SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

O09047

- C3AR_MOUSE

UniProt

O09047 - C3AR_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
C3a anaphylatoxin chemotactic receptor
Gene
C3ar1, C3r1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Receptor for the chemotactic and inflammatory peptide anaphylatoxin C3a. This receptor stimulates chemotaxis, granule enzyme release and superoxide anion production.

GO - Molecular functioni

  1. C3a anaphylatoxin receptor activity Source: InterPro

GO - Biological processi

  1. chemotaxis Source: UniProtKB-KW
  2. positive regulation of angiogenesis Source: BHF-UCL
  3. positive regulation of cytosolic calcium ion concentration Source: Ensembl
  4. positive regulation of macrophage chemotaxis Source: BHF-UCL
  5. positive regulation of neutrophil chemotaxis Source: BHF-UCL
  6. positive regulation vascular endothelial growth factor production Source: BHF-UCL
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Chemotaxis

Names & Taxonomyi

Protein namesi
Recommended name:
C3a anaphylatoxin chemotactic receptor
Short name:
C3AR
Short name:
C3a-R
Alternative name(s):
Complement component 3a receptor 1
Gene namesi
Name:C3ar1
Synonyms:C3r1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 6

Organism-specific databases

MGIiMGI:1097680. C3ar1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2323Extracellular Reviewed prediction
Add
BLAST
Transmembranei24 – 4623Helical; Name=1; Reviewed prediction
Add
BLAST
Topological domaini47 – 5711Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei58 – 8023Helical; Name=2; Reviewed prediction
Add
BLAST
Topological domaini81 – 9616Extracellular Reviewed prediction
Add
BLAST
Transmembranei97 – 11822Helical; Name=3; Reviewed prediction
Add
BLAST
Topological domaini119 – 13921Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei140 – 16021Helical; Name=4; Reviewed prediction
Add
BLAST
Topological domaini161 – 333173Extracellular Reviewed prediction
Add
BLAST
Transmembranei334 – 35320Helical; Name=5; Reviewed prediction
Add
BLAST
Topological domaini354 – 37017Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei371 – 39323Helical; Name=6; Reviewed prediction
Add
BLAST
Topological domaini394 – 41017Extracellular Reviewed prediction
Add
BLAST
Transmembranei411 – 43121Helical; Name=7; Reviewed prediction
Add
BLAST
Topological domaini432 – 47746Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 477477C3a anaphylatoxin chemotactic receptor
PRO_0000069204Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi9 – 91N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi95 ↔ 172 By similarity
Glycosylationi168 – 1681N-linked (GlcNAc...) Reviewed prediction
Modified residuei174 – 1741Sulfotyrosine By similarity
Modified residuei184 – 1841Sulfotyrosine By similarity
Glycosylationi197 – 1971N-linked (GlcNAc...) Reviewed prediction
Glycosylationi201 – 2011N-linked (GlcNAc...) Reviewed prediction
Modified residuei312 – 3121Sulfotyrosine By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Sulfation

Proteomic databases

PRIDEiO09047.

PTM databases

PhosphoSiteiO09047.

Expressioni

Tissue specificityi

Detected in varying levels in all tissues examined except the spleen. Especially abundant in heart and lung.

Gene expression databases

ArrayExpressiO09047.
BgeeiO09047.
CleanExiMM_C3AR1.
GenevestigatoriO09047.

Structurei

3D structure databases

ProteinModelPortaliO09047.
SMRiO09047. Positions 24-191, 325-441.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG148047.
HOGENOMiHOG000261616.
HOVERGENiHBG002433.
InParanoidiO09047.
KOiK04009.
OMAiLWVAGLK.
OrthoDBiEOG7PGDQQ.
PhylomeDBiO09047.
TreeFamiTF330976.

Family and domain databases

Gene3Di1.20.1070.10. 2 hits.
InterProiIPR001644. Anaphtx_C3AR1.
IPR002234. Anphylx_rcpt.
IPR000826. Formyl_rcpt-rel.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24225. PTHR24225. 1 hit.
PTHR24225:SF4. PTHR24225:SF4. 1 hit.
PfamiPF00001. 7tm_1. 2 hits.
[Graphical view]
PRINTSiPR01104. ANPHYLATOXNR.
PR01060. C3ANPHYLTXNR.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O09047-1 [UniParc]FASTAAdd to Basket

« Hide

MESFDADTNS TDLHSRPLFQ PQDIASMVIL GLTCLLGLLG NGLVLWVAGV    50
KMKTTVNTVW FLHLTLADFL CCLSLPFSLA HLILQGHWPY GLFLCKLIPS 100
IIILNMFASV FLLTAISLDR CLIVHKPIWC QNHRNVRTAF AICGCVWVVA 150
FVMCVPVFVY RDLFIMDNRS ICRYNFDSSR SYDYWDYVYK LSLPESNSTD 200
NSTAQLTGHM NDRSAPSSVQ ARDYFWTVTT ALQSQPFLTS PEDSFSLDSA 250
NQQPHYGGKP PNVLTAAVPS GFPVEDRKSN TLNADAFLSA HTELFPTASS 300
GHLYPYDFQG DYVDQFTYDN HVPTPLMAIT ITRLVVGFLV PFFIMVICYS 350
LIVFRMRKTN FTKSRNKTFR VAVAVVTVFF ICWTPYHLVG VLLLITDPES 400
SLGEAVMSWD HMSIALASAN SCFNPFLYAL LGKDFRKKAR QSIKGILEAA 450
FSEELTHSTN CTQDKASSKR NNMSTDV 477
Length:477
Mass (Da):53,576
Last modified:July 1, 1997 - v1
Checksum:i9873F464A1520984
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti173 – 1731R → K in AAB71814. 1 Publication
Sequence conflicti195 – 1951E → K in AAB71814. 1 Publication
Sequence conflicti243 – 2431D → N in AAB71814. 1 Publication
Sequence conflicti276 – 2761D → N in AAB71814. 1 Publication
Sequence conflicti380 – 3823FIC → LS in AAB71814. 1 Publication
Sequence conflicti391 – 3911V → I in AAB71814. 1 Publication
Sequence conflicti460 – 4601N → S in AAB71814. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U77461 Genomic DNA. Translation: AAC53204.1.
U77460 mRNA. Translation: AAC53203.1.
U97537 Genomic DNA. Translation: AAB71814.1.
AF053757 Genomic DNA. Translation: AAC40193.1.
BC003728 mRNA. Translation: AAH03728.1.
CCDSiCCDS20504.1.
RefSeqiNP_033909.1. NM_009779.2.
UniGeneiMm.2408.

Genome annotation databases

EnsembliENSMUST00000042081; ENSMUSP00000048092; ENSMUSG00000040552.
GeneIDi12267.
KEGGimmu:12267.
UCSCiuc009dps.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U77461 Genomic DNA. Translation: AAC53204.1 .
U77460 mRNA. Translation: AAC53203.1 .
U97537 Genomic DNA. Translation: AAB71814.1 .
AF053757 Genomic DNA. Translation: AAC40193.1 .
BC003728 mRNA. Translation: AAH03728.1 .
CCDSi CCDS20504.1.
RefSeqi NP_033909.1. NM_009779.2.
UniGenei Mm.2408.

3D structure databases

ProteinModelPortali O09047.
SMRi O09047. Positions 24-191, 325-441.
ModBasei Search...
MobiDBi Search...

Chemistry

GuidetoPHARMACOLOGYi 31.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei O09047.

Proteomic databases

PRIDEi O09047.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000042081 ; ENSMUSP00000048092 ; ENSMUSG00000040552 .
GeneIDi 12267.
KEGGi mmu:12267.
UCSCi uc009dps.1. mouse.

Organism-specific databases

CTDi 719.
MGIi MGI:1097680. C3ar1.

Phylogenomic databases

eggNOGi NOG148047.
HOGENOMi HOG000261616.
HOVERGENi HBG002433.
InParanoidi O09047.
KOi K04009.
OMAi LWVAGLK.
OrthoDBi EOG7PGDQQ.
PhylomeDBi O09047.
TreeFami TF330976.

Miscellaneous databases

NextBioi 280718.
PROi O09047.
SOURCEi Search...

Gene expression databases

ArrayExpressi O09047.
Bgeei O09047.
CleanExi MM_C3AR1.
Genevestigatori O09047.

Family and domain databases

Gene3Di 1.20.1070.10. 2 hits.
InterProi IPR001644. Anaphtx_C3AR1.
IPR002234. Anphylx_rcpt.
IPR000826. Formyl_rcpt-rel.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view ]
PANTHERi PTHR24225. PTHR24225. 1 hit.
PTHR24225:SF4. PTHR24225:SF4. 1 hit.
Pfami PF00001. 7tm_1. 2 hits.
[Graphical view ]
PRINTSi PR01104. ANPHYLATOXNR.
PR01060. C3ANPHYLTXNR.
PR00237. GPCRRHODOPSN.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The mouse anaphylatoxin C3a receptor: molecular cloning, genomic organization, and functional expression."
    Tornetta M.A., Foley J.J., Sarau H.M., Ames R.S.
    J. Immunol. 158:5277-5282(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
    Strain: 129/SvJ and C57BL/6.
    Tissue: Brain.
  2. "Cloning and functional characterization of the mouse C3a anaphylatoxin receptor gene."
    Hsu M.H., Ember J.A., Wang M., Prossnitz E.R., Hugli T.E., Ye R.D.
    Immunogenetics 47:64-72(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129/SvJ.
  3. "Cloning, expression, sequence determination, and chromosome localization of the mouse complement C3a anaphylatoxin receptor gene."
    Hollmann T.J., Haviland D.L., Kildsgaard J., Watts K., Wetsel R.A.
    Mol. Immunol. 35:137-148(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129/SvJ.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary gland.

Entry informationi

Entry nameiC3AR_MOUSE
AccessioniPrimary (citable) accession number: O09047
Secondary accession number(s): O35951
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 1, 1997
Last modified: September 3, 2014
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi