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Protein

C3a anaphylatoxin chemotactic receptor

Gene

C3ar1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for the chemotactic and inflammatory peptide anaphylatoxin C3a. This receptor stimulates chemotaxis, granule enzyme release and superoxide anion production.

GO - Molecular functioni

GO - Biological processi

  • chemotaxis Source: UniProtKB-KW
  • inflammatory response Source: GO_Central
  • phospholipase C-activating G-protein coupled receptor signaling pathway Source: GO_Central
  • positive regulation of angiogenesis Source: BHF-UCL
  • positive regulation of cytosolic calcium ion concentration Source: MGI
  • positive regulation of macrophage chemotaxis Source: BHF-UCL
  • positive regulation of neutrophil chemotaxis Source: BHF-UCL
  • positive regulation of vascular endothelial growth factor production Source: BHF-UCL
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Chemotaxis

Enzyme and pathway databases

ReactomeiR-MMU-375276. Peptide ligand-binding receptors.
R-MMU-418594. G alpha (i) signalling events.
R-MMU-6798695. Neutrophil degranulation.
R-MMU-977606. Regulation of Complement cascade.

Names & Taxonomyi

Protein namesi
Recommended name:
C3a anaphylatoxin chemotactic receptor
Short name:
C3AR
Short name:
C3a-R
Alternative name(s):
Complement component 3a receptor 1
Gene namesi
Name:C3ar1
Synonyms:C3r1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1097680. C3ar1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 23ExtracellularSequence analysisAdd BLAST23
Transmembranei24 – 46Helical; Name=1Sequence analysisAdd BLAST23
Topological domaini47 – 57CytoplasmicSequence analysisAdd BLAST11
Transmembranei58 – 80Helical; Name=2Sequence analysisAdd BLAST23
Topological domaini81 – 96ExtracellularSequence analysisAdd BLAST16
Transmembranei97 – 118Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini119 – 139CytoplasmicSequence analysisAdd BLAST21
Transmembranei140 – 160Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini161 – 333ExtracellularSequence analysisAdd BLAST173
Transmembranei334 – 353Helical; Name=5Sequence analysisAdd BLAST20
Topological domaini354 – 370CytoplasmicSequence analysisAdd BLAST17
Transmembranei371 – 393Helical; Name=6Sequence analysisAdd BLAST23
Topological domaini394 – 410ExtracellularSequence analysisAdd BLAST17
Transmembranei411 – 431Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini432 – 477CytoplasmicSequence analysisAdd BLAST46

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000692041 – 477C3a anaphylatoxin chemotactic receptorAdd BLAST477

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi9N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi95 ↔ 172PROSITE-ProRule annotation
Glycosylationi168N-linked (GlcNAc...)Sequence analysis1
Modified residuei174SulfotyrosineBy similarity1
Modified residuei184SulfotyrosineBy similarity1
Glycosylationi197N-linked (GlcNAc...)Sequence analysis1
Glycosylationi201N-linked (GlcNAc...)Sequence analysis1
Modified residuei312SulfotyrosineBy similarity1
Modified residuei452PhosphoserineCombined sources1
Modified residuei456PhosphothreonineCombined sources1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein, Sulfation

Proteomic databases

PaxDbiO09047.
PRIDEiO09047.

PTM databases

iPTMnetiO09047.
PhosphoSitePlusiO09047.

Expressioni

Tissue specificityi

Detected in varying levels in all tissues examined except the spleen. Especially abundant in heart and lung.

Gene expression databases

BgeeiENSMUSG00000040552.
CleanExiMM_C3AR1.
ExpressionAtlasiO09047. baseline and differential.
GenevisibleiO09047. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000048092.

Structurei

3D structure databases

ProteinModelPortaliO09047.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IUVF. Eukaryota.
ENOG410YBJQ. LUCA.
GeneTreeiENSGT00760000118990.
HOGENOMiHOG000261616.
HOVERGENiHBG002433.
InParanoidiO09047.
KOiK04009.
OMAiLWVAGLK.
OrthoDBiEOG091G0AEJ.
PhylomeDBiO09047.
TreeFamiTF330976.

Family and domain databases

InterProiIPR001644. Anaphtx_C3AR1.
IPR002234. Anphylx_rcpt.
IPR000826. Formyl_rcpt-rel.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24225. PTHR24225. 2 hits.
PTHR24225:SF28. PTHR24225:SF28. 2 hits.
PfamiPF00001. 7tm_1. 2 hits.
[Graphical view]
PRINTSiPR01104. ANPHYLATOXNR.
PR01060. C3ANPHYLTXNR.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O09047-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESFDADTNS TDLHSRPLFQ PQDIASMVIL GLTCLLGLLG NGLVLWVAGV
60 70 80 90 100
KMKTTVNTVW FLHLTLADFL CCLSLPFSLA HLILQGHWPY GLFLCKLIPS
110 120 130 140 150
IIILNMFASV FLLTAISLDR CLIVHKPIWC QNHRNVRTAF AICGCVWVVA
160 170 180 190 200
FVMCVPVFVY RDLFIMDNRS ICRYNFDSSR SYDYWDYVYK LSLPESNSTD
210 220 230 240 250
NSTAQLTGHM NDRSAPSSVQ ARDYFWTVTT ALQSQPFLTS PEDSFSLDSA
260 270 280 290 300
NQQPHYGGKP PNVLTAAVPS GFPVEDRKSN TLNADAFLSA HTELFPTASS
310 320 330 340 350
GHLYPYDFQG DYVDQFTYDN HVPTPLMAIT ITRLVVGFLV PFFIMVICYS
360 370 380 390 400
LIVFRMRKTN FTKSRNKTFR VAVAVVTVFF ICWTPYHLVG VLLLITDPES
410 420 430 440 450
SLGEAVMSWD HMSIALASAN SCFNPFLYAL LGKDFRKKAR QSIKGILEAA
460 470
FSEELTHSTN CTQDKASSKR NNMSTDV
Length:477
Mass (Da):53,576
Last modified:July 1, 1997 - v1
Checksum:i9873F464A1520984
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti173R → K in AAB71814 (PubMed:9382922).Curated1
Sequence conflicti195E → K in AAB71814 (PubMed:9382922).Curated1
Sequence conflicti243D → N in AAB71814 (PubMed:9382922).Curated1
Sequence conflicti276D → N in AAB71814 (PubMed:9382922).Curated1
Sequence conflicti380 – 382FIC → LS in AAB71814 (PubMed:9382922).Curated3
Sequence conflicti391V → I in AAB71814 (PubMed:9382922).Curated1
Sequence conflicti460N → S in AAB71814 (PubMed:9382922).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U77461 Genomic DNA. Translation: AAC53204.1.
U77460 mRNA. Translation: AAC53203.1.
U97537 Genomic DNA. Translation: AAB71814.1.
AF053757 Genomic DNA. Translation: AAC40193.1.
BC003728 mRNA. Translation: AAH03728.1.
CCDSiCCDS20504.1.
RefSeqiNP_033909.1. NM_009779.2.
UniGeneiMm.2408.

Genome annotation databases

EnsembliENSMUST00000042081; ENSMUSP00000048092; ENSMUSG00000040552.
GeneIDi12267.
KEGGimmu:12267.
UCSCiuc009dps.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U77461 Genomic DNA. Translation: AAC53204.1.
U77460 mRNA. Translation: AAC53203.1.
U97537 Genomic DNA. Translation: AAB71814.1.
AF053757 Genomic DNA. Translation: AAC40193.1.
BC003728 mRNA. Translation: AAH03728.1.
CCDSiCCDS20504.1.
RefSeqiNP_033909.1. NM_009779.2.
UniGeneiMm.2408.

3D structure databases

ProteinModelPortaliO09047.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000048092.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiO09047.
PhosphoSitePlusiO09047.

Proteomic databases

PaxDbiO09047.
PRIDEiO09047.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000042081; ENSMUSP00000048092; ENSMUSG00000040552.
GeneIDi12267.
KEGGimmu:12267.
UCSCiuc009dps.1. mouse.

Organism-specific databases

CTDi719.
MGIiMGI:1097680. C3ar1.

Phylogenomic databases

eggNOGiENOG410IUVF. Eukaryota.
ENOG410YBJQ. LUCA.
GeneTreeiENSGT00760000118990.
HOGENOMiHOG000261616.
HOVERGENiHBG002433.
InParanoidiO09047.
KOiK04009.
OMAiLWVAGLK.
OrthoDBiEOG091G0AEJ.
PhylomeDBiO09047.
TreeFamiTF330976.

Enzyme and pathway databases

ReactomeiR-MMU-375276. Peptide ligand-binding receptors.
R-MMU-418594. G alpha (i) signalling events.
R-MMU-6798695. Neutrophil degranulation.
R-MMU-977606. Regulation of Complement cascade.

Miscellaneous databases

PROiO09047.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000040552.
CleanExiMM_C3AR1.
ExpressionAtlasiO09047. baseline and differential.
GenevisibleiO09047. MM.

Family and domain databases

InterProiIPR001644. Anaphtx_C3AR1.
IPR002234. Anphylx_rcpt.
IPR000826. Formyl_rcpt-rel.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24225. PTHR24225. 2 hits.
PTHR24225:SF28. PTHR24225:SF28. 2 hits.
PfamiPF00001. 7tm_1. 2 hits.
[Graphical view]
PRINTSiPR01104. ANPHYLATOXNR.
PR01060. C3ANPHYLTXNR.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiC3AR_MOUSE
AccessioniPrimary (citable) accession number: O09047
Secondary accession number(s): O35951
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 1, 1997
Last modified: November 30, 2016
This is version 143 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.