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O08962

- KCNH2_RAT

UniProt

O08962 - KCNH2_RAT

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Protein
Potassium voltage-gated channel subfamily H member 2
Gene
Kcnh2, Erg
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. Channel properties are modulated by cAMP and subunit assembly. Mediates the rapidly activating component of the delayed rectifying potassium current in heart (IKr) By similarity.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi744 – 861118cNMP
Add
BLAST

GO - Molecular functioni

  1. inward rectifier potassium channel activity Source: RGD
  2. ion channel activity Source: RGD
  3. phosphorelay sensor kinase activity Source: InterPro
  4. potassium channel activity Source: RGD
  5. protein binding Source: BHF-UCL
  6. voltage-gated potassium channel activity Source: RGD

GO - Biological processi

  1. brain development Source: RGD
  2. potassium ion transmembrane transport Source: RefGenome
  3. potassium ion transport Source: RGD
  4. protein heterooligomerization Source: RGD
  5. regulation of heart rate by cardiac conduction Source: RefGenome
  6. regulation of membrane potential Source: RGD
  7. spinal cord development Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Potassium channel, Voltage-gated channel

Keywords - Biological processi

Ion transport, Potassium transport, Transport

Keywords - Ligandi

Potassium

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium voltage-gated channel subfamily H member 2
Alternative name(s):
Ether-a-go-go-related gene potassium channel 1
Short name:
ERG-1
Short name:
Eag-related protein 1
Short name:
Ether-a-go-go-related protein 1
Short name:
RERG
Short name:
r-ERG
Voltage-gated potassium channel subunit Kv11.1
Gene namesi
Name:Kcnh2
Synonyms:Erg
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi621414. Kcnh2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 405405Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei406 – 42621Helical; Name=Segment S1; Reviewed prediction
Add
BLAST
Topological domaini427 – 45226Extracellular Reviewed prediction
Add
BLAST
Transmembranei453 – 47321Helical; Name=Segment S2; Reviewed prediction
Add
BLAST
Topological domaini474 – 49724Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei498 – 51821Helical; Name=Segment S3; Reviewed prediction
Add
BLAST
Topological domaini519 – 5224Extracellular Reviewed prediction
Transmembranei523 – 54321Helical; Voltage-sensor; Name=Segment S4; Reviewed prediction
Add
BLAST
Topological domaini544 – 5496Cytoplasmic Reviewed prediction
Transmembranei550 – 57021Helical; Name=Segment S5; Reviewed prediction
Add
BLAST
Topological domaini571 – 61343Extracellular Reviewed prediction
Add
BLAST
Intramembranei614 – 63421Pore-forming; Name=Segment H5; Reviewed prediction
Add
BLAST
Topological domaini635 – 6406Extracellular Reviewed prediction
Transmembranei641 – 66121Helical; Name=Segment S6; Reviewed prediction
Add
BLAST
Topological domaini662 – 1163502Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of plasma membrane Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi630 – 6301G → S: Dominant negative mutant; abolishes ERG current. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11631163Potassium voltage-gated channel subfamily H member 2
PRO_0000054003Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei322 – 3221Phosphoserine By similarity
Glycosylationi600 – 6001N-linked (GlcNAc...) Reviewed prediction

Post-translational modificationi

Phosphorylated on serine and threonine residues By similarity.

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiO08962.
PRIDEiO08962.

PTM databases

PhosphoSiteiO08962.

Expressioni

Tissue specificityi

Highly expressed in brain and testis, slightly less so in heart, adrenal, retina and thymus. Detected at lower levels in lung, soleus, tibialis, and at very low levels in cornea and lens. A shorter transcript is detected in skeletal muscle. Found in pituitary.1 Publication

Gene expression databases

GenevestigatoriO08962.

Interactioni

Subunit structurei

The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha subunits that can associate with modulating beta subunits. Heteromultimer with KCNH6/ERG2 and KCNH7/ERG3. Heteromultimer with KCNE1 and KCNE2 By similarity. Interacts with ALG10B. Interacts with CANX By similarity.2 Publications

Protein-protein interaction databases

BioGridi250619. 1 interaction.
STRINGi10116.ENSRNOP00000013800.

Structurei

3D structure databases

ProteinModelPortaliO08962.
SMRiO08962. Positions 26-135, 572-613.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini17 – 8872PAS
Add
BLAST
Domaini92 – 14453PAC
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi626 – 6316Selectivity filter By similarity

Domaini

The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG2202.
HOGENOMiHOG000230793.
HOVERGENiHBG052232.
InParanoidiO08962.
KOiK04905.
PhylomeDBiO08962.

Family and domain databases

Gene3Di2.60.120.10. 2 hits.
InterProiIPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR005821. Ion_trans_dom.
IPR003938. K_chnl_volt-dep_EAG/ELK/ERG.
IPR003967. K_chnl_volt-dep_ERG.
IPR001610. PAC.
IPR000014. PAS.
IPR000700. PAS-assoc_C.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
PfamiPF00027. cNMP_binding. 1 hit.
PF00520. Ion_trans. 1 hit.
PF13426. PAS_9. 1 hit.
[Graphical view]
PRINTSiPR01463. EAGCHANLFMLY.
PR01470. ERGCHANNEL.
SMARTiSM00100. cNMP. 1 hit.
SM00086. PAC. 1 hit.
SM00091. PAS. 1 hit.
[Graphical view]
SUPFAMiSSF51206. SSF51206. 1 hit.
SSF55785. SSF55785. 1 hit.
TIGRFAMsiTIGR00229. sensory_box. 1 hit.
PROSITEiPS50042. CNMP_BINDING_3. 1 hit.
PS50113. PAC. 1 hit.
PS50112. PAS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O08962-1 [UniParc]FASTAAdd to Basket

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MPVRRGHVAP QNTFLDTIIR KFEGQSRKFI IANARVENCA VIYCNDGFCE     50
LCGYSRAEVM QRPCTCDFLH GPRTQRRAAA QIAQALLGAE ERKVEIAFYR 100
KDGSCFLCLV DVVPVKNEDG AVIMFILNFE VVMEKDMVGS PAHDTNHRGP 150
STSWLASGRA KTFRLKLPAL LALTARESPM RTGSTGSPGA PGAVVVDVDL 200
TPAAPSSESL ALDEVSAMDN HVAGLGPAEE RRALVGPASA SPVASIPGPH 250
PSPRAQSLNP DASGSSCSLA RTRSRESCAS VRRASSADDI EAMRAGALPL 300
PPRHASTGAM HPLRSGLLNS TSDSDLVRYR TISKIPQITL NFVDLKGDPF 350
LASPTSDREI IAPKIKERTH NVTEKVTQVL SLGADVLPEY KLQAPRIHRW 400
TILHYSPFKA VWDWLILLLV IYTAVFTPYS AAFLLKETED GSQAPDCGYA 450
CQPLAVVDLL VDIMFIVDIL INFRTTYVNA NEEVVSHPGR IAVHYFKGWF 500
LIDMVAAIPF DLLIFGSGSE ELIGLLKTAR LLRLVRVARK LDRYSEYGAA 550
VLFLLMCTFA LIAHWLACIW YAIGNMEQPH MDSHIGWLHN LGDQIGKPYN 600
SSGLGGPSIK DKYVTALYFT FSSLTSVGFG NVSPNTNSEK IFSICVMLIG 650
SLMYASIFGN VSAIIQRLYS GTARYHTQML RVREFIRFHQ IPNPLRQRLE 700
EYFQHAWSYT NGIDMNAVLK GFPECLQADI CLHLNRSLLQ HCKPFRGATK 750
GCLRALAMKF KTTHAPPGDT LVHAGDLLTA LYFISRGSIE ILRGDVVVAI 800
LGKNDIFGEP LNLYARPGKS NGDVRALTYC DLHKIHRDDL LEVLDMYPEF 850
SDHFWSSLEI TFNLRDTNMI PGSPSSAELE SGFNRQRKRK LSFRRRTDKD 900
TEQPGEVSAL GQGPARVGPG PSCRGQPGGP WGESPSSGPS SPESSEDEGP 950
GRSSSPLRLV PFSSPRPPGD SPGGEPLTED GEKSSDTCNP LSGAFSGVSN 1000
IFSFWGDSRG RQYQELPRCP APAPSLLNIP LSSPGRRSRG DVESRLDALQ 1050
RQLNRLETRL SADMATVLQL LQRQMTLVPP AYSAVTTPGP GPTSTSPLLP 1100
VGPVPTLTLD SLSQVSQFVA FEELPAGAPE LPQDGPTRRL SLPGQLGALT 1150
SQPLHRHGSD PGS 1163
Length:1,163
Mass (Da):126,952
Last modified:July 1, 1997 - v1
Checksum:iF0D75B0B532D9EA2
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti411 – 4111V → A in AAC53160. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z96106 mRNA. Translation: CAB09536.1.
U75210 mRNA. Translation: AAC53160.1.
RefSeqiNP_446401.1. NM_053949.1.
UniGeneiRn.10970.

Genome annotation databases

GeneIDi117018.
KEGGirno:117018.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z96106 mRNA. Translation: CAB09536.1 .
U75210 mRNA. Translation: AAC53160.1 .
RefSeqi NP_446401.1. NM_053949.1.
UniGenei Rn.10970.

3D structure databases

ProteinModelPortali O08962.
SMRi O08962. Positions 26-135, 572-613.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 250619. 1 interaction.
STRINGi 10116.ENSRNOP00000013800.

Chemistry

GuidetoPHARMACOLOGYi 572.

PTM databases

PhosphoSitei O08962.

Proteomic databases

PaxDbi O08962.
PRIDEi O08962.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 117018.
KEGGi rno:117018.

Organism-specific databases

CTDi 3757.
RGDi 621414. Kcnh2.

Phylogenomic databases

eggNOGi COG2202.
HOGENOMi HOG000230793.
HOVERGENi HBG052232.
InParanoidi O08962.
KOi K04905.
PhylomeDBi O08962.

Miscellaneous databases

NextBioi 619763.
PROi O08962.

Gene expression databases

Genevestigatori O08962.

Family and domain databases

Gene3Di 2.60.120.10. 2 hits.
InterProi IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR005821. Ion_trans_dom.
IPR003938. K_chnl_volt-dep_EAG/ELK/ERG.
IPR003967. K_chnl_volt-dep_ERG.
IPR001610. PAC.
IPR000014. PAS.
IPR000700. PAS-assoc_C.
IPR014710. RmlC-like_jellyroll.
[Graphical view ]
Pfami PF00027. cNMP_binding. 1 hit.
PF00520. Ion_trans. 1 hit.
PF13426. PAS_9. 1 hit.
[Graphical view ]
PRINTSi PR01463. EAGCHANLFMLY.
PR01470. ERGCHANNEL.
SMARTi SM00100. cNMP. 1 hit.
SM00086. PAC. 1 hit.
SM00091. PAS. 1 hit.
[Graphical view ]
SUPFAMi SSF51206. SSF51206. 1 hit.
SSF55785. SSF55785. 1 hit.
TIGRFAMsi TIGR00229. sensory_box. 1 hit.
PROSITEi PS50042. CNMP_BINDING_3. 1 hit.
PS50113. PAC. 1 hit.
PS50112. PAS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "RERG is a molecular correlate of the inward-rectifying K current in clonal rat pituitary cells."
    Bauer C.K., Engeland B., Wulfsen I., Ludwig J., Pongs O., Schwarz J.R.
    Recept. Channels 6:19-29(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain cortex.
  2. "Tissue and species distribution of mRNA for the IKr-like K+ channel, erg."
    Wymore R.S., Gintant G.A., Wymore R.T., Dixon J.E., McKinnon D., Cohen I.S.
    Circ. Res. 80:261-268(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 409-568.
  3. "Expression of mRNA for voltage-dependent and inward-rectifying K channels in GH3/B6 cells and rat pituitary."
    Wulfsen I., Hauber H.-P., Schiemann D., Bauer C.K., Schwarz J.R.
    J. Neuroendocrinol. 12:263-272(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  4. "Erg1, erg2 and erg3 K channel subunits are able to form heteromultimers."
    Wimmers S., Wulfsen I., Bauer C.K., Schwarz J.R.
    Pflugers Arch. 441:450-455(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH KCNH6 AND KCNH7, MUTAGENESIS OF GLY-630.
  5. "The IKr drug response is modulated by KCR1 in transfected cardiac and noncardiac cell lines."
    Kupershmidt S., Yang I.C.-H., Hayashi K., Wei J., Chanthaphaychith S., Petersen C.I., Johns D.C., George A.L. Jr., Roden D.M., Balser J.R.
    FASEB J. 17:2263-2265(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH ALG10B.

Entry informationi

Entry nameiKCNH2_RAT
AccessioniPrimary (citable) accession number: O08962
Secondary accession number(s): O08720
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2002
Last sequence update: July 1, 1997
Last modified: July 9, 2014
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi