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O09030

- I13R1_MOUSE

UniProt

O09030 - I13R1_MOUSE

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Protein
Interleukin-13 receptor subunit alpha-1
Gene
Il13ra1, Il13r, Il13ra
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Binds with low affinity to interleukin-13 (IL13). Together with IL4RA can form a functional receptor for IL13. Also serves as an alternate accessory protein to the common cytokine receptor gamma chain for interleukin-4 (IL4) signaling, but cannot replace the function of IL2RG in allowing enhanced interleukin-2 (IL2) binding activity By similarity.

GO - Molecular functioni

  1. interleukin-13 receptor activity Source: Ensembl

GO - Biological processi

  1. positive regulation of B cell proliferation Source: Ensembl
  2. positive regulation of immunoglobulin production Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-13 receptor subunit alpha-1
Short name:
IL-13 receptor subunit alpha-1
Short name:
IL-13R subunit alpha-1
Short name:
IL-13R-alpha-1
Short name:
IL-13RA1
Alternative name(s):
Interleukin-13-binding protein
Novel cytokine receptor 4
Short name:
NR4
CD_antigen: CD213a1
Gene namesi
Name:Il13ra1
Synonyms:Il13r, Il13ra
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome X

Organism-specific databases

MGIiMGI:105052. Il13ra1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini26 – 340315Extracellular Reviewed prediction
Add
BLAST
Transmembranei341 – 36424Helical; Reviewed prediction
Add
BLAST
Topological domaini365 – 42460Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525 Reviewed prediction
Add
BLAST
Chaini26 – 424399Interleukin-13 receptor subunit alpha-1
PRO_0000010940Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi35 – 351N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi44 ↔ 93 Reviewed prediction
Glycosylationi59 – 591N-linked (GlcNAc...) Reviewed prediction
Glycosylationi103 – 1031N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi132 ↔ 142 By similarity
Glycosylationi136 – 1361N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi171 ↔ 183 By similarity
Glycosylationi262 – 2621N-linked (GlcNAc...) Reviewed prediction
Glycosylationi338 – 3381N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiO09030.

PTM databases

PhosphoSiteiO09030.

Expressioni

Tissue specificityi

Spleen, liver, thymus, heart, lung, kidney, testis, stomach, brain, skin, and colon; but not skeletal muscle.

Gene expression databases

BgeeiO09030.
CleanExiMM_IL13RA1.
GenevestigatoriO09030.

Interactioni

Subunit structurei

Interleukin-13 receptor is a complex of IL4R, IL13RA1, and possibly other components. Interacts with TRAF3IP1 By similarity.

Protein-protein interaction databases

DIPiDIP-1167N.

Structurei

3D structure databases

ProteinModelPortaliO09030.
SMRiO09030. Positions 28-335.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini32 – 12190Fibronectin type-III 1
Add
BLAST
Domaini224 – 336113Fibronectin type-III 2
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi324 – 3285WSXWS motif
Motifi371 – 3799Box 1 motif

Domaini

The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
The box 1 motif is required for JAK interaction and/or activation.

Sequence similaritiesi

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG44457.
GeneTreeiENSGT00530000063295.
HOGENOMiHOG000230941.
HOVERGENiHBG052060.
InParanoidiO09030.
KOiK05076.
OMAiNKLCYED.
OrthoDBiEOG71P2B1.
PhylomeDBiO09030.
TreeFamiTF331549.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR003961. Fibronectin_type3.
IPR013783. Ig-like_fold.
IPR015321. IL-6_rcpt_alpha-bd.
IPR003532. Short_hematopoietin_rcpt_2_CS.
[Graphical view]
PfamiPF09240. IL6Ra-bind. 1 hit.
[Graphical view]
SMARTiSM00060. FN3. 1 hit.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 2 hits.
PROSITEiPS50853. FN3. 2 hits.
PS01356. HEMATOPO_REC_S_F2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O09030-1 [UniParc]FASTAAdd to Basket

« Hide

MARPALLGEL LVLLLWTATV GQVAAATEVQ PPVTNLSVSV ENLCTIIWTW    50
SPPEGASPNC TLRYFSHFDD QQDKKIAPET HRKEELPLDE KICLQVGSQC 100
SANESEKPSP LVKKCISPPE GDPESAVTEL KCIWHNLSYM KCSWLPGRNT 150
SPDTHYTLYY WYSSLEKSRQ CENIYREGQH IACSFKLTKV EPSFEHQNVQ 200
IMVKDNAGKI RPSCKIVSLT SYVKPDPPHI KHLLLKNGAL LVQWKNPQNF 250
RSRCLTYEVE VNNTQTDRHN ILEVEEDKCQ NSESDRNMEG TSCFQLPGVL 300
ADAVYTVRVR VKTNKLCFDD NKLWSDWSEA QSIGKEQNST FYTTMLLTIP 350
VFVAVAVIIL LFYLKRLKII IFPPIPDPGK IFKEMFGDQN DDTLHWKKYD 400
IYEKQSKEET DSVVLIENLK KAAP 424
Length:424
Mass (Da):48,402
Last modified:July 1, 1997 - v1
Checksum:iEB8330A0DC82C9F9
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S80963 mRNA. Translation: AAB50695.1.
BC052425 mRNA. Translation: AAH52425.2.
BC059939 mRNA. Translation: AAH59939.1.
CCDSiCCDS30057.1.
RefSeqiNP_598751.3. NM_133990.4.
UniGeneiMm.24208.

Genome annotation databases

EnsembliENSMUST00000033418; ENSMUSP00000033418; ENSMUSG00000017057.
GeneIDi16164.
KEGGimmu:16164.
UCSCiuc009sxj.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S80963 mRNA. Translation: AAB50695.1 .
BC052425 mRNA. Translation: AAH52425.2 .
BC059939 mRNA. Translation: AAH59939.1 .
CCDSi CCDS30057.1.
RefSeqi NP_598751.3. NM_133990.4.
UniGenei Mm.24208.

3D structure databases

ProteinModelPortali O09030.
SMRi O09030. Positions 28-335.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-1167N.

PTM databases

PhosphoSitei O09030.

Proteomic databases

PRIDEi O09030.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000033418 ; ENSMUSP00000033418 ; ENSMUSG00000017057 .
GeneIDi 16164.
KEGGi mmu:16164.
UCSCi uc009sxj.1. mouse.

Organism-specific databases

CTDi 3597.
MGIi MGI:105052. Il13ra1.

Phylogenomic databases

eggNOGi NOG44457.
GeneTreei ENSGT00530000063295.
HOGENOMi HOG000230941.
HOVERGENi HBG052060.
InParanoidi O09030.
KOi K05076.
OMAi NKLCYED.
OrthoDBi EOG71P2B1.
PhylomeDBi O09030.
TreeFami TF331549.

Miscellaneous databases

NextBioi 288995.
PROi O09030.
SOURCEi Search...

Gene expression databases

Bgeei O09030.
CleanExi MM_IL13RA1.
Genevestigatori O09030.

Family and domain databases

Gene3Di 2.60.40.10. 2 hits.
InterProi IPR003961. Fibronectin_type3.
IPR013783. Ig-like_fold.
IPR015321. IL-6_rcpt_alpha-bd.
IPR003532. Short_hematopoietin_rcpt_2_CS.
[Graphical view ]
Pfami PF09240. IL6Ra-bind. 1 hit.
[Graphical view ]
SMARTi SM00060. FN3. 1 hit.
[Graphical view ]
SUPFAMi SSF49265. SSF49265. 2 hits.
PROSITEi PS50853. FN3. 2 hits.
PS01356. HEMATOPO_REC_S_F2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of a binding subunit of the interleukin 13 receptor that is also a component of the interleukin 4 receptor."
    Hilton D.J., Zhang J.-G., Metcalf D., Alexander W.S., Nicola N.A., Willson T.A.
    Proc. Natl. Acad. Sci. U.S.A. 93:497-501(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Brain and Colon.

Entry informationi

Entry nameiI13R1_MOUSE
AccessioniPrimary (citable) accession number: O09030
Secondary accession number(s): Q7TT27
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 1, 1997
Last modified: July 9, 2014
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi