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O09012

- PEX5_MOUSE

UniProt

O09012 - PEX5_MOUSE

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Protein
Peroxisomal targeting signal 1 receptor
Gene
Pex5, Pxr1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Binds to the C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type) and plays an essential role in peroxisomal protein import.

GO - Molecular functioni

  1. peroxisome matrix targeting signal-1 binding Source: RefGenome
  2. peroxisome targeting sequence binding Source: MGI
  3. protein C-terminus binding Source: UniProtKB

GO - Biological processi

  1. cell development Source: MGI
  2. cellular lipid metabolic process Source: MGI
  3. cerebral cortex cell migration Source: MGI
  4. cerebral cortex neuron differentiation Source: MGI
  5. endoplasmic reticulum organization Source: MGI
  6. fatty acid beta-oxidation Source: MGI
  7. mitochondrial membrane organization Source: MGI
  8. mitochondrion organization Source: MGI
  9. negative regulation of protein homotetramerization Source: Ensembl
  10. neuromuscular process Source: MGI
  11. neuron migration Source: MGI
  12. peroxisome organization Source: MGI
  13. positive regulation of multicellular organism growth Source: MGI
  14. protein import into peroxisome matrix Source: UniProtKB
  15. protein import into peroxisome matrix, docking Source: RefGenome
  16. protein import into peroxisome matrix, translocation Source: Ensembl
  17. protein import into peroxisome membrane Source: Ensembl
  18. protein targeting to peroxisome Source: UniProtKB
  19. protein tetramerization Source: Ensembl
  20. very long-chain fatty acid metabolic process Source: MGI
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Protein family/group databases

TCDBi3.A.20.1.1. the peroxisomal protein importer (ppi) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Peroxisomal targeting signal 1 receptor
Short name:
PTS1 receptor
Short name:
PTS1R
Alternative name(s):
PTS1-BP
PXR1P
Peroxin-5
Peroxisomal C-terminal targeting signal import receptor
Peroxisome receptor 1
Gene namesi
Name:Pex5
Synonyms:Pxr1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 6

Organism-specific databases

MGIiMGI:1098808. Pex5.

Subcellular locationi

Cytoplasm. Peroxisome membrane; Peripheral membrane protein
Note: Its distribution appears to be dynamic. It is probably a cycling receptor found mainly in the cytoplasm and as well associated to the peroxisomal membrane through a docking factor (PEX13).

GO - Cellular componenti

  1. Golgi apparatus Source: Ensembl
  2. cytosol Source: RefGenome
  3. mitochondrion Source: GOC
  4. peroxisomal matrix Source: Ensembl
  5. peroxisomal membrane Source: RefGenome
  6. peroxisome Source: MGI
  7. protein complex Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane, Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 639639Peroxisomal targeting signal 1 receptor
PRO_0000106306Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki11 – 11Glycyl cysteine thioester (Cys-Gly) (interchain with G-Cter in ubiquitin) By similarity

Post-translational modificationi

Monoubiquitination at Cys-11 is required for proper export from peroxisomes and recycling By similarity.

Keywords - PTMi

Thioester bond, Ubl conjugation

Proteomic databases

MaxQBiO09012.
PaxDbiO09012.
PRIDEiO09012.

PTM databases

PhosphoSiteiO09012.

Expressioni

Gene expression databases

ArrayExpressiO09012.
BgeeiO09012.
CleanExiMM_PEX5.
GenevestigatoriO09012.

Interactioni

Subunit structurei

Interacts with PEX7, PEX12, PEX13 and PEX14. Interacts (Cys-linked ubiquitinated) with ZFAND6 By similarity.

Protein-protein interaction databases

IntActiO09012. 2 interactions.

Structurei

3D structure databases

ProteinModelPortaliO09012.
SMRiO09012. Positions 337-639.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati337 – 37034TPR 1
Add
BLAST
Repeati371 – 40434TPR 2
Add
BLAST
Repeati405 – 43834TPR 3
Add
BLAST
Repeati452 – 48534TPR 4
Add
BLAST
Repeati488 – 52134TPR 5
Add
BLAST
Repeati522 – 55534TPR 6
Add
BLAST
Repeati556 – 58934TPR 7
Add
BLAST

Sequence similaritiesi

Contains 7 TPR repeats.

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

eggNOGiCOG0457.
GeneTreeiENSGT00390000013941.
HOGENOMiHOG000158146.
HOVERGENiHBG053575.
InParanoidiO09012.
KOiK13342.
OMAiDYNEADW.
OrthoDBiEOG793B77.
PhylomeDBiO09012.
TreeFamiTF315044.

Family and domain databases

Gene3Di1.25.40.10. 2 hits.
InterProiIPR024111. PTS1R_family.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical.
IPR001440. TPR_1.
IPR019734. TPR_repeat.
[Graphical view]
PANTHERiPTHR10130. PTHR10130. 1 hit.
PfamiPF00515. TPR_1. 3 hits.
[Graphical view]
SMARTiSM00028. TPR. 4 hits.
[Graphical view]
PROSITEiPS50005. TPR. 5 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: O09012-1) [UniParc]FASTAAdd to Basket

Also known as: Long

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MAMRELVEGE CGGANPLMKL ATHFTQDKAL RQEGLRPGPW PPGASAAETV    50
SKPLGVGTED ELVSEFLQDQ NATLVSRAPQ TFKMDDLLAE MQEIEQSNFR 100
QAPQRAPGVA DLALSENWAQ EFLAAGDAVD VAQDYNETDW SQEFIAEVTD 150
PLSVSPARWA EEYLEQSEEK LWLGDQEGSS TADRWYDEYH PEEDLQHTAS 200
DFVSKVDDPK LANSEFLKFV RQIGEGQVSL ESAAGSGGAQ AEQWAAEFIQ 250
QQGTSEAWVD QFTRPGNKIA ALQVEFERAK SAIESDVDFW DKLQAELEEM 300
AKRDAEAHPW LSDYDDLTSA SYDKGYQFEE ENPLRDHPQP FEEGLHRLEE 350
GDLPNAVLLF EAAVQQDPKH MEAWQYLGTT QAENEQELLA ISALRRCLEL 400
KPDNRTALMA LAVSFTNESL QRQACETLRD WLRYSPAYAH LVAPGEEGAT 450
GAGPSKRILG SLLSDSLFLE VKDLFLAAVR LDPTSIDPDV QCGLGVLFNL 500
SGEYDKAVDC FTAALSVRPN DYLMWNKLGA TLANGNQSEE AVAAYRRALE 550
LQPGYIRSRY NLGISCINLG AHREAVEHFL EALNMQRKSR GPRGEGGAMS 600
ENIWSTLRLA LSMLGQSDAY GAADARDLSA LLAMFGLPQ 639
Length:639
Mass (Da):70,756
Last modified:April 3, 2007 - v2
Checksum:iA7013FF02926803C
GO
Isoform 2 (identifier: O09012-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     216-252: Missing.

Show »
Length:602
Mass (Da):66,806
Checksum:i33C7527C14BB1FE4
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei216 – 25237Missing in isoform 2.
VSP_024107Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti139 – 1391D → H in CAB09694. 1 Publication
Sequence conflicti150 – 1501D → G in CAB09694. 1 Publication
Sequence conflicti179 – 1791S → F in CAB09694. 1 Publication
Sequence conflicti207 – 2071D → N in CAB09694. 1 Publication
Sequence conflicti366 – 3661Q → R in CAB09694. 1 Publication
Sequence conflicti370 – 3701H → N in CAB09694. 1 Publication
Sequence conflicti376 – 3761Y → S in CAB09694. 1 Publication
Sequence conflicti473 – 4731D → E in BAE26240. 1 Publication
Sequence conflicti524 – 5241M → L in BAE26240. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z97018 mRNA. Translation: CAB09694.1.
AJ416473 mRNA. Translation: CAC94925.1.
AK088886 mRNA. Translation: BAC40632.1.
AK145111 mRNA. Translation: BAE26240.1.
AK145361 mRNA. Translation: BAE26388.1.
AK161470 mRNA. Translation: BAE36414.1.
BC029748 mRNA. Translation: AAH29748.1.
CCDSiCCDS20517.1. [O09012-1]
CCDS20518.1. [O09012-2]
RefSeqiNP_001264259.1. NM_001277330.1. [O09012-2]
NP_001264734.1. NM_001277805.1. [O09012-1]
NP_033021.2. NM_008995.2. [O09012-1]
NP_787947.1. NM_175933.2. [O09012-2]
XP_006505821.1. XM_006505758.1. [O09012-1]
XP_006505822.1. XM_006505759.1. [O09012-1]
UniGeneiMm.22418.

Genome annotation databases

EnsembliENSMUST00000035861; ENSMUSP00000049132; ENSMUSG00000005069. [O09012-1]
ENSMUST00000080557; ENSMUSP00000079398; ENSMUSG00000005069. [O09012-2]
ENSMUST00000112531; ENSMUSP00000108150; ENSMUSG00000005069. [O09012-2]
ENSMUST00000112532; ENSMUSP00000108151; ENSMUSG00000005069. [O09012-1]
GeneIDi19305.
KEGGimmu:19305.
UCSCiuc009dqs.1. mouse. [O09012-1]
uc009dqt.1. mouse. [O09012-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z97018 mRNA. Translation: CAB09694.1 .
AJ416473 mRNA. Translation: CAC94925.1 .
AK088886 mRNA. Translation: BAC40632.1 .
AK145111 mRNA. Translation: BAE26240.1 .
AK145361 mRNA. Translation: BAE26388.1 .
AK161470 mRNA. Translation: BAE36414.1 .
BC029748 mRNA. Translation: AAH29748.1 .
CCDSi CCDS20517.1. [O09012-1 ]
CCDS20518.1. [O09012-2 ]
RefSeqi NP_001264259.1. NM_001277330.1. [O09012-2 ]
NP_001264734.1. NM_001277805.1. [O09012-1 ]
NP_033021.2. NM_008995.2. [O09012-1 ]
NP_787947.1. NM_175933.2. [O09012-2 ]
XP_006505821.1. XM_006505758.1. [O09012-1 ]
XP_006505822.1. XM_006505759.1. [O09012-1 ]
UniGenei Mm.22418.

3D structure databases

ProteinModelPortali O09012.
SMRi O09012. Positions 337-639.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi O09012. 2 interactions.

Protein family/group databases

TCDBi 3.A.20.1.1. the peroxisomal protein importer (ppi) family.

PTM databases

PhosphoSitei O09012.

Proteomic databases

MaxQBi O09012.
PaxDbi O09012.
PRIDEi O09012.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000035861 ; ENSMUSP00000049132 ; ENSMUSG00000005069 . [O09012-1 ]
ENSMUST00000080557 ; ENSMUSP00000079398 ; ENSMUSG00000005069 . [O09012-2 ]
ENSMUST00000112531 ; ENSMUSP00000108150 ; ENSMUSG00000005069 . [O09012-2 ]
ENSMUST00000112532 ; ENSMUSP00000108151 ; ENSMUSG00000005069 . [O09012-1 ]
GeneIDi 19305.
KEGGi mmu:19305.
UCSCi uc009dqs.1. mouse. [O09012-1 ]
uc009dqt.1. mouse. [O09012-2 ]

Organism-specific databases

CTDi 5830.
MGIi MGI:1098808. Pex5.

Phylogenomic databases

eggNOGi COG0457.
GeneTreei ENSGT00390000013941.
HOGENOMi HOG000158146.
HOVERGENi HBG053575.
InParanoidi O09012.
KOi K13342.
OMAi DYNEADW.
OrthoDBi EOG793B77.
PhylomeDBi O09012.
TreeFami TF315044.

Miscellaneous databases

NextBioi 296267.
PROi O09012.
SOURCEi Search...

Gene expression databases

ArrayExpressi O09012.
Bgeei O09012.
CleanExi MM_PEX5.
Genevestigatori O09012.

Family and domain databases

Gene3Di 1.25.40.10. 2 hits.
InterProi IPR024111. PTS1R_family.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical.
IPR001440. TPR_1.
IPR019734. TPR_repeat.
[Graphical view ]
PANTHERi PTHR10130. PTHR10130. 1 hit.
Pfami PF00515. TPR_1. 3 hits.
[Graphical view ]
SMARTi SM00028. TPR. 4 hits.
[Graphical view ]
PROSITEi PS50005. TPR. 5 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "Studies on mammalian peroxines."
    Van Veldhoven P.P.
    Submitted (OCT-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Mammary gland.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: FVB/N.
    Tissue: Mammary tumor.

Entry informationi

Entry nameiPEX5_MOUSE
AccessioniPrimary (citable) accession number: O09012
Secondary accession number(s): Q3UM58, Q8K2V5, Q91YC7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: April 3, 2007
Last modified: July 9, 2014
This is version 127 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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