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Protein

Neuritin

Gene

Nrn1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Promotes neurite outgrowth and especially branching of neuritic processes in primary hippocampal and cortical cells.1 Publication

GO - Biological processi

  • nervous system development Source: RGD

Names & Taxonomyi

Protein namesi
Recommended name:
Neuritin
Gene namesi
Name:Nrn1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi621586. Nrn1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 27Sequence analysisAdd BLAST27
ChainiPRO_000026251628 – 116NeuritinAdd BLAST89
PropeptideiPRO_0000262517117 – 142Removed in mature formSequence analysisAdd BLAST26

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi116GPI-anchor amidated glycineSequence analysis1

Keywords - PTMi

Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

PaxDbiO08957.
PRIDEiO08957.

Expressioni

Tissue specificityi

Expressed predominantly in brain (at protein level). Highest expression in the dentate gyrus and lowest expression in the striatum. Concentrated on neuronal cell bodies and unevenly dispersed along neuritic projections in the nonmyelinated regions of the brain. Expressed in postmitotic-differentiating neurons of the developmental nervous system and neuronal structures associated with plasticity in the adult.2 Publications

Developmental stagei

Expression first detected in developing brain at embryonic day 15; the level of expression increases throughout embryonic development and postnatally into adulthood.1 Publication

Inductioni

Induced by neural activity and by the activity-regulated neurotrophins BDNF and NTF3.1 Publication

Interactioni

Subunit structurei

Component of the outer core of AMPAR complex. AMPAR complex consists of an inner core made of 4 pore-forming GluA/GRIA proteins (GRIA1, GRIA2, GRIA3 and GRIA4) and 4 major auxiliary subunits arranged in a twofold symmetry. One of the two pairs of distinct binding sites is occupied either by CNIH2, CNIH3 or CACNG2, CACNG3. The other harbors CACNG2, CACNG3, CACNG4, CACNG8 or GSG1L. This inner core of AMPAR complex is complemented by outer core constituents binding directly to the GluA/GRIA proteins at sites distinct from the interaction sites of the inner core constituents. Outer core constituents include at least PRRT1, PRRT2, CKAMP44/SHISA9, FRRS1L and NRN1. The proteins of the inner and outer core serve as a platform for other, more peripherally associated AMPAR constituents. Alone or in combination, these auxiliary subunits control the gating and pharmacology of the AMPAR complex and profoundly impact their biogenesis and protein processing.1 Publication

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000066878.

Family & Domainsi

Sequence similaritiesi

Belongs to the neuritin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IXWR. Eukaryota.
ENOG410YHS3. LUCA.
HOVERGENiHBG052772.
InParanoidiO08957.
PhylomeDBiO08957.

Family and domain databases

InterProiView protein in InterPro
IPR026144. Neuritin_fam.
PANTHERiPTHR15902. PTHR15902. 1 hit.
PfamiView protein in Pfam
PF15056. NRN1. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O08957-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLKLNGRYI SLILAVQIAY LVQAVRAAGK CDAVFKGFSD CLLKLGDSMA
60 70 80 90 100
NYPQGLDDKT NIKTVCTYWE DFHSCTVTAL TDCQEGAKDM WDKLRKESKN
110 120 130 140
LNIQGSLFEL CGSGNGAAGS LLPALSVLLV SLSAALATWL SF
Length:142
Mass (Da):15,289
Last modified:July 1, 1997 - v1
Checksum:i6E5CC0CC8D6392E6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U88958 mRNA. Translation: AAB53415.1.
BC087582 mRNA. Translation: AAH87582.1.
PIRiJC6305.
RefSeqiNP_445798.1. NM_053346.1.
UniGeneiRn.3546.

Genome annotation databases

GeneIDi83834.
KEGGirno:83834.

Similar proteinsi

Entry informationi

Entry nameiNRN1_RAT
AccessioniPrimary (citable) accession number: O08957
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: July 1, 1997
Last modified: September 27, 2017
This is version 63 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families