Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

Protocadherin 4

Gene
N/A
Organism
Rattus rattus (Black rat)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Potential calcium-dependent cell-adhesion protein.SAAS annotation
Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.SAAS annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesionSAAS annotation

Keywords - Ligandi

CalciumSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Protocadherin 4Imported
OrganismiRattus rattus (Black rat)Imported
Taxonomic identifieri10117 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Subcellular locationi

  • Cell membrane SAAS annotation; Single-pass type I membrane protein SAAS annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei685 – 71026HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membraneSAAS annotation, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424Sequence analysisAdd
BLAST
Chaini25 – 928904Sequence analysisPRO_5004156909Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliO08963.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini137 – 239103CadherinInterPro annotationAdd
BLAST
Domaini240 – 344105CadherinInterPro annotationAdd
BLAST
Domaini353 – 44896CadherinInterPro annotationAdd
BLAST
Domaini449 – 558110CadherinInterPro annotationAdd
BLAST
Domaini575 – 679105CadherinInterPro annotationAdd
BLAST

Sequence similaritiesi

Contains cadherin domains.SAAS annotation

Keywords - Domaini

RepeatSAAS annotation, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

HOVERGENiHBG054878.

Family and domain databases

Gene3Di2.60.40.60. 5 hits.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR032455. Cadherin_C.
IPR031904. Cadherin_CBD.
IPR020894. Cadherin_CS.
IPR013164. Cadherin_N.
[Graphical view]
PfamiPF00028. Cadherin. 5 hits.
PF08266. Cadherin_2. 1 hit.
PF16492. Cadherin_C_2. 1 hit.
PF15974. Cadherin_tail. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 5 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 6 hits.
PROSITEiPS00232. CADHERIN_1. 5 hits.
PS50268. CADHERIN_2. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O08963-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTASQNQHRH GRLVLFCTLM GTLCKIGVGQ IRYSVPEETD KGTVVGNISK
60 70 80 90 100
DLGLEPRELA ERGVRIVSRG RSQLFSHESA GRNLVTASRI DREELCAQSI
110 120 130 140 150
PCLVNINILV EEKGKLFGVE ITDINDNNPK FHVGDLEVKI NEIAAPGARY
160 170 180 190 200
PLPKAVDPDV GINSLQSYQL SPNRHFSLDI QRGDDGTINP ELVLENTLDR
210 220 230 240 250
EEEPSHHLIL TASDAERRRS STALIQVTVL DTNDNAPVFD QPVYRVKVLE
260 270 280 290 300
NVTPGTLLLT VRASDPDEGA NGKVTYKFQK INDKQSLLFH LHENTGEMTV
310 320 330 340 350
AKNLDYEECS LYEMEIQAED VGALLGRSKV VIMVEDVNDN RPEVTITSLF
360 370 380 390 400
NPVLENSLPG TVIAFLNVHD RDSGKNGQVV CYTHDNLPFK LEKSIDNYYR
410 420 430 440 450
LVTWKYLDRE KVSIYNITVI ASDLGAHSVT ETYIALIVAD TNDNPPRFPH
460 470 480 490 500
TSYTAYIPEN NLRGASIFSL TAHDPDSQEN AQVTYSVSED TIQGVPLSSY
510 520 530 540 550
ISINSDTGVL YALHSFDFEK IQDLQLLVVA TDSGSPPLSS NVSLSLFVLD
560 570 580 590 600
QNDNAPEILY PSFPTDGSTG VELAPRSAEP GYLVTKVVAV DKDSGQNAWL
610 620 630 640 650
SYRLLKASEP GLFSVGLHTG EVRTARALLD RDALKQNLVM AVQDHGQPPL
660 670 680 690 700
SATVTLTVAV ANSIPEVLAD LSSIRTPGVP EDSDITLHLV VAVAVVSCVF
710 720 730 740 750
LVFVIVLLAL RLQRWQKSRQ LQGSKGGLAP APPSHFVGID GVQAFLQTYS
760 770 780 790 800
HEVSLTSGSQ TSHIIFPQPN YADMLINQEG CEKNDSLLTS IDFHESNRED
810 820 830 840 850
ACAPQAPPNT DWRFSQAQRP GTSGSQNGDE TGTWPNNQFD TEMLQAMILA
860 870 880 890 900
SASEAADGSS TLGGGTGTMG LSARYGPQFT LQHVPDYRQN VYIPGSNATL
910 920
TNAAGKRDGK APAGGNGNNN KSGKKEKK
Length:928
Mass (Da):101,153
Last modified:July 1, 1997 - v1
Checksum:i250D86651B236393
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB004276 mRNA. Translation: BAA20359.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB004276 mRNA. Translation: BAA20359.1.

3D structure databases

ProteinModelPortaliO08963.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG054878.

Family and domain databases

Gene3Di2.60.40.60. 5 hits.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR032455. Cadherin_C.
IPR031904. Cadherin_CBD.
IPR020894. Cadherin_CS.
IPR013164. Cadherin_N.
[Graphical view]
PfamiPF00028. Cadherin. 5 hits.
PF08266. Cadherin_2. 1 hit.
PF16492. Cadherin_C_2. 1 hit.
PF15974. Cadherin_tail. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 5 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 6 hits.
PROSITEiPS00232. CADHERIN_1. 5 hits.
PS50268. CADHERIN_2. 5 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "A common protocadherin tail: multiple protocadherins share the same sequence in their cytoplasmic domains and are expressed in different regions of brain."
    Obata S., Sago H., Mori N., Davidson M., St John T., Suzuki S.T.
    Cell Adhes. Commun. 6:323-333(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiO08963_RATRT
AccessioniPrimary (citable) accession number: O08963
Entry historyi
Integrated into UniProtKB/TrEMBL: July 1, 1997
Last sequence update: July 1, 1997
Last modified: June 8, 2016
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.