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O08992

- SDCB1_MOUSE

UniProt

O08992 - SDCB1_MOUSE

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Protein

Syntenin-1

Gene

Sdcbp

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Seems to function as an adapter protein. In adherens junctions may function to couple syndecans to cytoskeletal proteins or signaling components. Seems to couple transcription factor SOX4 to the IL-5 receptor (IL5RA). May also play a role in vesicular trafficking. Seems to be required for the targeting of TGFA to the cell surface in the early secretory pathway.

GO - Molecular functioni

  1. interleukin-5 receptor binding Source: UniProtKB

GO - Biological processi

  1. positive regulation of phosphorylation Source: Ensembl
  2. Ras protein signal transduction Source: MGI
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_235102. Neurofascin interactions.
REACT_241951. Ephrin signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Syntenin-1
Alternative name(s):
Scaffold protein Pbp1
Syndecan-binding protein 1
Gene namesi
Name:Sdcbp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 4

Organism-specific databases

MGIiMGI:1337026. Sdcbp.

Subcellular locationi

Membrane By similarity; Peripheral membrane protein By similarity. Melanosome By similarity

GO - Cellular componenti

  1. blood microparticle Source: Ensembl
  2. cytoplasm Source: Ensembl
  3. extracellular vesicular exosome Source: Ensembl
  4. interleukin-5 receptor complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 299298Syntenin-1PRO_0000184002Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserineBy similarity

Post-translational modificationi

Phosphorylated on tyrosine residues.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiO08992.
PaxDbiO08992.
PRIDEiO08992.

PTM databases

PhosphoSiteiO08992.

Expressioni

Gene expression databases

BgeeiO08992.
CleanExiMM_SDCBP.
ExpressionAtlasiO08992. baseline and differential.
GenevestigatoriO08992.

Interactioni

Subunit structurei

Monomer and homodimer. Interacts with SDC1, SDC2, SDC3, SDC4, NRXN2, EPHA7, EPHB1, NF2 isoform 1, TGFA, IL5RA, neurofascin, SDCBP2 and PTPRJ.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
Efnb1P527953EBI-538265,EBI-8107507

Protein-protein interaction databases

BioGridi207300. 1 interaction.
IntActiO08992. 5 interactions.
MINTiMINT-140766.

Structurei

3D structure databases

ProteinModelPortaliO08992.
SMRiO08992. Positions 114-272.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini115 – 19480PDZ 1PROSITE-ProRule annotationAdd
BLAST
Domaini199 – 27375PDZ 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 2 PDZ (DHR) domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG140434.
GeneTreeiENSGT00390000014465.
HOGENOMiHOG000231604.
HOVERGENiHBG053211.
InParanoidiO08992.
KOiK17254.
OMAiMVRPVTG.
OrthoDBiEOG75MVWZ.
PhylomeDBiO08992.
TreeFamiTF327131.

Family and domain databases

Gene3Di2.30.42.10. 2 hits.
InterProiIPR001478. PDZ.
[Graphical view]
PfamiPF00595. PDZ. 2 hits.
[Graphical view]
SMARTiSM00228. PDZ. 2 hits.
[Graphical view]
SUPFAMiSSF50156. SSF50156. 2 hits.
PROSITEiPS50106. PDZ. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O08992-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSLYPSLEDL KVDKVIQAQT AYSANPASQA FVLVDASAAL PPDGNLYPKL
60 70 80 90 100
YPELSQYMGL SLNEAEICES MPMVSGAPAQ GQLVARPSSV NYMVAPVTGN
110 120 130 140 150
DAGIRRAEIK QGIREVILCK DQDGKIGLRL KSIDNGIFVQ LVQANSPASL
160 170 180 190 200
VGLRFGDQVL QINGENCAGW SSDKAHKVLK QAFGEKITMT IRDRPFERTV
210 220 230 240 250
TMHKDSSGHV GFIFKSGKIT SIVKDSSAAR NGLLTDHHIC EINGQNVIGL
260 270 280 290
KDAQIADILS TAGTVVTITI MPTFIFEHII KRMAPSIMKS LMDHTIPEV
Length:299
Mass (Da):32,379
Last modified:July 1, 1997 - v1
Checksum:i04FFF7A33A7F0195
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF003693 mRNA. Translation: AAB61293.1.
AK028429 mRNA. Translation: BAC25946.1.
AK033412 mRNA. Translation: BAC28275.1.
AK146085 mRNA. Translation: BAE26889.1.
AK150278 mRNA. Translation: BAE29434.1.
AK150321 mRNA. Translation: BAE29466.1.
AK150623 mRNA. Translation: BAE29713.1.
AK150721 mRNA. Translation: BAE29799.1.
AK150801 mRNA. Translation: BAE29864.1.
AK152017 mRNA. Translation: BAE30879.1.
AK152434 mRNA. Translation: BAE31216.1.
AK152552 mRNA. Translation: BAE31306.1.
AK159677 mRNA. Translation: BAE35280.1.
AK167513 mRNA. Translation: BAE39588.1.
AK168004 mRNA. Translation: BAE39992.1.
AK168777 mRNA. Translation: BAE40613.1.
AK169219 mRNA. Translation: BAE40990.1.
AK169687 mRNA. Translation: BAE41305.1.
AK171162 mRNA. Translation: BAE42284.1.
AL772306 Genomic DNA. Translation: CAM27239.1.
BC019400 mRNA. Translation: AAH19400.1.
CCDSiCCDS51110.1.
RefSeqiNP_001091697.1. NM_001098227.1.
NP_058087.2. NM_016807.2.
XP_006538147.1. XM_006538084.1.
UniGeneiMm.247473.
Mm.491105.

Genome annotation databases

EnsembliENSMUST00000029912; ENSMUSP00000029912; ENSMUSG00000028249.
GeneIDi53378.
KEGGimmu:53378.
UCSCiuc008rxn.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF003693 mRNA. Translation: AAB61293.1 .
AK028429 mRNA. Translation: BAC25946.1 .
AK033412 mRNA. Translation: BAC28275.1 .
AK146085 mRNA. Translation: BAE26889.1 .
AK150278 mRNA. Translation: BAE29434.1 .
AK150321 mRNA. Translation: BAE29466.1 .
AK150623 mRNA. Translation: BAE29713.1 .
AK150721 mRNA. Translation: BAE29799.1 .
AK150801 mRNA. Translation: BAE29864.1 .
AK152017 mRNA. Translation: BAE30879.1 .
AK152434 mRNA. Translation: BAE31216.1 .
AK152552 mRNA. Translation: BAE31306.1 .
AK159677 mRNA. Translation: BAE35280.1 .
AK167513 mRNA. Translation: BAE39588.1 .
AK168004 mRNA. Translation: BAE39992.1 .
AK168777 mRNA. Translation: BAE40613.1 .
AK169219 mRNA. Translation: BAE40990.1 .
AK169687 mRNA. Translation: BAE41305.1 .
AK171162 mRNA. Translation: BAE42284.1 .
AL772306 Genomic DNA. Translation: CAM27239.1 .
BC019400 mRNA. Translation: AAH19400.1 .
CCDSi CCDS51110.1.
RefSeqi NP_001091697.1. NM_001098227.1.
NP_058087.2. NM_016807.2.
XP_006538147.1. XM_006538084.1.
UniGenei Mm.247473.
Mm.491105.

3D structure databases

ProteinModelPortali O08992.
SMRi O08992. Positions 114-272.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 207300. 1 interaction.
IntActi O08992. 5 interactions.
MINTi MINT-140766.

PTM databases

PhosphoSitei O08992.

Proteomic databases

MaxQBi O08992.
PaxDbi O08992.
PRIDEi O08992.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000029912 ; ENSMUSP00000029912 ; ENSMUSG00000028249 .
GeneIDi 53378.
KEGGi mmu:53378.
UCSCi uc008rxn.1. mouse.

Organism-specific databases

CTDi 6386.
MGIi MGI:1337026. Sdcbp.

Phylogenomic databases

eggNOGi NOG140434.
GeneTreei ENSGT00390000014465.
HOGENOMi HOG000231604.
HOVERGENi HBG053211.
InParanoidi O08992.
KOi K17254.
OMAi MVRPVTG.
OrthoDBi EOG75MVWZ.
PhylomeDBi O08992.
TreeFami TF327131.

Enzyme and pathway databases

Reactomei REACT_235102. Neurofascin interactions.
REACT_241951. Ephrin signaling.

Miscellaneous databases

ChiTaRSi Sdcbp. mouse.
NextBioi 310193.
PROi O08992.
SOURCEi Search...

Gene expression databases

Bgeei O08992.
CleanExi MM_SDCBP.
ExpressionAtlasi O08992. baseline and differential.
Genevestigatori O08992.

Family and domain databases

Gene3Di 2.30.42.10. 2 hits.
InterProi IPR001478. PDZ.
[Graphical view ]
Pfami PF00595. PDZ. 2 hits.
[Graphical view ]
SMARTi SM00228. PDZ. 2 hits.
[Graphical view ]
SUPFAMi SSF50156. SSF50156. 2 hits.
PROSITEi PS50106. PDZ. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A new family of scaffold proteins."
    Burbelo P.D.
    Submitted (JUN-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Hsu S.I.-H., Hentschel D.M., Bonventre J.V.
    Submitted (MAY-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J, DBA/2 and NOD.
    Tissue: Amnion, Bone marrow, Heart, Kidney, Liver and Thymus.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiSDCB1_MOUSE
AccessioniPrimary (citable) accession number: O08992
Secondary accession number(s): A2AKJ7, Q544P5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2002
Last sequence update: July 1, 1997
Last modified: November 26, 2014
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3