Mras

Functionⁱ

May serve as an important signal transducer for a novel upstream stimuli in controlling cell proliferation. Weakly activates the MAP kinase pathway (By similarity).By similarity

Regions

Feature key	Position(s)	DescriptionActions	Length
Nucleotide bindingⁱ	20 – 27	GTPBy similarity	8
Nucleotide bindingⁱ	67 – 71	GTPBy similarity	5
Nucleotide bindingⁱ	126 – 129	GTPBy similarity	4

GO - Molecular functionⁱ

GTPase activity Source: InterPro
GTP binding Source: UniProtKB-KW
GTP-dependent protein binding Source: MGI

Complete GO annotation...

GO - Biological processⁱ

signal transduction Source: InterPro

Complete GO annotation...

Keywordsⁱ

Ligand	GTP-binding, Nucleotide-binding

Ligand

GTP-binding, Nucleotide-binding

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Ras-related protein M-Ras Alternative name(s): Muscle and microspikes Ras Ras-related protein R-Ras3 X-Ras
Gene namesⁱ	Name:Mras Synonyms:Xras
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 9

Organism-specific databases

MGIⁱ	MGI:1100856. Mras.

Subcellular locationⁱ

Cell membrane Curated; Lipid-anchor Curated; Cytoplasmic side Curated

GO - Cellular componentⁱ

extracellular exosome Source: MGI
plasma membrane Source: UniProtKB-SubCell

Complete GO annotation...

Keywords - Cellular componentⁱ

Cell membrane, Membrane

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000082655	1 – 205	Ras-related protein M-RasAdd BLAST		205
PropeptideⁱPRO_0000281305	206 – 208	Removed in mature formBy similarity		3

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	205	Cysteine methyl esterBy similarity		1
Lipidationⁱ	205	S-geranylgeranyl cysteineBy similarity		1

Keywords - PTMⁱ

Lipoprotein, Methylation, Prenylation

Proteomic databases

PaxDbⁱ	O08989.
PeptideAtlas More...PeptideAtlasⁱ	O08989.
PRIDEⁱ	O08989.

PTM databases

iPTMnetⁱ	O08989.
PhosphoSitePlusⁱ	O08989.

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000032470.
CleanExⁱ	MM_MRAS.
ExpressionAtlasⁱ	O08989. baseline and differential.
Genevisibleⁱ	O08989. MM.

Interactionⁱ

Subunit structureⁱ

Forms a multiprotein complex with SHOC2, Raf (RAF1) and protein phosphatase 1 (PPP1CA, PPP1CB and PPP1CC). Interacts (active GTP-bound form preferentially) with RGS14 (By similarity). Interacts with RGL3.By similarity1 Publication

GO - Molecular functionⁱ

GTP-dependent protein binding Source: MGI

Complete GO annotation...

Protein-protein interaction databases

BioGridⁱ	201483. 2 interactors.
IntActⁱ	O08989. 1 interactor.
STRINGⁱ	10090.ENSMUSP00000035045.

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Show more details

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	13 – 19	Combined sources	7
Helixⁱ	26 – 35	Combined sources	10
Helixⁱ	39 – 41	Combined sources	3
Helixⁱ	44 – 46	Combined sources	3
Beta strandⁱ	48 – 56	Combined sources	9
Beta strandⁱ	59 – 67	Combined sources	9
Helixⁱ	72 – 74	Combined sources	3
Helixⁱ	78 – 84	Combined sources	7
Beta strandⁱ	86 – 93	Combined sources	8
Helixⁱ	97 – 101	Combined sources	5
Helixⁱ	103 – 114	Combined sources	12
Beta strandⁱ	121 – 126	Combined sources	6
Helixⁱ	131 – 133	Combined sources	3
Helixⁱ	138 – 148	Combined sources	11
Beta strandⁱ	152 – 156	Combined sources	5
Beta strandⁱ	158 – 160	Combined sources	3
Helixⁱ	164 – 177	Combined sources	14

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1X1R	X-ray	1.30	A	1-178	[»]
	1X1S	X-ray	2.20	A	1-178	[»]
	3KKO	X-ray	1.90	A/B/P	1-178	[»]
	3KKP	X-ray	1.35	A	1-178	[»]
	3KKQ	X-ray	1.20	A	1-178	[»]
	3PIR	X-ray	2.75	A	1-178	[»]
	3PIT	X-ray	1.55	A	1-178	[»]
ProteinModelPortalⁱ	O08989.
SMRⁱ	O08989.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	O08989.

EvolutionaryTraceⁱ

O08989.

Family & Domainsⁱ

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	42 – 50	Effector region		9

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	185 – 191	Poly-Lys		7

Sequence similaritiesⁱ

Belongs to the small GTPase superfamily. Ras family.Curated

Phylogenomic databases

eggNOGⁱ	KOG0395. Eukaryota. COG1100. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00860000133672.
HOGENOMⁱ	HOG000233973.
HOVERGENⁱ	HBG009351.
InParanoidⁱ	O08989.
KEGG Orthology (KO) More...KOⁱ	K07831.
OMAⁱ	FHEVVRI.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0UAU.
PhylomeDBⁱ	O08989.
TreeFamⁱ	TF312796.

Family and domain databases

InterProⁱ	View protein in InterPro IPR027417. P-loop_NTPase. IPR005225. Small_GTP-bd_dom. IPR001806. Small_GTPase. IPR020849. Small_GTPase_Ras.
PANTHERⁱ	PTHR24070. PTHR24070. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00071. Ras. 1 hit.
SUPFAMⁱ	SSF52540. SSF52540. 1 hit.
TIGRFAMsⁱ	TIGR00231. small_GTP. 1 hit.
PROSITEⁱ	View protein in PROSITE PS51421. RAS. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

O08989-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MATSAVPSEN LPTYKLVVVG DGGVGKSALT IQFFQKIFVP DYDPTIEDSY 
        60         70         80         90        100
LKHTEIDNQW AILDVLDTAG QEEFSAMREQ YMRTGDGFLI VYSVTDKASF 
       110        120        130        140        150
EHVDRFHQLI LRVKDRESFP MILVANKVDL MHLRKVTRDQ GKEMATKYNI 
       160        170        180        190        200
PYIETSAKDP PLNVDKTFHD LVRVIRQQVP EKNQKKKKKT KWRGDRATGT 

HKLQCVIL

Length:208

Mass (Da):23,901

Last modified:July 1, 1997 - v1

Checksum:ⁱ975CFDD1FDF37FCF

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB004879 mRNA. Translation: BAA20538.1. AF043581 mRNA. Translation: AAD02277.1. AF031159 mRNA. Translation: AAD01926.1. BC024389 mRNA. Translation: AAH24389.1.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS23433.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_032650.1. NM_008624.3. XP_006510888.1. XM_006510825.2.
UniGeneⁱ	Mm.2045.

Genome annotation databases

Ensemblⁱ	ENSMUST00000035045; ENSMUSP00000035045; ENSMUSG00000032470. ENSMUST00000119472; ENSMUSP00000112407; ENSMUSG00000032470. ENSMUST00000122384; ENSMUSP00000113275; ENSMUSG00000032470.
GeneIDⁱ	17532.
KEGGⁱ	mmu:17532.
UCSC genome browser More...UCSCⁱ	uc009rec.1. mouse.

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB004879 mRNA. Translation: BAA20538.1. AF043581 mRNA. Translation: AAD02277.1. AF031159 mRNA. Translation: AAD01926.1. BC024389 mRNA. Translation: AAH24389.1.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS23433.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_032650.1. NM_008624.3. XP_006510888.1. XM_006510825.2.
UniGeneⁱ	Mm.2045.

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1X1R	X-ray	1.30	A	1-178	[»]
	1X1S	X-ray	2.20	A	1-178	[»]
	3KKO	X-ray	1.90	A/B/P	1-178	[»]
	3KKP	X-ray	1.35	A	1-178	[»]
	3KKQ	X-ray	1.20	A	1-178	[»]
	3PIR	X-ray	2.75	A	1-178	[»]
	3PIT	X-ray	1.55	A	1-178	[»]
ProteinModelPortalⁱ	O08989.
SMRⁱ	O08989.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	201483. 2 interactors.
IntActⁱ	O08989. 1 interactor.
STRINGⁱ	10090.ENSMUSP00000035045.

PTM databases

iPTMnetⁱ	O08989.
PhosphoSitePlusⁱ	O08989.

Proteomic databases

PaxDbⁱ	O08989.
PeptideAtlas More...PeptideAtlasⁱ	O08989.
PRIDEⁱ	O08989.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000035045; ENSMUSP00000035045; ENSMUSG00000032470. ENSMUST00000119472; ENSMUSP00000112407; ENSMUSG00000032470. ENSMUST00000122384; ENSMUSP00000113275; ENSMUSG00000032470.
GeneIDⁱ	17532.
KEGGⁱ	mmu:17532.
UCSC genome browser More...UCSCⁱ	uc009rec.1. mouse.

Organism-specific databases

CTDⁱ	22808.
MGIⁱ	MGI:1100856. Mras.

Phylogenomic databases

eggNOGⁱ	KOG0395. Eukaryota. COG1100. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00860000133672.
HOGENOMⁱ	HOG000233973.
HOVERGENⁱ	HBG009351.
InParanoidⁱ	O08989.
KEGG Orthology (KO) More...KOⁱ	K07831.
OMAⁱ	FHEVVRI.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0UAU.
PhylomeDBⁱ	O08989.
TreeFamⁱ	TF312796.

Miscellaneous databases

ChiTaRSⁱ	Mras. mouse.
EvolutionaryTraceⁱ	O08989.
Protein Ontology More...PROⁱ	PR:O08989.
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000032470.
CleanExⁱ	MM_MRAS.
ExpressionAtlasⁱ	O08989. baseline and differential.
Genevisibleⁱ	O08989. MM.

Family and domain databases

InterProⁱ	View protein in InterPro IPR027417. P-loop_NTPase. IPR005225. Small_GTP-bd_dom. IPR001806. Small_GTPase. IPR020849. Small_GTPase_Ras.
PANTHERⁱ	PTHR24070. PTHR24070. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00071. Ras. 1 hit.
SUPFAMⁱ	SSF52540. SSF52540. 1 hit.
TIGRFAMsⁱ	TIGR00231. small_GTP. 1 hit.
PROSITEⁱ	View protein in PROSITE PS51421. RAS. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	RASM_MOUSE
Accessionⁱ	O08989Primary (citable) accession number: O08989
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 21, 2001
	Last sequence update:	July 1, 1997
	Last modified:	June 7, 2017
	This is version 148 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
SIMILARITY comments
Index of protein domains and families

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - O08989 (RASM_MOUSE)

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Ras-related protein M-Ras

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Motif

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ