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O09044

- SNP23_MOUSE

UniProt

O09044 - SNP23_MOUSE

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Protein

Synaptosomal-associated protein 23

Gene

Snap23

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Essential component of the high affinity receptor for the general membrane fusion machinery and an important regulator of transport vesicle docking and fusion.By similarity

GO - Biological processi

  1. exocytosis Source: MGI
  2. protein transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Enzyme and pathway databases

ReactomeiREACT_199054. Translocation of GLUT4 to the plasma membrane.
REACT_234979. Clathrin derived vesicle budding.

Names & Taxonomyi

Protein namesi
Recommended name:
Synaptosomal-associated protein 23
Short name:
SNAP-23
Alternative name(s):
Syndet
Vesicle-membrane fusion protein SNAP-23
Gene namesi
Name:Snap23
Synonyms:Sndt
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 2

Organism-specific databases

MGIiMGI:109356. Snap23.

Subcellular locationi

Cell membrane; Peripheral membrane protein. Cell membrane By similarity; Lipid-anchor By similarity. Cell junctionsynapsesynaptosome
Note: Mainly localized to the plasma membrane.

GO - Cellular componenti

  1. cell junction Source: UniProtKB-KW
  2. cytoplasmic vesicle Source: MGI
  3. neuron projection Source: UniProtKB-KW
  4. plasma membrane Source: MGI
  5. synapse Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Synapse, Synaptosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 210210Synaptosomal-associated protein 23PRO_0000213599Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity
Modified residuei20 – 201Phosphoserine1 Publication
Modified residuei23 – 231Phosphoserine1 Publication
Modified residuei34 – 341Phosphoserine1 Publication
Lipidationi79 – 791S-palmitoyl cysteineBy similarity
Lipidationi80 – 801S-palmitoyl cysteineBy similarity
Lipidationi83 – 831S-palmitoyl cysteineBy similarity
Lipidationi85 – 851S-palmitoyl cysteineBy similarity
Lipidationi87 – 871S-palmitoyl cysteineBy similarity
Modified residuei110 – 1101Phosphoserine2 Publications

Keywords - PTMi

Acetylation, Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

MaxQBiO09044.
PaxDbiO09044.
PRIDEiO09044.

PTM databases

PhosphoSiteiO09044.

Expressioni

Tissue specificityi

Expressed in non-neuronal tissues.

Gene expression databases

BgeeiO09044.
CleanExiMM_SNAP23.
ExpressionAtlasiO09044. baseline and differential.
GenevestigatoriO09044.

Interactioni

Subunit structurei

Homotetramer (via coiled-coil domain), also forms heterotetramers with STX4 and VAMP3. Binds simultaneously to SNAPIN and SYN4. Found in a complex with VAMP8 and STX1A (By similarity). Binds tightly to multiple syntaxins and synaptobrevins/VAMPs. Found in a complex with VAMP8 and STX4 in pancreas. Interacts with STX1A and STX12.By similarity2 Publications

Protein-protein interaction databases

BioGridi203367. 7 interactions.
DIPiDIP-41401N.
IntActiO09044. 6 interactions.
MINTiMINT-269238.

Structurei

3D structure databases

ProteinModelPortaliO09044.
SMRiO09044. Positions 23-76, 146-204.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini14 – 7663t-SNARE coiled-coil homology 1PROSITE-ProRule annotationAdd
BLAST
Domaini145 – 20763t-SNARE coiled-coil homology 2PROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili23 – 7654By similarityAdd
BLAST

Sequence similaritiesi

Belongs to the SNAP-25 family.Curated
Contains 2 t-SNARE coiled-coil homology domains.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

eggNOGiNOG259235.
GeneTreeiENSGT00390000012186.
HOGENOMiHOG000231599.
HOVERGENiHBG056971.
InParanoidiO09044.
KOiK08508.
OrthoDBiEOG75F4F5.
PhylomeDBiO09044.

Family and domain databases

InterProiIPR000928. SNAP-25.
IPR000727. T_SNARE_dom.
[Graphical view]
PfamiPF00835. SNAP-25. 1 hit.
PF05739. SNARE. 1 hit.
[Graphical view]
SMARTiSM00397. t_SNARE. 2 hits.
[Graphical view]
PROSITEiPS50192. T_SNARE. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O09044-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDNLSPEEVQ LRAHQVTDES LESTRRILGL AIESQDAGIK TITMLDEQGE
60 70 80 90 100
QLNRIEEGMD QINKDMREAE KTLTELNKCC GLCICPCNRT KNFESGKNYK
110 120 130 140 150
ATWGDGGDNS PSNVVSKQPS RITNGQPQQT TGAASGGYIK RITNDAREDE
160 170 180 190 200
MEENLTQVGS ILGNLKNMAL DMGNEIDAQN QQIQKITEKA DTNKNRIDIA
210
NTRAKKLIDS
Length:210
Mass (Da):23,261
Last modified:July 1, 1997 - v1
Checksum:i6919E127E16BA2C9
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti6 – 61P → S in AAB62932. 1 PublicationCurated
Sequence conflicti204 – 2041A → P in AAB62932. 1 PublicationCurated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB000822 mRNA. Translation: BAA20345.1.
U73143 mRNA. Translation: AAB53597.1.
AF007169 mRNA. Translation: AAB62932.1.
AF213257
, AF213251, AF213252, AF213253, AF213254, AF213255, AF213256 Genomic DNA. Translation: AAF23503.1.
AK019162 mRNA. Translation: BAB31577.1.
BC070456 mRNA. Translation: AAH70456.1.
CCDSiCCDS16622.1.
PIRiJC5512.
RefSeqiNP_001171263.1. NM_001177792.1.
NP_001171264.1. NM_001177793.1.
NP_033248.1. NM_009222.3.
XP_006499120.1. XM_006499057.1.
UniGeneiMm.245715.

Genome annotation databases

EnsembliENSMUST00000028743; ENSMUSP00000028743; ENSMUSG00000027287.
ENSMUST00000110711; ENSMUSP00000106339; ENSMUSG00000027287.
GeneIDi20619.
KEGGimmu:20619.
UCSCiuc008lwg.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB000822 mRNA. Translation: BAA20345.1 .
U73143 mRNA. Translation: AAB53597.1 .
AF007169 mRNA. Translation: AAB62932.1 .
AF213257
, AF213251 , AF213252 , AF213253 , AF213254 , AF213255 , AF213256 Genomic DNA. Translation: AAF23503.1 .
AK019162 mRNA. Translation: BAB31577.1 .
BC070456 mRNA. Translation: AAH70456.1 .
CCDSi CCDS16622.1.
PIRi JC5512.
RefSeqi NP_001171263.1. NM_001177792.1.
NP_001171264.1. NM_001177793.1.
NP_033248.1. NM_009222.3.
XP_006499120.1. XM_006499057.1.
UniGenei Mm.245715.

3D structure databases

ProteinModelPortali O09044.
SMRi O09044. Positions 23-76, 146-204.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 203367. 7 interactions.
DIPi DIP-41401N.
IntActi O09044. 6 interactions.
MINTi MINT-269238.

PTM databases

PhosphoSitei O09044.

Proteomic databases

MaxQBi O09044.
PaxDbi O09044.
PRIDEi O09044.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000028743 ; ENSMUSP00000028743 ; ENSMUSG00000027287 .
ENSMUST00000110711 ; ENSMUSP00000106339 ; ENSMUSG00000027287 .
GeneIDi 20619.
KEGGi mmu:20619.
UCSCi uc008lwg.1. mouse.

Organism-specific databases

CTDi 8773.
MGIi MGI:109356. Snap23.

Phylogenomic databases

eggNOGi NOG259235.
GeneTreei ENSGT00390000012186.
HOGENOMi HOG000231599.
HOVERGENi HBG056971.
InParanoidi O09044.
KOi K08508.
OrthoDBi EOG75F4F5.
PhylomeDBi O09044.

Enzyme and pathway databases

Reactomei REACT_199054. Translocation of GLUT4 to the plasma membrane.
REACT_234979. Clathrin derived vesicle budding.

Miscellaneous databases

NextBioi 299005.
PROi O09044.
SOURCEi Search...

Gene expression databases

Bgeei O09044.
CleanExi MM_SNAP23.
ExpressionAtlasi O09044. baseline and differential.
Genevestigatori O09044.

Family and domain databases

InterProi IPR000928. SNAP-25.
IPR000727. T_SNARE_dom.
[Graphical view ]
Pfami PF00835. SNAP-25. 1 hit.
PF05739. SNARE. 1 hit.
[Graphical view ]
SMARTi SM00397. t_SNARE. 2 hits.
[Graphical view ]
PROSITEi PS50192. T_SNARE. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Adipose tissue.
  2. "Syndet is a novel SNAP-25 related protein expressed in many tissues."
    Wang G., Witkin J.W., Hao G., Bankaitis V.A., Scherer P.E., Baldini G.
    J. Cell Sci. 110:505-513(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "SNARE expression in mouse plasma cells."
    Olken S.K., Doerre S., Corley R.B.
    Submitted (JUN-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  4. "Structure and chromosomal localization of the mouse SNAP-23 gene."
    Vaidyanathan V.V., Roche P.A.
    Gene 247:181-189(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129/SvJ.
  5. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Embryo.
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Eye.
  7. "Syntaxin 12, a member of the syntaxin family localized to the endosome."
    Tang B.L., Tan A.E., Lim L.K., Lee S.S., Low D.Y., Hong W.
    J. Biol. Chem. 273:6944-6950(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH STX1A AND STX12.
  8. "A role of VAMP8/endobrevin in regulated exocytosis of pancreatic acinar cells."
    Wang C.-C., Ng C.P., Lu L., Atlashkin V., Zhang W., Seet L.-F., Hong W.
    Dev. Cell 7:359-371(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN A COMPLEX WITH VAMP8 AND STX4.
  9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  10. "Specific phosphopeptide enrichment with immobilized titanium ion affinity chromatography adsorbent for phosphoproteome analysis."
    Zhou H., Ye M., Dong J., Han G., Jiang X., Wu R., Zou H.
    J. Proteome Res. 7:3957-3967(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-110, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  11. "The phagosomal proteome in interferon-gamma-activated macrophages."
    Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
    Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-20; SER-23; SER-34 AND SER-110, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiSNP23_MOUSE
AccessioniPrimary (citable) accession number: O09044
Secondary accession number(s): O35620
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: July 1, 1997
Last modified: November 26, 2014
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3