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Protein

Ras-related protein M-Ras

Gene

Mras

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May serve as an important signal transducer for a novel upstream stimuli in controlling cell proliferation. Weakly activates the MAP kinase pathway (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi20 – 278GTPBy similarity
Nucleotide bindingi67 – 715GTPBy similarity
Nucleotide bindingi126 – 1294GTPBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein M-Ras
Alternative name(s):
Muscle and microspikes Ras
Ras-related protein R-Ras3
X-Ras
Gene namesi
Name:Mras
Synonyms:Xras
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1100856. Mras.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 205205Ras-related protein M-RasPRO_0000082655Add
BLAST
Propeptidei206 – 2083Removed in mature formBy similarityPRO_0000281305

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei205 – 2051Cysteine methyl esterBy similarity
Lipidationi205 – 2051S-geranylgeranyl cysteineBy similarity

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Proteomic databases

PaxDbiO08989.
PRIDEiO08989.

PTM databases

iPTMnetiO08989.
PhosphoSiteiO08989.

Expressioni

Gene expression databases

BgeeiO08989.
CleanExiMM_MRAS.
ExpressionAtlasiO08989. baseline and differential.
GenevisibleiO08989. MM.

Interactioni

Subunit structurei

Forms a multiprotein complex with SHOC2, Raf (RAF1) and protein phosphatase 1 (PPP1CA, PPP1CB and PPP1CC). Interacts (active GTP-bound form preferentially) with RGS14 (By similarity). Interacts with RGL3.By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi201483. 2 interactions.
IntActiO08989. 1 interaction.
STRINGi10090.ENSMUSP00000035045.

Structurei

Secondary structure

1
208
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi13 – 197Combined sources
Helixi26 – 3510Combined sources
Helixi39 – 413Combined sources
Helixi44 – 463Combined sources
Beta strandi48 – 569Combined sources
Beta strandi59 – 679Combined sources
Helixi72 – 743Combined sources
Helixi78 – 847Combined sources
Beta strandi86 – 938Combined sources
Helixi97 – 1015Combined sources
Helixi103 – 11412Combined sources
Beta strandi121 – 1266Combined sources
Helixi131 – 1333Combined sources
Helixi138 – 14811Combined sources
Beta strandi152 – 1565Combined sources
Beta strandi158 – 1603Combined sources
Helixi164 – 17714Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1X1RX-ray1.30A1-178[»]
1X1SX-ray2.20A1-178[»]
3KKOX-ray1.90A/B/P1-178[»]
3KKPX-ray1.35A1-178[»]
3KKQX-ray1.20A1-178[»]
3PIRX-ray2.75A1-178[»]
3PITX-ray1.55A1-178[»]
ProteinModelPortaliO08989.
SMRiO08989. Positions 10-178.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO08989.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi42 – 509Effector region

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi185 – 1917Poly-Lys

Sequence similaritiesi

Belongs to the small GTPase superfamily. Ras family.Curated

Phylogenomic databases

eggNOGiKOG0395. Eukaryota.
COG1100. LUCA.
HOGENOMiHOG000233973.
HOVERGENiHBG009351.
InParanoidiO08989.
KOiK07831.
OMAiWVIMDVL.
OrthoDBiEOG7QVM41.
PhylomeDBiO08989.
TreeFamiTF312796.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR020849. Small_GTPase_Ras.
[Graphical view]
PANTHERiPTHR24070. PTHR24070. 1 hit.
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51421. RAS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O08989-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATSAVPSEN LPTYKLVVVG DGGVGKSALT IQFFQKIFVP DYDPTIEDSY
60 70 80 90 100
LKHTEIDNQW AILDVLDTAG QEEFSAMREQ YMRTGDGFLI VYSVTDKASF
110 120 130 140 150
EHVDRFHQLI LRVKDRESFP MILVANKVDL MHLRKVTRDQ GKEMATKYNI
160 170 180 190 200
PYIETSAKDP PLNVDKTFHD LVRVIRQQVP EKNQKKKKKT KWRGDRATGT

HKLQCVIL
Length:208
Mass (Da):23,901
Last modified:July 1, 1997 - v1
Checksum:i975CFDD1FDF37FCF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB004879 mRNA. Translation: BAA20538.1.
AF043581 mRNA. Translation: AAD02277.1.
AF031159 mRNA. Translation: AAD01926.1.
BC024389 mRNA. Translation: AAH24389.1.
CCDSiCCDS23433.1.
RefSeqiNP_032650.1. NM_008624.3.
XP_006510888.1. XM_006510825.1.
UniGeneiMm.2045.

Genome annotation databases

EnsembliENSMUST00000035045; ENSMUSP00000035045; ENSMUSG00000032470.
ENSMUST00000119472; ENSMUSP00000112407; ENSMUSG00000032470.
ENSMUST00000122384; ENSMUSP00000113275; ENSMUSG00000032470.
GeneIDi17532.
KEGGimmu:17532.
UCSCiuc009rec.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB004879 mRNA. Translation: BAA20538.1.
AF043581 mRNA. Translation: AAD02277.1.
AF031159 mRNA. Translation: AAD01926.1.
BC024389 mRNA. Translation: AAH24389.1.
CCDSiCCDS23433.1.
RefSeqiNP_032650.1. NM_008624.3.
XP_006510888.1. XM_006510825.1.
UniGeneiMm.2045.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1X1RX-ray1.30A1-178[»]
1X1SX-ray2.20A1-178[»]
3KKOX-ray1.90A/B/P1-178[»]
3KKPX-ray1.35A1-178[»]
3KKQX-ray1.20A1-178[»]
3PIRX-ray2.75A1-178[»]
3PITX-ray1.55A1-178[»]
ProteinModelPortaliO08989.
SMRiO08989. Positions 10-178.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi201483. 2 interactions.
IntActiO08989. 1 interaction.
STRINGi10090.ENSMUSP00000035045.

PTM databases

iPTMnetiO08989.
PhosphoSiteiO08989.

Proteomic databases

PaxDbiO08989.
PRIDEiO08989.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000035045; ENSMUSP00000035045; ENSMUSG00000032470.
ENSMUST00000119472; ENSMUSP00000112407; ENSMUSG00000032470.
ENSMUST00000122384; ENSMUSP00000113275; ENSMUSG00000032470.
GeneIDi17532.
KEGGimmu:17532.
UCSCiuc009rec.1. mouse.

Organism-specific databases

CTDi22808.
MGIiMGI:1100856. Mras.

Phylogenomic databases

eggNOGiKOG0395. Eukaryota.
COG1100. LUCA.
HOGENOMiHOG000233973.
HOVERGENiHBG009351.
InParanoidiO08989.
KOiK07831.
OMAiWVIMDVL.
OrthoDBiEOG7QVM41.
PhylomeDBiO08989.
TreeFamiTF312796.

Miscellaneous databases

ChiTaRSiMras. mouse.
EvolutionaryTraceiO08989.
PROiO08989.
SOURCEiSearch...

Gene expression databases

BgeeiO08989.
CleanExiMM_MRAS.
ExpressionAtlasiO08989. baseline and differential.
GenevisibleiO08989. MM.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR020849. Small_GTPase_Ras.
[Graphical view]
PANTHERiPTHR24070. PTHR24070. 1 hit.
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51421. RAS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Novel small GTPase M-Ras participates in reorganization of actin cytoskeleton."
    Matsumoto K., Asano T., Endo T.
    Oncogene 15:2409-2417(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Interleukin-9-induced expression of M-Ras/R-Ras3 oncogene in T-helper clones."
    Louahed J., Grasso L., De Smet C., van Roost E., Wildmann C., Nicolaides N.C., Levitt R.C., Renauld J.-C.
    Blood 94:1701-1710(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6J.
  3. "Characterization of a transforming, novel ras-related molecule."
    Leslie K.B., Schrader J.W.
    Submitted (OCT-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Kidney.
  5. "A novel potential effector of M-Ras and p21 Ras negatively regulates p21 Ras-mediated gene induction and cell growth."
    Ehrhardt G.R., Korherr C., Wieler J.S., Knaus M., Schrader J.W.
    Oncogene 20:188-197(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH RGL3.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Kidney, Lung and Testis.

Entry informationi

Entry nameiRASM_MOUSE
AccessioniPrimary (citable) accession number: O08989
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: July 1, 1997
Last modified: June 8, 2016
This is version 138 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.