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O09030 (I13R1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 121. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Interleukin-13 receptor subunit alpha-1

Short name=IL-13 receptor subunit alpha-1
Short name=IL-13R subunit alpha-1
Short name=IL-13R-alpha-1
Short name=IL-13RA1
Alternative name(s):
Interleukin-13-binding protein
Novel cytokine receptor 4
Short name=NR4
CD_antigen=CD213a1
Gene names
Name:Il13ra1
Synonyms:Il13r, Il13ra
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length424 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Binds with low affinity to interleukin-13 (IL13). Together with IL4RA can form a functional receptor for IL13. Also serves as an alternate accessory protein to the common cytokine receptor gamma chain for interleukin-4 (IL4) signaling, but cannot replace the function of IL2RG in allowing enhanced interleukin-2 (IL2) binding activity By similarity.

Subunit structure

Interleukin-13 receptor is a complex of IL4R, IL13RA1, and possibly other components. Interacts with TRAF3IP1 By similarity.

Subcellular location

Membrane; Single-pass type I membrane protein.

Tissue specificity

Spleen, liver, thymus, heart, lung, kidney, testis, stomach, brain, skin, and colon; but not skeletal muscle.

Domain

The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.

The box 1 motif is required for JAK interaction and/or activation.

Sequence similarities

Belongs to the type I cytokine receptor family. Type 5 subfamily.

Contains 2 fibronectin type-III domains.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2525 Potential
Chain26 – 424399Interleukin-13 receptor subunit alpha-1
PRO_0000010940

Regions

Topological domain26 – 340315Extracellular Potential
Transmembrane341 – 36424Helical; Potential
Topological domain365 – 42460Cytoplasmic Potential
Domain32 – 12190Fibronectin type-III 1
Domain224 – 336113Fibronectin type-III 2
Motif324 – 3285WSXWS motif
Motif371 – 3799Box 1 motif

Amino acid modifications

Glycosylation351N-linked (GlcNAc...) Potential
Glycosylation591N-linked (GlcNAc...) Potential
Glycosylation1031N-linked (GlcNAc...) Potential
Glycosylation1361N-linked (GlcNAc...) Potential
Glycosylation2621N-linked (GlcNAc...) Potential
Glycosylation3381N-linked (GlcNAc...) Potential
Disulfide bond44 ↔ 93 Potential
Disulfide bond132 ↔ 142 By similarity
Disulfide bond171 ↔ 183 By similarity

Sequences

Sequence LengthMass (Da)Tools
O09030 [UniParc].

Last modified July 1, 1997. Version 1.
Checksum: EB8330A0DC82C9F9

FASTA42448,402
        10         20         30         40         50         60 
MARPALLGEL LVLLLWTATV GQVAAATEVQ PPVTNLSVSV ENLCTIIWTW SPPEGASPNC 

        70         80         90        100        110        120 
TLRYFSHFDD QQDKKIAPET HRKEELPLDE KICLQVGSQC SANESEKPSP LVKKCISPPE 

       130        140        150        160        170        180 
GDPESAVTEL KCIWHNLSYM KCSWLPGRNT SPDTHYTLYY WYSSLEKSRQ CENIYREGQH 

       190        200        210        220        230        240 
IACSFKLTKV EPSFEHQNVQ IMVKDNAGKI RPSCKIVSLT SYVKPDPPHI KHLLLKNGAL 

       250        260        270        280        290        300 
LVQWKNPQNF RSRCLTYEVE VNNTQTDRHN ILEVEEDKCQ NSESDRNMEG TSCFQLPGVL 

       310        320        330        340        350        360 
ADAVYTVRVR VKTNKLCFDD NKLWSDWSEA QSIGKEQNST FYTTMLLTIP VFVAVAVIIL 

       370        380        390        400        410        420 
LFYLKRLKII IFPPIPDPGK IFKEMFGDQN DDTLHWKKYD IYEKQSKEET DSVVLIENLK 


KAAP 

« Hide

References

« Hide 'large scale' references
[1]"Cloning and characterization of a binding subunit of the interleukin 13 receptor that is also a component of the interleukin 4 receptor."
Hilton D.J., Zhang J.-G., Metcalf D., Alexander W.S., Nicola N.A., Willson T.A.
Proc. Natl. Acad. Sci. U.S.A. 93:497-501(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N.
Tissue: Brain and Colon.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
S80963 mRNA. Translation: AAB50695.1.
BC052425 mRNA. Translation: AAH52425.2.
BC059939 mRNA. Translation: AAH59939.1.
CCDSCCDS30057.1.
RefSeqNP_598751.3. NM_133990.4.
UniGeneMm.24208.

3D structure databases

ProteinModelPortalO09030.
SMRO09030. Positions 28-335.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

DIPDIP-1167N.

PTM databases

PhosphoSiteO09030.

Proteomic databases

PRIDEO09030.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000033418; ENSMUSP00000033418; ENSMUSG00000017057.
GeneID16164.
KEGGmmu:16164.
UCSCuc009sxj.1. mouse.

Organism-specific databases

CTD3597.
MGIMGI:105052. Il13ra1.

Phylogenomic databases

eggNOGNOG44457.
GeneTreeENSGT00530000063295.
HOGENOMHOG000230941.
HOVERGENHBG052060.
InParanoidO09030.
KOK05076.
OMANKLCYED.
OrthoDBEOG71P2B1.
PhylomeDBO09030.
TreeFamTF331549.

Gene expression databases

BgeeO09030.
CleanExMM_IL13RA1.
GenevestigatorO09030.

Family and domain databases

Gene3D2.60.40.10. 2 hits.
InterProIPR003961. Fibronectin_type3.
IPR013783. Ig-like_fold.
IPR015321. IL-6_rcpt_alpha-bd.
IPR003532. Short_hematopoietin_rcpt_2_CS.
[Graphical view]
PfamPF09240. IL6Ra-bind. 1 hit.
[Graphical view]
SMARTSM00060. FN3. 1 hit.
[Graphical view]
SUPFAMSSF49265. SSF49265. 2 hits.
PROSITEPS50853. FN3. 2 hits.
PS01356. HEMATOPO_REC_S_F2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio288995.
PROO09030.
SOURCESearch...

Entry information

Entry nameI13R1_MOUSE
AccessionPrimary (citable) accession number: O09030
Secondary accession number(s): Q7TT27
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 1, 1997
Last modified: July 9, 2014
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot