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O08997

- ATOX1_MOUSE

UniProt

O08997 - ATOX1_MOUSE

Protein

Copper transport protein ATOX1

Gene

Atox1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Binds and deliver cytosolic copper to the copper ATPase proteins. May be important in cellular antioxidant defense By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi12 – 121CopperPROSITE-ProRule annotation
    Metal bindingi15 – 151CopperPROSITE-ProRule annotation

    GO - Molecular functioni

    1. copper chaperone activity Source: Ensembl

    GO - Biological processi

    1. cellular copper ion homeostasis Source: MGI
    2. copper ion transport Source: MGI
    3. response to oxidative stress Source: Ensembl

    Keywords - Molecular functioni

    Chaperone

    Keywords - Biological processi

    Copper transport, Ion transport, Transport

    Keywords - Ligandi

    Copper, Metal-binding

    Enzyme and pathway databases

    ReactomeiREACT_189141. Detoxification of Reactive Oxygen Species.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Copper transport protein ATOX1
    Alternative name(s):
    Metal transport protein ATX1
    Gene namesi
    Name:Atox1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 11

    Organism-specific databases

    MGIiMGI:1333855. Atox1.

    Subcellular locationi

    GO - Cellular componenti

    1. cytosol Source: Reactome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 6868Copper transport protein ATOX1PRO_0000212538Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei60 – 601N6-acetyllysine1 Publication

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiO08997.
    PaxDbiO08997.
    PRIDEiO08997.

    PTM databases

    PhosphoSiteiO08997.

    Expressioni

    Gene expression databases

    BgeeiO08997.
    CleanExiMM_ATOX1.
    GenevestigatoriO08997.

    Interactioni

    Subunit structurei

    Interacts with ATP7B.By similarity

    Protein-protein interaction databases

    IntActiO08997. 2 interactions.
    MINTiMINT-1855862.
    STRINGi10090.ENSMUSP00000104485.

    Structurei

    3D structure databases

    ProteinModelPortaliO08997.
    SMRiO08997. Positions 2-66.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini2 – 6867HMAPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the ATX1 family.Curated
    Contains 1 HMA domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG238748.
    GeneTreeiENSGT00390000005805.
    HOGENOMiHOG000038877.
    HOVERGENiHBG050610.
    InParanoidiQ5NCU2.
    KOiK07213.
    OrthoDBiEOG786H6B.
    PhylomeDBiO08997.
    TreeFamiTF352589.

    Family and domain databases

    InterProiIPR017969. Heavy-metal-associated_CS.
    IPR006121. HeavyMe-assoc_HMA.
    [Graphical view]
    PfamiPF00403. HMA. 1 hit.
    [Graphical view]
    SUPFAMiSSF55008. SSF55008. 1 hit.
    PROSITEiPS01047. HMA_1. 1 hit.
    PS50846. HMA_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O08997-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPKHEFSVDM TCEGCAEAVS RVLNKLGGVE FNIDLPNKKV CIDSEHSSDT   50
    LLATLNKTGK AVSYLGPK 68
    Length:68
    Mass (Da):7,338
    Last modified:July 1, 1997 - v1
    Checksum:i85D11908CCDC6372
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF004591 mRNA. Translation: AAB61465.1.
    AK002432 mRNA. Translation: BAB22098.1.
    AL596207 Genomic DNA. Translation: CAI35353.1.
    BC027632 mRNA. Translation: AAH27632.1.
    CCDSiCCDS36158.1.
    RefSeqiNP_033850.1. NM_009720.2.
    UniGeneiMm.217759.

    Genome annotation databases

    EnsembliENSMUST00000108857; ENSMUSP00000104485; ENSMUSG00000018585.
    GeneIDi11927.
    KEGGimmu:11927.
    UCSCiuc007izj.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF004591 mRNA. Translation: AAB61465.1 .
    AK002432 mRNA. Translation: BAB22098.1 .
    AL596207 Genomic DNA. Translation: CAI35353.1 .
    BC027632 mRNA. Translation: AAH27632.1 .
    CCDSi CCDS36158.1.
    RefSeqi NP_033850.1. NM_009720.2.
    UniGenei Mm.217759.

    3D structure databases

    ProteinModelPortali O08997.
    SMRi O08997. Positions 2-66.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi O08997. 2 interactions.
    MINTi MINT-1855862.
    STRINGi 10090.ENSMUSP00000104485.

    PTM databases

    PhosphoSitei O08997.

    Proteomic databases

    MaxQBi O08997.
    PaxDbi O08997.
    PRIDEi O08997.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000108857 ; ENSMUSP00000104485 ; ENSMUSG00000018585 .
    GeneIDi 11927.
    KEGGi mmu:11927.
    UCSCi uc007izj.1. mouse.

    Organism-specific databases

    CTDi 475.
    MGIi MGI:1333855. Atox1.

    Phylogenomic databases

    eggNOGi NOG238748.
    GeneTreei ENSGT00390000005805.
    HOGENOMi HOG000038877.
    HOVERGENi HBG050610.
    InParanoidi Q5NCU2.
    KOi K07213.
    OrthoDBi EOG786H6B.
    PhylomeDBi O08997.
    TreeFami TF352589.

    Enzyme and pathway databases

    Reactomei REACT_189141. Detoxification of Reactive Oxygen Species.

    Miscellaneous databases

    NextBioi 280009.
    PROi O08997.
    SOURCEi Search...

    Gene expression databases

    Bgeei O08997.
    CleanExi MM_ATOX1.
    Genevestigatori O08997.

    Family and domain databases

    InterProi IPR017969. Heavy-metal-associated_CS.
    IPR006121. HeavyMe-assoc_HMA.
    [Graphical view ]
    Pfami PF00403. HMA. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55008. SSF55008. 1 hit.
    PROSITEi PS01047. HMA_1. 1 hit.
    PS50846. HMA_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Structure, expression, and chromosomal localization of the mouse Atox1 gene."
      Hamza I., Klomp L.W.J., Gaedigk R., White R.A., Gitlin J.D.
      Genomics 63:294-297(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: BALB/c.
      Tissue: Lung.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Kidney.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Thymus.
    5. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
      Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
      Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-60, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Embryonic fibroblast.

    Entry informationi

    Entry nameiATOX1_MOUSE
    AccessioniPrimary (citable) accession number: O08997
    Secondary accession number(s): Q5NCU2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: July 1, 1997
    Last modified: October 1, 2014
    This is version 103 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3