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O09047

- C3AR_MOUSE

UniProt

O09047 - C3AR_MOUSE

Protein

C3a anaphylatoxin chemotactic receptor

Gene

C3ar1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 123 (01 Oct 2014)
      Sequence version 1 (01 Jul 1997)
      Previous versions | rss
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    Functioni

    Receptor for the chemotactic and inflammatory peptide anaphylatoxin C3a. This receptor stimulates chemotaxis, granule enzyme release and superoxide anion production.

    GO - Molecular functioni

    1. C3a anaphylatoxin receptor activity Source: InterPro

    GO - Biological processi

    1. chemotaxis Source: UniProtKB-KW
    2. positive regulation of angiogenesis Source: BHF-UCL
    3. positive regulation of cytosolic calcium ion concentration Source: Ensembl
    4. positive regulation of macrophage chemotaxis Source: BHF-UCL
    5. positive regulation of neutrophil chemotaxis Source: BHF-UCL
    6. positive regulation vascular endothelial growth factor production Source: BHF-UCL

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Chemotaxis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    C3a anaphylatoxin chemotactic receptor
    Short name:
    C3AR
    Short name:
    C3a-R
    Alternative name(s):
    Complement component 3a receptor 1
    Gene namesi
    Name:C3ar1
    Synonyms:C3r1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 6

    Organism-specific databases

    MGIiMGI:1097680. C3ar1.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 477477C3a anaphylatoxin chemotactic receptorPRO_0000069204Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi9 – 91N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi95 ↔ 172PROSITE-ProRule annotation
    Glycosylationi168 – 1681N-linked (GlcNAc...)Sequence Analysis
    Modified residuei174 – 1741SulfotyrosineBy similarity
    Modified residuei184 – 1841SulfotyrosineBy similarity
    Glycosylationi197 – 1971N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi201 – 2011N-linked (GlcNAc...)Sequence Analysis
    Modified residuei312 – 3121SulfotyrosineBy similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Sulfation

    Proteomic databases

    PRIDEiO09047.

    PTM databases

    PhosphoSiteiO09047.

    Expressioni

    Tissue specificityi

    Detected in varying levels in all tissues examined except the spleen. Especially abundant in heart and lung.

    Gene expression databases

    ArrayExpressiO09047.
    BgeeiO09047.
    CleanExiMM_C3AR1.
    GenevestigatoriO09047.

    Structurei

    3D structure databases

    ProteinModelPortaliO09047.
    SMRiO09047. Positions 24-191, 325-441.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2323ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini47 – 5711CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini81 – 9616ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini119 – 13921CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini161 – 333173ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini354 – 37017CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini394 – 41017ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini432 – 47746CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei24 – 4623Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei58 – 8023Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei97 – 11822Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei140 – 16021Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei334 – 35320Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei371 – 39323Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei411 – 43121Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG148047.
    HOGENOMiHOG000261616.
    HOVERGENiHBG002433.
    InParanoidiO09047.
    KOiK04009.
    OMAiLWVAGLK.
    OrthoDBiEOG7PGDQQ.
    PhylomeDBiO09047.
    TreeFamiTF330976.

    Family and domain databases

    Gene3Di1.20.1070.10. 2 hits.
    InterProiIPR001644. Anaphtx_C3AR1.
    IPR002234. Anphylx_rcpt.
    IPR000826. Formyl_rcpt-rel.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view]
    PANTHERiPTHR24225. PTHR24225. 1 hit.
    PTHR24225:SF4. PTHR24225:SF4. 1 hit.
    PfamiPF00001. 7tm_1. 2 hits.
    [Graphical view]
    PRINTSiPR01104. ANPHYLATOXNR.
    PR01060. C3ANPHYLTXNR.
    PR00237. GPCRRHODOPSN.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O09047-1 [UniParc]FASTAAdd to Basket

    « Hide

    MESFDADTNS TDLHSRPLFQ PQDIASMVIL GLTCLLGLLG NGLVLWVAGV    50
    KMKTTVNTVW FLHLTLADFL CCLSLPFSLA HLILQGHWPY GLFLCKLIPS 100
    IIILNMFASV FLLTAISLDR CLIVHKPIWC QNHRNVRTAF AICGCVWVVA 150
    FVMCVPVFVY RDLFIMDNRS ICRYNFDSSR SYDYWDYVYK LSLPESNSTD 200
    NSTAQLTGHM NDRSAPSSVQ ARDYFWTVTT ALQSQPFLTS PEDSFSLDSA 250
    NQQPHYGGKP PNVLTAAVPS GFPVEDRKSN TLNADAFLSA HTELFPTASS 300
    GHLYPYDFQG DYVDQFTYDN HVPTPLMAIT ITRLVVGFLV PFFIMVICYS 350
    LIVFRMRKTN FTKSRNKTFR VAVAVVTVFF ICWTPYHLVG VLLLITDPES 400
    SLGEAVMSWD HMSIALASAN SCFNPFLYAL LGKDFRKKAR QSIKGILEAA 450
    FSEELTHSTN CTQDKASSKR NNMSTDV 477
    Length:477
    Mass (Da):53,576
    Last modified:July 1, 1997 - v1
    Checksum:i9873F464A1520984
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti173 – 1731R → K in AAB71814. (PubMed:9382922)Curated
    Sequence conflicti195 – 1951E → K in AAB71814. (PubMed:9382922)Curated
    Sequence conflicti243 – 2431D → N in AAB71814. (PubMed:9382922)Curated
    Sequence conflicti276 – 2761D → N in AAB71814. (PubMed:9382922)Curated
    Sequence conflicti380 – 3823FIC → LS in AAB71814. (PubMed:9382922)Curated
    Sequence conflicti391 – 3911V → I in AAB71814. (PubMed:9382922)Curated
    Sequence conflicti460 – 4601N → S in AAB71814. (PubMed:9382922)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U77461 Genomic DNA. Translation: AAC53204.1.
    U77460 mRNA. Translation: AAC53203.1.
    U97537 Genomic DNA. Translation: AAB71814.1.
    AF053757 Genomic DNA. Translation: AAC40193.1.
    BC003728 mRNA. Translation: AAH03728.1.
    CCDSiCCDS20504.1.
    RefSeqiNP_033909.1. NM_009779.2.
    UniGeneiMm.2408.

    Genome annotation databases

    EnsembliENSMUST00000042081; ENSMUSP00000048092; ENSMUSG00000040552.
    GeneIDi12267.
    KEGGimmu:12267.
    UCSCiuc009dps.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U77461 Genomic DNA. Translation: AAC53204.1 .
    U77460 mRNA. Translation: AAC53203.1 .
    U97537 Genomic DNA. Translation: AAB71814.1 .
    AF053757 Genomic DNA. Translation: AAC40193.1 .
    BC003728 mRNA. Translation: AAH03728.1 .
    CCDSi CCDS20504.1.
    RefSeqi NP_033909.1. NM_009779.2.
    UniGenei Mm.2408.

    3D structure databases

    ProteinModelPortali O09047.
    SMRi O09047. Positions 24-191, 325-441.
    ModBasei Search...
    MobiDBi Search...

    Chemistry

    GuidetoPHARMACOLOGYi 31.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei O09047.

    Proteomic databases

    PRIDEi O09047.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000042081 ; ENSMUSP00000048092 ; ENSMUSG00000040552 .
    GeneIDi 12267.
    KEGGi mmu:12267.
    UCSCi uc009dps.1. mouse.

    Organism-specific databases

    CTDi 719.
    MGIi MGI:1097680. C3ar1.

    Phylogenomic databases

    eggNOGi NOG148047.
    HOGENOMi HOG000261616.
    HOVERGENi HBG002433.
    InParanoidi O09047.
    KOi K04009.
    OMAi LWVAGLK.
    OrthoDBi EOG7PGDQQ.
    PhylomeDBi O09047.
    TreeFami TF330976.

    Miscellaneous databases

    NextBioi 280718.
    PROi O09047.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O09047.
    Bgeei O09047.
    CleanExi MM_C3AR1.
    Genevestigatori O09047.

    Family and domain databases

    Gene3Di 1.20.1070.10. 2 hits.
    InterProi IPR001644. Anaphtx_C3AR1.
    IPR002234. Anphylx_rcpt.
    IPR000826. Formyl_rcpt-rel.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view ]
    PANTHERi PTHR24225. PTHR24225. 1 hit.
    PTHR24225:SF4. PTHR24225:SF4. 1 hit.
    Pfami PF00001. 7tm_1. 2 hits.
    [Graphical view ]
    PRINTSi PR01104. ANPHYLATOXNR.
    PR01060. C3ANPHYLTXNR.
    PR00237. GPCRRHODOPSN.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The mouse anaphylatoxin C3a receptor: molecular cloning, genomic organization, and functional expression."
      Tornetta M.A., Foley J.J., Sarau H.M., Ames R.S.
      J. Immunol. 158:5277-5282(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
      Strain: 129/SvJ and C57BL/6.
      Tissue: Brain.
    2. "Cloning and functional characterization of the mouse C3a anaphylatoxin receptor gene."
      Hsu M.H., Ember J.A., Wang M., Prossnitz E.R., Hugli T.E., Ye R.D.
      Immunogenetics 47:64-72(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 129/SvJ.
    3. "Cloning, expression, sequence determination, and chromosome localization of the mouse complement C3a anaphylatoxin receptor gene."
      Hollmann T.J., Haviland D.L., Kildsgaard J., Watts K., Wetsel R.A.
      Mol. Immunol. 35:137-148(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 129/SvJ.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Mammary gland.

    Entry informationi

    Entry nameiC3AR_MOUSE
    AccessioniPrimary (citable) accession number: O09047
    Secondary accession number(s): O35951
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: July 1, 1997
    Last modified: October 1, 2014
    This is version 123 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3