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Protein

Peroxisomal targeting signal 1 receptor

Gene

Pex5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds to the C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type) and plays an essential role in peroxisomal protein import.

GO - Molecular functioni

  • enzyme binding Source: MGI
  • peroxisome matrix targeting signal-1 binding Source: UniProtKB
  • peroxisome targeting sequence binding Source: MGI
  • protein C-terminus binding Source: UniProtKB
  • protein N-terminus binding Source: MGI
  • small GTPase binding Source: MGI

GO - Biological processi

  • cell development Source: MGI
  • cellular lipid metabolic process Source: MGI
  • cerebral cortex cell migration Source: MGI
  • cerebral cortex neuron differentiation Source: MGI
  • endoplasmic reticulum organization Source: MGI
  • fatty acid beta-oxidation Source: MGI
  • mitochondrial membrane organization Source: MGI
  • mitochondrion organization Source: MGI
  • negative regulation of protein homotetramerization Source: MGI
  • neuromuscular process Source: MGI
  • neuron migration Source: MGI
  • peroxisome organization Source: MGI
  • positive regulation of multicellular organism growth Source: MGI
  • protein import into peroxisome matrix Source: UniProtKB
  • protein import into peroxisome matrix, docking Source: MGI
  • protein import into peroxisome matrix, translocation Source: MGI
  • protein import into peroxisome membrane Source: MGI
  • protein targeting to peroxisome Source: UniProtKB
  • protein tetramerization Source: MGI
  • very long-chain fatty acid metabolic process Source: MGI

Keywordsi

Biological processProtein transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-8866654 E3 ubiquitin ligases ubiquitinate target proteins

Protein family/group databases

TCDBi3.A.20.1.1 the peroxisomal protein importer (ppi) family

Names & Taxonomyi

Protein namesi
Recommended name:
Peroxisomal targeting signal 1 receptor
Short name:
PTS1 receptor
Short name:
PTS1R
Alternative name(s):
PTS1-BP
PXR1P
Peroxin-5
Peroxisomal C-terminal targeting signal import receptor
Peroxisome receptor 1
Gene namesi
Name:Pex5
Synonyms:Pxr1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1098808 Pex5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Membrane, Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001063061 – 639Peroxisomal targeting signal 1 receptorAdd BLAST639

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki11Glycyl cysteine thioester (Cys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Modified residuei115PhosphoserineBy similarity1
Modified residuei153PhosphoserineBy similarity1
Modified residuei155PhosphoserineBy similarity1
Modified residuei167PhosphoserineBy similarity1
Modified residuei281PhosphoserineBy similarity1

Post-translational modificationi

Monoubiquitination at Cys-11 is required for proper export from peroxisomes and recycling.By similarity

Keywords - PTMi

Phosphoprotein, Thioester bond, Ubl conjugation

Proteomic databases

MaxQBiO09012
PaxDbiO09012
PeptideAtlasiO09012
PRIDEiO09012

PTM databases

iPTMnetiO09012
PhosphoSitePlusiO09012

Expressioni

Gene expression databases

BgeeiENSMUSG00000005069
CleanExiMM_PEX5
ExpressionAtlasiO09012 baseline and differential
GenevisibleiO09012 MM

Interactioni

Subunit structurei

Interacts with PEX7, PEX12, PEX13 and PEX14. Interacts (Cys-linked ubiquitinated) with ZFAND6 (By similarity).By similarity

GO - Molecular functioni

  • enzyme binding Source: MGI
  • protein C-terminus binding Source: UniProtKB
  • protein N-terminus binding Source: MGI
  • small GTPase binding Source: MGI

Protein-protein interaction databases

BioGridi202526, 1 interactor
IntActiO09012, 3 interactors
STRINGi10090.ENSMUSP00000049132

Structurei

3D structure databases

ProteinModelPortaliO09012
SMRiO09012
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati337 – 370TPR 1Add BLAST34
Repeati371 – 404TPR 2Add BLAST34
Repeati405 – 438TPR 3Add BLAST34
Repeati452 – 485TPR 4Add BLAST34
Repeati488 – 521TPR 5Add BLAST34
Repeati522 – 555TPR 6Add BLAST34
Repeati556 – 589TPR 7Add BLAST34

Sequence similaritiesi

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

eggNOGiKOG1125 Eukaryota
ENOG410XQ6Q LUCA
GeneTreeiENSGT00390000013941
HOGENOMiHOG000158146
HOVERGENiHBG053575
InParanoidiO09012
KOiK13342
OMAiDYNEADW
OrthoDBiEOG091G07HM
PhylomeDBiO09012
TreeFamiTF315044

Family and domain databases

Gene3Di1.25.40.10, 1 hit
InterProiView protein in InterPro
IPR024113 PTS1R
IPR024111 PTS1R_family
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR019734 TPR_repeat
PANTHERiPTHR10130 PTHR10130, 1 hit
PTHR10130:SF2 PTHR10130:SF2, 1 hit
SMARTiView protein in SMART
SM00028 TPR, 4 hits
SUPFAMiSSF48452 SSF48452, 1 hit
PROSITEiView protein in PROSITE
PS50005 TPR, 5 hits
PS50293 TPR_REGION, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O09012-1) [UniParc]FASTAAdd to basket
Also known as: Long

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAMRELVEGE CGGANPLMKL ATHFTQDKAL RQEGLRPGPW PPGASAAETV
60 70 80 90 100
SKPLGVGTED ELVSEFLQDQ NATLVSRAPQ TFKMDDLLAE MQEIEQSNFR
110 120 130 140 150
QAPQRAPGVA DLALSENWAQ EFLAAGDAVD VAQDYNETDW SQEFIAEVTD
160 170 180 190 200
PLSVSPARWA EEYLEQSEEK LWLGDQEGSS TADRWYDEYH PEEDLQHTAS
210 220 230 240 250
DFVSKVDDPK LANSEFLKFV RQIGEGQVSL ESAAGSGGAQ AEQWAAEFIQ
260 270 280 290 300
QQGTSEAWVD QFTRPGNKIA ALQVEFERAK SAIESDVDFW DKLQAELEEM
310 320 330 340 350
AKRDAEAHPW LSDYDDLTSA SYDKGYQFEE ENPLRDHPQP FEEGLHRLEE
360 370 380 390 400
GDLPNAVLLF EAAVQQDPKH MEAWQYLGTT QAENEQELLA ISALRRCLEL
410 420 430 440 450
KPDNRTALMA LAVSFTNESL QRQACETLRD WLRYSPAYAH LVAPGEEGAT
460 470 480 490 500
GAGPSKRILG SLLSDSLFLE VKDLFLAAVR LDPTSIDPDV QCGLGVLFNL
510 520 530 540 550
SGEYDKAVDC FTAALSVRPN DYLMWNKLGA TLANGNQSEE AVAAYRRALE
560 570 580 590 600
LQPGYIRSRY NLGISCINLG AHREAVEHFL EALNMQRKSR GPRGEGGAMS
610 620 630
ENIWSTLRLA LSMLGQSDAY GAADARDLSA LLAMFGLPQ
Length:639
Mass (Da):70,756
Last modified:April 3, 2007 - v2
Checksum:iA7013FF02926803C
GO
Isoform 2 (identifier: O09012-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     216-252: Missing.

Show »
Length:602
Mass (Da):66,806
Checksum:i33C7527C14BB1FE4
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti139D → H in CAB09694 (PubMed:9288097).Curated1
Sequence conflicti150D → G in CAB09694 (PubMed:9288097).Curated1
Sequence conflicti179S → F in CAB09694 (PubMed:9288097).Curated1
Sequence conflicti207D → N in CAB09694 (PubMed:9288097).Curated1
Sequence conflicti366Q → R in CAB09694 (PubMed:9288097).Curated1
Sequence conflicti370H → N in CAB09694 (PubMed:9288097).Curated1
Sequence conflicti376Y → S in CAB09694 (PubMed:9288097).Curated1
Sequence conflicti473D → E in BAE26240 (Ref. 2) Curated1
Sequence conflicti524M → L in BAE26240 (Ref. 2) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_024107216 – 252Missing in isoform 2. 2 PublicationsAdd BLAST37

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z97018 mRNA Translation: CAB09694.1
AJ416473 mRNA Translation: CAC94925.1
AK088886 mRNA Translation: BAC40632.1
AK145111 mRNA Translation: BAE26240.1
AK145361 mRNA Translation: BAE26388.1
AK161470 mRNA Translation: BAE36414.1
BC029748 mRNA Translation: AAH29748.1
CCDSiCCDS20517.1 [O09012-1]
CCDS20518.1 [O09012-2]
RefSeqiNP_001264259.1, NM_001277330.1 [O09012-2]
NP_001264734.1, NM_001277805.1 [O09012-1]
NP_033021.2, NM_008995.2 [O09012-1]
NP_787947.1, NM_175933.2 [O09012-2]
XP_006505821.1, XM_006505758.3 [O09012-1]
XP_006505822.1, XM_006505759.3 [O09012-1]
XP_017176951.1, XM_017321462.1 [O09012-2]
UniGeneiMm.22418

Genome annotation databases

EnsembliENSMUST00000035861; ENSMUSP00000049132; ENSMUSG00000005069 [O09012-1]
ENSMUST00000080557; ENSMUSP00000079398; ENSMUSG00000005069 [O09012-2]
ENSMUST00000112531; ENSMUSP00000108150; ENSMUSG00000005069 [O09012-2]
ENSMUST00000112532; ENSMUSP00000108151; ENSMUSG00000005069 [O09012-1]
GeneIDi19305
KEGGimmu:19305
UCSCiuc009dqs.1 mouse [O09012-1]
uc009dqt.1 mouse [O09012-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiPEX5_MOUSE
AccessioniPrimary (citable) accession number: O09012
Secondary accession number(s): Q3UM58, Q8K2V5, Q91YC7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: April 3, 2007
Last modified: April 25, 2018
This is version 157 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health