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Protein

Transcription initiation factor IIA subunit 2

Gene

Gtf2a2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation. TFIIA in a complex with TBP mediates transcriptional activity (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-RNO-674695 RNA Polymerase II Pre-transcription Events
R-RNO-6807505 RNA polymerase II transcribes snRNA genes
R-RNO-73776 RNA Polymerase II Promoter Escape
R-RNO-73779 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
R-RNO-75953 RNA Polymerase II Transcription Initiation
R-RNO-76042 RNA Polymerase II Transcription Initiation And Promoter Clearance

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription initiation factor IIA subunit 2
Alternative name(s):
General transcription factor IIA subunit 2
Transcription initiation factor IIA gamma chain
Short name:
TFIIA-gamma
Gene namesi
Name:Gtf2a2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 8

Organism-specific databases

RGDi620720 Gtf2a2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001940441 – 109Transcription initiation factor IIA subunit 2Add BLAST109

Proteomic databases

PaxDbiO08950

Expressioni

Gene expression databases

BgeeiENSRNOG00000056701
GenevisibleiO08950 RN

Interactioni

Subunit structurei

TFIIA is a heterodimer of the large unprocessed subunit 1 and a small subunit gamma. It was originally believed to be a heterotrimer of an alpha (p35), a beta (p19) and a gamma subunit (p12). Interacts with NCOA6 general coactivator. TFIIA forms a complex with TBP. Interacts with HSF1 (via transactivation domain). Interacts with HSF1 (via transactivation domain). Interacts with HSF1 (via transactivation domain).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000014706

Structurei

3D structure databases

ProteinModelPortaliO08950
SMRiO08950
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TFIIA subunit 2 family.Curated

Phylogenomic databases

eggNOGiKOG3463 Eukaryota
COG5123 LUCA
GeneTreeiENSGT00390000014572
HOGENOMiHOG000167251
HOVERGENiHBG000826
InParanoidiO08950
KOiK03123
OMAiFKMESNE
OrthoDBiEOG091G0X1Z
PhylomeDBiO08950
TreeFamiTF315131

Family and domain databases

CDDicd10014 TFIIA_gamma_C, 1 hit
cd10145 TFIIA_gamma_N, 1 hit
Gene3Di1.10.287.190, 1 hit
2.30.18.10, 1 hit
InterProiView protein in InterPro
IPR009083 TFIIA_a-hlx
IPR009088 TFIIA_b-brl
IPR003194 TFIIA_gsu
IPR015871 TFIIA_gsu_C
IPR015872 TFIIA_gsu_N
PANTHERiPTHR10966 PTHR10966, 1 hit
PfamiView protein in Pfam
PF02751 TFIIA_gamma_C, 1 hit
PF02268 TFIIA_gamma_N, 1 hit
PIRSFiPIRSF009415 Hum_TFIIA_gamma, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD009224 TFIIA_gsu_N, 1 hit
SUPFAMiSSF50784 SSF50784, 1 hit

Sequencei

Sequence statusi: Complete.

O08950-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAYQLYRNTT LGNSLQESLD ELIQSQQITP QLALQVLLQF DKAINSALAQ
60 70 80 90 100
RVRNRVNFRG SLNTYRFCDN VWTFVLNDVE FREVTELIKV DKVKIVACDG

KNTGSNTTE
Length:109
Mass (Da):12,473
Last modified:July 1, 1997 - v1
Checksum:i8BEE65B0D9982AFA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF000944 mRNA Translation: AAB58717.1
RefSeqiNP_445797.1, NM_053345.1
XP_006243442.1, XM_006243380.3
XP_008773362.1, XM_008775140.2
UniGeneiRn.4053

Genome annotation databases

EnsembliENSRNOT00000085496; ENSRNOP00000068825; ENSRNOG00000056701
GeneIDi103695118
83828
KEGGirno:103695118
rno:83828
UCSCiRGD:620720 rat

Similar proteinsi

Entry informationi

Entry nameiT2AG_RAT
AccessioniPrimary (citable) accession number: O08950
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 1, 1997
Last modified: March 28, 2018
This is version 116 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health