWLDG
110 120 130 140 150
GKAALSAAAA HHHSPWTVSP FSKTPLHPSA AGAPGGPLSV YPGAAGGSGG
160 170 180 190 200
GSGSSVASLT PTAAHSGSHL FGFPPTPPKE VSPDPSTTGA ASPASSSAGG
210 220 230 240 250
SVARGEDKDG VKYQVSLSES MKMEGGSPLR PGLATMGTQP ATHHPIPTYP
260 270 280 290 300
SYVPAAAHDY GSSLFHPGGF LGGPASSFTP KQRSKARSCS EGRECVNCGA
310 320 330 340 350
TATPLWRRDG TGHYLCNACG LYHKMNGQNR PLIKPKRRLS AARRAGTCCA
360 370 380 390 400
NCQTTTTTLW RRNANGDPVC NACGLYYKLH NVNRPLTMKK EGIQTRNRKM
410 420 430 440 450
SSKSKKSKKG AECFEELSKC MQEKSPPFSA AALAGHMAPV GHLPPFSHSG
460 470 480
HILPTPTPIH PSSSLSFGHP HPSSMVTAMG
Length:480
Mass (Da):50,468
Last modified:May 27, 2002 - v2
Checksum:i7E0DCE9B53F49C8A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB000096 mRNA Translation: BAA19053.2
CCDSiCCDS20333.1
RefSeqiNP_032116.4, NM_008090.5
XP_006505602.1, XM_006505539.3
UniGeneiMm.491156

Genome annotation databases

EnsembliENSMUST00000015197; ENSMUSP00000015197; ENSMUSG00000015053
ENSMUST00000170089; ENSMUSP00000128198; ENSMUSG00000015053
GeneIDi14461
KEGGimmu:14461
UCSCiuc009cvc.2 mouse

Similar proteinsi

Entry informationi

Entry nameiGATA2_MOUSE
AccessioniPrimary (citable) accession number: O09100
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 27, 2002
Last modified: April 25, 2018
This is version 139 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health