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O08992

- SDCB1_MOUSE

UniProt

O08992 - SDCB1_MOUSE

Protein

Syntenin-1

Gene

Sdcbp

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 116 (01 Oct 2014)
      Sequence version 1 (01 Jul 1997)
      Previous versions | rss
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    Functioni

    Seems to function as an adapter protein. In adherens junctions may function to couple syndecans to cytoskeletal proteins or signaling components. Seems to couple transcription factor SOX4 to the IL-5 receptor (IL5RA). May also play a role in vesicular trafficking. Seems to be required for the targeting of TGFA to the cell surface in the early secretory pathway.

    GO - Molecular functioni

    1. interleukin-5 receptor binding Source: UniProtKB
    2. protein binding Source: UniProtKB

    GO - Biological processi

    1. positive regulation of phosphorylation Source: Ensembl
    2. Ras protein signal transduction Source: MGI

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Syntenin-1
    Alternative name(s):
    Scaffold protein Pbp1
    Syndecan-binding protein 1
    Gene namesi
    Name:Sdcbp
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 4

    Organism-specific databases

    MGIiMGI:1337026. Sdcbp.

    Subcellular locationi

    Membrane By similarity; Peripheral membrane protein By similarity. Melanosome By similarity

    GO - Cellular componenti

    1. extracellular vesicular exosome Source: Ensembl
    2. interleukin-5 receptor complex Source: UniProtKB
    3. melanosome Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 299298Syntenin-1PRO_0000184002Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylserineBy similarity

    Post-translational modificationi

    Phosphorylated on tyrosine residues.By similarity

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiO08992.
    PaxDbiO08992.
    PRIDEiO08992.

    PTM databases

    PhosphoSiteiO08992.

    Expressioni

    Gene expression databases

    ArrayExpressiO08992.
    BgeeiO08992.
    CleanExiMM_SDCBP.
    GenevestigatoriO08992.

    Interactioni

    Subunit structurei

    Monomer and homodimer. Interacts with SDC1, SDC2, SDC3, SDC4, NRXN2, EPHA7, EPHB1, NF2 isoform 1, TGFA, IL5RA, neurofascin, SDCBP2 and PTPRJ.By similarity

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    Efnb1P527953EBI-538265,EBI-8107507

    Protein-protein interaction databases

    BioGridi207300. 1 interaction.
    IntActiO08992. 5 interactions.
    MINTiMINT-140766.

    Structurei

    3D structure databases

    ProteinModelPortaliO08992.
    SMRiO08992. Positions 114-272.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini115 – 19480PDZ 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini199 – 27375PDZ 2PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 2 PDZ (DHR) domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiNOG140434.
    GeneTreeiENSGT00390000014465.
    HOGENOMiHOG000231604.
    HOVERGENiHBG053211.
    InParanoidiA2AKJ7.
    KOiK17254.
    OMAiMVRPVTG.
    OrthoDBiEOG75MVWZ.
    PhylomeDBiO08992.
    TreeFamiTF327131.

    Family and domain databases

    Gene3Di2.30.42.10. 2 hits.
    InterProiIPR001478. PDZ.
    [Graphical view]
    PfamiPF00595. PDZ. 2 hits.
    [Graphical view]
    SMARTiSM00228. PDZ. 2 hits.
    [Graphical view]
    SUPFAMiSSF50156. SSF50156. 2 hits.
    PROSITEiPS50106. PDZ. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O08992-1 [UniParc]FASTAAdd to Basket

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    MSLYPSLEDL KVDKVIQAQT AYSANPASQA FVLVDASAAL PPDGNLYPKL    50
    YPELSQYMGL SLNEAEICES MPMVSGAPAQ GQLVARPSSV NYMVAPVTGN 100
    DAGIRRAEIK QGIREVILCK DQDGKIGLRL KSIDNGIFVQ LVQANSPASL 150
    VGLRFGDQVL QINGENCAGW SSDKAHKVLK QAFGEKITMT IRDRPFERTV 200
    TMHKDSSGHV GFIFKSGKIT SIVKDSSAAR NGLLTDHHIC EINGQNVIGL 250
    KDAQIADILS TAGTVVTITI MPTFIFEHII KRMAPSIMKS LMDHTIPEV 299
    Length:299
    Mass (Da):32,379
    Last modified:July 1, 1997 - v1
    Checksum:i04FFF7A33A7F0195
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF003693 mRNA. Translation: AAB61293.1.
    AK028429 mRNA. Translation: BAC25946.1.
    AK033412 mRNA. Translation: BAC28275.1.
    AK146085 mRNA. Translation: BAE26889.1.
    AK150278 mRNA. Translation: BAE29434.1.
    AK150321 mRNA. Translation: BAE29466.1.
    AK150623 mRNA. Translation: BAE29713.1.
    AK150721 mRNA. Translation: BAE29799.1.
    AK150801 mRNA. Translation: BAE29864.1.
    AK152017 mRNA. Translation: BAE30879.1.
    AK152434 mRNA. Translation: BAE31216.1.
    AK152552 mRNA. Translation: BAE31306.1.
    AK159677 mRNA. Translation: BAE35280.1.
    AK167513 mRNA. Translation: BAE39588.1.
    AK168004 mRNA. Translation: BAE39992.1.
    AK168777 mRNA. Translation: BAE40613.1.
    AK169219 mRNA. Translation: BAE40990.1.
    AK169687 mRNA. Translation: BAE41305.1.
    AK171162 mRNA. Translation: BAE42284.1.
    AL772306 Genomic DNA. Translation: CAM27239.1.
    BC019400 mRNA. Translation: AAH19400.1.
    CCDSiCCDS51110.1.
    RefSeqiNP_001091697.1. NM_001098227.1.
    NP_058087.2. NM_016807.2.
    XP_006538147.1. XM_006538084.1.
    UniGeneiMm.247473.
    Mm.491105.

    Genome annotation databases

    EnsembliENSMUST00000029912; ENSMUSP00000029912; ENSMUSG00000028249.
    GeneIDi53378.
    KEGGimmu:53378.
    UCSCiuc008rxn.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF003693 mRNA. Translation: AAB61293.1 .
    AK028429 mRNA. Translation: BAC25946.1 .
    AK033412 mRNA. Translation: BAC28275.1 .
    AK146085 mRNA. Translation: BAE26889.1 .
    AK150278 mRNA. Translation: BAE29434.1 .
    AK150321 mRNA. Translation: BAE29466.1 .
    AK150623 mRNA. Translation: BAE29713.1 .
    AK150721 mRNA. Translation: BAE29799.1 .
    AK150801 mRNA. Translation: BAE29864.1 .
    AK152017 mRNA. Translation: BAE30879.1 .
    AK152434 mRNA. Translation: BAE31216.1 .
    AK152552 mRNA. Translation: BAE31306.1 .
    AK159677 mRNA. Translation: BAE35280.1 .
    AK167513 mRNA. Translation: BAE39588.1 .
    AK168004 mRNA. Translation: BAE39992.1 .
    AK168777 mRNA. Translation: BAE40613.1 .
    AK169219 mRNA. Translation: BAE40990.1 .
    AK169687 mRNA. Translation: BAE41305.1 .
    AK171162 mRNA. Translation: BAE42284.1 .
    AL772306 Genomic DNA. Translation: CAM27239.1 .
    BC019400 mRNA. Translation: AAH19400.1 .
    CCDSi CCDS51110.1.
    RefSeqi NP_001091697.1. NM_001098227.1.
    NP_058087.2. NM_016807.2.
    XP_006538147.1. XM_006538084.1.
    UniGenei Mm.247473.
    Mm.491105.

    3D structure databases

    ProteinModelPortali O08992.
    SMRi O08992. Positions 114-272.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 207300. 1 interaction.
    IntActi O08992. 5 interactions.
    MINTi MINT-140766.

    PTM databases

    PhosphoSitei O08992.

    Proteomic databases

    MaxQBi O08992.
    PaxDbi O08992.
    PRIDEi O08992.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000029912 ; ENSMUSP00000029912 ; ENSMUSG00000028249 .
    GeneIDi 53378.
    KEGGi mmu:53378.
    UCSCi uc008rxn.1. mouse.

    Organism-specific databases

    CTDi 6386.
    MGIi MGI:1337026. Sdcbp.

    Phylogenomic databases

    eggNOGi NOG140434.
    GeneTreei ENSGT00390000014465.
    HOGENOMi HOG000231604.
    HOVERGENi HBG053211.
    InParanoidi A2AKJ7.
    KOi K17254.
    OMAi MVRPVTG.
    OrthoDBi EOG75MVWZ.
    PhylomeDBi O08992.
    TreeFami TF327131.

    Miscellaneous databases

    ChiTaRSi SDCBP. mouse.
    NextBioi 310193.
    PROi O08992.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O08992.
    Bgeei O08992.
    CleanExi MM_SDCBP.
    Genevestigatori O08992.

    Family and domain databases

    Gene3Di 2.30.42.10. 2 hits.
    InterProi IPR001478. PDZ.
    [Graphical view ]
    Pfami PF00595. PDZ. 2 hits.
    [Graphical view ]
    SMARTi SM00228. PDZ. 2 hits.
    [Graphical view ]
    SUPFAMi SSF50156. SSF50156. 2 hits.
    PROSITEi PS50106. PDZ. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A new family of scaffold proteins."
      Burbelo P.D.
      Submitted (JUN-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. Hsu S.I.-H., Hentschel D.M., Bonventre J.V.
      Submitted (MAY-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J, DBA/2 and NOD.
      Tissue: Amnion, Bone marrow, Heart, Kidney, Liver and Thymus.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

    Entry informationi

    Entry nameiSDCB1_MOUSE
    AccessioniPrimary (citable) accession number: O08992
    Secondary accession number(s): A2AKJ7, Q544P5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 2, 2002
    Last sequence update: July 1, 1997
    Last modified: October 1, 2014
    This is version 116 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3