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Protein

Neuritin

Gene

Nrn1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Promotes neurite outgrowth and especially branching of neuritic processes in primary hippocampal and cortical cells.1 Publication

GO - Biological processi

  • nervous system development Source: RGD
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Neuritin
Gene namesi
Name:Nrn1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi621586. Nrn1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2727Sequence analysisAdd
BLAST
Chaini28 – 11689NeuritinPRO_0000262516Add
BLAST
Propeptidei117 – 14226Removed in mature formSequence analysisPRO_0000262517Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi116 – 1161GPI-anchor amidated glycineSequence analysis

Keywords - PTMi

Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

PaxDbiO08957.
PRIDEiO08957.

Expressioni

Tissue specificityi

Expressed predominantly in brain (at protein level). Highest expression in the dentate gyrus and lowest expression in the striatum. Concentrated on neuronal cell bodies and unevenly dispersed along neuritic projections in the nonmyelinated regions of the brain. Expressed in postmitotic-differentiating neurons of the developmental nervous system and neuronal structures associated with plasticity in the adult.2 Publications

Developmental stagei

Expression first detected in developing brain at embryonic day 15; the level of expression increases throughout embryonic development and postnatally into adulthood.1 Publication

Inductioni

Induced by neural activity and by the activity-regulated neurotrophins BDNF and NTF3.1 Publication

Interactioni

Subunit structurei

Component of the outer core of AMPAR complex. AMPAR complex consists of an inner core made of 4 pore-forming GluA/GRIA proteins (GRIA1, GRIA2, GRIA3 and GRIA4) and 4 major auxiliary subunits arranged in a twofold symmetry. One of the two pairs of distinct binding sites is occupied either by CNIH2, CNIH3 or CACNG2, CACNG3. The other harbors CACNG2, CACNG3, CACNG4, CACNG8 or GSG1L. This inner core of AMPAR complex is complemented by outer core constituents binding directly to the GluA/GRIA proteins at sites distinct from the interaction sites of the inner core constituents. Outer core constituents include at least PRRT1, PRRT2, CKAMP44/SHISA9, FRRS1L and NRN1. The proteins of the inner and outer core serve as a platform for other, more peripherally associated AMPAR constituents. Alone or in combination, these auxiliary subunits control the gating and pharmacology of the AMPAR complex and profoundly impact their biogenesis and protein processing.1 Publication

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000066878.

Family & Domainsi

Sequence similaritiesi

Belongs to the neuritin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IXWR. Eukaryota.
ENOG410YHS3. LUCA.
HOVERGENiHBG052772.
InParanoidiO08957.
PhylomeDBiO08957.

Family and domain databases

InterProiIPR026144. Neuritin_fam.
[Graphical view]
PANTHERiPTHR15902. PTHR15902. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O08957-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLKLNGRYI SLILAVQIAY LVQAVRAAGK CDAVFKGFSD CLLKLGDSMA
60 70 80 90 100
NYPQGLDDKT NIKTVCTYWE DFHSCTVTAL TDCQEGAKDM WDKLRKESKN
110 120 130 140
LNIQGSLFEL CGSGNGAAGS LLPALSVLLV SLSAALATWL SF
Length:142
Mass (Da):15,289
Last modified:July 1, 1997 - v1
Checksum:i6E5CC0CC8D6392E6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U88958 mRNA. Translation: AAB53415.1.
BC087582 mRNA. Translation: AAH87582.1.
PIRiJC6305.
RefSeqiNP_445798.1. NM_053346.1.
UniGeneiRn.3546.

Genome annotation databases

GeneIDi83834.
KEGGirno:83834.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U88958 mRNA. Translation: AAB53415.1.
BC087582 mRNA. Translation: AAH87582.1.
PIRiJC6305.
RefSeqiNP_445798.1. NM_053346.1.
UniGeneiRn.3546.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000066878.

Proteomic databases

PaxDbiO08957.
PRIDEiO08957.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi83834.
KEGGirno:83834.

Organism-specific databases

CTDi51299.
RGDi621586. Nrn1.

Phylogenomic databases

eggNOGiENOG410IXWR. Eukaryota.
ENOG410YHS3. LUCA.
HOVERGENiHBG052772.
InParanoidiO08957.
PhylomeDBiO08957.

Miscellaneous databases

PROiO08957.

Family and domain databases

InterProiIPR026144. Neuritin_fam.
[Graphical view]
PANTHERiPTHR15902. PTHR15902. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Neuritin: a gene induced by neural activity and neurotrophins that promotes neuritogenesis."
    Naeve G.S., Ramakrishnan M., Kramer R., Hevroni D., Citri Y., Theill L.E.
    Proc. Natl. Acad. Sci. U.S.A. 94:2648-2653(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INDUCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
    Tissue: Hippocampus.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  3. Lubec G., Kang S.U., Lubec S.
    Submitted (SEP-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 37-59, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: Sprague-Dawley.
    Tissue: Brain.
  4. "High-resolution proteomics unravel architecture and molecular diversity of native AMPA receptor complexes."
    Schwenk J., Harmel N., Brechet A., Zolles G., Berkefeld H., Muller C.S., Bildl W., Baehrens D., Huber B., Kulik A., Klocker N., Schulte U., Fakler B.
    Neuron 74:621-633(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN AMPAR COMPLEX, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.

Entry informationi

Entry nameiNRN1_RAT
AccessioniPrimary (citable) accession number: O08957
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: July 1, 1997
Last modified: June 8, 2016
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.