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O09039 (SH2B3_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 108. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
SH2B adapter protein 3
Alternative name(s):
Lymphocyte adapter protein
Lymphocyte-specific adapter protein Lnk
Signal transduction protein Lnk
Gene names
Name:Sh2b3
Synonyms:Lnk
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length548 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Links T-cell receptor activation signal to phospholipase C-gamma-1, GRB2 and phosphatidylinositol 3-kinase By similarity.

Post-translational modification

Tyrosine phosphorylated By similarity.

Sequence similarities

Belongs to the SH2B adapter family.

Contains 1 PH domain.

Contains 1 SH2 domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 548548SH2B adapter protein 3
PRO_0000084455

Regions

Domain168 – 279112PH
Domain336 – 43499SH2

Amino acid modifications

Modified residue1291Phosphoserine By similarity

Sequences

Sequence LengthMass (Da)Tools
O09039 [UniParc].

Last modified May 1, 2000. Version 2.
Checksum: D21DCE46185962B8

FASTA54860,487
        10         20         30         40         50         60 
MNEPTVQPSR TSSAPASPAS PRGWSDFCEQ HAAAAARELA RQYWLFARAH PQPPRADLVS 

        70         80         90        100        110        120 
LQFAELFQRH FCREVRESLA GPPGHDYRAT APPRPALPKA RSSEDLGPRP ACALQHLRRG 

       130        140        150        160        170        180 
LRQLFRRRSA GELPGATSDT NDIDTTAASR PGPARKLLPW GLREPPTEAL KEVVLRYSLA 

       190        200        210        220        230        240 
DEAAMDSGAR WQRGRLVLRS PGPGHSHFLQ LFDPPKSSKP KLQEACSSIR EVRPCTRLEM 

       250        260        270        280        290        300 
PDNLYTFVLK VQDQTDIIFE VGDEQQLNSW LAELRASTGL GLEHPDTELP LSLAAEPGPA 

       310        320        330        340        350        360 
RSPRGSTDSL DQGASPGVLL DPACQKTDHF LSCYPWFHGP ISRVRAAQLV QLQGPDAHGV 

       370        380        390        400        410        420 
FLVRQSESRR GEYVLTFNLQ GRAKHLRLVL TERGQCRVQH LHFPSVVDML RHFQRSPIPL 

       430        440        450        460        470        480 
ECGAACDVRL SGYVVVLSQA PGSSNTVLFP FSLPHWDSEL GHPHLSSVGC PPSHGAEALP 

       490        500        510        520        530        540 
GQVTPPEQIF HLVPSPEELA NSLRQLELES VSSARDSDYD MDSSSRGHLR AIDNQYTPLS 


QLCREADV 

« Hide

References

« Hide 'large scale' references
[1]"Control of B cell production by the adaptor protein lnk. Definition Of a conserved family of signal-modulating proteins."
Takaki S., Sauer K., Iritani B.M., Chien S., Ebihara Y., Tsuji K., Takatsu K., Perlmutter R.M.
Immunity 13:599-609(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: 129/Sv.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N.
Tissue: Mammary gland.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U89992 mRNA. Translation: AAB58580.2.
U89993 Genomic DNA. Translation: AAB58581.1.
BC006759 mRNA. Translation: AAH06759.1.
RefSeqNP_032533.1. NM_008507.3.
XP_006530232.1. XM_006530169.1.
XP_006530233.1. XM_006530170.1.
XP_006530234.1. XM_006530171.1.
XP_006530235.1. XM_006530172.1.
XP_006530236.1. XM_006530173.1.
UniGeneMm.65493.

3D structure databases

ProteinModelPortalO09039.
SMRO09039. Positions 22-79, 171-281, 331-413.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000113926.

PTM databases

PhosphoSiteO09039.

Proteomic databases

PRIDEO09039.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000040308; ENSMUSP00000041611; ENSMUSG00000042594.
ENSMUST00000086310; ENSMUSP00000083490; ENSMUSG00000042594.
ENSMUST00000122426; ENSMUSP00000113926; ENSMUSG00000042594.
GeneID16923.
KEGGmmu:16923.
UCSCuc008zkg.1. mouse.

Organism-specific databases

CTD10019.
MGIMGI:893598. Sh2b3.

Phylogenomic databases

eggNOGNOG77816.
GeneTreeENSGT00530000063355.
HOGENOMHOG000047355.
HOVERGENHBG093951.
InParanoidO09039.
KOK12459.
OMAPWSLARE.
OrthoDBEOG70CR6F.
PhylomeDBO09039.
TreeFamTF323184.

Gene expression databases

ArrayExpressO09039.
BgeeO09039.
CleanExMM_SH2B3.
GenevestigatorO09039.

Family and domain databases

Gene3D2.30.29.30. 1 hit.
3.30.505.10. 1 hit.
InterProIPR011993. PH_like_dom.
IPR015012. Phe_ZIP.
IPR001849. Pleckstrin_homology.
IPR000980. SH2.
[Graphical view]
PfamPF00169. PH. 1 hit.
PF08916. Phe_ZIP. 1 hit.
PF00017. SH2. 1 hit.
[Graphical view]
PRINTSPR00401. SH2DOMAIN.
SMARTSM00233. PH. 1 hit.
SM00252. SH2. 1 hit.
[Graphical view]
SUPFAMSSF109805. SSF109805. 1 hit.
SSF55550. SSF55550. 1 hit.
PROSITEPS50001. SH2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSSH2B3. mouse.
NextBio290976.
PROO09039.
SOURCESearch...

Entry information

Entry nameSH2B3_MOUSE
AccessionPrimary (citable) accession number: O09039
Entry history
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: May 1, 2000
Last modified: April 16, 2014
This is version 108 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot