Reviewed, UniProtKB/Swiss-Prot O09018 (COT2_RAT)

Names and origin

Protein names

Recommended name:
    COUP transcription factor 2
      Short name=COUP-TF2
Alternative name(s):
    COUP transcription factor II
      Short name=COUP-TF II
    Nuclear receptor subfamily 2 group F member 2
    Apolipoprotein AI regulatory protein 1
      Short name=ARP-1
    Ovalbumin upstream promoter beta nuclear receptor
    COUPb

Gene names

Name:	Nr2f2
Synonyms:	Arp1, Tfcoup2

Organism

Rattus norvegicus (Rat)

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	414 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Regulation of the apolipoprotein A-I gene transcription. Binds to DNA site A By similarity.
Subunit structure	Binds DNA as a homodimer By similarity. Interacts with SQSTM1. Ref.2
Subcellular location	Nucleus.
Sequence similarities	Belongs to the nuclear hormone receptor family. NR2 subfamily. Contains 1 nuclear receptor DNA-binding domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Domain	Zinc-finger
Ligand	DNA-binding Metal-binding Zinc
Molecular function	Receptor
Gene Ontology (GO)
Biological process	transcription Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	sequence-specific DNA binding Inferred from direct assay. Source: RGD steroid hormone receptor activity Inferred from electronic annotation. Source: InterPro transcription factor activity Inferred from electronic annotation. Source: InterPro zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 414	414	COUP transcription factor 2		PRO_0000053608
Regions
	DNA binding	76 – 151	76	Nuclear receptor
	Zinc finger	79 – 99	21	NR C4-type
	Zinc finger	115 – 139	25	NR C4-type
	Region	337 – 414	78	Important for dimerization
	Compositional bias	71 – 75	5	Poly-Gln

Sequences

	Sequence		Length	Mass (Da)
	O09018-1 [UniParc]. Last modified July 1, 1997. Version 1. Checksum: 5AA05165DD3F675A	FASTA	414	45,601
	10 20 30 40 50 60 MAMVVSTWRD PQDEVPGSQG SQASQAPPVP GPPPGAPHTP QTPGQGGPAS TPAQTAAGSQ 70 80 90 100 110 120 GGPGGPGSDK QQQQQHIECV VCGDKSSGKH YGQFTCEGCK SFFKRSVRRN LSYTCRANRN 130 140 150 160 170 180 CPIDQHHRNQ CQYCRLKKCL KVGMRREAVQ RGRMPPTQPT HGQFALTNGD PLNCHSYLSG 190 200 210 220 230 240 YISLLLRAEP YPTSRFGSQC MQPNNIMGIE NICELAARML FSAVEWARNI PFFPDLQITD 250 260 270 280 290 300 QVALLRLTWS ELFVLNAAQC SMPLHVAPLL AAAGLHASPM SADRVVAFMD HIRIFQEQVE 310 320 330 340 350 360 KLKALHVDSA EYSCLKAIVL FTSDACGLSD VAHVESLQEK SQCALEEYVR SQYPNQPTRF 370 380 390 400 410 GKLLLRLPSL RTVSSSVIEQ LFFVRLVGKT PIETLIRDML LSGSSFNWPY MAIQ

References

[1]	"Cloning and expression of COUPb and COUPg in the rat anterior pituitary." Boutin J.-M., Ronsin B., Devost D., Lipkin S.M., Rosenfeld M.G., Morel G. Submitted (MAY-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Pituitary.
[2]	"A p56(lck) ligand serves as a coactivator of an orphan nuclear hormone receptor." Marcus S.L., Winrow C.J., Capone J.P., Rachubinski R.A. J. Biol. Chem. 271:27197-27200(1996) [PubMed: 8910285] [Abstract] Cited for: INTERACTION WITH SQSTM1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF003944 mRNA. Translation: AAB61297.1.
IPI	IPI00192619.
RefSeq	NP_542956.1.
UniGene	Rn.17815
3D structure databases
SMR	O09018. Positions 77-157, 181-401.
ModBase	Search...
Protein-protein interaction databases
STRING	O09018.
Genome annotation databases
Ensembl	ENSRNOT00000014152; ENSRNOP00000014152; ENSRNOG00000010308; Rattus norvegicus. [Genome view]
GeneID	113984.
KEGG	rno:113984.
UCSC	NM_080778. rat.
Organism-specific databases
CTD	113984.
RGD	69305. Nr2f2.
Phylogenomic databases
eggNOG	roNOG07521.
HOVERGEN	O09018.
InParanoid	O09018.
OMA	KQPQHIE.
PhylomeDB	O09018.
Gene expression databases
ArrayExpress	O09018.
Genevestigator	O09018.
GermOnline	ENSRNOG00000010308. Rattus norvegicus.
Family and domain databases
InterPro	IPR003068. COUP_TF. IPR008946. Nucl_hormone_rcpt_ligand-bd. IPR000536. Nucl_hrmn_rcpt_lig-bd_core. IPR001723. Str_hrmn_rcpt. IPR013629. Znf_C4_C. IPR001628. Znf_hrmn_rcpt. IPR013088. Znf_NHR/GATA. [Graphical view]
Gene3D	G3DSA:1.10.565.10. Nucl_hrmn_rcpt_lig_bd. 1 hit. G3DSA:3.30.50.10. Znf_NHR/GATA. 1 hit.
Pfam	PF00104. Hormone_recep. 1 hit. PF00105. zf-C4. 1 hit. PF08420. zf-C4_C. 1 hit. [Graphical view]
PRINTS	PR01282. COUPTNFACTOR. PR00398. STRDHORMONER. PR00047. STROIDFINGER.
SMART	SM00430. HOLI. 1 hit. SM00399. ZnF_C4. 1 hit. [Graphical view]
PROSITE	PS00031. NUCLEAR_REC_DBD_1. 1 hit. PS51030. NUCLEAR_REC_DBD_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	618125.

Entry information

Entry name

COT2_RAT

Accession

Primary (citable) accession number: O09018

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 15, 1998
Last sequence update:	July 1, 1997
Last modified:	February 9, 2010
This is version 79 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)