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Protein

Gamma-aminobutyric acid receptor subunit pi

Gene

Gabrp

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. In the uterus, the function of the receptor appears to be related to tissue contractility. The binding of this pI subunit with other GABA(A) receptor subunits alters the sensitivity of recombinant receptors to modulatory agents such as pregnanolone.

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Chloride channel, Ion channel

Keywords - Biological processi

Ion transport, Transport

Keywords - Ligandi

Chloride

Names & Taxonomyi

Protein namesi
Recommended name:
Gamma-aminobutyric acid receptor subunit pi
Alternative name(s):
GABA(A) receptor subunit pi
Gene namesi
Name:Gabrp
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi620532. Gabrp.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini17 – 242ExtracellularSequence analysisAdd BLAST226
Transmembranei243 – 266HelicalSequence analysisAdd BLAST24
Transmembranei270 – 292HelicalSequence analysisAdd BLAST23
Transmembranei305 – 327HelicalSequence analysisAdd BLAST23
Topological domaini328 – 416CytoplasmicSequence analysisAdd BLAST89
Transmembranei417 – 438HelicalSequence analysisAdd BLAST22

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL1907607.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 16Sequence analysisAdd BLAST16
ChainiPRO_000000049417 – 440Gamma-aminobutyric acid receptor subunit piAdd BLAST424

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi43N-linked (GlcNAc...)Sequence analysis1
Glycosylationi102N-linked (GlcNAc...)Sequence analysis1
Glycosylationi145N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi160 ↔ 174By similarity
Glycosylationi196N-linked (GlcNAc...)Sequence analysis1
Glycosylationi228N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO09028.
PRIDEiO09028.

Interactioni

Subunit structurei

Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and epsilon. A sixth class of subunit: Rho form homomeric GABA receptors that do not appear to coexist with GABA(A) receptor subunits but with GABA(C) receptor subunits. Subunit Pi can also bind this complex.

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000048081.

Structurei

3D structure databases

ProteinModelPortaliO09028.
SMRiO09028.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3643. Eukaryota.
ENOG410XPWH. LUCA.
HOGENOMiHOG000231335.
HOVERGENiHBG051707.
InParanoidiO09028.
KOiK05189.
PhylomeDBiO09028.

Family and domain databases

Gene3Di2.70.170.10. 1 hit.
InterProiIPR006028. GABAA/Glycine_rcpt.
IPR008100. GABAAp_rcpt.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
[Graphical view]
PANTHERiPTHR18945. PTHR18945. 1 hit.
PfamiPF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 1 hit.
[Graphical view]
PRINTSiPR00253. GABAARECEPTR.
PR01724. GABAARPI.
PR00252. NRIONCHANNEL.
SUPFAMiSSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 1 hit.
TIGRFAMsiTIGR00860. LIC. 1 hit.
PROSITEiPS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O09028-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSYSLYLAFV CLNLLAQRMC IQGNQFNVEV SRSDKLSLPG FENLTAGYNK
60 70 80 90 100
FLRPNFGGDP VRIALTLDIA SISSISESNM DYTATIYLRQ RWTDPRLVFE
110 120 130 140 150
GNKSFTLDAR LVEFLWVPDT YIVESKKSFL HEVTVGNRLI RLFSNGTVLY
160 170 180 190 200
ALRITTTVTC NMDLSKYPMD TQTCKLQLES WGYDGNDVEF SWLRGNDSVR
210 220 230 240 250
GLENLRLAQY TIQQYFTLVT VSQQETGNYT RLVLQFELRR NVLYFILETY
260 270 280 290 300
VPSTFLVVLS WVSFWISLES VPARTCIGVT TVLSMTTLMI GSRTSLPNTN
310 320 330 340 350
CFIKAIDVYL GICFSFVFGA LLEYAVAHYS SLQQMAVKDR GPAKDSEEVN
360 370 380 390 400
ITNIINSSIS SFKRKISFAS IEISGDNVNY SDLTMKASDK FKFVFREKIG
410 420 430 440
RIIDYFTIQN PSNVDRYSKL LFPLIFMLAN VFYWAYYMYF
Length:440
Mass (Da):50,481
Last modified:July 1, 1997 - v1
Checksum:iB4C7AE8923E43853
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U95368 mRNA. Translation: AAC53255.1.
RefSeqiNP_112291.1. NM_031029.1.
UniGeneiRn.21401.

Genome annotation databases

GeneIDi81658.
KEGGirno:81658.
UCSCiRGD:620532. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U95368 mRNA. Translation: AAC53255.1.
RefSeqiNP_112291.1. NM_031029.1.
UniGeneiRn.21401.

3D structure databases

ProteinModelPortaliO09028.
SMRiO09028.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000048081.

Chemistry databases

ChEMBLiCHEMBL1907607.

Proteomic databases

PaxDbiO09028.
PRIDEiO09028.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi81658.
KEGGirno:81658.
UCSCiRGD:620532. rat.

Organism-specific databases

CTDi2568.
RGDi620532. Gabrp.

Phylogenomic databases

eggNOGiKOG3643. Eukaryota.
ENOG410XPWH. LUCA.
HOGENOMiHOG000231335.
HOVERGENiHBG051707.
InParanoidiO09028.
KOiK05189.
PhylomeDBiO09028.

Miscellaneous databases

PROiO09028.

Family and domain databases

Gene3Di2.70.170.10. 1 hit.
InterProiIPR006028. GABAA/Glycine_rcpt.
IPR008100. GABAAp_rcpt.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
[Graphical view]
PANTHERiPTHR18945. PTHR18945. 1 hit.
PfamiPF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 1 hit.
[Graphical view]
PRINTSiPR00253. GABAARECEPTR.
PR01724. GABAARPI.
PR00252. NRIONCHANNEL.
SUPFAMiSSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 1 hit.
TIGRFAMsiTIGR00860. LIC. 1 hit.
PROSITEiPS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGBRP_RAT
AccessioniPrimary (citable) accession number: O09028
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 1, 1997
Last modified: November 2, 2016
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.