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Protein

Ras-related protein M-Ras

Gene

Mras

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May serve as an important signal transducer for a novel upstream stimuli in controlling cell proliferation. Weakly activates the MAP kinase pathway (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi20 – 27GTPBy similarity8
Nucleotide bindingi67 – 71GTPBy similarity5
Nucleotide bindingi126 – 129GTPBy similarity4

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein M-Ras
Alternative name(s):
Muscle and microspikes Ras
Ras-related protein R-Ras3
X-Ras
Gene namesi
Name:Mras
Synonyms:Xras
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1100856. Mras.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000826551 – 205Ras-related protein M-RasAdd BLAST205
PropeptideiPRO_0000281305206 – 208Removed in mature formBy similarity3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei205Cysteine methyl esterBy similarity1
Lipidationi205S-geranylgeranyl cysteineBy similarity1

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Proteomic databases

PaxDbiO08989.
PeptideAtlasiO08989.
PRIDEiO08989.

PTM databases

iPTMnetiO08989.
PhosphoSitePlusiO08989.

Expressioni

Gene expression databases

BgeeiENSMUSG00000032470.
CleanExiMM_MRAS.
ExpressionAtlasiO08989. baseline and differential.
GenevisibleiO08989. MM.

Interactioni

Subunit structurei

Forms a multiprotein complex with SHOC2, Raf (RAF1) and protein phosphatase 1 (PPP1CA, PPP1CB and PPP1CC). Interacts (active GTP-bound form preferentially) with RGS14 (By similarity). Interacts with RGL3.By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi201483. 2 interactors.
IntActiO08989. 1 interactor.
STRINGi10090.ENSMUSP00000035045.

Structurei

Secondary structure

1208
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi13 – 19Combined sources7
Helixi26 – 35Combined sources10
Helixi39 – 41Combined sources3
Helixi44 – 46Combined sources3
Beta strandi48 – 56Combined sources9
Beta strandi59 – 67Combined sources9
Helixi72 – 74Combined sources3
Helixi78 – 84Combined sources7
Beta strandi86 – 93Combined sources8
Helixi97 – 101Combined sources5
Helixi103 – 114Combined sources12
Beta strandi121 – 126Combined sources6
Helixi131 – 133Combined sources3
Helixi138 – 148Combined sources11
Beta strandi152 – 156Combined sources5
Beta strandi158 – 160Combined sources3
Helixi164 – 177Combined sources14

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1X1RX-ray1.30A1-178[»]
1X1SX-ray2.20A1-178[»]
3KKOX-ray1.90A/B/P1-178[»]
3KKPX-ray1.35A1-178[»]
3KKQX-ray1.20A1-178[»]
3PIRX-ray2.75A1-178[»]
3PITX-ray1.55A1-178[»]
ProteinModelPortaliO08989.
SMRiO08989.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO08989.

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi42 – 50Effector region9

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi185 – 191Poly-Lys7

Sequence similaritiesi

Belongs to the small GTPase superfamily. Ras family.Curated

Phylogenomic databases

eggNOGiKOG0395. Eukaryota.
COG1100. LUCA.
GeneTreeiENSGT00860000133672.
HOGENOMiHOG000233973.
HOVERGENiHBG009351.
InParanoidiO08989.
KOiK07831.
OMAiWVIMDVL.
OrthoDBiEOG091G0UAU.
PhylomeDBiO08989.
TreeFamiTF312796.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR020849. Small_GTPase_Ras.
[Graphical view]
PANTHERiPTHR24070. PTHR24070. 1 hit.
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51421. RAS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O08989-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATSAVPSEN LPTYKLVVVG DGGVGKSALT IQFFQKIFVP DYDPTIEDSY
60 70 80 90 100
LKHTEIDNQW AILDVLDTAG QEEFSAMREQ YMRTGDGFLI VYSVTDKASF
110 120 130 140 150
EHVDRFHQLI LRVKDRESFP MILVANKVDL MHLRKVTRDQ GKEMATKYNI
160 170 180 190 200
PYIETSAKDP PLNVDKTFHD LVRVIRQQVP EKNQKKKKKT KWRGDRATGT

HKLQCVIL
Length:208
Mass (Da):23,901
Last modified:July 1, 1997 - v1
Checksum:i975CFDD1FDF37FCF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB004879 mRNA. Translation: BAA20538.1.
AF043581 mRNA. Translation: AAD02277.1.
AF031159 mRNA. Translation: AAD01926.1.
BC024389 mRNA. Translation: AAH24389.1.
CCDSiCCDS23433.1.
RefSeqiNP_032650.1. NM_008624.3.
XP_006510888.1. XM_006510825.2.
UniGeneiMm.2045.

Genome annotation databases

EnsembliENSMUST00000035045; ENSMUSP00000035045; ENSMUSG00000032470.
ENSMUST00000119472; ENSMUSP00000112407; ENSMUSG00000032470.
ENSMUST00000122384; ENSMUSP00000113275; ENSMUSG00000032470.
GeneIDi17532.
KEGGimmu:17532.
UCSCiuc009rec.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB004879 mRNA. Translation: BAA20538.1.
AF043581 mRNA. Translation: AAD02277.1.
AF031159 mRNA. Translation: AAD01926.1.
BC024389 mRNA. Translation: AAH24389.1.
CCDSiCCDS23433.1.
RefSeqiNP_032650.1. NM_008624.3.
XP_006510888.1. XM_006510825.2.
UniGeneiMm.2045.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1X1RX-ray1.30A1-178[»]
1X1SX-ray2.20A1-178[»]
3KKOX-ray1.90A/B/P1-178[»]
3KKPX-ray1.35A1-178[»]
3KKQX-ray1.20A1-178[»]
3PIRX-ray2.75A1-178[»]
3PITX-ray1.55A1-178[»]
ProteinModelPortaliO08989.
SMRiO08989.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi201483. 2 interactors.
IntActiO08989. 1 interactor.
STRINGi10090.ENSMUSP00000035045.

PTM databases

iPTMnetiO08989.
PhosphoSitePlusiO08989.

Proteomic databases

PaxDbiO08989.
PeptideAtlasiO08989.
PRIDEiO08989.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000035045; ENSMUSP00000035045; ENSMUSG00000032470.
ENSMUST00000119472; ENSMUSP00000112407; ENSMUSG00000032470.
ENSMUST00000122384; ENSMUSP00000113275; ENSMUSG00000032470.
GeneIDi17532.
KEGGimmu:17532.
UCSCiuc009rec.1. mouse.

Organism-specific databases

CTDi22808.
MGIiMGI:1100856. Mras.

Phylogenomic databases

eggNOGiKOG0395. Eukaryota.
COG1100. LUCA.
GeneTreeiENSGT00860000133672.
HOGENOMiHOG000233973.
HOVERGENiHBG009351.
InParanoidiO08989.
KOiK07831.
OMAiWVIMDVL.
OrthoDBiEOG091G0UAU.
PhylomeDBiO08989.
TreeFamiTF312796.

Miscellaneous databases

ChiTaRSiMras. mouse.
EvolutionaryTraceiO08989.
PROiO08989.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000032470.
CleanExiMM_MRAS.
ExpressionAtlasiO08989. baseline and differential.
GenevisibleiO08989. MM.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR020849. Small_GTPase_Ras.
[Graphical view]
PANTHERiPTHR24070. PTHR24070. 1 hit.
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51421. RAS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRASM_MOUSE
AccessioniPrimary (citable) accession number: O08989
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: July 1, 1997
Last modified: November 30, 2016
This is version 143 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.