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O09047

- C3AR_MOUSE

UniProt

O09047 - C3AR_MOUSE

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Protein

C3a anaphylatoxin chemotactic receptor

Gene

C3ar1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Receptor for the chemotactic and inflammatory peptide anaphylatoxin C3a. This receptor stimulates chemotaxis, granule enzyme release and superoxide anion production.

GO - Molecular functioni

  1. C3a anaphylatoxin receptor activity Source: InterPro

GO - Biological processi

  1. chemotaxis Source: UniProtKB-KW
  2. positive regulation of angiogenesis Source: BHF-UCL
  3. positive regulation of cytosolic calcium ion concentration Source: Ensembl
  4. positive regulation of macrophage chemotaxis Source: BHF-UCL
  5. positive regulation of neutrophil chemotaxis Source: BHF-UCL
  6. positive regulation vascular endothelial growth factor production Source: BHF-UCL
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Chemotaxis

Enzyme and pathway databases

ReactomeiREACT_235286. Peptide ligand-binding receptors.
REACT_250376. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
C3a anaphylatoxin chemotactic receptor
Short name:
C3AR
Short name:
C3a-R
Alternative name(s):
Complement component 3a receptor 1
Gene namesi
Name:C3ar1
Synonyms:C3r1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 6

Organism-specific databases

MGIiMGI:1097680. C3ar1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2323ExtracellularSequence AnalysisAdd
BLAST
Transmembranei24 – 4623Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini47 – 5711CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei58 – 8023Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini81 – 9616ExtracellularSequence AnalysisAdd
BLAST
Transmembranei97 – 11822Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini119 – 13921CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei140 – 16021Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini161 – 333173ExtracellularSequence AnalysisAdd
BLAST
Transmembranei334 – 35320Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini354 – 37017CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei371 – 39323Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini394 – 41017ExtracellularSequence AnalysisAdd
BLAST
Transmembranei411 – 43121Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini432 – 47746CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 477477C3a anaphylatoxin chemotactic receptorPRO_0000069204Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi9 – 91N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi95 ↔ 172PROSITE-ProRule annotation
Glycosylationi168 – 1681N-linked (GlcNAc...)Sequence Analysis
Modified residuei174 – 1741SulfotyrosineBy similarity
Modified residuei184 – 1841SulfotyrosineBy similarity
Glycosylationi197 – 1971N-linked (GlcNAc...)Sequence Analysis
Glycosylationi201 – 2011N-linked (GlcNAc...)Sequence Analysis
Modified residuei312 – 3121SulfotyrosineBy similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Sulfation

Proteomic databases

PRIDEiO09047.

PTM databases

PhosphoSiteiO09047.

Expressioni

Tissue specificityi

Detected in varying levels in all tissues examined except the spleen. Especially abundant in heart and lung.

Gene expression databases

BgeeiO09047.
CleanExiMM_C3AR1.
ExpressionAtlasiO09047. baseline and differential.
GenevestigatoriO09047.

Structurei

3D structure databases

ProteinModelPortaliO09047.
SMRiO09047. Positions 24-191, 325-441.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG148047.
HOGENOMiHOG000261616.
HOVERGENiHBG002433.
InParanoidiO09047.
KOiK04009.
OMAiLWVAGLK.
OrthoDBiEOG7PGDQQ.
PhylomeDBiO09047.
TreeFamiTF330976.

Family and domain databases

Gene3Di1.20.1070.10. 2 hits.
InterProiIPR001644. Anaphtx_C3AR1.
IPR002234. Anphylx_rcpt.
IPR000826. Formyl_rcpt-rel.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24225. PTHR24225. 1 hit.
PTHR24225:SF4. PTHR24225:SF4. 1 hit.
PfamiPF00001. 7tm_1. 2 hits.
[Graphical view]
PRINTSiPR01104. ANPHYLATOXNR.
PR01060. C3ANPHYLTXNR.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O09047-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MESFDADTNS TDLHSRPLFQ PQDIASMVIL GLTCLLGLLG NGLVLWVAGV
60 70 80 90 100
KMKTTVNTVW FLHLTLADFL CCLSLPFSLA HLILQGHWPY GLFLCKLIPS
110 120 130 140 150
IIILNMFASV FLLTAISLDR CLIVHKPIWC QNHRNVRTAF AICGCVWVVA
160 170 180 190 200
FVMCVPVFVY RDLFIMDNRS ICRYNFDSSR SYDYWDYVYK LSLPESNSTD
210 220 230 240 250
NSTAQLTGHM NDRSAPSSVQ ARDYFWTVTT ALQSQPFLTS PEDSFSLDSA
260 270 280 290 300
NQQPHYGGKP PNVLTAAVPS GFPVEDRKSN TLNADAFLSA HTELFPTASS
310 320 330 340 350
GHLYPYDFQG DYVDQFTYDN HVPTPLMAIT ITRLVVGFLV PFFIMVICYS
360 370 380 390 400
LIVFRMRKTN FTKSRNKTFR VAVAVVTVFF ICWTPYHLVG VLLLITDPES
410 420 430 440 450
SLGEAVMSWD HMSIALASAN SCFNPFLYAL LGKDFRKKAR QSIKGILEAA
460 470
FSEELTHSTN CTQDKASSKR NNMSTDV
Length:477
Mass (Da):53,576
Last modified:July 1, 1997 - v1
Checksum:i9873F464A1520984
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti173 – 1731R → K in AAB71814. (PubMed:9382922)Curated
Sequence conflicti195 – 1951E → K in AAB71814. (PubMed:9382922)Curated
Sequence conflicti243 – 2431D → N in AAB71814. (PubMed:9382922)Curated
Sequence conflicti276 – 2761D → N in AAB71814. (PubMed:9382922)Curated
Sequence conflicti380 – 3823FIC → LS in AAB71814. (PubMed:9382922)Curated
Sequence conflicti391 – 3911V → I in AAB71814. (PubMed:9382922)Curated
Sequence conflicti460 – 4601N → S in AAB71814. (PubMed:9382922)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U77461 Genomic DNA. Translation: AAC53204.1.
U77460 mRNA. Translation: AAC53203.1.
U97537 Genomic DNA. Translation: AAB71814.1.
AF053757 Genomic DNA. Translation: AAC40193.1.
BC003728 mRNA. Translation: AAH03728.1.
CCDSiCCDS20504.1.
RefSeqiNP_033909.1. NM_009779.2.
UniGeneiMm.2408.

Genome annotation databases

EnsembliENSMUST00000042081; ENSMUSP00000048092; ENSMUSG00000040552.
GeneIDi12267.
KEGGimmu:12267.
UCSCiuc009dps.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U77461 Genomic DNA. Translation: AAC53204.1 .
U77460 mRNA. Translation: AAC53203.1 .
U97537 Genomic DNA. Translation: AAB71814.1 .
AF053757 Genomic DNA. Translation: AAC40193.1 .
BC003728 mRNA. Translation: AAH03728.1 .
CCDSi CCDS20504.1.
RefSeqi NP_033909.1. NM_009779.2.
UniGenei Mm.2408.

3D structure databases

ProteinModelPortali O09047.
SMRi O09047. Positions 24-191, 325-441.
ModBasei Search...
MobiDBi Search...

Chemistry

GuidetoPHARMACOLOGYi 31.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei O09047.

Proteomic databases

PRIDEi O09047.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000042081 ; ENSMUSP00000048092 ; ENSMUSG00000040552 .
GeneIDi 12267.
KEGGi mmu:12267.
UCSCi uc009dps.1. mouse.

Organism-specific databases

CTDi 719.
MGIi MGI:1097680. C3ar1.

Phylogenomic databases

eggNOGi NOG148047.
HOGENOMi HOG000261616.
HOVERGENi HBG002433.
InParanoidi O09047.
KOi K04009.
OMAi LWVAGLK.
OrthoDBi EOG7PGDQQ.
PhylomeDBi O09047.
TreeFami TF330976.

Enzyme and pathway databases

Reactomei REACT_235286. Peptide ligand-binding receptors.
REACT_250376. G alpha (i) signalling events.

Miscellaneous databases

NextBioi 280718.
PROi O09047.
SOURCEi Search...

Gene expression databases

Bgeei O09047.
CleanExi MM_C3AR1.
ExpressionAtlasi O09047. baseline and differential.
Genevestigatori O09047.

Family and domain databases

Gene3Di 1.20.1070.10. 2 hits.
InterProi IPR001644. Anaphtx_C3AR1.
IPR002234. Anphylx_rcpt.
IPR000826. Formyl_rcpt-rel.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view ]
PANTHERi PTHR24225. PTHR24225. 1 hit.
PTHR24225:SF4. PTHR24225:SF4. 1 hit.
Pfami PF00001. 7tm_1. 2 hits.
[Graphical view ]
PRINTSi PR01104. ANPHYLATOXNR.
PR01060. C3ANPHYLTXNR.
PR00237. GPCRRHODOPSN.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The mouse anaphylatoxin C3a receptor: molecular cloning, genomic organization, and functional expression."
    Tornetta M.A., Foley J.J., Sarau H.M., Ames R.S.
    J. Immunol. 158:5277-5282(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
    Strain: 129/SvJ and C57BL/6.
    Tissue: Brain.
  2. "Cloning and functional characterization of the mouse C3a anaphylatoxin receptor gene."
    Hsu M.H., Ember J.A., Wang M., Prossnitz E.R., Hugli T.E., Ye R.D.
    Immunogenetics 47:64-72(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129/SvJ.
  3. "Cloning, expression, sequence determination, and chromosome localization of the mouse complement C3a anaphylatoxin receptor gene."
    Hollmann T.J., Haviland D.L., Kildsgaard J., Watts K., Wetsel R.A.
    Mol. Immunol. 35:137-148(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129/SvJ.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary gland.

Entry informationi

Entry nameiC3AR_MOUSE
AccessioniPrimary (citable) accession number: O09047
Secondary accession number(s): O35951
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 1, 1997
Last modified: November 26, 2014
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3