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Protein

Transcription initiation factor IIA subunit 2

Gene

Gtf2a2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation. TFIIA in a complex with TBP mediates transcriptional activity (By similarity).By similarity

GO - Molecular functioni

  • transcription coactivator activity Source: Ensembl
  • transcription factor binding Source: RGD

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-RNO-674695. RNA Polymerase II Pre-transcription Events.
R-RNO-73776. RNA Polymerase II Promoter Escape.
R-RNO-73779. RNA Polymerase II Transcription Pre-Initiation And Promoter Opening.
R-RNO-75953. RNA Polymerase II Transcription Initiation.
R-RNO-76042. RNA Polymerase II Transcription Initiation And Promoter Clearance.

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription initiation factor IIA subunit 2
Alternative name(s):
General transcription factor IIA subunit 2
Transcription initiation factor IIA gamma chain
Short name:
TFIIA-gamma
Gene namesi
Name:Gtf2a2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 8

Organism-specific databases

RGDi620720. Gtf2a2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 109109Transcription initiation factor IIA subunit 2PRO_0000194044Add
BLAST

Proteomic databases

PaxDbiO08950.
PRIDEiO08950.

Expressioni

Gene expression databases

GenevisibleiO08950. RN.

Interactioni

Subunit structurei

TFIIA is a heterodimer of the large unprocessed subunit 1 and a small subunit gamma. It was originally believed to be a heterotrimer of an alpha, a beta and a gamma subunit. Interacts with NCOA6 general coactivator. TFIIA forms a complex with TBP (By similarity).By similarity

GO - Molecular functioni

  • transcription factor binding Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000014706.

Structurei

3D structure databases

ProteinModelPortaliO08950.
SMRiO08950. Positions 3-99.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TFIIA subunit 2 family.Curated

Phylogenomic databases

eggNOGiKOG3463. Eukaryota.
COG5123. LUCA.
GeneTreeiENSGT00390000014572.
HOGENOMiHOG000167251.
HOVERGENiHBG000826.
InParanoidiO08950.
KOiK03123.
OMAiATAYYEF.
OrthoDBiEOG7RFTKP.
PhylomeDBiO08950.
TreeFamiTF315131.

Family and domain databases

Gene3Di1.10.287.190. 1 hit.
2.30.18.10. 1 hit.
InterProiIPR009083. TFIIA_a-hlx.
IPR009088. TFIIA_b-brl.
IPR003194. TFIIA_gsu.
IPR015871. TFIIA_gsu_C.
IPR015872. TFIIA_gsu_N.
[Graphical view]
PANTHERiPTHR10966. PTHR10966. 1 hit.
PfamiPF02751. TFIIA_gamma_C. 1 hit.
PF02268. TFIIA_gamma_N. 1 hit.
[Graphical view]
PIRSFiPIRSF009415. Hum_TFIIA_gamma. 1 hit.
ProDomiPD009224. TFIIA_gsu_N. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF47396. SSF47396. 1 hit.
SSF50784. SSF50784. 1 hit.

Sequencei

Sequence statusi: Complete.

O08950-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAYQLYRNTT LGNSLQESLD ELIQSQQITP QLALQVLLQF DKAINSALAQ
60 70 80 90 100
RVRNRVNFRG SLNTYRFCDN VWTFVLNDVE FREVTELIKV DKVKIVACDG

KNTGSNTTE
Length:109
Mass (Da):12,473
Last modified:July 1, 1997 - v1
Checksum:i8BEE65B0D9982AFA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF000944 mRNA. Translation: AAB58717.1.
RefSeqiNP_445797.1. NM_053345.1.
XP_006243442.1. XM_006243380.2.
XP_008773362.1. XM_008775140.1.
UniGeneiRn.4053.

Genome annotation databases

EnsembliENSRNOT00000085496; ENSRNOP00000068825; ENSRNOG00000056701.
GeneIDi103695118.
83828.
KEGGirno:103695118.
rno:83828.
UCSCiRGD:620720. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF000944 mRNA. Translation: AAB58717.1.
RefSeqiNP_445797.1. NM_053345.1.
XP_006243442.1. XM_006243380.2.
XP_008773362.1. XM_008775140.1.
UniGeneiRn.4053.

3D structure databases

ProteinModelPortaliO08950.
SMRiO08950. Positions 3-99.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000014706.

Proteomic databases

PaxDbiO08950.
PRIDEiO08950.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000085496; ENSRNOP00000068825; ENSRNOG00000056701.
GeneIDi103695118.
83828.
KEGGirno:103695118.
rno:83828.
UCSCiRGD:620720. rat.

Organism-specific databases

CTDi2958.
RGDi620720. Gtf2a2.

Phylogenomic databases

eggNOGiKOG3463. Eukaryota.
COG5123. LUCA.
GeneTreeiENSGT00390000014572.
HOGENOMiHOG000167251.
HOVERGENiHBG000826.
InParanoidiO08950.
KOiK03123.
OMAiATAYYEF.
OrthoDBiEOG7RFTKP.
PhylomeDBiO08950.
TreeFamiTF315131.

Enzyme and pathway databases

ReactomeiR-RNO-674695. RNA Polymerase II Pre-transcription Events.
R-RNO-73776. RNA Polymerase II Promoter Escape.
R-RNO-73779. RNA Polymerase II Transcription Pre-Initiation And Promoter Opening.
R-RNO-75953. RNA Polymerase II Transcription Initiation.
R-RNO-76042. RNA Polymerase II Transcription Initiation And Promoter Clearance.

Miscellaneous databases

NextBioi616460.
PROiO08950.

Gene expression databases

GenevisibleiO08950. RN.

Family and domain databases

Gene3Di1.10.287.190. 1 hit.
2.30.18.10. 1 hit.
InterProiIPR009083. TFIIA_a-hlx.
IPR009088. TFIIA_b-brl.
IPR003194. TFIIA_gsu.
IPR015871. TFIIA_gsu_C.
IPR015872. TFIIA_gsu_N.
[Graphical view]
PANTHERiPTHR10966. PTHR10966. 1 hit.
PfamiPF02751. TFIIA_gamma_C. 1 hit.
PF02268. TFIIA_gamma_N. 1 hit.
[Graphical view]
PIRSFiPIRSF009415. Hum_TFIIA_gamma. 1 hit.
ProDomiPD009224. TFIIA_gsu_N. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF47396. SSF47396. 1 hit.
SSF50784. SSF50784. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Upadhyaya A.B., Dejong J.
    Submitted (APR-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.

Entry informationi

Entry nameiT2AG_RAT
AccessioniPrimary (citable) accession number: O08950
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 1, 1997
Last modified: May 11, 2016
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.