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O09012

- PEX5_MOUSE

UniProt

O09012 - PEX5_MOUSE

Protein

Peroxisomal targeting signal 1 receptor

Gene

Pex5

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 128 (01 Oct 2014)
      Sequence version 2 (03 Apr 2007)
      Previous versions | rss
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    Functioni

    Binds to the C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type) and plays an essential role in peroxisomal protein import.

    GO - Molecular functioni

    1. peroxisome matrix targeting signal-1 binding Source: RefGenome
    2. peroxisome targeting sequence binding Source: MGI
    3. protein C-terminus binding Source: UniProtKB

    GO - Biological processi

    1. cell development Source: MGI
    2. cellular lipid metabolic process Source: MGI
    3. cerebral cortex cell migration Source: MGI
    4. cerebral cortex neuron differentiation Source: MGI
    5. endoplasmic reticulum organization Source: MGI
    6. fatty acid beta-oxidation Source: MGI
    7. mitochondrial membrane organization Source: MGI
    8. mitochondrion organization Source: MGI
    9. negative regulation of protein homotetramerization Source: Ensembl
    10. neuromuscular process Source: MGI
    11. neuron migration Source: MGI
    12. peroxisome organization Source: MGI
    13. positive regulation of multicellular organism growth Source: MGI
    14. protein import into peroxisome matrix Source: UniProtKB
    15. protein import into peroxisome matrix, docking Source: RefGenome
    16. protein import into peroxisome matrix, translocation Source: Ensembl
    17. protein import into peroxisome membrane Source: Ensembl
    18. protein targeting to peroxisome Source: UniProtKB
    19. protein tetramerization Source: Ensembl
    20. very long-chain fatty acid metabolic process Source: MGI

    Keywords - Biological processi

    Protein transport, Transport

    Protein family/group databases

    TCDBi3.A.20.1.1. the peroxisomal protein importer (ppi) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Peroxisomal targeting signal 1 receptor
    Short name:
    PTS1 receptor
    Short name:
    PTS1R
    Alternative name(s):
    PTS1-BP
    PXR1P
    Peroxin-5
    Peroxisomal C-terminal targeting signal import receptor
    Peroxisome receptor 1
    Gene namesi
    Name:Pex5
    Synonyms:Pxr1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 6

    Organism-specific databases

    MGIiMGI:1098808. Pex5.

    Subcellular locationi

    Cytoplasm. Peroxisome membrane; Peripheral membrane protein
    Note: Its distribution appears to be dynamic. It is probably a cycling receptor found mainly in the cytoplasm and as well associated to the peroxisomal membrane through a docking factor (PEX13).

    GO - Cellular componenti

    1. cytosol Source: RefGenome
    2. Golgi apparatus Source: Ensembl
    3. mitochondrion Source: GOC
    4. peroxisomal matrix Source: Ensembl
    5. peroxisomal membrane Source: RefGenome
    6. peroxisome Source: MGI
    7. protein complex Source: Ensembl

    Keywords - Cellular componenti

    Cytoplasm, Membrane, Peroxisome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 639639Peroxisomal targeting signal 1 receptorPRO_0000106306Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Cross-linki11 – 11Glycyl cysteine thioester (Cys-Gly) (interchain with G-Cter in ubiquitin)By similarity

    Post-translational modificationi

    Monoubiquitination at Cys-11 is required for proper export from peroxisomes and recycling.By similarity

    Keywords - PTMi

    Thioester bond, Ubl conjugation

    Proteomic databases

    MaxQBiO09012.
    PaxDbiO09012.
    PRIDEiO09012.

    PTM databases

    PhosphoSiteiO09012.

    Expressioni

    Gene expression databases

    ArrayExpressiO09012.
    BgeeiO09012.
    CleanExiMM_PEX5.
    GenevestigatoriO09012.

    Interactioni

    Subunit structurei

    Interacts with PEX7, PEX12, PEX13 and PEX14. Interacts (Cys-linked ubiquitinated) with ZFAND6 By similarity.By similarity

    Protein-protein interaction databases

    IntActiO09012. 2 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliO09012.
    SMRiO09012. Positions 337-639.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati337 – 37034TPR 1Add
    BLAST
    Repeati371 – 40434TPR 2Add
    BLAST
    Repeati405 – 43834TPR 3Add
    BLAST
    Repeati452 – 48534TPR 4Add
    BLAST
    Repeati488 – 52134TPR 5Add
    BLAST
    Repeati522 – 55534TPR 6Add
    BLAST
    Repeati556 – 58934TPR 7Add
    BLAST

    Sequence similaritiesi

    Contains 7 TPR repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, TPR repeat

    Phylogenomic databases

    eggNOGiCOG0457.
    GeneTreeiENSGT00390000013941.
    HOGENOMiHOG000158146.
    HOVERGENiHBG053575.
    InParanoidiO09012.
    KOiK13342.
    OMAiDYNEADW.
    OrthoDBiEOG793B77.
    PhylomeDBiO09012.
    TreeFamiTF315044.

    Family and domain databases

    Gene3Di1.25.40.10. 2 hits.
    InterProiIPR024111. PTS1R_family.
    IPR013026. TPR-contain_dom.
    IPR011990. TPR-like_helical.
    IPR001440. TPR_1.
    IPR019734. TPR_repeat.
    [Graphical view]
    PANTHERiPTHR10130. PTHR10130. 1 hit.
    PfamiPF00515. TPR_1. 3 hits.
    [Graphical view]
    SMARTiSM00028. TPR. 4 hits.
    [Graphical view]
    PROSITEiPS50005. TPR. 5 hits.
    PS50293. TPR_REGION. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: O09012-1) [UniParc]FASTAAdd to Basket

    Also known as: Long

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAMRELVEGE CGGANPLMKL ATHFTQDKAL RQEGLRPGPW PPGASAAETV    50
    SKPLGVGTED ELVSEFLQDQ NATLVSRAPQ TFKMDDLLAE MQEIEQSNFR 100
    QAPQRAPGVA DLALSENWAQ EFLAAGDAVD VAQDYNETDW SQEFIAEVTD 150
    PLSVSPARWA EEYLEQSEEK LWLGDQEGSS TADRWYDEYH PEEDLQHTAS 200
    DFVSKVDDPK LANSEFLKFV RQIGEGQVSL ESAAGSGGAQ AEQWAAEFIQ 250
    QQGTSEAWVD QFTRPGNKIA ALQVEFERAK SAIESDVDFW DKLQAELEEM 300
    AKRDAEAHPW LSDYDDLTSA SYDKGYQFEE ENPLRDHPQP FEEGLHRLEE 350
    GDLPNAVLLF EAAVQQDPKH MEAWQYLGTT QAENEQELLA ISALRRCLEL 400
    KPDNRTALMA LAVSFTNESL QRQACETLRD WLRYSPAYAH LVAPGEEGAT 450
    GAGPSKRILG SLLSDSLFLE VKDLFLAAVR LDPTSIDPDV QCGLGVLFNL 500
    SGEYDKAVDC FTAALSVRPN DYLMWNKLGA TLANGNQSEE AVAAYRRALE 550
    LQPGYIRSRY NLGISCINLG AHREAVEHFL EALNMQRKSR GPRGEGGAMS 600
    ENIWSTLRLA LSMLGQSDAY GAADARDLSA LLAMFGLPQ 639
    Length:639
    Mass (Da):70,756
    Last modified:April 3, 2007 - v2
    Checksum:iA7013FF02926803C
    GO
    Isoform 2 (identifier: O09012-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         216-252: Missing.

    Show »
    Length:602
    Mass (Da):66,806
    Checksum:i33C7527C14BB1FE4
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti139 – 1391D → H in CAB09694. (PubMed:9288097)Curated
    Sequence conflicti150 – 1501D → G in CAB09694. (PubMed:9288097)Curated
    Sequence conflicti179 – 1791S → F in CAB09694. (PubMed:9288097)Curated
    Sequence conflicti207 – 2071D → N in CAB09694. (PubMed:9288097)Curated
    Sequence conflicti366 – 3661Q → R in CAB09694. (PubMed:9288097)Curated
    Sequence conflicti370 – 3701H → N in CAB09694. (PubMed:9288097)Curated
    Sequence conflicti376 – 3761Y → S in CAB09694. (PubMed:9288097)Curated
    Sequence conflicti473 – 4731D → E in BAE26240. 1 PublicationCurated
    Sequence conflicti524 – 5241M → L in BAE26240. 1 PublicationCurated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei216 – 25237Missing in isoform 2. 2 PublicationsVSP_024107Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z97018 mRNA. Translation: CAB09694.1.
    AJ416473 mRNA. Translation: CAC94925.1.
    AK088886 mRNA. Translation: BAC40632.1.
    AK145111 mRNA. Translation: BAE26240.1.
    AK145361 mRNA. Translation: BAE26388.1.
    AK161470 mRNA. Translation: BAE36414.1.
    BC029748 mRNA. Translation: AAH29748.1.
    CCDSiCCDS20517.1. [O09012-1]
    CCDS20518.1. [O09012-2]
    RefSeqiNP_001264259.1. NM_001277330.1. [O09012-2]
    NP_001264734.1. NM_001277805.1. [O09012-1]
    NP_033021.2. NM_008995.2. [O09012-1]
    NP_787947.1. NM_175933.2. [O09012-2]
    XP_006505821.1. XM_006505758.1. [O09012-1]
    XP_006505822.1. XM_006505759.1. [O09012-1]
    UniGeneiMm.22418.

    Genome annotation databases

    EnsembliENSMUST00000035861; ENSMUSP00000049132; ENSMUSG00000005069. [O09012-1]
    ENSMUST00000080557; ENSMUSP00000079398; ENSMUSG00000005069. [O09012-2]
    ENSMUST00000112531; ENSMUSP00000108150; ENSMUSG00000005069. [O09012-2]
    ENSMUST00000112532; ENSMUSP00000108151; ENSMUSG00000005069. [O09012-1]
    GeneIDi19305.
    KEGGimmu:19305.
    UCSCiuc009dqs.1. mouse. [O09012-1]
    uc009dqt.1. mouse. [O09012-2]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z97018 mRNA. Translation: CAB09694.1 .
    AJ416473 mRNA. Translation: CAC94925.1 .
    AK088886 mRNA. Translation: BAC40632.1 .
    AK145111 mRNA. Translation: BAE26240.1 .
    AK145361 mRNA. Translation: BAE26388.1 .
    AK161470 mRNA. Translation: BAE36414.1 .
    BC029748 mRNA. Translation: AAH29748.1 .
    CCDSi CCDS20517.1. [O09012-1 ]
    CCDS20518.1. [O09012-2 ]
    RefSeqi NP_001264259.1. NM_001277330.1. [O09012-2 ]
    NP_001264734.1. NM_001277805.1. [O09012-1 ]
    NP_033021.2. NM_008995.2. [O09012-1 ]
    NP_787947.1. NM_175933.2. [O09012-2 ]
    XP_006505821.1. XM_006505758.1. [O09012-1 ]
    XP_006505822.1. XM_006505759.1. [O09012-1 ]
    UniGenei Mm.22418.

    3D structure databases

    ProteinModelPortali O09012.
    SMRi O09012. Positions 337-639.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi O09012. 2 interactions.

    Protein family/group databases

    TCDBi 3.A.20.1.1. the peroxisomal protein importer (ppi) family.

    PTM databases

    PhosphoSitei O09012.

    Proteomic databases

    MaxQBi O09012.
    PaxDbi O09012.
    PRIDEi O09012.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000035861 ; ENSMUSP00000049132 ; ENSMUSG00000005069 . [O09012-1 ]
    ENSMUST00000080557 ; ENSMUSP00000079398 ; ENSMUSG00000005069 . [O09012-2 ]
    ENSMUST00000112531 ; ENSMUSP00000108150 ; ENSMUSG00000005069 . [O09012-2 ]
    ENSMUST00000112532 ; ENSMUSP00000108151 ; ENSMUSG00000005069 . [O09012-1 ]
    GeneIDi 19305.
    KEGGi mmu:19305.
    UCSCi uc009dqs.1. mouse. [O09012-1 ]
    uc009dqt.1. mouse. [O09012-2 ]

    Organism-specific databases

    CTDi 5830.
    MGIi MGI:1098808. Pex5.

    Phylogenomic databases

    eggNOGi COG0457.
    GeneTreei ENSGT00390000013941.
    HOGENOMi HOG000158146.
    HOVERGENi HBG053575.
    InParanoidi O09012.
    KOi K13342.
    OMAi DYNEADW.
    OrthoDBi EOG793B77.
    PhylomeDBi O09012.
    TreeFami TF315044.

    Miscellaneous databases

    NextBioi 296267.
    PROi O09012.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O09012.
    Bgeei O09012.
    CleanExi MM_PEX5.
    Genevestigatori O09012.

    Family and domain databases

    Gene3Di 1.25.40.10. 2 hits.
    InterProi IPR024111. PTS1R_family.
    IPR013026. TPR-contain_dom.
    IPR011990. TPR-like_helical.
    IPR001440. TPR_1.
    IPR019734. TPR_repeat.
    [Graphical view ]
    PANTHERi PTHR10130. PTHR10130. 1 hit.
    Pfami PF00515. TPR_1. 3 hits.
    [Graphical view ]
    SMARTi SM00028. TPR. 4 hits.
    [Graphical view ]
    PROSITEi PS50005. TPR. 5 hits.
    PS50293. TPR_REGION. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. "Studies on mammalian peroxines."
      Van Veldhoven P.P.
      Submitted (OCT-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    3. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Mammary gland.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Strain: FVB/N.
      Tissue: Mammary tumor.

    Entry informationi

    Entry nameiPEX5_MOUSE
    AccessioniPrimary (citable) accession number: O09012
    Secondary accession number(s): Q3UM58, Q8K2V5, Q91YC7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: April 3, 2007
    Last modified: October 1, 2014
    This is version 128 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3