O09039 (SH2B3_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
SH2B adapter protein 3

Alternative name(s):
Lymphocyte adapter protein
Lymphocyte-specific adapter protein Lnk
Signal transduction protein Lnk

Gene names

Name:	Sh2b3
Synonyms:	Lnk

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	548 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Links T-cell receptor activation signal to phospholipase C-gamma-1, GRB2 and phosphatidylinositol 3-kinase By similarity.
Post-translational modification	Tyrosine phosphorylated By similarity.
Sequence similarities	Belongs to the SH2B adapter family. Contains 1 PH domain. Contains 1 SH2 domain.

Ontologies

Keywords
Domain	SH2 domain
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell differentiation Inferred from mutant phenotype PubMed 14612394. Source: MGI embryonic hemopoiesis Inferred from direct assay PubMed 14612394. Source: MGI intracellular signal transduction Inferred from direct assay PubMed 11805142. Source: MGI
Molecular_function	phosphate ion binding Inferred from electronic annotation. Source: Compara phospholipid binding Inferred from electronic annotation. Source: InterPro signal transducer activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 548	548	SH2B adapter protein 3		PRO_0000084455
Regions
	Domain	168 – 279	112	PH
	Domain	336 – 434	99	SH2
Amino acid modifications
	Modified residue	129	1	Phosphoserine By similarity

Sequences

	Sequence		Length	Mass (Da)
	O09039 [UniParc]. Last modified May 1, 2000. Version 2. Checksum: D21DCE46185962B8	FASTA	548	60,487
	10 20 30 40 50 60 MNEPTVQPSR TSSAPASPAS PRGWSDFCEQ HAAAAARELA RQYWLFARAH PQPPRADLVS 70 80 90 100 110 120 LQFAELFQRH FCREVRESLA GPPGHDYRAT APPRPALPKA RSSEDLGPRP ACALQHLRRG 130 140 150 160 170 180 LRQLFRRRSA GELPGATSDT NDIDTTAASR PGPARKLLPW GLREPPTEAL KEVVLRYSLA 190 200 210 220 230 240 DEAAMDSGAR WQRGRLVLRS PGPGHSHFLQ LFDPPKSSKP KLQEACSSIR EVRPCTRLEM 250 260 270 280 290 300 PDNLYTFVLK VQDQTDIIFE VGDEQQLNSW LAELRASTGL GLEHPDTELP LSLAAEPGPA 310 320 330 340 350 360 RSPRGSTDSL DQGASPGVLL DPACQKTDHF LSCYPWFHGP ISRVRAAQLV QLQGPDAHGV 370 380 390 400 410 420 FLVRQSESRR GEYVLTFNLQ GRAKHLRLVL TERGQCRVQH LHFPSVVDML RHFQRSPIPL 430 440 450 460 470 480 ECGAACDVRL SGYVVVLSQA PGSSNTVLFP FSLPHWDSEL GHPHLSSVGC PPSHGAEALP 490 500 510 520 530 540 GQVTPPEQIF HLVPSPEELA NSLRQLELES VSSARDSDYD MDSSSRGHLR AIDNQYTPLS QLCREADV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Control of B cell production by the adaptor protein lnk. Definition Of a conserved family of signal-modulating proteins." Takaki S., Sauer K., Iritani B.M., Chien S., Ebihara Y., Tsuji K., Takatsu K., Perlmutter R.M. Immunity 13:599-609(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: 129/Sv.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: FVB/N. Tissue: Mammary gland.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U89992 mRNA. Translation: AAB58580.2. U89993 Genomic DNA. Translation: AAB58581.1. BC006759 mRNA. Translation: AAH06759.1.
IPI	IPI00113783.
RefSeq	NP_032533.1. NM_008507.3.
UniGene	Mm.65493.
3D structure databases
ProteinModelPortal	O09039.
SMR	O09039. Positions 171-281, 331-413.
ModBase	Search...
Protein-protein interaction databases
STRING	10090.ENSMUSP00000113926.
PTM databases
PhosphoSite	O09039.
Proteomic databases
PRIDE	O09039.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000040308; ENSMUSP00000041611; ENSMUSG00000042594. ENSMUST00000086310; ENSMUSP00000083490; ENSMUSG00000042594. ENSMUST00000122426; ENSMUSP00000113926; ENSMUSG00000042594.
GeneID	16923.
KEGG	mmu:16923.
UCSC	uc008zkg.1. mouse.
Organism-specific databases
CTD	10019.
MGI	MGI:893598. Sh2b3.
Phylogenomic databases
eggNOG	NOG77816.
GeneTree	ENSGT00530000063355.
HOGENOM	HOG000047355.
HOVERGEN	HBG093951.
InParanoid	O09039.
KO	K12459.
OMA	PWSLARE.
OrthoDB	EOG4S1T7G.
Gene expression databases
ArrayExpress	O09039.
Bgee	O09039.
CleanEx	MM_SH2B3.
Genevestigator	O09039.
GermOnline	ENSMUSG00000042594. Mus musculus.
Family and domain databases
Gene3D	2.30.29.30. 1 hit. 3.30.505.10. 1 hit.
InterPro	IPR011993. PH_like_dom. IPR015012. Phe_ZIP. IPR001849. Pleckstrin_homology. IPR000980. SH2. [Graphical view]
Pfam	PF00169. PH. 1 hit. PF08916. Phe_ZIP. 1 hit. PF00017. SH2. 1 hit. [Graphical view]
PRINTS	PR00401. SH2DOMAIN.
SMART	SM00233. PH. 1 hit. SM00252. SH2. 1 hit. [Graphical view]
SUPFAM	SSF109805. Phe_ZIP. 1 hit.
PROSITE	PS50003. PH_DOMAIN. False negative. PS50001. SH2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	SH2B3. mouse.
NextBio	290976.
SOURCE	Search...

Entry information

Entry name

SH2B3_MOUSE

Accession

Primary (citable) accession number: O09039

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 27, 2001
Last sequence update:	May 1, 2000
Last modified:	May 1, 2013
This is version 101 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program