C3a anaphylatoxin chemotactic receptor

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O09047 (C3AR_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 107. History...

Clusters with 100%, 90%, 50% identity |

Documents (3) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
C3a anaphylatoxin chemotactic receptor
Short name=C3AR
Short name=C3a-R

Alternative name(s):
Complement component 3a receptor 1

Gene names

Name:	C3ar1
Synonyms:	C3r1

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	477 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Receptor for the chemotactic and inflammatory peptide anaphylatoxin C3a. This receptor stimulates chemotaxis, granule enzyme release and superoxide anion production.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Tissue specificity	Detected in varying levels in all tissues examined except the spleen. Especially abundant in heart and lung.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Biological process	Chemotaxis
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein Sulfation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	chemotaxis Inferred from electronic annotation. Source: UniProtKB-KW positive regulation of angiogenesis Inferred from mutant phenotype PubMed 16452172. Source: BHF-UCL positive regulation of macrophage chemotaxis Inferred from mutant phenotype PubMed 16452172. Source: BHF-UCL positive regulation of neutrophil chemotaxis Inferred from mutant phenotype PubMed 16452172. Source: BHF-UCL positive regulation vascular endothelial growth factor production Inferred from mutant phenotype PubMed 16452172. Source: BHF-UCL
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	C3a anaphylatoxin receptor activity Inferred from electronic annotation. Source: InterPro N-formyl peptide receptor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 477

477

C3a anaphylatoxin chemotactic receptor

PRO_0000069204

Regions

Topological domain

1 – 23

Extracellular Potential

Transmembrane

24 – 46

Helical; Name=1; Potential

Topological domain

47 – 57

Cytoplasmic Potential

Transmembrane

58 – 80

Helical; Name=2; Potential

Topological domain

81 – 96

Extracellular Potential

Transmembrane

97 – 118

Helical; Name=3; Potential

Topological domain

119 – 139

Cytoplasmic Potential

Transmembrane

140 – 160

Helical; Name=4; Potential

Topological domain

161 – 333

173

Extracellular Potential

Transmembrane

334 – 353

Helical; Name=5; Potential

Topological domain

354 – 370

Cytoplasmic Potential

Transmembrane

371 – 393

Helical; Name=6; Potential

Topological domain

394 – 410

Extracellular Potential

Transmembrane

411 – 431

Helical; Name=7; Potential

Topological domain

432 – 477

Cytoplasmic Potential

Amino acid modifications

Modified residue

174

Sulfotyrosine By similarity

Modified residue

184

Sulfotyrosine By similarity

Modified residue

312

Sulfotyrosine By similarity

Glycosylation

N-linked (GlcNAc...) Potential

Glycosylation

168

N-linked (GlcNAc...) Potential

Glycosylation

197

N-linked (GlcNAc...) Potential

Glycosylation

201

N-linked (GlcNAc...) Potential

Disulfide bond

95 ↔ 172

By similarity

Experimental info

Sequence conflict

173

R → K in AAB71814. Ref.2

Sequence conflict

195

E → K in AAB71814. Ref.2

Sequence conflict

243

D → N in AAB71814. Ref.2

Sequence conflict

276

D → N in AAB71814. Ref.2

Sequence conflict

380 – 382

FIC → LS in AAB71814. Ref.2

Sequence conflict

391

V → I in AAB71814. Ref.2

Sequence conflict

460

N → S in AAB71814. Ref.2

Sequences

Sequence

Length

Mass (Da)

Tools

O09047 [UniParc].

Last modified July 1, 1997. Version 1.
Checksum: 9873F464A1520984
Show »

FASTA

477

53,576

        10         20         30         40         50         60 
MESFDADTNS TDLHSRPLFQ PQDIASMVIL GLTCLLGLLG NGLVLWVAGV KMKTTVNTVW 

        70         80         90        100        110        120 
FLHLTLADFL CCLSLPFSLA HLILQGHWPY GLFLCKLIPS IIILNMFASV FLLTAISLDR 

       130        140        150        160        170        180 
CLIVHKPIWC QNHRNVRTAF AICGCVWVVA FVMCVPVFVY RDLFIMDNRS ICRYNFDSSR 

       190        200        210        220        230        240 
SYDYWDYVYK LSLPESNSTD NSTAQLTGHM NDRSAPSSVQ ARDYFWTVTT ALQSQPFLTS 

       250        260        270        280        290        300 
PEDSFSLDSA NQQPHYGGKP PNVLTAAVPS GFPVEDRKSN TLNADAFLSA HTELFPTASS 

       310        320        330        340        350        360 
GHLYPYDFQG DYVDQFTYDN HVPTPLMAIT ITRLVVGFLV PFFIMVICYS LIVFRMRKTN 

       370        380        390        400        410        420 
FTKSRNKTFR VAVAVVTVFF ICWTPYHLVG VLLLITDPES SLGEAVMSWD HMSIALASAN 

       430        440        450        460        470 
SCFNPFLYAL LGKDFRKKAR QSIKGILEAA FSEELTHSTN CTQDKASSKR NNMSTDV

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The mouse anaphylatoxin C3a receptor: molecular cloning, genomic organization, and functional expression." Tornetta M.A., Foley J.J., Sarau H.M., Ames R.S. J. Immunol. 158:5277-5282(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA]. Strain: 129/SvJ and C57BL/6. Tissue: Brain.
[2]	"Cloning and functional characterization of the mouse C3a anaphylatoxin receptor gene." Hsu M.H., Ember J.A., Wang M., Prossnitz E.R., Hugli T.E., Ye R.D. Immunogenetics 47:64-72(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: 129/SvJ.
[3]	"Cloning, expression, sequence determination, and chromosome localization of the mouse complement C3a anaphylatoxin receptor gene." Hollmann T.J., Haviland D.L., Kildsgaard J., Watts K., Wetsel R.A. Mol. Immunol. 35:137-148(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: 129/SvJ.
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: FVB/N. Tissue: Mammary gland.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U77461 Genomic DNA. Translation: AAC53204.1. U77460 mRNA. Translation: AAC53203.1. U97537 Genomic DNA. Translation: AAB71814.1. AF053757 Genomic DNA. Translation: AAC40193.1. BC003728 mRNA. Translation: AAH03728.1.
IPI	IPI00113802.
RefSeq	NP_033909.1. NM_009779.2.
UniGene	Mm.2408.
3D structure databases
ProteinModelPortal	O09047.
SMR	O09047. Positions 27-193, 325-441.
ModBase	Search...
Protein family/group databases
GPCRDB	Search...
PTM databases
PhosphoSite	O09047.
Proteomic databases
PRIDE	O09047.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000042081; ENSMUSP00000048092; ENSMUSG00000040552.
GeneID	12267.
KEGG	mmu:12267.
Organism-specific databases
CTD	719.
MGI	MGI:1097680. C3ar1.
Phylogenomic databases
eggNOG	NOG148047.
HOGENOM	HOG000261616.
HOVERGEN	HBG002433.
InParanoid	O09047.
KO	K04009.
OMA	LWVAGLK.
OrthoDB	EOG4PC9S8.
Gene expression databases
ArrayExpress	O09047.
Bgee	O09047.
CleanEx	MM_C3AR1.
Genevestigator	O09047.
GermOnline	ENSMUSG00000040552. Mus musculus.
Family and domain databases
InterPro	IPR002234. Anphylx_rcpt. IPR001644. C3A_anaphtx_rcpt. IPR000826. Formyl_pep_rcpt. IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. [Graphical view]
PANTHER	PTHR24225. PTHR24225. 1 hit.
Pfam	PF00001. 7tm_1. 2 hits. [Graphical view]
PRINTS	PR01104. ANPHYLATOXNR. PR01060. C3ANPHYLTXNR. PR00237. GPCRRHODOPSN.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	280718.
SOURCE	Search...

Entry information

Entry name

C3AR_MOUSE

Accession

Primary (citable) accession number: O09047
Secondary accession number(s): O35951

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	July 1, 1997
Last modified:	May 1, 2013
This is version 107 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein family/group databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents