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Protein

Nuclear receptor subfamily 2 group F member 6

Gene

Nr2f6

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Transcription factor predominantly involved in transcriptional repression. Binds to promoter/enhancer response elements that contain the imperfect 5'-AGGTCA-3' direct or inverted repeats with various spacings which are also recognized by other nuclear hormone receptors. Involved in modulation of hormonal responses. Represses transcriptional activity of the lutropin-choriogonadotropic hormone receptor/LHCGR gene, the renin/REN gene and the oxytocin-neurophysin/OXT gene. Represses the triiodothyronine-dependent and -independent transcriptional activity of the thyroid hormone receptor gene in a cell type-specific manner. The corepressing function towards thyroid hormone receptor beta/THRB involves at least in part the inhibition of THRB binding to triiodothyronine response elements (TREs) by NR2F6. Inhibits NFATC transcription factor DNA binding and subsequently its transcriptional activity. Acts as transcriptional repressor of IL-17 expression in Th-17 differentiated CD4+ T cells and may be involved in induction and/or maintenance of peripheral immunological tolerance and autoimmunity. Involved in development of forebrain circadian clock; is required early in the development of the locus coeruleus (LC) (By similarity).By similarity1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi54 – 12976Nuclear receptorPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri57 – 7721NR C4-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri93 – 11725NR C4-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor, Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear receptor subfamily 2 group F member 6
Alternative name(s):
COUPg
Ovalbumin upstream promoter gamma nuclear receptor
V-erbA-related protein 2
Short name:
EAR-2
Gene namesi
Name:Nr2f6
Synonyms:Ear2, Erbal2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi621685. Nr2f6.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 390390Nuclear receptor subfamily 2 group F member 6PRO_0000053615Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei35 – 351PhosphoserineBy similarity
Modified residuei41 – 411PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiO09017.

PTM databases

PhosphoSiteiO09017.

Interactioni

Subunit structurei

Binds DNA as dimer; homodimer and heterodimer with NR2F2 and probably NR2F1. Interacts with THRB (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000022898.

Structurei

3D structure databases

ProteinModelPortaliO09017.
SMRiO09017. Positions 55-135.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni163 – 390228Ligand-bindingBy similarityAdd
BLAST
Regioni314 – 39077Important for dimerizationBy similarityAdd
BLAST

Sequence similaritiesi

Contains 1 nuclear receptor DNA-binding domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri57 – 7721NR C4-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri93 – 11725NR C4-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG3575. Eukaryota.
ENOG410XRZC. LUCA.
HOGENOMiHOG000260820.
HOVERGENiHBG005606.
InParanoidiO09017.
KOiK08549.
PhylomeDBiO09017.

Family and domain databases

Gene3Di1.10.565.10. 1 hit.
3.30.50.10. 1 hit.
InterProiIPR003068. COUP_TF.
IPR000536. Nucl_hrmn_rcpt_lig-bd.
IPR001723. Nuclear_hrmn_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PRINTSiPR01282. COUPTNFACTOR.
PR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTiSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 1 hit.
PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O09017-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAMVTGGWGG PGGDTNGVDK AGGSYPRATE DDSASPPGAT SDAEPGDEER
60 70 80 90 100
PGLQVDCVVC GDKSSGKHYG VFTCEGCKSF FKRTIRRNLS YTCRSNRDCQ
110 120 130 140 150
IDQHHRNQCQ YCRLKKCFRV GMRKEAVQPG PIPHALPGPA ACSPPGAAGV
160 170 180 190 200
EPFAGPPVSE LIAQLLRAEP YPAAGRFGGG GAVLGIDNVC ELAARLLFST
210 220 230 240 250
VEWARHAPFF PELPAADQVG LLRLSWSELF VLNAAQAPVP LHTAPLLAAA
260 270 280 290 300
GLHAGPMAAE RAVAFMDQVR AFQEQVDKLG RLQVDAAEYG CLKAIALFTP
310 320 330 340 350
DACGLSDPAH VESLQEKAQV ALTEYVRAQY PSQPQRFGRL LLRLPALRAV
360 370 380 390
PASLISQLFF MRLVGKTPIE TLIRDMLLSG STFNWPYGSG
Length:390
Mass (Da):41,730
Last modified:July 1, 1997 - v1
Checksum:iB08FAC93F76A7783
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF003926 mRNA. Translation: AAB61296.1.
RefSeqiNP_620813.1. NM_139113.1.
UniGeneiRn.25840.

Genome annotation databases

GeneIDi245980.
KEGGirno:245980.
UCSCiRGD:621685. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF003926 mRNA. Translation: AAB61296.1.
RefSeqiNP_620813.1. NM_139113.1.
UniGeneiRn.25840.

3D structure databases

ProteinModelPortaliO09017.
SMRiO09017. Positions 55-135.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000022898.

PTM databases

PhosphoSiteiO09017.

Proteomic databases

PaxDbiO09017.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi245980.
KEGGirno:245980.
UCSCiRGD:621685. rat.

Organism-specific databases

CTDi2063.
RGDi621685. Nr2f6.

Phylogenomic databases

eggNOGiKOG3575. Eukaryota.
ENOG410XRZC. LUCA.
HOGENOMiHOG000260820.
HOVERGENiHBG005606.
InParanoidiO09017.
KOiK08549.
PhylomeDBiO09017.

Miscellaneous databases

PROiO09017.

Family and domain databases

Gene3Di1.10.565.10. 1 hit.
3.30.50.10. 1 hit.
InterProiIPR003068. COUP_TF.
IPR000536. Nucl_hrmn_rcpt_lig-bd.
IPR001723. Nuclear_hrmn_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PRINTSiPR01282. COUPTNFACTOR.
PR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTiSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 1 hit.
PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNR2F6_RAT
AccessioniPrimary (citable) accession number: O09017
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: July 1, 1997
Last modified: June 8, 2016
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.