Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Peroxisomal targeting signal 1 receptor

Gene

Pex5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Binds to the C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type) and plays an essential role in peroxisomal protein import.

GO - Molecular functioni

GO - Biological processi

  • cell development Source: MGI
  • cellular lipid metabolic process Source: MGI
  • cerebral cortex cell migration Source: MGI
  • cerebral cortex neuron differentiation Source: MGI
  • endoplasmic reticulum organization Source: MGI
  • fatty acid beta-oxidation Source: MGI
  • mitochondrial membrane organization Source: MGI
  • mitochondrion organization Source: MGI
  • negative regulation of protein homotetramerization Source: MGI
  • neuromuscular process Source: MGI
  • neuron migration Source: MGI
  • peroxisome organization Source: MGI
  • positive regulation of multicellular organism growth Source: MGI
  • protein import into peroxisome matrix Source: UniProtKB
  • protein import into peroxisome matrix, docking Source: MGI
  • protein import into peroxisome membrane Source: MGI
  • protein targeting to peroxisome Source: UniProtKB
  • very long-chain fatty acid metabolic process Source: MGI
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Protein family/group databases

TCDBi3.A.20.1.1. the peroxisomal protein importer (ppi) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Peroxisomal targeting signal 1 receptor
Short name:
PTS1 receptor
Short name:
PTS1R
Alternative name(s):
PTS1-BP
PXR1P
Peroxin-5
Peroxisomal C-terminal targeting signal import receptor
Peroxisome receptor 1
Gene namesi
Name:Pex5
Synonyms:Pxr1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1098808. Pex5.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane, Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001063061 – 639Peroxisomal targeting signal 1 receptorAdd BLAST639

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki11Glycyl cysteine thioester (Cys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Modified residuei115PhosphoserineBy similarity1
Modified residuei153PhosphoserineBy similarity1
Modified residuei155PhosphoserineBy similarity1
Modified residuei167PhosphoserineBy similarity1
Modified residuei281PhosphoserineBy similarity1

Post-translational modificationi

Monoubiquitination at Cys-11 is required for proper export from peroxisomes and recycling.By similarity

Keywords - PTMi

Phosphoprotein, Thioester bond, Ubl conjugation

Proteomic databases

MaxQBiO09012.
PaxDbiO09012.
PeptideAtlasiO09012.
PRIDEiO09012.

PTM databases

iPTMnetiO09012.
PhosphoSitePlusiO09012.

Expressioni

Gene expression databases

BgeeiENSMUSG00000005069.
CleanExiMM_PEX5.
ExpressionAtlasiO09012. baseline and differential.
GenevisibleiO09012. MM.

Interactioni

Subunit structurei

Interacts with PEX7, PEX12, PEX13 and PEX14. Interacts (Cys-linked ubiquitinated) with ZFAND6 (By similarity).By similarity

GO - Molecular functioni

  • enzyme binding Source: MGI
  • protein C-terminus binding Source: UniProtKB
  • protein N-terminus binding Source: MGI
  • small GTPase binding Source: MGI

Protein-protein interaction databases

IntActiO09012. 2 interactors.
STRINGi10090.ENSMUSP00000049132.

Structurei

3D structure databases

ProteinModelPortaliO09012.
SMRiO09012.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati337 – 370TPR 1Add BLAST34
Repeati371 – 404TPR 2Add BLAST34
Repeati405 – 438TPR 3Add BLAST34
Repeati452 – 485TPR 4Add BLAST34
Repeati488 – 521TPR 5Add BLAST34
Repeati522 – 555TPR 6Add BLAST34
Repeati556 – 589TPR 7Add BLAST34

Sequence similaritiesi

Contains 7 TPR repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

eggNOGiKOG1125. Eukaryota.
ENOG410XQ6Q. LUCA.
GeneTreeiENSGT00390000013941.
HOGENOMiHOG000158146.
HOVERGENiHBG053575.
InParanoidiO09012.
KOiK13342.
OMAiDYNEADW.
OrthoDBiEOG091G07HM.
PhylomeDBiO09012.
TreeFamiTF315044.

Family and domain databases

Gene3Di1.25.40.10. 2 hits.
InterProiIPR024111. PTS1R_family.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
[Graphical view]
PANTHERiPTHR10130. PTHR10130. 1 hit.
PfamiPF13374. TPR_10. 1 hit.
[Graphical view]
SMARTiSM00028. TPR. 4 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 1 hit.
PROSITEiPS50005. TPR. 5 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O09012-1) [UniParc]FASTAAdd to basket
Also known as: Long

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAMRELVEGE CGGANPLMKL ATHFTQDKAL RQEGLRPGPW PPGASAAETV
60 70 80 90 100
SKPLGVGTED ELVSEFLQDQ NATLVSRAPQ TFKMDDLLAE MQEIEQSNFR
110 120 130 140 150
QAPQRAPGVA DLALSENWAQ EFLAAGDAVD VAQDYNETDW SQEFIAEVTD
160 170 180 190 200
PLSVSPARWA EEYLEQSEEK LWLGDQEGSS TADRWYDEYH PEEDLQHTAS
210 220 230 240 250
DFVSKVDDPK LANSEFLKFV RQIGEGQVSL ESAAGSGGAQ AEQWAAEFIQ
260 270 280 290 300
QQGTSEAWVD QFTRPGNKIA ALQVEFERAK SAIESDVDFW DKLQAELEEM
310 320 330 340 350
AKRDAEAHPW LSDYDDLTSA SYDKGYQFEE ENPLRDHPQP FEEGLHRLEE
360 370 380 390 400
GDLPNAVLLF EAAVQQDPKH MEAWQYLGTT QAENEQELLA ISALRRCLEL
410 420 430 440 450
KPDNRTALMA LAVSFTNESL QRQACETLRD WLRYSPAYAH LVAPGEEGAT
460 470 480 490 500
GAGPSKRILG SLLSDSLFLE VKDLFLAAVR LDPTSIDPDV QCGLGVLFNL
510 520 530 540 550
SGEYDKAVDC FTAALSVRPN DYLMWNKLGA TLANGNQSEE AVAAYRRALE
560 570 580 590 600
LQPGYIRSRY NLGISCINLG AHREAVEHFL EALNMQRKSR GPRGEGGAMS
610 620 630
ENIWSTLRLA LSMLGQSDAY GAADARDLSA LLAMFGLPQ
Length:639
Mass (Da):70,756
Last modified:April 3, 2007 - v2
Checksum:iA7013FF02926803C
GO
Isoform 2 (identifier: O09012-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     216-252: Missing.

Show »
Length:602
Mass (Da):66,806
Checksum:i33C7527C14BB1FE4
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti139D → H in CAB09694 (PubMed:9288097).Curated1
Sequence conflicti150D → G in CAB09694 (PubMed:9288097).Curated1
Sequence conflicti179S → F in CAB09694 (PubMed:9288097).Curated1
Sequence conflicti207D → N in CAB09694 (PubMed:9288097).Curated1
Sequence conflicti366Q → R in CAB09694 (PubMed:9288097).Curated1
Sequence conflicti370H → N in CAB09694 (PubMed:9288097).Curated1
Sequence conflicti376Y → S in CAB09694 (PubMed:9288097).Curated1
Sequence conflicti473D → E in BAE26240 (Ref. 2) Curated1
Sequence conflicti524M → L in BAE26240 (Ref. 2) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_024107216 – 252Missing in isoform 2. 2 PublicationsAdd BLAST37

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z97018 mRNA. Translation: CAB09694.1.
AJ416473 mRNA. Translation: CAC94925.1.
AK088886 mRNA. Translation: BAC40632.1.
AK145111 mRNA. Translation: BAE26240.1.
AK145361 mRNA. Translation: BAE26388.1.
AK161470 mRNA. Translation: BAE36414.1.
BC029748 mRNA. Translation: AAH29748.1.
CCDSiCCDS20517.1. [O09012-1]
CCDS20518.1. [O09012-2]
RefSeqiNP_001264259.1. NM_001277330.1. [O09012-2]
NP_001264734.1. NM_001277805.1. [O09012-1]
NP_033021.2. NM_008995.2. [O09012-1]
NP_787947.1. NM_175933.2. [O09012-2]
XP_006505821.1. XM_006505758.3. [O09012-1]
XP_006505822.1. XM_006505759.3. [O09012-1]
XP_017176951.1. XM_017321462.1. [O09012-2]
UniGeneiMm.22418.

Genome annotation databases

EnsembliENSMUST00000035861; ENSMUSP00000049132; ENSMUSG00000005069. [O09012-1]
ENSMUST00000080557; ENSMUSP00000079398; ENSMUSG00000005069. [O09012-2]
ENSMUST00000112531; ENSMUSP00000108150; ENSMUSG00000005069. [O09012-2]
ENSMUST00000112532; ENSMUSP00000108151; ENSMUSG00000005069. [O09012-1]
GeneIDi19305.
KEGGimmu:19305.
UCSCiuc009dqs.1. mouse. [O09012-1]
uc009dqt.1. mouse. [O09012-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z97018 mRNA. Translation: CAB09694.1.
AJ416473 mRNA. Translation: CAC94925.1.
AK088886 mRNA. Translation: BAC40632.1.
AK145111 mRNA. Translation: BAE26240.1.
AK145361 mRNA. Translation: BAE26388.1.
AK161470 mRNA. Translation: BAE36414.1.
BC029748 mRNA. Translation: AAH29748.1.
CCDSiCCDS20517.1. [O09012-1]
CCDS20518.1. [O09012-2]
RefSeqiNP_001264259.1. NM_001277330.1. [O09012-2]
NP_001264734.1. NM_001277805.1. [O09012-1]
NP_033021.2. NM_008995.2. [O09012-1]
NP_787947.1. NM_175933.2. [O09012-2]
XP_006505821.1. XM_006505758.3. [O09012-1]
XP_006505822.1. XM_006505759.3. [O09012-1]
XP_017176951.1. XM_017321462.1. [O09012-2]
UniGeneiMm.22418.

3D structure databases

ProteinModelPortaliO09012.
SMRiO09012.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiO09012. 2 interactors.
STRINGi10090.ENSMUSP00000049132.

Protein family/group databases

TCDBi3.A.20.1.1. the peroxisomal protein importer (ppi) family.

PTM databases

iPTMnetiO09012.
PhosphoSitePlusiO09012.

Proteomic databases

MaxQBiO09012.
PaxDbiO09012.
PeptideAtlasiO09012.
PRIDEiO09012.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000035861; ENSMUSP00000049132; ENSMUSG00000005069. [O09012-1]
ENSMUST00000080557; ENSMUSP00000079398; ENSMUSG00000005069. [O09012-2]
ENSMUST00000112531; ENSMUSP00000108150; ENSMUSG00000005069. [O09012-2]
ENSMUST00000112532; ENSMUSP00000108151; ENSMUSG00000005069. [O09012-1]
GeneIDi19305.
KEGGimmu:19305.
UCSCiuc009dqs.1. mouse. [O09012-1]
uc009dqt.1. mouse. [O09012-2]

Organism-specific databases

CTDi5830.
MGIiMGI:1098808. Pex5.

Phylogenomic databases

eggNOGiKOG1125. Eukaryota.
ENOG410XQ6Q. LUCA.
GeneTreeiENSGT00390000013941.
HOGENOMiHOG000158146.
HOVERGENiHBG053575.
InParanoidiO09012.
KOiK13342.
OMAiDYNEADW.
OrthoDBiEOG091G07HM.
PhylomeDBiO09012.
TreeFamiTF315044.

Miscellaneous databases

PROiO09012.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000005069.
CleanExiMM_PEX5.
ExpressionAtlasiO09012. baseline and differential.
GenevisibleiO09012. MM.

Family and domain databases

Gene3Di1.25.40.10. 2 hits.
InterProiIPR024111. PTS1R_family.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
[Graphical view]
PANTHERiPTHR10130. PTHR10130. 1 hit.
PfamiPF13374. TPR_10. 1 hit.
[Graphical view]
SMARTiSM00028. TPR. 4 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 1 hit.
PROSITEiPS50005. TPR. 5 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPEX5_MOUSE
AccessioniPrimary (citable) accession number: O09012
Secondary accession number(s): Q3UM58, Q8K2V5, Q91YC7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: April 3, 2007
Last modified: November 2, 2016
This is version 146 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.