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Protein

Synaptosomal-associated protein 23

Gene

Snap23

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Essential component of the high affinity receptor for the general membrane fusion machinery and an important regulator of transport vesicle docking and fusion.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processProtein transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-1236974 ER-Phagosome pathway
R-MMU-421837 Clathrin derived vesicle budding
R-MMU-6798695 Neutrophil degranulation

Names & Taxonomyi

Protein namesi
Recommended name:
Synaptosomal-associated protein 23
Short name:
SNAP-23
Alternative name(s):
Syndet
Vesicle-membrane fusion protein SNAP-23
Gene namesi
Name:Snap23
Synonyms:Sndt
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:109356 Snap23

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Synapse, Synaptosome

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi119P → A: Inhibits interaction with ZDHHC13 and ZDHHC17. 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002135991 – 210Synaptosomal-associated protein 23Add BLAST210

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei5PhosphoserineBy similarity1
Modified residuei20PhosphoserineCombined sources1
Modified residuei23PhosphoserineCombined sources1
Modified residuei34PhosphoserineCombined sources1
Lipidationi79S-palmitoyl cysteineBy similarity1
Lipidationi80S-palmitoyl cysteineBy similarity1
Lipidationi83S-palmitoyl cysteineBy similarity1
Lipidationi85S-palmitoyl cysteineBy similarity1
Lipidationi87S-palmitoyl cysteineBy similarity1
Modified residuei110PhosphoserineCombined sources1
Modified residuei160PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

EPDiO09044
MaxQBiO09044
PaxDbiO09044
PRIDEiO09044

PTM databases

iPTMnetiO09044
PhosphoSitePlusiO09044
SwissPalmiO09044

Expressioni

Tissue specificityi

Expressed in non-neuronal tissues.

Gene expression databases

BgeeiENSMUSG00000027287
CleanExiMM_SNAP23
ExpressionAtlasiO09044 baseline and differential
GenevisibleiO09044 MM

Interactioni

Subunit structurei

Homotetramer (via coiled-coil domain), also forms heterotetramers with STX4 and VAMP3 (By similarity). Found in a complex with VAMP8 and STX1A (By similarity). Found in a complex with VAMP8 and STX4 in pancreas (PubMed:15363411). Interacts simultaneously with SNAPIN and SYN4 (By similarity). Interacts with STX1A (PubMed:9507000). Interacts with STX12 (PubMed:9507000). Interacts tightly to multiple syntaxins and synaptobrevins/VAMPs (By similarity). Interacts with ZDHHC13 (via ANK repeats) (PubMed:26198635). Interacts with ZDHHC17 (via ANK repeats) (PubMed:26198635).By similarity3 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

Protein-protein interaction databases

BioGridi203367, 11 interactors
CORUMiO09044
DIPiDIP-41401N
IntActiO09044, 10 interactors
MINTiO09044
STRINGi10090.ENSMUSP00000112138

Structurei

3D structure databases

ProteinModelPortaliO09044
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini14 – 76t-SNARE coiled-coil homology 1PROSITE-ProRule annotationAdd BLAST63
Domaini145 – 207t-SNARE coiled-coil homology 2PROSITE-ProRule annotationAdd BLAST63

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili23 – 76By similarityAdd BLAST54

Sequence similaritiesi

Belongs to the SNAP-25 family.Curated

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

eggNOGiKOG3065 Eukaryota
ENOG410Y3Y0 LUCA
GeneTreeiENSGT00390000012186
HOGENOMiHOG000231599
HOVERGENiHBG056971
InParanoidiO09044
KOiK08508
PhylomeDBiO09044

Family and domain databases

InterProiView protein in InterPro
IPR000928 SNAP-25
IPR000727 T_SNARE_dom
PfamiView protein in Pfam
PF00835 SNAP-25, 1 hit
SMARTiView protein in SMART
SM00397 t_SNARE, 2 hits
PROSITEiView protein in PROSITE
PS50192 T_SNARE, 2 hits

Sequencei

Sequence statusi: Complete.

O09044-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDNLSPEEVQ LRAHQVTDES LESTRRILGL AIESQDAGIK TITMLDEQGE
60 70 80 90 100
QLNRIEEGMD QINKDMREAE KTLTELNKCC GLCICPCNRT KNFESGKNYK
110 120 130 140 150
ATWGDGGDNS PSNVVSKQPS RITNGQPQQT TGAASGGYIK RITNDAREDE
160 170 180 190 200
MEENLTQVGS ILGNLKNMAL DMGNEIDAQN QQIQKITEKA DTNKNRIDIA
210
NTRAKKLIDS
Length:210
Mass (Da):23,261
Last modified:July 1, 1997 - v1
Checksum:i6919E127E16BA2C9
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti6P → S in AAB62932 (Ref. 3) Curated1
Sequence conflicti204A → P in AAB62932 (Ref. 3) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB000822 mRNA Translation: BAA20345.1
U73143 mRNA Translation: AAB53597.1
AF007169 mRNA Translation: AAB62932.1
AF213257
, AF213251, AF213252, AF213253, AF213254, AF213255, AF213256 Genomic DNA Translation: AAF23503.1
AK019162 mRNA Translation: BAB31577.1
BC070456 mRNA Translation: AAH70456.1
CCDSiCCDS16622.1
PIRiJC5512
RefSeqiNP_001171263.1, NM_001177792.1
NP_001171264.1, NM_001177793.1
NP_033248.1, NM_009222.3
XP_006499120.1, XM_006499057.3
UniGeneiMm.245715

Genome annotation databases

EnsembliENSMUST00000028743; ENSMUSP00000028743; ENSMUSG00000027287
ENSMUST00000110711; ENSMUSP00000106339; ENSMUSG00000027287
GeneIDi20619
KEGGimmu:20619
UCSCiuc008lwg.1 mouse

Similar proteinsi

Entry informationi

Entry nameiSNP23_MOUSE
AccessioniPrimary (citable) accession number: O09044
Secondary accession number(s): O35620
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: July 1, 1997
Last modified: April 25, 2018
This is version 148 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health