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O09039

- SH2B3_MOUSE

UniProt

O09039 - SH2B3_MOUSE

Protein

SH2B adapter protein 3

Gene

Sh2b3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 113 (01 Oct 2014)
      Sequence version 2 (01 May 2000)
      Previous versions | rss
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    Functioni

    Links T-cell receptor activation signal to phospholipase C-gamma-1, GRB2 and phosphatidylinositol 3-kinase.By similarity

    GO - Molecular functioni

    1. phosphate ion binding Source: Ensembl
    2. protein binding Source: MGI
    3. signal transducer activity Source: InterPro

    GO - Biological processi

    1. cell differentiation Source: MGI
    2. embryonic hemopoiesis Source: MGI
    3. hemopoiesis Source: MGI
    4. intracellular signal transduction Source: MGI

    Enzyme and pathway databases

    ReactomeiREACT_198649. Factors involved in megakaryocyte development and platelet production.
    REACT_227425. Regulation of KIT signaling.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    SH2B adapter protein 3
    Alternative name(s):
    Lymphocyte adapter protein
    Lymphocyte-specific adapter protein Lnk
    Signal transduction protein Lnk
    Gene namesi
    Name:Sh2b3
    Synonyms:Lnk
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 5

    Organism-specific databases

    MGIiMGI:893598. Sh2b3.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 548548SH2B adapter protein 3PRO_0000084455Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei129 – 1291PhosphoserineBy similarity

    Post-translational modificationi

    Tyrosine phosphorylated.By similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PRIDEiO09039.

    PTM databases

    PhosphoSiteiO09039.

    Expressioni

    Gene expression databases

    ArrayExpressiO09039.
    BgeeiO09039.
    CleanExiMM_SH2B3.
    GenevestigatoriO09039.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000113926.

    Structurei

    3D structure databases

    ProteinModelPortaliO09039.
    SMRiO09039. Positions 22-79, 171-281, 331-413.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini168 – 279112PHAdd
    BLAST
    Domaini336 – 43499SH2PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the SH2B adapter family.Curated
    Contains 1 PH domain.Curated
    Contains 1 SH2 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    SH2 domain

    Phylogenomic databases

    eggNOGiNOG77816.
    GeneTreeiENSGT00530000063355.
    HOGENOMiHOG000047355.
    HOVERGENiHBG093951.
    InParanoidiO09039.
    KOiK12459.
    OMAiAREHPQH.
    OrthoDBiEOG70CR6F.
    PhylomeDBiO09039.
    TreeFamiTF323184.

    Family and domain databases

    Gene3Di2.30.29.30. 1 hit.
    3.30.505.10. 1 hit.
    InterProiIPR001849. PH_domain.
    IPR011993. PH_like_dom.
    IPR015012. Phe_ZIP.
    IPR000980. SH2.
    [Graphical view]
    PfamiPF00169. PH. 1 hit.
    PF08916. Phe_ZIP. 1 hit.
    PF00017. SH2. 1 hit.
    [Graphical view]
    PRINTSiPR00401. SH2DOMAIN.
    SMARTiSM00233. PH. 1 hit.
    SM00252. SH2. 1 hit.
    [Graphical view]
    SUPFAMiSSF109805. SSF109805. 1 hit.
    SSF55550. SSF55550. 1 hit.
    PROSITEiPS50001. SH2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O09039-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNEPTVQPSR TSSAPASPAS PRGWSDFCEQ HAAAAARELA RQYWLFARAH    50
    PQPPRADLVS LQFAELFQRH FCREVRESLA GPPGHDYRAT APPRPALPKA 100
    RSSEDLGPRP ACALQHLRRG LRQLFRRRSA GELPGATSDT NDIDTTAASR 150
    PGPARKLLPW GLREPPTEAL KEVVLRYSLA DEAAMDSGAR WQRGRLVLRS 200
    PGPGHSHFLQ LFDPPKSSKP KLQEACSSIR EVRPCTRLEM PDNLYTFVLK 250
    VQDQTDIIFE VGDEQQLNSW LAELRASTGL GLEHPDTELP LSLAAEPGPA 300
    RSPRGSTDSL DQGASPGVLL DPACQKTDHF LSCYPWFHGP ISRVRAAQLV 350
    QLQGPDAHGV FLVRQSESRR GEYVLTFNLQ GRAKHLRLVL TERGQCRVQH 400
    LHFPSVVDML RHFQRSPIPL ECGAACDVRL SGYVVVLSQA PGSSNTVLFP 450
    FSLPHWDSEL GHPHLSSVGC PPSHGAEALP GQVTPPEQIF HLVPSPEELA 500
    NSLRQLELES VSSARDSDYD MDSSSRGHLR AIDNQYTPLS QLCREADV 548
    Length:548
    Mass (Da):60,487
    Last modified:May 1, 2000 - v2
    Checksum:iD21DCE46185962B8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U89992 mRNA. Translation: AAB58580.2.
    U89993 Genomic DNA. Translation: AAB58581.1.
    BC006759 mRNA. Translation: AAH06759.1.
    CCDSiCCDS19641.1.
    RefSeqiNP_032533.1. NM_008507.3.
    XP_006530232.1. XM_006530169.1.
    XP_006530233.1. XM_006530170.1.
    XP_006530234.1. XM_006530171.1.
    XP_006530235.1. XM_006530172.1.
    XP_006530236.1. XM_006530173.1.
    UniGeneiMm.65493.

    Genome annotation databases

    EnsembliENSMUST00000040308; ENSMUSP00000041611; ENSMUSG00000042594.
    ENSMUST00000086310; ENSMUSP00000083490; ENSMUSG00000042594.
    ENSMUST00000122426; ENSMUSP00000113926; ENSMUSG00000042594.
    GeneIDi16923.
    KEGGimmu:16923.
    UCSCiuc008zkg.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U89992 mRNA. Translation: AAB58580.2 .
    U89993 Genomic DNA. Translation: AAB58581.1 .
    BC006759 mRNA. Translation: AAH06759.1 .
    CCDSi CCDS19641.1.
    RefSeqi NP_032533.1. NM_008507.3.
    XP_006530232.1. XM_006530169.1.
    XP_006530233.1. XM_006530170.1.
    XP_006530234.1. XM_006530171.1.
    XP_006530235.1. XM_006530172.1.
    XP_006530236.1. XM_006530173.1.
    UniGenei Mm.65493.

    3D structure databases

    ProteinModelPortali O09039.
    SMRi O09039. Positions 22-79, 171-281, 331-413.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000113926.

    PTM databases

    PhosphoSitei O09039.

    Proteomic databases

    PRIDEi O09039.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000040308 ; ENSMUSP00000041611 ; ENSMUSG00000042594 .
    ENSMUST00000086310 ; ENSMUSP00000083490 ; ENSMUSG00000042594 .
    ENSMUST00000122426 ; ENSMUSP00000113926 ; ENSMUSG00000042594 .
    GeneIDi 16923.
    KEGGi mmu:16923.
    UCSCi uc008zkg.1. mouse.

    Organism-specific databases

    CTDi 10019.
    MGIi MGI:893598. Sh2b3.

    Phylogenomic databases

    eggNOGi NOG77816.
    GeneTreei ENSGT00530000063355.
    HOGENOMi HOG000047355.
    HOVERGENi HBG093951.
    InParanoidi O09039.
    KOi K12459.
    OMAi AREHPQH.
    OrthoDBi EOG70CR6F.
    PhylomeDBi O09039.
    TreeFami TF323184.

    Enzyme and pathway databases

    Reactomei REACT_198649. Factors involved in megakaryocyte development and platelet production.
    REACT_227425. Regulation of KIT signaling.

    Miscellaneous databases

    ChiTaRSi SH2B3. mouse.
    NextBioi 290976.
    PROi O09039.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O09039.
    Bgeei O09039.
    CleanExi MM_SH2B3.
    Genevestigatori O09039.

    Family and domain databases

    Gene3Di 2.30.29.30. 1 hit.
    3.30.505.10. 1 hit.
    InterProi IPR001849. PH_domain.
    IPR011993. PH_like_dom.
    IPR015012. Phe_ZIP.
    IPR000980. SH2.
    [Graphical view ]
    Pfami PF00169. PH. 1 hit.
    PF08916. Phe_ZIP. 1 hit.
    PF00017. SH2. 1 hit.
    [Graphical view ]
    PRINTSi PR00401. SH2DOMAIN.
    SMARTi SM00233. PH. 1 hit.
    SM00252. SH2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF109805. SSF109805. 1 hit.
    SSF55550. SSF55550. 1 hit.
    PROSITEi PS50001. SH2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Control of B cell production by the adaptor protein lnk. Definition Of a conserved family of signal-modulating proteins."
      Takaki S., Sauer K., Iritani B.M., Chien S., Ebihara Y., Tsuji K., Takatsu K., Perlmutter R.M.
      Immunity 13:599-609(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: 129/Sv.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Mammary gland.

    Entry informationi

    Entry nameiSH2B3_MOUSE
    AccessioniPrimary (citable) accession number: O09039
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 27, 2001
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 113 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3