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Protein

Peroxisomal targeting signal 1 receptor

Gene

Pex5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Binds to the C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type) and plays an essential role in peroxisomal protein import.

GO - Molecular functioni

GO - Biological processi

  • cell development Source: MGI
  • cellular lipid metabolic process Source: MGI
  • cerebral cortex cell migration Source: MGI
  • cerebral cortex neuron differentiation Source: MGI
  • endoplasmic reticulum organization Source: MGI
  • fatty acid beta-oxidation Source: MGI
  • mitochondrial membrane organization Source: MGI
  • mitochondrion organization Source: MGI
  • negative regulation of protein homotetramerization Source: MGI
  • neuromuscular process Source: MGI
  • neuron migration Source: MGI
  • peroxisome organization Source: MGI
  • positive regulation of multicellular organism growth Source: MGI
  • protein import into peroxisome matrix Source: UniProtKB
  • protein import into peroxisome matrix, docking Source: MGI
  • protein import into peroxisome matrix, translocation Source: MGI
  • protein import into peroxisome membrane Source: MGI
  • protein targeting to peroxisome Source: MGI
  • protein tetramerization Source: MGI
  • very long-chain fatty acid metabolic process Source: MGI
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Protein family/group databases

TCDBi3.A.20.1.1. the peroxisomal protein importer (ppi) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Peroxisomal targeting signal 1 receptor
Short name:
PTS1 receptor
Short name:
PTS1R
Alternative name(s):
PTS1-BP
PXR1P
Peroxin-5
Peroxisomal C-terminal targeting signal import receptor
Peroxisome receptor 1
Gene namesi
Name:Pex5
Synonyms:Pxr1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1098808. Pex5.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: MGI
  • cytosol Source: MGI
  • Golgi apparatus Source: MGI
  • intracellular Source: MGI
  • membrane Source: MGI
  • mitochondrion Source: GOC
  • peroxisomal matrix Source: MGI
  • peroxisomal membrane Source: MGI
  • peroxisome Source: MGI
  • protein complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane, Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 639639Peroxisomal targeting signal 1 receptorPRO_0000106306Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki11 – 11Glycyl cysteine thioester (Cys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Modified residuei115 – 1151PhosphoserineBy similarity
Modified residuei153 – 1531PhosphoserineBy similarity
Modified residuei155 – 1551PhosphoserineBy similarity
Modified residuei167 – 1671PhosphoserineBy similarity
Modified residuei281 – 2811PhosphoserineBy similarity

Post-translational modificationi

Monoubiquitination at Cys-11 is required for proper export from peroxisomes and recycling.By similarity

Keywords - PTMi

Phosphoprotein, Thioester bond, Ubl conjugation

Proteomic databases

MaxQBiO09012.
PaxDbiO09012.
PRIDEiO09012.

PTM databases

PhosphoSiteiO09012.

Expressioni

Gene expression databases

BgeeiO09012.
CleanExiMM_PEX5.
ExpressionAtlasiO09012. baseline and differential.
GenevisibleiO09012. MM.

Interactioni

Subunit structurei

Interacts with PEX7, PEX12, PEX13 and PEX14. Interacts (Cys-linked ubiquitinated) with ZFAND6 (By similarity).By similarity

Protein-protein interaction databases

IntActiO09012. 2 interactions.
STRINGi10090.ENSMUSP00000049132.

Structurei

3D structure databases

ProteinModelPortaliO09012.
SMRiO09012. Positions 337-639.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati337 – 37034TPR 1Add
BLAST
Repeati371 – 40434TPR 2Add
BLAST
Repeati405 – 43834TPR 3Add
BLAST
Repeati452 – 48534TPR 4Add
BLAST
Repeati488 – 52134TPR 5Add
BLAST
Repeati522 – 55534TPR 6Add
BLAST
Repeati556 – 58934TPR 7Add
BLAST

Sequence similaritiesi

Contains 7 TPR repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

eggNOGiCOG0457.
GeneTreeiENSGT00390000013941.
HOGENOMiHOG000158146.
HOVERGENiHBG053575.
InParanoidiO09012.
KOiK13342.
OMAiDYNEADW.
OrthoDBiEOG793B77.
PhylomeDBiO09012.
TreeFamiTF315044.

Family and domain databases

Gene3Di1.25.40.10. 2 hits.
InterProiIPR024111. PTS1R_family.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR001440. TPR_1.
IPR019734. TPR_repeat.
[Graphical view]
PANTHERiPTHR10130. PTHR10130. 1 hit.
PfamiPF00515. TPR_1. 3 hits.
[Graphical view]
SMARTiSM00028. TPR. 4 hits.
[Graphical view]
PROSITEiPS50005. TPR. 5 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O09012-1) [UniParc]FASTAAdd to basket

Also known as: Long

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAMRELVEGE CGGANPLMKL ATHFTQDKAL RQEGLRPGPW PPGASAAETV
60 70 80 90 100
SKPLGVGTED ELVSEFLQDQ NATLVSRAPQ TFKMDDLLAE MQEIEQSNFR
110 120 130 140 150
QAPQRAPGVA DLALSENWAQ EFLAAGDAVD VAQDYNETDW SQEFIAEVTD
160 170 180 190 200
PLSVSPARWA EEYLEQSEEK LWLGDQEGSS TADRWYDEYH PEEDLQHTAS
210 220 230 240 250
DFVSKVDDPK LANSEFLKFV RQIGEGQVSL ESAAGSGGAQ AEQWAAEFIQ
260 270 280 290 300
QQGTSEAWVD QFTRPGNKIA ALQVEFERAK SAIESDVDFW DKLQAELEEM
310 320 330 340 350
AKRDAEAHPW LSDYDDLTSA SYDKGYQFEE ENPLRDHPQP FEEGLHRLEE
360 370 380 390 400
GDLPNAVLLF EAAVQQDPKH MEAWQYLGTT QAENEQELLA ISALRRCLEL
410 420 430 440 450
KPDNRTALMA LAVSFTNESL QRQACETLRD WLRYSPAYAH LVAPGEEGAT
460 470 480 490 500
GAGPSKRILG SLLSDSLFLE VKDLFLAAVR LDPTSIDPDV QCGLGVLFNL
510 520 530 540 550
SGEYDKAVDC FTAALSVRPN DYLMWNKLGA TLANGNQSEE AVAAYRRALE
560 570 580 590 600
LQPGYIRSRY NLGISCINLG AHREAVEHFL EALNMQRKSR GPRGEGGAMS
610 620 630
ENIWSTLRLA LSMLGQSDAY GAADARDLSA LLAMFGLPQ
Length:639
Mass (Da):70,756
Last modified:April 3, 2007 - v2
Checksum:iA7013FF02926803C
GO
Isoform 2 (identifier: O09012-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     216-252: Missing.

Show »
Length:602
Mass (Da):66,806
Checksum:i33C7527C14BB1FE4
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti139 – 1391D → H in CAB09694 (PubMed:9288097).Curated
Sequence conflicti150 – 1501D → G in CAB09694 (PubMed:9288097).Curated
Sequence conflicti179 – 1791S → F in CAB09694 (PubMed:9288097).Curated
Sequence conflicti207 – 2071D → N in CAB09694 (PubMed:9288097).Curated
Sequence conflicti366 – 3661Q → R in CAB09694 (PubMed:9288097).Curated
Sequence conflicti370 – 3701H → N in CAB09694 (PubMed:9288097).Curated
Sequence conflicti376 – 3761Y → S in CAB09694 (PubMed:9288097).Curated
Sequence conflicti473 – 4731D → E in BAE26240 (Ref. 2) Curated
Sequence conflicti524 – 5241M → L in BAE26240 (Ref. 2) Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei216 – 25237Missing in isoform 2. 2 PublicationsVSP_024107Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z97018 mRNA. Translation: CAB09694.1.
AJ416473 mRNA. Translation: CAC94925.1.
AK088886 mRNA. Translation: BAC40632.1.
AK145111 mRNA. Translation: BAE26240.1.
AK145361 mRNA. Translation: BAE26388.1.
AK161470 mRNA. Translation: BAE36414.1.
BC029748 mRNA. Translation: AAH29748.1.
CCDSiCCDS20517.1. [O09012-1]
CCDS20518.1. [O09012-2]
RefSeqiNP_001264259.1. NM_001277330.1. [O09012-2]
NP_001264734.1. NM_001277805.1. [O09012-1]
NP_033021.2. NM_008995.2. [O09012-1]
NP_787947.1. NM_175933.2. [O09012-2]
XP_006505821.1. XM_006505758.2. [O09012-1]
XP_006505822.1. XM_006505759.2. [O09012-1]
UniGeneiMm.22418.

Genome annotation databases

EnsembliENSMUST00000035861; ENSMUSP00000049132; ENSMUSG00000005069. [O09012-1]
ENSMUST00000080557; ENSMUSP00000079398; ENSMUSG00000005069. [O09012-2]
ENSMUST00000112531; ENSMUSP00000108150; ENSMUSG00000005069. [O09012-2]
ENSMUST00000112532; ENSMUSP00000108151; ENSMUSG00000005069. [O09012-1]
GeneIDi19305.
KEGGimmu:19305.
UCSCiuc009dqs.1. mouse. [O09012-1]
uc009dqt.1. mouse. [O09012-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z97018 mRNA. Translation: CAB09694.1.
AJ416473 mRNA. Translation: CAC94925.1.
AK088886 mRNA. Translation: BAC40632.1.
AK145111 mRNA. Translation: BAE26240.1.
AK145361 mRNA. Translation: BAE26388.1.
AK161470 mRNA. Translation: BAE36414.1.
BC029748 mRNA. Translation: AAH29748.1.
CCDSiCCDS20517.1. [O09012-1]
CCDS20518.1. [O09012-2]
RefSeqiNP_001264259.1. NM_001277330.1. [O09012-2]
NP_001264734.1. NM_001277805.1. [O09012-1]
NP_033021.2. NM_008995.2. [O09012-1]
NP_787947.1. NM_175933.2. [O09012-2]
XP_006505821.1. XM_006505758.2. [O09012-1]
XP_006505822.1. XM_006505759.2. [O09012-1]
UniGeneiMm.22418.

3D structure databases

ProteinModelPortaliO09012.
SMRiO09012. Positions 337-639.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiO09012. 2 interactions.
STRINGi10090.ENSMUSP00000049132.

Protein family/group databases

TCDBi3.A.20.1.1. the peroxisomal protein importer (ppi) family.

PTM databases

PhosphoSiteiO09012.

Proteomic databases

MaxQBiO09012.
PaxDbiO09012.
PRIDEiO09012.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000035861; ENSMUSP00000049132; ENSMUSG00000005069. [O09012-1]
ENSMUST00000080557; ENSMUSP00000079398; ENSMUSG00000005069. [O09012-2]
ENSMUST00000112531; ENSMUSP00000108150; ENSMUSG00000005069. [O09012-2]
ENSMUST00000112532; ENSMUSP00000108151; ENSMUSG00000005069. [O09012-1]
GeneIDi19305.
KEGGimmu:19305.
UCSCiuc009dqs.1. mouse. [O09012-1]
uc009dqt.1. mouse. [O09012-2]

Organism-specific databases

CTDi5830.
MGIiMGI:1098808. Pex5.

Phylogenomic databases

eggNOGiCOG0457.
GeneTreeiENSGT00390000013941.
HOGENOMiHOG000158146.
HOVERGENiHBG053575.
InParanoidiO09012.
KOiK13342.
OMAiDYNEADW.
OrthoDBiEOG793B77.
PhylomeDBiO09012.
TreeFamiTF315044.

Miscellaneous databases

NextBioi296267.
PROiO09012.
SOURCEiSearch...

Gene expression databases

BgeeiO09012.
CleanExiMM_PEX5.
ExpressionAtlasiO09012. baseline and differential.
GenevisibleiO09012. MM.

Family and domain databases

Gene3Di1.25.40.10. 2 hits.
InterProiIPR024111. PTS1R_family.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR001440. TPR_1.
IPR019734. TPR_repeat.
[Graphical view]
PANTHERiPTHR10130. PTHR10130. 1 hit.
PfamiPF00515. TPR_1. 3 hits.
[Graphical view]
SMARTiSM00028. TPR. 4 hits.
[Graphical view]
PROSITEiPS50005. TPR. 5 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "Studies on mammalian peroxines."
    Van Veldhoven P.P.
    Submitted (OCT-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Mammary gland.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: FVB/N.
    Tissue: Mammary tumor.

Entry informationi

Entry nameiPEX5_MOUSE
AccessioniPrimary (citable) accession number: O09012
Secondary accession number(s): Q3UM58, Q8K2V5, Q91YC7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: April 3, 2007
Last modified: June 24, 2015
This is version 134 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.