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Protein

Atypical chemokine receptor 2

Gene

Ackr2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Acts as a receptor for chemokines including CCL2, CCL3, CCL3L1, CCL4, CCL5, CCL7, CCL8, CCL11, CCL13, CCL17, CCL22, CCL23, CCL24, SCYA2/MCP-1, SCY3/MIP-1-alpha, SCYA5/RANTES and SCYA7/MCP-3. Upon active ligand stimulation, activates a beta-arrestin 1 (ARRB1)-dependent, G protein-independent signaling pathway that results in the phosphorylation of the actin-binding protein cofilin (CFL1) through a RAC1-PAK1-LIMK1 signaling pathway. Activation of this pathway results in up-regulation of ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation. By scavenging chemokines in tissues, on the surfaces of lymphatic vessels, and in placenta, plays an essential role in the resolution (termination) of the inflammatory response and in the regulation of adaptive immune responses. Plays a major role in the immune silencing of macrophages during the resolution of inflammation. Acts as a regulator of inflammatory leukocyte interactions with lymphatic endothelial cells (LECs) and is required for immature/mature dendritic cells discrimination by LECs.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processInflammatory response

Names & Taxonomyi

Protein namesi
Recommended name:
Atypical chemokine receptor 2
Alternative name(s):
C-C chemokine receptor D6
CCR10-related receptor
Chemokine-binding protein 2
Chemokine-binding protein D6
Gene namesi
Name:Ackr2
Synonyms:Ccbp2, Ccr10rr, D6
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi

Organism-specific databases

RGDi620323 Ackr2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 49ExtracellularSequence analysisAdd BLAST49
Transmembranei50 – 70Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini71 – 92CytoplasmicSequence analysisAdd BLAST22
Transmembranei93 – 113Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini114 – 118ExtracellularSequence analysis5
Transmembranei119 – 140Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini141 – 162CytoplasmicSequence analysisAdd BLAST22
Transmembranei163 – 183Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini184 – 217ExtracellularSequence analysisAdd BLAST34
Transmembranei218 – 238Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini239 – 250CytoplasmicSequence analysisAdd BLAST12
Transmembranei251 – 271Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini272 – 293ExtracellularSequence analysisAdd BLAST22
Transmembranei294 – 314Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini315 – 382CytoplasmicSequence analysisAdd BLAST68

Keywords - Cellular componenti

Cell membrane, Endosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000692211 – 382Atypical chemokine receptor 2Add BLAST382

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi17N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi117 ↔ 195PROSITE-ProRule annotation

Post-translational modificationi

Phosphorylated on serine residues in the C-terminal cytoplasmic tail.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiO09027

PTM databases

PhosphoSitePlusiO09027

Expressioni

Tissue specificityi

Predominantly expressed in spleen.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000026343

Structurei

3D structure databases

ProteinModelPortaliO09027
SMRiO09027
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni327 – 382C-terminal cytoplasmic tailBy similarityAdd BLAST56

Domaini

The C-terminal cytoplasmic tail controls its phosphorylation, stability, intracellular trafficking itinerary, and chemokine scavenging properties.By similarity

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Atypical chemokine receptor subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
HOGENOMiHOG000234122
HOVERGENiHBG106917
InParanoidiO09027
PhylomeDBiO09027

Family and domain databases

InterProiView protein in InterPro
IPR033037 Ackr2
IPR000355 Chemokine_rcpt
IPR001277 CXCR4/ACKR2
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PANTHERiPTHR10489:SF735 PTHR10489:SF735, 1 hit
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00657 CCCHEMOKINER
PR00645 CXCCHMKINER4
PR00237 GPCRRHODOPSN
PROSITEiView protein in PROSITE
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

O09027-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPTIASPLPL ATTGPENGSS IYDYDYLDDV TVLVCSKDEV LSFGRVFLPV
60 70 80 90 100
VYSLIFVLGL AGNLLLLVVL LHSVPQRRRM IELYLLNLAV SNLLFVVTMP
110 120 130 140 150
FWAISVAWHW VFGSFLCKVV STLYSINFYC GIFFITCMSL DKYLEIVHAQ
160 170 180 190 200
PLHRPKTRFR NLLLIVMVWI TALAVSVPEM VFVKVHQTLD GVWHCYADFG
210 220 230 240 250
GHATIWKLYL RFQMNLLGFL FPLLAMIFFY SRIGCVLVRL RPPGQGRALR
260 270 280 290 300
MAAALVVVFF LLWFPYNLTL FLHSLLDLHV FGNCKISHRL DYMLQVTESL
310 320 330 340 350
AFSHCCFTPV LYAFSSHSFR QYLKAVLSVV LRRHQAPGTA HAPPCSHSES
360 370 380
SRVTAQEDVV SMNDLGERQA DISLNKGEIG NN
Length:382
Mass (Da):43,293
Last modified:July 1, 1997 - v1
Checksum:iE8714CE23DB96772
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U92803 mRNA Translation: AAB61572.1
UniGeneiRn.10771
Rn.234526

Genome annotation databases

UCSCiRGD:620323 rat

Similar proteinsi

Entry informationi

Entry nameiACKR2_RAT
AccessioniPrimary (citable) accession number: O09027
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: July 1, 1997
Last modified: May 23, 2018
This is version 120 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

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