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O09047 (C3AR_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 118. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
C3a anaphylatoxin chemotactic receptor

Short name=C3AR
Short name=C3a-R
Alternative name(s):
Complement component 3a receptor 1
Gene names
Name:C3ar1
Synonyms:C3r1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length477 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Receptor for the chemotactic and inflammatory peptide anaphylatoxin C3a. This receptor stimulates chemotaxis, granule enzyme release and superoxide anion production.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Tissue specificity

Detected in varying levels in all tissues examined except the spleen. Especially abundant in heart and lung.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 477477C3a anaphylatoxin chemotactic receptor
PRO_0000069204

Regions

Topological domain1 – 2323Extracellular Potential
Transmembrane24 – 4623Helical; Name=1; Potential
Topological domain47 – 5711Cytoplasmic Potential
Transmembrane58 – 8023Helical; Name=2; Potential
Topological domain81 – 9616Extracellular Potential
Transmembrane97 – 11822Helical; Name=3; Potential
Topological domain119 – 13921Cytoplasmic Potential
Transmembrane140 – 16021Helical; Name=4; Potential
Topological domain161 – 333173Extracellular Potential
Transmembrane334 – 35320Helical; Name=5; Potential
Topological domain354 – 37017Cytoplasmic Potential
Transmembrane371 – 39323Helical; Name=6; Potential
Topological domain394 – 41017Extracellular Potential
Transmembrane411 – 43121Helical; Name=7; Potential
Topological domain432 – 47746Cytoplasmic Potential

Amino acid modifications

Modified residue1741Sulfotyrosine By similarity
Modified residue1841Sulfotyrosine By similarity
Modified residue3121Sulfotyrosine By similarity
Glycosylation91N-linked (GlcNAc...) Potential
Glycosylation1681N-linked (GlcNAc...) Potential
Glycosylation1971N-linked (GlcNAc...) Potential
Glycosylation2011N-linked (GlcNAc...) Potential
Disulfide bond95 ↔ 172 By similarity

Experimental info

Sequence conflict1731R → K in AAB71814. Ref.2
Sequence conflict1951E → K in AAB71814. Ref.2
Sequence conflict2431D → N in AAB71814. Ref.2
Sequence conflict2761D → N in AAB71814. Ref.2
Sequence conflict380 – 3823FIC → LS in AAB71814. Ref.2
Sequence conflict3911V → I in AAB71814. Ref.2
Sequence conflict4601N → S in AAB71814. Ref.2

Sequences

Sequence LengthMass (Da)Tools
O09047 [UniParc].

Last modified July 1, 1997. Version 1.
Checksum: 9873F464A1520984

FASTA47753,576
        10         20         30         40         50         60 
MESFDADTNS TDLHSRPLFQ PQDIASMVIL GLTCLLGLLG NGLVLWVAGV KMKTTVNTVW 

        70         80         90        100        110        120 
FLHLTLADFL CCLSLPFSLA HLILQGHWPY GLFLCKLIPS IIILNMFASV FLLTAISLDR 

       130        140        150        160        170        180 
CLIVHKPIWC QNHRNVRTAF AICGCVWVVA FVMCVPVFVY RDLFIMDNRS ICRYNFDSSR 

       190        200        210        220        230        240 
SYDYWDYVYK LSLPESNSTD NSTAQLTGHM NDRSAPSSVQ ARDYFWTVTT ALQSQPFLTS 

       250        260        270        280        290        300 
PEDSFSLDSA NQQPHYGGKP PNVLTAAVPS GFPVEDRKSN TLNADAFLSA HTELFPTASS 

       310        320        330        340        350        360 
GHLYPYDFQG DYVDQFTYDN HVPTPLMAIT ITRLVVGFLV PFFIMVICYS LIVFRMRKTN 

       370        380        390        400        410        420 
FTKSRNKTFR VAVAVVTVFF ICWTPYHLVG VLLLITDPES SLGEAVMSWD HMSIALASAN 

       430        440        450        460        470 
SCFNPFLYAL LGKDFRKKAR QSIKGILEAA FSEELTHSTN CTQDKASSKR NNMSTDV 

« Hide

References

« Hide 'large scale' references
[1]"The mouse anaphylatoxin C3a receptor: molecular cloning, genomic organization, and functional expression."
Tornetta M.A., Foley J.J., Sarau H.M., Ames R.S.
J. Immunol. 158:5277-5282(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
Strain: 129/SvJ and C57BL/6.
Tissue: Brain.
[2]"Cloning and functional characterization of the mouse C3a anaphylatoxin receptor gene."
Hsu M.H., Ember J.A., Wang M., Prossnitz E.R., Hugli T.E., Ye R.D.
Immunogenetics 47:64-72(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 129/SvJ.
[3]"Cloning, expression, sequence determination, and chromosome localization of the mouse complement C3a anaphylatoxin receptor gene."
Hollmann T.J., Haviland D.L., Kildsgaard J., Watts K., Wetsel R.A.
Mol. Immunol. 35:137-148(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 129/SvJ.
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N.
Tissue: Mammary gland.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U77461 Genomic DNA. Translation: AAC53204.1.
U77460 mRNA. Translation: AAC53203.1.
U97537 Genomic DNA. Translation: AAB71814.1.
AF053757 Genomic DNA. Translation: AAC40193.1.
BC003728 mRNA. Translation: AAH03728.1.
RefSeqNP_033909.1. NM_009779.2.
UniGeneMm.2408.

3D structure databases

ProteinModelPortalO09047.
SMRO09047. Positions 22-441.
ModBaseSearch...
MobiDBSearch...

Chemistry

GuidetoPHARMACOLOGY31.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteO09047.

Proteomic databases

PRIDEO09047.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000042081; ENSMUSP00000048092; ENSMUSG00000040552.
GeneID12267.
KEGGmmu:12267.
UCSCuc009dps.1. mouse.

Organism-specific databases

CTD719.
MGIMGI:1097680. C3ar1.

Phylogenomic databases

eggNOGNOG148047.
HOGENOMHOG000261616.
HOVERGENHBG002433.
InParanoidO09047.
KOK04009.
OMALWVAGLK.
OrthoDBEOG7PGDQQ.
PhylomeDBO09047.
TreeFamTF330976.

Gene expression databases

ArrayExpressO09047.
BgeeO09047.
CleanExMM_C3AR1.
GenevestigatorO09047.

Family and domain databases

Gene3D1.20.1070.10. 2 hits.
InterProIPR001644. Anaphtx_C3AR1.
IPR002234. Anphylx_rcpt.
IPR000826. Formyl_pep_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERPTHR24225. PTHR24225. 1 hit.
PTHR24225:SF4. PTHR24225:SF4. 1 hit.
PfamPF00001. 7tm_1. 2 hits.
[Graphical view]
PRINTSPR01104. ANPHYLATOXNR.
PR01060. C3ANPHYLTXNR.
PR00237. GPCRRHODOPSN.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio280718.
PROO09047.
SOURCESearch...

Entry information

Entry nameC3AR_MOUSE
AccessionPrimary (citable) accession number: O09047
Secondary accession number(s): O35951
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 1, 1997
Last modified: April 16, 2014
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries