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Protein

SH2B adapter protein 3

Gene

Sh2b3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Links T-cell receptor activation signal to phospholipase C-gamma-1, GRB2 and phosphatidylinositol 3-kinase.By similarity

GO - Molecular functioni

  1. phosphate ion binding Source: Ensembl
  2. signal transducer activity Source: InterPro

GO - Biological processi

  1. cell differentiation Source: MGI
  2. embryonic hemopoiesis Source: MGI
  3. hemopoiesis Source: MGI
  4. intracellular signal transduction Source: MGI
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_280010. Factors involved in megakaryocyte development and platelet production.
REACT_354765. Regulation of KIT signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
SH2B adapter protein 3
Alternative name(s):
Lymphocyte adapter protein
Lymphocyte-specific adapter protein Lnk
Signal transduction protein Lnk
Gene namesi
Name:Sh2b3
Synonyms:Lnk
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:893598. Sh2b3.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 548548SH2B adapter protein 3PRO_0000084455Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei129 – 1291PhosphoserineBy similarity

Post-translational modificationi

Tyrosine phosphorylated.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO09039.
PRIDEiO09039.

PTM databases

PhosphoSiteiO09039.

Expressioni

Gene expression databases

BgeeiO09039.
CleanExiMM_SH2B3.
ExpressionAtlasiO09039. baseline and differential.
GenevestigatoriO09039.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000113926.

Structurei

3D structure databases

ProteinModelPortaliO09039.
SMRiO09039. Positions 22-79, 171-281, 331-413.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini168 – 279112PHAdd
BLAST
Domaini336 – 43499SH2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the SH2B adapter family.Curated
Contains 1 PH domain.Curated
Contains 1 SH2 domain.PROSITE-ProRule annotation

Keywords - Domaini

SH2 domain

Phylogenomic databases

eggNOGiNOG77816.
GeneTreeiENSGT00530000063355.
HOGENOMiHOG000047355.
HOVERGENiHBG093951.
InParanoidiO09039.
KOiK12459.
OMAiAREHPQH.
OrthoDBiEOG70CR6F.
PhylomeDBiO09039.
TreeFamiTF323184.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
3.30.505.10. 1 hit.
InterProiIPR001849. PH_domain.
IPR011993. PH_like_dom.
IPR015012. Phe_ZIP.
IPR000980. SH2.
IPR030523. SH2B.
IPR030522. SH2B3.
[Graphical view]
PANTHERiPTHR10872. PTHR10872. 1 hit.
PTHR10872:SF1. PTHR10872:SF1. 1 hit.
PfamiPF00169. PH. 1 hit.
PF08916. Phe_ZIP. 1 hit.
PF00017. SH2. 1 hit.
[Graphical view]
PRINTSiPR00401. SH2DOMAIN.
SMARTiSM00233. PH. 1 hit.
SM00252. SH2. 1 hit.
[Graphical view]
SUPFAMiSSF109805. SSF109805. 1 hit.
SSF55550. SSF55550. 1 hit.
PROSITEiPS50001. SH2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O09039-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNEPTVQPSR TSSAPASPAS PRGWSDFCEQ HAAAAARELA RQYWLFARAH
60 70 80 90 100
PQPPRADLVS LQFAELFQRH FCREVRESLA GPPGHDYRAT APPRPALPKA
110 120 130 140 150
RSSEDLGPRP ACALQHLRRG LRQLFRRRSA GELPGATSDT NDIDTTAASR
160 170 180 190 200
PGPARKLLPW GLREPPTEAL KEVVLRYSLA DEAAMDSGAR WQRGRLVLRS
210 220 230 240 250
PGPGHSHFLQ LFDPPKSSKP KLQEACSSIR EVRPCTRLEM PDNLYTFVLK
260 270 280 290 300
VQDQTDIIFE VGDEQQLNSW LAELRASTGL GLEHPDTELP LSLAAEPGPA
310 320 330 340 350
RSPRGSTDSL DQGASPGVLL DPACQKTDHF LSCYPWFHGP ISRVRAAQLV
360 370 380 390 400
QLQGPDAHGV FLVRQSESRR GEYVLTFNLQ GRAKHLRLVL TERGQCRVQH
410 420 430 440 450
LHFPSVVDML RHFQRSPIPL ECGAACDVRL SGYVVVLSQA PGSSNTVLFP
460 470 480 490 500
FSLPHWDSEL GHPHLSSVGC PPSHGAEALP GQVTPPEQIF HLVPSPEELA
510 520 530 540
NSLRQLELES VSSARDSDYD MDSSSRGHLR AIDNQYTPLS QLCREADV
Length:548
Mass (Da):60,487
Last modified:May 1, 2000 - v2
Checksum:iD21DCE46185962B8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U89992 mRNA. Translation: AAB58580.2.
U89993 Genomic DNA. Translation: AAB58581.1.
BC006759 mRNA. Translation: AAH06759.1.
CCDSiCCDS19641.1.
RefSeqiNP_032533.1. NM_008507.3.
XP_006530232.1. XM_006530169.2.
XP_006530233.1. XM_006530170.2.
XP_006530234.1. XM_006530171.2.
XP_006530235.1. XM_006530172.1.
XP_006530236.1. XM_006530173.2.
UniGeneiMm.65493.

Genome annotation databases

EnsembliENSMUST00000040308; ENSMUSP00000041611; ENSMUSG00000042594.
ENSMUST00000086310; ENSMUSP00000083490; ENSMUSG00000042594.
ENSMUST00000122426; ENSMUSP00000113926; ENSMUSG00000042594.
GeneIDi16923.
KEGGimmu:16923.
UCSCiuc008zkg.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U89992 mRNA. Translation: AAB58580.2.
U89993 Genomic DNA. Translation: AAB58581.1.
BC006759 mRNA. Translation: AAH06759.1.
CCDSiCCDS19641.1.
RefSeqiNP_032533.1. NM_008507.3.
XP_006530232.1. XM_006530169.2.
XP_006530233.1. XM_006530170.2.
XP_006530234.1. XM_006530171.2.
XP_006530235.1. XM_006530172.1.
XP_006530236.1. XM_006530173.2.
UniGeneiMm.65493.

3D structure databases

ProteinModelPortaliO09039.
SMRiO09039. Positions 22-79, 171-281, 331-413.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000113926.

PTM databases

PhosphoSiteiO09039.

Proteomic databases

MaxQBiO09039.
PRIDEiO09039.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000040308; ENSMUSP00000041611; ENSMUSG00000042594.
ENSMUST00000086310; ENSMUSP00000083490; ENSMUSG00000042594.
ENSMUST00000122426; ENSMUSP00000113926; ENSMUSG00000042594.
GeneIDi16923.
KEGGimmu:16923.
UCSCiuc008zkg.1. mouse.

Organism-specific databases

CTDi10019.
MGIiMGI:893598. Sh2b3.

Phylogenomic databases

eggNOGiNOG77816.
GeneTreeiENSGT00530000063355.
HOGENOMiHOG000047355.
HOVERGENiHBG093951.
InParanoidiO09039.
KOiK12459.
OMAiAREHPQH.
OrthoDBiEOG70CR6F.
PhylomeDBiO09039.
TreeFamiTF323184.

Enzyme and pathway databases

ReactomeiREACT_280010. Factors involved in megakaryocyte development and platelet production.
REACT_354765. Regulation of KIT signaling.

Miscellaneous databases

ChiTaRSiSh2b3. mouse.
NextBioi290976.
PROiO09039.
SOURCEiSearch...

Gene expression databases

BgeeiO09039.
CleanExiMM_SH2B3.
ExpressionAtlasiO09039. baseline and differential.
GenevestigatoriO09039.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
3.30.505.10. 1 hit.
InterProiIPR001849. PH_domain.
IPR011993. PH_like_dom.
IPR015012. Phe_ZIP.
IPR000980. SH2.
IPR030523. SH2B.
IPR030522. SH2B3.
[Graphical view]
PANTHERiPTHR10872. PTHR10872. 1 hit.
PTHR10872:SF1. PTHR10872:SF1. 1 hit.
PfamiPF00169. PH. 1 hit.
PF08916. Phe_ZIP. 1 hit.
PF00017. SH2. 1 hit.
[Graphical view]
PRINTSiPR00401. SH2DOMAIN.
SMARTiSM00233. PH. 1 hit.
SM00252. SH2. 1 hit.
[Graphical view]
SUPFAMiSSF109805. SSF109805. 1 hit.
SSF55550. SSF55550. 1 hit.
PROSITEiPS50001. SH2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Control of B cell production by the adaptor protein lnk. Definition Of a conserved family of signal-modulating proteins."
    Takaki S., Sauer K., Iritani B.M., Chien S., Ebihara Y., Tsuji K., Takatsu K., Perlmutter R.M.
    Immunity 13:599-609(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: 129/Sv.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary gland.

Entry informationi

Entry nameiSH2B3_MOUSE
AccessioniPrimary (citable) accession number: O09039
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: May 1, 2000
Last modified: April 29, 2015
This is version 119 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.