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Protein

Diazepam-binding inhibitor-like 5

Gene

Dbil5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in the energy metabolism of the mature sperm.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei55 – 551Acyl-CoABy similarity
Binding sitei74 – 741Acyl-CoABy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

Lipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Diazepam-binding inhibitor-like 5
Alternative name(s):
Endozepine-like peptide
Short name:
ELP
Gene namesi
Name:Dbil5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:108039. Dbil5.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 8787Diazepam-binding inhibitor-like 5PRO_0000214024Add
BLAST

Proteomic databases

PaxDbiO09035.
PeptideAtlasiO09035.
PRIDEiO09035.

PTM databases

iPTMnetiO09035.

Expressioni

Tissue specificityi

Exclusively expressed in late spermatids and spermatozoa. Not found in epididymis, spleen, bone marrow, skin, liver, brain, heart, kidney, muscle.

Developmental stagei

Expression is seen first at day 45 of post-natal development (post-meiotic transcription).

Gene expression databases

BgeeiO09035.
CleanExiMM_DBIL5.
ExpressionAtlasiO09035. baseline and differential.
GenevisibleiO09035. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000039763.

Structurei

3D structure databases

ProteinModelPortaliO09035.
SMRiO09035. Positions 2-84.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 8786ACBPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni29 – 335Acyl-CoA bindingBy similarity

Sequence similaritiesi

Belongs to the ACBP family.Curated
Contains 1 ACB (acyl-CoA-binding) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0817. Eukaryota.
COG4281. LUCA.
HOGENOMiHOG000261845.
HOVERGENiHBG000398.
InParanoidiO09035.
OMAiDAMRIYV.
OrthoDBiEOG7SN8G8.
PhylomeDBiO09035.
TreeFamiTF335802.

Family and domain databases

Gene3Di1.20.80.10. 1 hit.
InterProiIPR022408. Acyl-CoA-binding_prot_CS.
IPR000582. Acyl-CoA-binding_protein.
IPR014352. FERM/acyl-CoA-bd_prot_3-hlx.
[Graphical view]
PfamiPF00887. ACBP. 1 hit.
[Graphical view]
PRINTSiPR00689. ACOABINDINGP.
SUPFAMiSSF47027. SSF47027. 1 hit.
PROSITEiPS00880. ACB_1. 1 hit.
PS51228. ACB_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O09035-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQVEFEMAC ASLKQLKGPV SDQEKLLVYS FYKQATQGDC NIPVPPATDV
60 70 80
RAKAKYEAWM VNKGMSKMDA MRIYIAKVEE LKKKEPC
Length:87
Mass (Da):9,865
Last modified:July 1, 1997 - v1
Checksum:iA508364C7A8DE6E1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S83465 mRNA. Translation: AAB50915.1.
AF229807 Genomic DNA. Translation: AAF79124.1.
BC048474 mRNA. Translation: AAH48474.1.
CCDSiCCDS25062.1.
RefSeqiNP_067269.1. NM_021294.2.
UniGeneiMm.347413.

Genome annotation databases

EnsembliENSMUST00000040806; ENSMUSP00000039763; ENSMUSG00000038057.
GeneIDi13168.
KEGGimmu:13168.
UCSCiuc007kfk.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S83465 mRNA. Translation: AAB50915.1.
AF229807 Genomic DNA. Translation: AAF79124.1.
BC048474 mRNA. Translation: AAH48474.1.
CCDSiCCDS25062.1.
RefSeqiNP_067269.1. NM_021294.2.
UniGeneiMm.347413.

3D structure databases

ProteinModelPortaliO09035.
SMRiO09035. Positions 2-84.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000039763.

PTM databases

iPTMnetiO09035.

Proteomic databases

PaxDbiO09035.
PeptideAtlasiO09035.
PRIDEiO09035.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000040806; ENSMUSP00000039763; ENSMUSG00000038057.
GeneIDi13168.
KEGGimmu:13168.
UCSCiuc007kfk.1. mouse.

Organism-specific databases

CTDi13168.
MGIiMGI:108039. Dbil5.

Phylogenomic databases

eggNOGiKOG0817. Eukaryota.
COG4281. LUCA.
HOGENOMiHOG000261845.
HOVERGENiHBG000398.
InParanoidiO09035.
OMAiDAMRIYV.
OrthoDBiEOG7SN8G8.
PhylomeDBiO09035.
TreeFamiTF335802.

Miscellaneous databases

PROiO09035.
SOURCEiSearch...

Gene expression databases

BgeeiO09035.
CleanExiMM_DBIL5.
ExpressionAtlasiO09035. baseline and differential.
GenevisibleiO09035. MM.

Family and domain databases

Gene3Di1.20.80.10. 1 hit.
InterProiIPR022408. Acyl-CoA-binding_prot_CS.
IPR000582. Acyl-CoA-binding_protein.
IPR014352. FERM/acyl-CoA-bd_prot_3-hlx.
[Graphical view]
PfamiPF00887. ACBP. 1 hit.
[Graphical view]
PRINTSiPR00689. ACOABINDINGP.
SUPFAMiSSF47027. SSF47027. 1 hit.
PROSITEiPS00880. ACB_1. 1 hit.
PS51228. ACB_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A novel endozepine-like peptide (ELP) is exclusively expressed in male germ cells."
    Pusch W., Balvers M., Hunt N., Ivell R.
    Mol. Cell. Endocrinol. 122:69-80(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Testis.
  2. "Structure and expression of the mouse gene encoding the endozepine-like peptide from haploid male germ cells."
    Valentin M., Balvers M., Pusch W., Weinbauer G.F., Knudsen J., Ivell R.
    Eur. J. Biochem. 267:5438-5449(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129/Sv.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Testis.

Entry informationi

Entry nameiDBIL5_MOUSE
AccessioniPrimary (citable) accession number: O09035
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: July 1, 1997
Last modified: July 6, 2016
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.