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Reviewed, UniProtKB/Swiss-Prot O09005 (DEGS1_MOUSE)

Last modified June 16, 2009. Version 67. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Sphingolipid delta(4)-desaturase DES1
    EC=1.14.-.-
Alternative name(s):
    Degenerative spermatocyte homolog 1
Gene names
Name: Degs1
Synonyms: Degs, Des1, Mdes
OrganismMus musculus (Mouse)
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

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Protein attributes

Sequence length323 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Function

Has sphingolipid-delta-4-desaturase activity. Converts D-erythro-sphinganine to D-erythro-sphingosine (E-sphing-4-enine). Ref.2

Subcellular location

Endoplasmic reticulum membrane; Multi-pass membrane protein By similarity.

Tissue specificity

Detected in testis. Detected in pachytene spermatocytes and round spermatids. Ref.1

Sequence similarities

Belongs to the fatty acid desaturase family. DEGS subfamily.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 323323Sphingolipid delta(4)-desaturase DES1
PRO_0000312729

Regions

Transmembrane41 – 6121 Potential
Transmembrane68 – 8821 Potential
Transmembrane104 – 12421 Potential
Transmembrane152 – 17221 Potential
Transmembrane184 – 20421 Potential
Transmembrane209 – 22921 Potential

Amino acid modifications

Modified residue3071Phosphoserine By similarity

Experimental info

Sequence conflict2031V → A in AAM12532. Ref.2

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Sequences

Sequence LengthMass (Da)Tools
O09005-1 [UniParc].

Last modified July 1, 1997. Version 1.
Checksum: C1840C24E6FF29E0

FASTA32338,241
        10         20         30         40         50         60 
MGSRVSREEF EWVYTDQPHA ARRKEILAKY PEIKSLMKPD HNLIWIVAMM LLVQLASFYL 

        70         80         90        100        110        120 
VKDLDWKWVI FWSYVFGSCL NHSMTLAIHE ISHNFPFGHH KALWNRWFGM FANLSLGVPY 

       130        140        150        160        170        180 
SISFKRYHMD HHRYLGADKI DVDIPTDFEG WFFCTTFRKF VWVILQPLFY AFRPLFINPK 

       190        200        210        220        230        240 
PITYLEIINT VIQITFDIII YYVFGVKSLV YMLAATLLGL GLHPISGHFI AEHYMFLKGH 

       250        260        270        280        290        300 
ETYSYYGPLN LLTFNVGYHN EHHDFPNVPG KNLPMVRKIA SEYYDDLPHY NSWIKVLYDF 

       310        320 
VTDDTISPYS RMKRPPKGNE ILE

« Hide

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References

« Hide 'large scale' references
[1]"Mdes, a mouse homolog of the Drosophila degenerative spermatocyte gene is expressed during mouse spermatogenesis."
Endo K., Matsuda Y., Kobayashi S.
Dev. Growth Differ. 39:399-403(1997) [PubMed: 9227906] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
Strain: ddY.
Tissue: Testis.
[2]"Identification and characterization of a sphingolipid delta 4-desaturase family."
Ternes P., Franke S., Zaehringer U., Sperling P., Heinz E.
J. Biol. Chem. 277:25512-25518(2002) [PubMed: 11937514] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
Strain: C57BL/6.
Tissue: Kidney.
[3]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Bone marrow macrophage, Egg, Kidney, Ovary and Uterus.
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N.
Tissue: Mammary tumor.

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Cross-references

Sequence databases

Y08460 mRNA. Translation: CAA69714.1.
AF466376 mRNA. Translation: AAM12532.1.
AK002617 mRNA. Translation: BAB22233.1.
AK077257 mRNA. Translation: BAC36713.1.
AK149811 mRNA. Translation: BAE29098.1.
AK163404 mRNA. Translation: BAE37337.1.
BC003751 mRNA. Translation: AAH03751.1.
IPIIPI00113731.
RefSeqNP_031879.1.
UniGeneMm.29648

3D structure databases

ModBaseSearch...

PTM databases

PhosphoSiteO09005.

Proteomic databases

PRIDEO09005.

Genome annotation databases

EnsemblENSMUSG00000038633. Mus musculus. [Contig view]
GeneID13244.
KEGGmmu:13244.

Organism-specific databases

MGIMGI:1097711. Degs1.

Phylogenomic databases

HOGENOMO09005.
HOVERGENO09005.
OMAO09005. HNSAFGH.

Gene expression databases

ArrayExpressO09005.
BgeeO09005.
CleanExMM_DEGS1.

Family and domain databases

InterProIPR005804. Fatty_acid_desaturase-1.
IPR011388. Sphingolipid_d4-desaturase.
IPR013866. Sphingolipid_d4-desaturase_N.
[Graphical view]
PfamPF00487. FA_desaturase. 1 hit.
PF08557. Lipid_DES. 1 hit.
[Graphical view]
PIRSFPIRSF017228. Sphnglp_dlt4_des. 1 hit.
ProDomPD001081. FA_desat_sub. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetSearch...

Other Resources

NextBio283464.
SOURCESearch...

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Entry information

Entry nameDEGS1_MOUSE
AccessionPrimary (citable) accession number: O09005
Secondary accession number(s): Q8R4H3
Entry history
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: July 1, 1997
Last modified: June 16, 2009
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents