##gff-version 3 O08966 UniProtKB Chain 1 556 . . . ID=PRO_0000333876;Note=Solute carrier family 22 member 1 O08966 UniProtKB Topological domain 1 21 . . . Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 O08966 UniProtKB Transmembrane 22 42 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 O08966 UniProtKB Topological domain 43 150 . . . Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 O08966 UniProtKB Transmembrane 151 171 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 O08966 UniProtKB Topological domain 172 177 . . . Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 O08966 UniProtKB Transmembrane 178 198 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 O08966 UniProtKB Topological domain 199 211 . . . Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 O08966 UniProtKB Transmembrane 212 231 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 O08966 UniProtKB Topological domain 232 238 . . . Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 O08966 UniProtKB Transmembrane 239 259 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 O08966 UniProtKB Topological domain 260 263 . . . Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 O08966 UniProtKB Transmembrane 264 284 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 O08966 UniProtKB Topological domain 285 348 . . . Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 O08966 UniProtKB Transmembrane 349 369 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 O08966 UniProtKB Topological domain 370 377 . . . Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 O08966 UniProtKB Transmembrane 378 398 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 O08966 UniProtKB Topological domain 399 403 . . . Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 O08966 UniProtKB Transmembrane 404 424 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 O08966 UniProtKB Topological domain 425 429 . . . Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 O08966 UniProtKB Transmembrane 430 452 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 O08966 UniProtKB Topological domain 453 465 . . . Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 O08966 UniProtKB Transmembrane 466 486 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 O08966 UniProtKB Topological domain 487 493 . . . Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 O08966 UniProtKB Transmembrane 494 514 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 O08966 UniProtKB Topological domain 515 556 . . . Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 O08966 UniProtKB Motif 284 288 . . . Note=Proline-rich sequence;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:O15245 O08966 UniProtKB Modified residue 334 334 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:21183079;Dbxref=PMID:21183079 O08966 UniProtKB Modified residue 543 543 . . . Note=Phosphothreonine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:O15245 O08966 UniProtKB Glycosylation 71 71 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 O08966 UniProtKB Mutagenesis 32 32 . . . Note=Increased trospium uptake. Increased trospium affinity. No change in fenoterol uptake. L->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:35469921;Dbxref=PMID:35469921 O08966 UniProtKB Mutagenesis 36 36 . . . Note=Decreased fenoterol uptake. Decreased fenoterol affinity. No change in trospium uptake. No change in terbutaline affinity. Y->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:35469921;Dbxref=PMID:35469921 O08966 UniProtKB Sequence conflict 26 26 . . . Note=C->Y;Ontology_term=ECO:0000305;evidence=ECO:0000305 O08966 UniProtKB Sequence conflict 144 144 . . . Note=G->V;Ontology_term=ECO:0000305;evidence=ECO:0000305 O08966 UniProtKB Sequence conflict 506 506 . . . Note=S->T;Ontology_term=ECO:0000305;evidence=ECO:0000305