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Protein

Nuclear receptor subfamily 2 group F member 6

Gene

Nr2f6

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Transcription factor predominantly involved in transcriptional repression. Binds to promoter/enhancer response elements that contain the imperfect 5'-AGGTCA-3' direct or inverted repeats with various spacings which are also recognized by other nuclear hormone receptors. Involved in modulation of hormonal responses. Represses transcriptional activity of the lutropin-choriogonadotropic hormone receptor/LHCGR gene, the renin/REN gene and the oxytocin-neurophysin/OXT gene. Represses the triiodothyronine-dependent and -independent transcriptional activity of the thyroid hormone receptor gene in a cell type-specific manner. The corepressing function towards thyroid hormone receptor beta/THRB involves at least in part the inhibition of THRB binding to triiodothyronine response elements (TREs) by NR2F6. Inhibits NFATC transcription factor DNA binding and subsequently its transcriptional activity. Acts as transcriptional repressor of IL-17 expression in Th-17 differentiated CD4+ T cells and may be involved in induction and/or maintenance of peripheral immunological tolerance and autoimmunity. Involved in development of forebrain circadian clock; is required early in the development of the locus coeruleus (LC) (By similarity).By similarity1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi54 – 129Nuclear receptorPROSITE-ProRule annotationAdd BLAST76
Zinc fingeri57 – 77NR C4-typePROSITE-ProRule annotationAdd BLAST21
Zinc fingeri93 – 117NR C4-typePROSITE-ProRule annotationAdd BLAST25

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Receptor, Repressor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear receptor subfamily 2 group F member 6
Alternative name(s):
COUPg
Ovalbumin upstream promoter gamma nuclear receptor
V-erbA-related protein 2
Short name:
EAR-2
Gene namesi
Name:Nr2f6
Synonyms:Ear2, Erbal2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi621685 Nr2f6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000536151 – 390Nuclear receptor subfamily 2 group F member 6Add BLAST390

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei35PhosphoserineBy similarity1
Modified residuei41PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiO09017

PTM databases

PhosphoSitePlusiO09017

Interactioni

Subunit structurei

Binds DNA as dimer; homodimer and heterodimer with NR2F2 and probably NR2F1. Interacts with THRB (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000022898

Structurei

3D structure databases

ProteinModelPortaliO09017
SMRiO09017
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini157 – 380NR LBDPROSITE-ProRule annotationAdd BLAST224

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni314 – 390Important for dimerizationBy similarityAdd BLAST77

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri57 – 77NR C4-typePROSITE-ProRule annotationAdd BLAST21
Zinc fingeri93 – 117NR C4-typePROSITE-ProRule annotationAdd BLAST25

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG3575 Eukaryota
ENOG410XRZC LUCA
HOGENOMiHOG000260820
HOVERGENiHBG005606
InParanoidiO09017
KOiK08549
PhylomeDBiO09017

Family and domain databases

Gene3Di3.30.50.10, 1 hit
InterProiView protein in InterPro
IPR003068 COUP_TF
IPR035500 NHR_like_dom_sf
IPR000536 Nucl_hrmn_rcpt_lig-bd
IPR001723 Nuclear_hrmn_rcpt
IPR001628 Znf_hrmn_rcpt
IPR013088 Znf_NHR/GATA
PfamiView protein in Pfam
PF00104 Hormone_recep, 1 hit
PF00105 zf-C4, 1 hit
PRINTSiPR01282 COUPTNFACTOR
PR00398 STRDHORMONER
PR00047 STROIDFINGER
SMARTiView protein in SMART
SM00430 HOLI, 1 hit
SM00399 ZnF_C4, 1 hit
SUPFAMiSSF48508 SSF48508, 1 hit
PROSITEiView protein in PROSITE
PS51843 NR_LBD, 1 hit
PS00031 NUCLEAR_REC_DBD_1, 1 hit
PS51030 NUCLEAR_REC_DBD_2, 1 hit

Sequencei

Sequence statusi: Complete.

O09017-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAMVTGGWGG PGGDTNGVDK AGGSYPRATE DDSASPPGAT SDAEPGDEER
60 70 80 90 100
PGLQVDCVVC GDKSSGKHYG VFTCEGCKSF FKRTIRRNLS YTCRSNRDCQ
110 120 130 140 150
IDQHHRNQCQ YCRLKKCFRV GMRKEAVQPG PIPHALPGPA ACSPPGAAGV
160 170 180 190 200
EPFAGPPVSE LIAQLLRAEP YPAAGRFGGG GAVLGIDNVC ELAARLLFST
210 220 230 240 250
VEWARHAPFF PELPAADQVG LLRLSWSELF VLNAAQAPVP LHTAPLLAAA
260 270 280 290 300
GLHAGPMAAE RAVAFMDQVR AFQEQVDKLG RLQVDAAEYG CLKAIALFTP
310 320 330 340 350
DACGLSDPAH VESLQEKAQV ALTEYVRAQY PSQPQRFGRL LLRLPALRAV
360 370 380 390
PASLISQLFF MRLVGKTPIE TLIRDMLLSG STFNWPYGSG
Length:390
Mass (Da):41,730
Last modified:July 1, 1997 - v1
Checksum:iB08FAC93F76A7783
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF003926 mRNA Translation: AAB61296.1
RefSeqiNP_620813.1, NM_139113.1
UniGeneiRn.25840

Genome annotation databases

GeneIDi245980
KEGGirno:245980
UCSCiRGD:621685 rat

Similar proteinsi

Entry informationi

Entry nameiNR2F6_RAT
AccessioniPrimary (citable) accession number: O09017
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: July 1, 1997
Last modified: March 28, 2018
This is version 131 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health