O09027 (CCBP2_RAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Chemokine-binding protein 2

Alternative name(s):
C-C chemokine receptor D6
CCR10-related receptor
Chemokine-binding protein D6

Gene names

Name:	Ccbp2
Synonyms:	Ccr10rr, D6

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	382 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Receptor for C-C type chemokines including SCYA2/MCP-1, SCY3/MIP-1-alpha, SCYA4/MIP-1-beta and SCYA5/RANTES.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Tissue specificity	Predominantly expressed in spleen.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	chemokine-mediated signaling pathway Inferred from electronic annotation. Source: GOC chemotaxis Inferred from electronic annotation. Source: InterPro elevation of cytosolic calcium ion concentration Inferred from electronic annotation. Source: InterPro neutrophil activation Inferred from electronic annotation. Source: InterPro
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	C-X-C chemokine receptor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 382	382	Chemokine-binding protein 2		PRO_0000069221
Regions
	Topological domain	1 – 49	49	Extracellular Potential
	Transmembrane	50 – 70	21	Helical; Name=1; Potential
	Topological domain	71 – 92	22	Cytoplasmic Potential
	Transmembrane	93 – 113	21	Helical; Name=2; Potential
	Topological domain	114 – 118	5	Extracellular Potential
	Transmembrane	119 – 140	22	Helical; Name=3; Potential
	Topological domain	141 – 162	22	Cytoplasmic Potential
	Transmembrane	163 – 183	21	Helical; Name=4; Potential
	Topological domain	184 – 217	34	Extracellular Potential
	Transmembrane	218 – 238	21	Helical; Name=5; Potential
	Topological domain	239 – 250	12	Cytoplasmic Potential
	Transmembrane	251 – 271	21	Helical; Name=6; Potential
	Topological domain	272 – 293	22	Extracellular Potential
	Transmembrane	294 – 314	21	Helical; Name=7; Potential
	Topological domain	315 – 382	68	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	17	1	N-linked (GlcNAc...) Potential
	Disulfide bond	117 ↔ 195		By similarity

Sequences

	Sequence		Length	Mass (Da)
	O09027 [UniParc]. Last modified July 1, 1997. Version 1. Checksum: E8714CE23DB96772	FASTA	382	43,293
	10 20 30 40 50 60 MPTIASPLPL ATTGPENGSS IYDYDYLDDV TVLVCSKDEV LSFGRVFLPV VYSLIFVLGL 70 80 90 100 110 120 AGNLLLLVVL LHSVPQRRRM IELYLLNLAV SNLLFVVTMP FWAISVAWHW VFGSFLCKVV 130 140 150 160 170 180 STLYSINFYC GIFFITCMSL DKYLEIVHAQ PLHRPKTRFR NLLLIVMVWI TALAVSVPEM 190 200 210 220 230 240 VFVKVHQTLD GVWHCYADFG GHATIWKLYL RFQMNLLGFL FPLLAMIFFY SRIGCVLVRL 250 260 270 280 290 300 RPPGQGRALR MAAALVVVFF LLWFPYNLTL FLHSLLDLHV FGNCKISHRL DYMLQVTESL 310 320 330 340 350 360 AFSHCCFTPV LYAFSSHSFR QYLKAVLSVV LRRHQAPGTA HAPPCSHSES SRVTAQEDVV 370 380 SMNDLGERQA DISLNKGEIG NN

References

[1]	"Molecular cloning and expression of a novel rat CC-chemokine receptor (rCCR10rR) that binds MCP-1 and MIP-1beta with high affinity." Bonini J.A., Steiner D.F. DNA Cell Biol. 16:1023-1030(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: Sprague-Dawley.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U92803 mRNA. Translation: AAB61572.1.
IPI	IPI00192630.
UniGene	Rn.10771.
3D structure databases
ProteinModelPortal	O09027.
ModBase	Search...
Protein-protein interaction databases
STRING	10116.ENSRNOP00000026343.
Protein family/group databases
GPCRDB	Search...
PTM databases
PhosphoSite	O09027.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
UCSC	RGD:620323. rat.
Organism-specific databases
RGD	620323. Ccbp2.
Phylogenomic databases
eggNOG	NOG297330.
HOGENOM	HOG000234122.
HOVERGEN	HBG106917.
InParanoid	O09027.
OrthoDB	EOG4KWJT9.
Gene expression databases
ArrayExpress	O09027.
Genevestigator	O09027.
GermOnline	ENSRNOG00000019472. Rattus norvegicus.
Family and domain databases
InterPro	IPR001277. Chemokine_CXCR4. IPR000355. Chemokine_rcpt. IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. [Graphical view]
PANTHER	PTHR24227. PTHR24227. 1 hit.
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR00657. CCCHEMOKINER. PR00645. CXCCHMKINER4. PR00237. GPCRRHODOPSN.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. False negative. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CCBP2_RAT

Accession

Primary (citable) accession number: O09027

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 20, 2001
Last sequence update:	July 1, 1997
Last modified:	May 29, 2013
This is version 94 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program