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Protein

Copper transport protein ATOX1

Gene

Atox1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds and deliver cytosolic copper to the copper ATPase proteins. May be important in cellular antioxidant defense (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi12CopperPROSITE-ProRule annotation1
Metal bindingi15CopperPROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

  • cellular copper ion homeostasis Source: MGI
  • copper ion transport Source: MGI
  • intracellular copper ion transport Source: MGI
  • response to oxidative stress Source: MGI

Keywordsi

Molecular functionChaperone
Biological processCopper transport, Ion transport, Transport
LigandCopper, Metal-binding

Enzyme and pathway databases

ReactomeiR-MMU-6803544 Ion influx/efflux at host-pathogen interface

Names & Taxonomyi

Protein namesi
Recommended name:
Copper transport protein ATOX1
Alternative name(s):
Metal transport protein ATX1
Gene namesi
Name:Atox1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1333855 Atox1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002125381 – 68Copper transport protein ATOX1Add BLAST68

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei47PhosphoserineBy similarity1
Modified residuei60N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiO08997
MaxQBiO08997
PaxDbiO08997
PeptideAtlasiO08997
PRIDEiO08997
TopDownProteomicsiO08997

PTM databases

iPTMnetiO08997
PhosphoSitePlusiO08997
SwissPalmiO08997

Expressioni

Gene expression databases

BgeeiENSMUSG00000018585
CleanExiMM_ATOX1
GenevisibleiO08997 MM

Interactioni

Subunit structurei

Interacts with ATP7B (By similarity). Interacts with ATP7A (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiO08997, 2 interactors
MINTiO08997
STRINGi10090.ENSMUSP00000104485

Structurei

3D structure databases

ProteinModelPortaliO08997
SMRiO08997
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 68HMAPROSITE-ProRule annotationAdd BLAST67

Sequence similaritiesi

Belongs to the ATX1 family.Curated

Phylogenomic databases

eggNOGiKOG1603 Eukaryota
COG2608 LUCA
GeneTreeiENSGT00390000005805
HOGENOMiHOG000038877
HOVERGENiHBG050610
InParanoidiO08997
KOiK07213
OMAiHEFFVDM
OrthoDBiEOG091G1614
PhylomeDBiO08997
TreeFamiTF352589

Family and domain databases

CDDicd00371 HMA, 1 hit
InterProiView protein in InterPro
IPR017969 Heavy-metal-associated_CS
IPR006121 HMA_dom
IPR036163 HMA_dom_sf
PfamiView protein in Pfam
PF00403 HMA, 1 hit
SUPFAMiSSF55008 SSF55008, 1 hit
PROSITEiView protein in PROSITE
PS01047 HMA_1, 1 hit
PS50846 HMA_2, 1 hit

Sequencei

Sequence statusi: Complete.

O08997-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPKHEFSVDM TCEGCAEAVS RVLNKLGGVE FNIDLPNKKV CIDSEHSSDT
60
LLATLNKTGK AVSYLGPK
Length:68
Mass (Da):7,338
Last modified:July 1, 1997 - v1
Checksum:i85D11908CCDC6372
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF004591 mRNA Translation: AAB61465.1
AK002432 mRNA Translation: BAB22098.1
AL596207 Genomic DNA No translation available.
BC027632 mRNA Translation: AAH27632.1
CCDSiCCDS36158.1
RefSeqiNP_033850.1, NM_009720.2
UniGeneiMm.217759

Genome annotation databases

EnsembliENSMUST00000108857; ENSMUSP00000104485; ENSMUSG00000018585
GeneIDi11927
KEGGimmu:11927
UCSCiuc007izj.1 mouse

Similar proteinsi

Entry informationi

Entry nameiATOX1_MOUSE
AccessioniPrimary (citable) accession number: O08997
Secondary accession number(s): Q5NCU2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: July 1, 1997
Last modified: June 20, 2018
This is version 131 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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