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Protein

Endothelial transcription factor GATA-2

Gene

Gata2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transcriptional activator which regulates endothelin-1 gene expression in endothelial cells. Binds to the consensus sequence 5'-AGATAG-3'.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri295 – 31925GATA-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri349 – 37325GATA-type 2PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. C2H2 zinc finger domain binding Source: MGI
  2. chromatin binding Source: MGI
  3. DNA binding Source: MGI
  4. enhancer sequence-specific DNA binding Source: MGI
  5. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: MGI
  6. RNA polymerase II distal enhancer sequence-specific DNA binding Source: MGI
  7. sequence-specific DNA binding transcription factor activity Source: MGI
  8. transcription factor binding Source: MGI
  9. zinc ion binding Source: InterPro

GO - Biological processi

  1. cell differentiation Source: MGI
  2. cell differentiation in hindbrain Source: MGI
  3. cell fate determination Source: MGI
  4. cell maturation Source: MGI
  5. central nervous system neuron development Source: MGI
  6. commitment of neuronal cell to specific neuron type in forebrain Source: MGI
  7. definitive hemopoiesis Source: MGI
  8. embryonic placenta development Source: MGI
  9. eosinophil fate commitment Source: MGI
  10. GABAergic neuron differentiation Source: MGI
  11. homeostasis of number of cells within a tissue Source: MGI
  12. inner ear morphogenesis Source: MGI
  13. negative regulation of fat cell differentiation Source: MGI
  14. negative regulation of fat cell proliferation Source: MGI
  15. negative regulation of macrophage differentiation Source: MGI
  16. negative regulation of myeloid cell differentiation Source: MGI
  17. negative regulation of neural precursor cell proliferation Source: MGI
  18. negative regulation of Notch signaling pathway Source: MGI
  19. negative regulation of transcription from RNA polymerase II promoter Source: MGI
  20. neuron differentiation Source: MGI
  21. neuron fate commitment Source: MGI
  22. phagocytosis Source: UniProtKB-KW
  23. pituitary gland development Source: MGI
  24. positive regulation of angiogenesis Source: MGI
  25. positive regulation of erythrocyte differentiation Source: MGI
  26. positive regulation of megakaryocyte differentiation Source: MGI
  27. positive regulation of phagocytosis Source: UniProtKB
  28. positive regulation of transcription from RNA polymerase II promoter Source: MGI
  29. regulation of forebrain neuron differentiation Source: MGI
  30. regulation of histone acetylation Source: MGI
  31. semicircular canal development Source: MGI
  32. somatic stem cell maintenance Source: MGI
  33. transcription, DNA-templated Source: MGI
  34. urogenital system development Source: MGI
  35. ventral spinal cord interneuron differentiation Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Phagocytosis, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_198649. Factors involved in megakaryocyte development and platelet production.

Names & Taxonomyi

Protein namesi
Recommended name:
Endothelial transcription factor GATA-2
Alternative name(s):
GATA-binding protein 2
Gene namesi
Name:Gata2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 6

Organism-specific databases

MGIiMGI:95662. Gata2.

Subcellular locationi

GO - Cellular componenti

  1. nucleoplasm Source: MGI
  2. nucleus Source: MGI
  3. protein complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 480480Endothelial transcription factor GATA-2PRO_0000083404Add
BLAST

Proteomic databases

PRIDEiO09100.

PTM databases

PhosphoSiteiO09100.

Expressioni

Gene expression databases

BgeeiO09100.
CleanExiMM_GATA2.
ExpressionAtlasiO09100. baseline and differential.
GenevestigatoriO09100.

Interactioni

Subunit structurei

Interacts with BRD3.1 Publication

Protein-protein interaction databases

BioGridi199839. 2 interactions.

Structurei

3D structure databases

ProteinModelPortaliO09100.
SMRiO09100. Positions 293-397.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 2 GATA-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri295 – 31925GATA-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri349 – 37325GATA-type 2PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5641.
HOGENOMiHOG000047701.
HOVERGENiHBG051705.
InParanoidiO09100.
KOiK17894.
OMAiNKKGAEC.
OrthoDBiEOG7CCBRF.
PhylomeDBiO09100.
TreeFamiTF315391.

Family and domain databases

Gene3Di3.30.50.10. 2 hits.
InterProiIPR029522. GATA-2.
IPR016374. TF_GATA-1/2/3.
IPR000679. Znf_GATA.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PANTHERiPTHR10071:SF149. PTHR10071:SF149. 1 hit.
PfamiPF00320. GATA. 2 hits.
[Graphical view]
PIRSFiPIRSF003027. TF_GATA-1/2/3. 1 hit.
PRINTSiPR00619. GATAZNFINGER.
SMARTiSM00401. ZnF_GATA. 2 hits.
[Graphical view]
PROSITEiPS00344. GATA_ZN_FINGER_1. 2 hits.
PS50114. GATA_ZN_FINGER_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O09100-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEVAPEQPRW MAHPAVLNAQ HPDSHHPGLA HNYMEPAQLL PPDEVDVFFN
60 70 80 90 100
HLDSQGNPYY ANPAHARARV SYSPAHARLT GGQMCRPHLL HSPGLPWLDG
110 120 130 140 150
GKAALSAAAA HHHSPWTVSP FSKTPLHPSA AGAPGGPLSV YPGAAGGSGG
160 170 180 190 200
GSGSSVASLT PTAAHSGSHL FGFPPTPPKE VSPDPSTTGA ASPASSSAGG
210 220 230 240 250
SVARGEDKDG VKYQVSLSES MKMEGGSPLR PGLATMGTQP ATHHPIPTYP
260 270 280 290 300
SYVPAAAHDY GSSLFHPGGF LGGPASSFTP KQRSKARSCS EGRECVNCGA
310 320 330 340 350
TATPLWRRDG TGHYLCNACG LYHKMNGQNR PLIKPKRRLS AARRAGTCCA
360 370 380 390 400
NCQTTTTTLW RRNANGDPVC NACGLYYKLH NVNRPLTMKK EGIQTRNRKM
410 420 430 440 450
SSKSKKSKKG AECFEELSKC MQEKSPPFSA AALAGHMAPV GHLPPFSHSG
460 470 480
HILPTPTPIH PSSSLSFGHP HPSSMVTAMG
Length:480
Mass (Da):50,468
Last modified:May 27, 2002 - v2
Checksum:i7E0DCE9B53F49C8A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB000096 mRNA. Translation: BAA19053.2.
CCDSiCCDS20333.1.
RefSeqiNP_032116.4. NM_008090.5.
XP_006505602.1. XM_006505539.1.
UniGeneiMm.491156.

Genome annotation databases

EnsembliENSMUST00000015197; ENSMUSP00000015197; ENSMUSG00000015053.
ENSMUST00000170089; ENSMUSP00000128198; ENSMUSG00000015053.
GeneIDi14461.
KEGGimmu:14461.
UCSCiuc009cvc.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB000096 mRNA. Translation: BAA19053.2.
CCDSiCCDS20333.1.
RefSeqiNP_032116.4. NM_008090.5.
XP_006505602.1. XM_006505539.1.
UniGeneiMm.491156.

3D structure databases

ProteinModelPortaliO09100.
SMRiO09100. Positions 293-397.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi199839. 2 interactions.

PTM databases

PhosphoSiteiO09100.

Proteomic databases

PRIDEiO09100.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000015197; ENSMUSP00000015197; ENSMUSG00000015053.
ENSMUST00000170089; ENSMUSP00000128198; ENSMUSG00000015053.
GeneIDi14461.
KEGGimmu:14461.
UCSCiuc009cvc.2. mouse.

Organism-specific databases

CTDi2624.
MGIiMGI:95662. Gata2.

Phylogenomic databases

eggNOGiCOG5641.
HOGENOMiHOG000047701.
HOVERGENiHBG051705.
InParanoidiO09100.
KOiK17894.
OMAiNKKGAEC.
OrthoDBiEOG7CCBRF.
PhylomeDBiO09100.
TreeFamiTF315391.

Enzyme and pathway databases

ReactomeiREACT_198649. Factors involved in megakaryocyte development and platelet production.

Miscellaneous databases

NextBioi286096.
PROiO09100.
SOURCEiSearch...

Gene expression databases

BgeeiO09100.
CleanExiMM_GATA2.
ExpressionAtlasiO09100. baseline and differential.
GenevestigatoriO09100.

Family and domain databases

Gene3Di3.30.50.10. 2 hits.
InterProiIPR029522. GATA-2.
IPR016374. TF_GATA-1/2/3.
IPR000679. Znf_GATA.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PANTHERiPTHR10071:SF149. PTHR10071:SF149. 1 hit.
PfamiPF00320. GATA. 2 hits.
[Graphical view]
PIRSFiPIRSF003027. TF_GATA-1/2/3. 1 hit.
PRINTSiPR00619. GATAZNFINGER.
SMARTiSM00401. ZnF_GATA. 2 hits.
[Graphical view]
PROSITEiPS00344. GATA_ZN_FINGER_1. 2 hits.
PS50114. GATA_ZN_FINGER_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Suwabe N., Minegishi N., Yamamoto M.
    Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver.
  2. "Alternative promoters regulate transcription of the mouse GATA-2 gene."
    Minegishi N., Ohta J., Suwabe N., Nakauchi H., Ishihara H., Hayashi N., Yamamoto M.
    J. Biol. Chem. 273:3625-3634(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENOMIC ORGANIZATION.
  3. "Bromodomain protein Brd3 associates with acetylated GATA1 to promote its chromatin occupancy at erythroid target genes."
    Lamonica J.M., Deng W., Kadauke S., Campbell A.E., Gamsjaeger R., Wang H., Cheng Y., Billin A.N., Hardison R.C., Mackay J.P., Blobel G.A.
    Proc. Natl. Acad. Sci. U.S.A. 108:E159-E168(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH BRD3.

Entry informationi

Entry nameiGATA2_MOUSE
AccessioniPrimary (citable) accession number: O09100
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 27, 2002
Last modified: March 4, 2015
This is version 112 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.