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Protein

SH2B adapter protein 3

Gene

Sh2b3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Links T-cell receptor activation signal to phospholipase C-gamma-1, GRB2 and phosphatidylinositol 3-kinase.By similarity

GO - Molecular functioni

GO - Biological processi

  • cell differentiation Source: MGI
  • embryonic hemopoiesis Source: MGI
  • hemopoiesis Source: MGI
  • intracellular signal transduction Source: MGI

Enzyme and pathway databases

ReactomeiR-MMU-1433559 Regulation of KIT signaling
R-MMU-983231 Factors involved in megakaryocyte development and platelet production

Names & Taxonomyi

Protein namesi
Recommended name:
SH2B adapter protein 3
Alternative name(s):
Lymphocyte adapter protein
Lymphocyte-specific adapter protein Lnk
Signal transduction protein Lnk
Gene namesi
Name:Sh2b3
Synonyms:Lnk
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:893598 Sh2b3

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000844551 – 548SH2B adapter protein 3Add BLAST548

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei13PhosphoserineCombined sources1
Modified residuei102PhosphoserineBy similarity1
Modified residuei129PhosphoserineBy similarity1
Modified residuei302PhosphoserineCombined sources1

Post-translational modificationi

Tyrosine phosphorylated.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO09039
PaxDbiO09039
PRIDEiO09039

PTM databases

iPTMnetiO09039
PhosphoSitePlusiO09039

Expressioni

Gene expression databases

BgeeiENSMUSG00000042594
CleanExiMM_SH2B3
ExpressionAtlasiO09039 baseline and differential
GenevisibleiO09039 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000041611

Structurei

3D structure databases

ProteinModelPortaliO09039
SMRiO09039
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini168 – 279PHAdd BLAST112
Domaini336 – 434SH2PROSITE-ProRule annotationAdd BLAST99

Sequence similaritiesi

Belongs to the SH2B adapter family.Curated

Keywords - Domaini

SH2 domain

Phylogenomic databases

eggNOGiENOG410IFCS Eukaryota
ENOG410YMBM LUCA
GeneTreeiENSGT00530000063355
HOGENOMiHOG000047355
HOVERGENiHBG093951
InParanoidiO09039
KOiK12459
OMAiPHWDSEL
OrthoDBiEOG091G04RI
PhylomeDBiO09039
TreeFamiTF323184

Family and domain databases

CDDicd10412 SH2_SH2B3, 1 hit
Gene3Di2.30.29.30, 1 hit
3.30.505.10, 1 hit
InterProiView protein in InterPro
IPR011993 PH-like_dom_sf
IPR015012 Phe_ZIP
IPR036290 Phe_ZIP_sf
IPR000980 SH2
IPR036860 SH2_dom_sf
IPR030523 SH2B
IPR030522 SH2B3
IPR035059 SH2B3_SH2
PANTHERiPTHR10872 PTHR10872, 1 hit
PTHR10872:SF1 PTHR10872:SF1, 1 hit
PfamiView protein in Pfam
PF08916 Phe_ZIP, 1 hit
PF00017 SH2, 1 hit
PRINTSiPR00401 SH2DOMAIN
SMARTiView protein in SMART
SM00252 SH2, 1 hit
SUPFAMiSSF109805 SSF109805, 1 hit
SSF55550 SSF55550, 1 hit
PROSITEiView protein in PROSITE
PS50001 SH2, 1 hit

Sequencei

Sequence statusi: Complete.

O09039-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNEPTVQPSR TSSAPASPAS PRGWSDFCEQ HAAAAARELA RQYWLFARAH
60 70 80 90 100
PQPPRADLVS LQFAELFQRH FCREVRESLA GPPGHDYRAT APPRPALPKA
110 120 130 140 150
RSSEDLGPRP ACALQHLRRG LRQLFRRRSA GELPGATSDT NDIDTTAASR
160 170 180 190 200
PGPARKLLPW GLREPPTEAL KEVVLRYSLA DEAAMDSGAR WQRGRLVLRS
210 220 230 240 250
PGPGHSHFLQ LFDPPKSSKP KLQEACSSIR EVRPCTRLEM PDNLYTFVLK
260 270 280 290 300
VQDQTDIIFE VGDEQQLNSW LAELRASTGL GLEHPDTELP LSLAAEPGPA
310 320 330 340 350
RSPRGSTDSL DQGASPGVLL DPACQKTDHF LSCYPWFHGP ISRVRAAQLV
360 370 380 390 400
QLQGPDAHGV FLVRQSESRR GEYVLTFNLQ GRAKHLRLVL TERGQCRVQH
410 420 430 440 450
LHFPSVVDML RHFQRSPIPL ECGAACDVRL SGYVVVLSQA PGSSNTVLFP
460 470 480 490 500
FSLPHWDSEL GHPHLSSVGC PPSHGAEALP GQVTPPEQIF HLVPSPEELA
510 520 530 540
NSLRQLELES VSSARDSDYD MDSSSRGHLR AIDNQYTPLS QLCREADV
Length:548
Mass (Da):60,487
Last modified:May 1, 2000 - v2
Checksum:iD21DCE46185962B8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U89992 mRNA Translation: AAB58580.2
U89993 Genomic DNA Translation: AAB58581.1
BC006759 mRNA Translation: AAH06759.1
CCDSiCCDS19641.1
RefSeqiNP_001293055.1, NM_001306126.1
NP_001293056.1, NM_001306127.1
NP_032533.1, NM_008507.4
XP_006530233.1, XM_006530170.3
XP_006530234.1, XM_006530171.3
XP_006530235.1, XM_006530172.1
XP_006530236.1, XM_006530173.3
UniGeneiMm.65493

Genome annotation databases

EnsembliENSMUST00000040308; ENSMUSP00000041611; ENSMUSG00000042594
ENSMUST00000086310; ENSMUSP00000083490; ENSMUSG00000042594
ENSMUST00000122426; ENSMUSP00000113926; ENSMUSG00000042594
GeneIDi16923
KEGGimmu:16923
UCSCiuc008zkg.1 mouse

Similar proteinsi

Entry informationi

Entry nameiSH2B3_MOUSE
AccessioniPrimary (citable) accession number: O09039
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: May 1, 2000
Last modified: June 20, 2018
This is version 140 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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