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O09030

- I13R1_MOUSE

UniProt

O09030 - I13R1_MOUSE

Protein

Interleukin-13 receptor subunit alpha-1

Gene

Il13ra1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 122 (01 Oct 2014)
      Sequence version 1 (01 Jul 1997)
      Previous versions | rss
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    Functioni

    Binds with low affinity to interleukin-13 (IL13). Together with IL4RA can form a functional receptor for IL13. Also serves as an alternate accessory protein to the common cytokine receptor gamma chain for interleukin-4 (IL4) signaling, but cannot replace the function of IL2RG in allowing enhanced interleukin-2 (IL2) binding activity By similarity.By similarity

    GO - Molecular functioni

    1. interleukin-13 receptor activity Source: Ensembl

    GO - Biological processi

    1. positive regulation of B cell proliferation Source: Ensembl
    2. positive regulation of immunoglobulin production Source: Ensembl

    Keywords - Molecular functioni

    Receptor

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Interleukin-13 receptor subunit alpha-1
    Short name:
    IL-13 receptor subunit alpha-1
    Short name:
    IL-13R subunit alpha-1
    Short name:
    IL-13R-alpha-1
    Short name:
    IL-13RA1
    Alternative name(s):
    Interleukin-13-binding protein
    Novel cytokine receptor 4
    Short name:
    NR4
    CD_antigen: CD213a1
    Gene namesi
    Name:Il13ra1
    Synonyms:Il13r, Il13ra
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome X

    Organism-specific databases

    MGIiMGI:105052. Il13ra1.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2525Sequence AnalysisAdd
    BLAST
    Chaini26 – 424399Interleukin-13 receptor subunit alpha-1PRO_0000010940Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi35 – 351N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi44 ↔ 93Sequence Analysis
    Glycosylationi59 – 591N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi103 – 1031N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi132 ↔ 142By similarity
    Glycosylationi136 – 1361N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi171 ↔ 183By similarity
    Glycosylationi262 – 2621N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi338 – 3381N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiO09030.

    PTM databases

    PhosphoSiteiO09030.

    Expressioni

    Tissue specificityi

    Spleen, liver, thymus, heart, lung, kidney, testis, stomach, brain, skin, and colon; but not skeletal muscle.

    Gene expression databases

    BgeeiO09030.
    CleanExiMM_IL13RA1.
    GenevestigatoriO09030.

    Interactioni

    Subunit structurei

    Interleukin-13 receptor is a complex of IL4R, IL13RA1, and possibly other components. Interacts with TRAF3IP1 By similarity.By similarity

    Protein-protein interaction databases

    DIPiDIP-1167N.

    Structurei

    3D structure databases

    ProteinModelPortaliO09030.
    SMRiO09030. Positions 28-335.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini26 – 340315ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini365 – 42460CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei341 – 36424HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini32 – 12190Fibronectin type-III 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini224 – 336113Fibronectin type-III 2PROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi324 – 3285WSXWS motif
    Motifi371 – 3799Box 1 motif

    Domaini

    The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
    The box 1 motif is required for JAK interaction and/or activation.

    Sequence similaritiesi

    Contains 2 fibronectin type-III domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG44457.
    GeneTreeiENSGT00530000063295.
    HOGENOMiHOG000230941.
    HOVERGENiHBG052060.
    InParanoidiO09030.
    KOiK05076.
    OMAiNKLCYED.
    OrthoDBiEOG71P2B1.
    PhylomeDBiO09030.
    TreeFamiTF331549.

    Family and domain databases

    Gene3Di2.60.40.10. 2 hits.
    InterProiIPR003961. Fibronectin_type3.
    IPR013783. Ig-like_fold.
    IPR015321. IL-6_rcpt_alpha-bd.
    IPR003532. Short_hematopoietin_rcpt_2_CS.
    [Graphical view]
    PfamiPF09240. IL6Ra-bind. 1 hit.
    [Graphical view]
    SMARTiSM00060. FN3. 1 hit.
    [Graphical view]
    SUPFAMiSSF49265. SSF49265. 2 hits.
    PROSITEiPS50853. FN3. 2 hits.
    PS01356. HEMATOPO_REC_S_F2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O09030-1 [UniParc]FASTAAdd to Basket

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    MARPALLGEL LVLLLWTATV GQVAAATEVQ PPVTNLSVSV ENLCTIIWTW    50
    SPPEGASPNC TLRYFSHFDD QQDKKIAPET HRKEELPLDE KICLQVGSQC 100
    SANESEKPSP LVKKCISPPE GDPESAVTEL KCIWHNLSYM KCSWLPGRNT 150
    SPDTHYTLYY WYSSLEKSRQ CENIYREGQH IACSFKLTKV EPSFEHQNVQ 200
    IMVKDNAGKI RPSCKIVSLT SYVKPDPPHI KHLLLKNGAL LVQWKNPQNF 250
    RSRCLTYEVE VNNTQTDRHN ILEVEEDKCQ NSESDRNMEG TSCFQLPGVL 300
    ADAVYTVRVR VKTNKLCFDD NKLWSDWSEA QSIGKEQNST FYTTMLLTIP 350
    VFVAVAVIIL LFYLKRLKII IFPPIPDPGK IFKEMFGDQN DDTLHWKKYD 400
    IYEKQSKEET DSVVLIENLK KAAP 424
    Length:424
    Mass (Da):48,402
    Last modified:July 1, 1997 - v1
    Checksum:iEB8330A0DC82C9F9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S80963 mRNA. Translation: AAB50695.1.
    BC052425 mRNA. Translation: AAH52425.2.
    BC059939 mRNA. Translation: AAH59939.1.
    CCDSiCCDS30057.1.
    RefSeqiNP_598751.3. NM_133990.4.
    UniGeneiMm.24208.

    Genome annotation databases

    EnsembliENSMUST00000033418; ENSMUSP00000033418; ENSMUSG00000017057.
    GeneIDi16164.
    KEGGimmu:16164.
    UCSCiuc009sxj.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S80963 mRNA. Translation: AAB50695.1 .
    BC052425 mRNA. Translation: AAH52425.2 .
    BC059939 mRNA. Translation: AAH59939.1 .
    CCDSi CCDS30057.1.
    RefSeqi NP_598751.3. NM_133990.4.
    UniGenei Mm.24208.

    3D structure databases

    ProteinModelPortali O09030.
    SMRi O09030. Positions 28-335.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-1167N.

    PTM databases

    PhosphoSitei O09030.

    Proteomic databases

    PRIDEi O09030.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000033418 ; ENSMUSP00000033418 ; ENSMUSG00000017057 .
    GeneIDi 16164.
    KEGGi mmu:16164.
    UCSCi uc009sxj.1. mouse.

    Organism-specific databases

    CTDi 3597.
    MGIi MGI:105052. Il13ra1.

    Phylogenomic databases

    eggNOGi NOG44457.
    GeneTreei ENSGT00530000063295.
    HOGENOMi HOG000230941.
    HOVERGENi HBG052060.
    InParanoidi O09030.
    KOi K05076.
    OMAi NKLCYED.
    OrthoDBi EOG71P2B1.
    PhylomeDBi O09030.
    TreeFami TF331549.

    Miscellaneous databases

    NextBioi 288995.
    PROi O09030.
    SOURCEi Search...

    Gene expression databases

    Bgeei O09030.
    CleanExi MM_IL13RA1.
    Genevestigatori O09030.

    Family and domain databases

    Gene3Di 2.60.40.10. 2 hits.
    InterProi IPR003961. Fibronectin_type3.
    IPR013783. Ig-like_fold.
    IPR015321. IL-6_rcpt_alpha-bd.
    IPR003532. Short_hematopoietin_rcpt_2_CS.
    [Graphical view ]
    Pfami PF09240. IL6Ra-bind. 1 hit.
    [Graphical view ]
    SMARTi SM00060. FN3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49265. SSF49265. 2 hits.
    PROSITEi PS50853. FN3. 2 hits.
    PS01356. HEMATOPO_REC_S_F2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and characterization of a binding subunit of the interleukin 13 receptor that is also a component of the interleukin 4 receptor."
      Hilton D.J., Zhang J.-G., Metcalf D., Alexander W.S., Nicola N.A., Willson T.A.
      Proc. Natl. Acad. Sci. U.S.A. 93:497-501(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Brain and Colon.

    Entry informationi

    Entry nameiI13R1_MOUSE
    AccessioniPrimary (citable) accession number: O09030
    Secondary accession number(s): Q7TT27
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: July 1, 1997
    Last modified: October 1, 2014
    This is version 122 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3