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Protein

Cyclin-G2

Gene

Ccng2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May play a role in growth regulation and in negative regulation of cell cycle progession.

GO - Biological processi

  • cell division Source: UniProtKB-KW
  • mitotic nuclear division Source: UniProtKB-KW
  • regulation of cell cycle Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Cyclin

Keywords - Biological processi

Cell cycle, Cell division, Mitosis

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-G2
Gene namesi
Name:Ccng2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1095734. Ccng2.

Subcellular locationi

  • Cytoplasm
  • Nucleus

  • Note: Primarily found in the cytoplasm. A minor portion can be detected in some cells in the nucleus.

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000804701 – 344Cyclin-G2Add BLAST344

Proteomic databases

PaxDbiO08918.
PRIDEiO08918.

PTM databases

iPTMnetiO08918.
PhosphoSitePlusiO08918.

Expressioni

Tissue specificityi

Highest levels in intestine. Intermediate levels in spleen, brain and kidney. Low levels in testis, stomach, pancreas, liver, salivary gland and muscle. According to PubMed:9139721 also abundant in thymus.

Developmental stagei

Expression levels oscillate moderately through the cell cycle.

Inductioni

Activated in B-cells by agents causing growth inhibition or growth arrest.

Gene expression databases

BgeeiENSMUSG00000029385.
CleanExiMM_CCNG2.
ExpressionAtlasiO08918. baseline and differential.
GenevisibleiO08918. MM.

Interactioni

Protein-protein interaction databases

DIPiDIP-24180N.
STRINGi10090.ENSMUSP00000031331.

Structurei

3D structure databases

ProteinModelPortaliO08918.
SMRiO08918.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cyclin family. Cyclin G subfamily.Curated

Phylogenomic databases

eggNOGiKOG0653. Eukaryota.
COG5024. LUCA.
GeneTreeiENSGT00530000062971.
HOGENOMiHOG000059559.
HOVERGENiHBG050839.
InParanoidiO08918.
KOiK10146.
OMAiDLWSLTS.
OrthoDBiEOG091G0HQN.
PhylomeDBiO08918.
TreeFamiTF101007.

Family and domain databases

Gene3Di1.10.472.10. 1 hit.
InterProiIPR028895. CCNG2.
IPR013763. Cyclin-like.
IPR006671. Cyclin_N.
[Graphical view]
PANTHERiPTHR10177:SF60. PTHR10177:SF60. 2 hits.
PfamiPF00134. Cyclin_N. 1 hit.
[Graphical view]
SMARTiSM00385. CYCLIN. 1 hit.
[Graphical view]
SUPFAMiSSF47954. SSF47954. 1 hit.

Sequencei

Sequence statusi: Complete.

O08918-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKDLGAKHLA GGEGVQLFGL LNFYLEQEQR YQPREKGLIL MEATPENDNT
60 70 80 90 100
LCSRLRNAKV EDLRSLTNFF GSGTETFVLA VNILDRFLAL MKVKPKHLSC
110 120 130 140 150
IGVCCFLLAA RLAEEEGDVP PTHDVIRISQ CKCTASDIKR MEKIISEKLH
160 170 180 190 200
YELEATTALN FLHLYHAIVF CHTSERKEIL SLDKLEAQLK ACNCRVVFSK
210 220 230 240 250
ARPSVLALCL LNLEIETIKS VELLEILLLV KKHLKLSDTE FFYWRELVSK
260 270 280 290 300
CLAEYSSPRC CKPDLKKLVW IVSRRTAQNL HSSYYSVPEL PTIPEGGCFD
310 320 330 340
GSESEDSGED MSCGEESLSS SPPSDQECTF FFDFQVAQTL CFPP
Length:344
Mass (Da):38,848
Last modified:December 1, 2000 - v3
Checksum:iF6A02698C286D853
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U95826 mRNA. Translation: AAB58693.1.
AF005885 mRNA. Translation: AAC28496.1.
AF079877 Genomic DNA. Translation: AAC32372.1.
AB035264 Genomic DNA. Translation: BAA87065.1.
CCDSiCCDS19437.1.
RefSeqiNP_031661.3. NM_007635.4.
UniGeneiMm.3527.

Genome annotation databases

EnsembliENSMUST00000031331; ENSMUSP00000031331; ENSMUSG00000029385.
ENSMUST00000121127; ENSMUSP00000113278; ENSMUSG00000029385.
GeneIDi12452.
KEGGimmu:12452.
UCSCiuc008yee.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U95826 mRNA. Translation: AAB58693.1.
AF005885 mRNA. Translation: AAC28496.1.
AF079877 Genomic DNA. Translation: AAC32372.1.
AB035264 Genomic DNA. Translation: BAA87065.1.
CCDSiCCDS19437.1.
RefSeqiNP_031661.3. NM_007635.4.
UniGeneiMm.3527.

3D structure databases

ProteinModelPortaliO08918.
SMRiO08918.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-24180N.
STRINGi10090.ENSMUSP00000031331.

PTM databases

iPTMnetiO08918.
PhosphoSitePlusiO08918.

Proteomic databases

PaxDbiO08918.
PRIDEiO08918.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000031331; ENSMUSP00000031331; ENSMUSG00000029385.
ENSMUST00000121127; ENSMUSP00000113278; ENSMUSG00000029385.
GeneIDi12452.
KEGGimmu:12452.
UCSCiuc008yee.2. mouse.

Organism-specific databases

CTDi901.
MGIiMGI:1095734. Ccng2.

Phylogenomic databases

eggNOGiKOG0653. Eukaryota.
COG5024. LUCA.
GeneTreeiENSGT00530000062971.
HOGENOMiHOG000059559.
HOVERGENiHBG050839.
InParanoidiO08918.
KOiK10146.
OMAiDLWSLTS.
OrthoDBiEOG091G0HQN.
PhylomeDBiO08918.
TreeFamiTF101007.

Miscellaneous databases

PROiO08918.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000029385.
CleanExiMM_CCNG2.
ExpressionAtlasiO08918. baseline and differential.
GenevisibleiO08918. MM.

Family and domain databases

Gene3Di1.10.472.10. 1 hit.
InterProiIPR028895. CCNG2.
IPR013763. Cyclin-like.
IPR006671. Cyclin_N.
[Graphical view]
PANTHERiPTHR10177:SF60. PTHR10177:SF60. 2 hits.
PfamiPF00134. Cyclin_N. 1 hit.
[Graphical view]
SMARTiSM00385. CYCLIN. 1 hit.
[Graphical view]
SUPFAMiSSF47954. SSF47954. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCCNG2_MOUSE
AccessioniPrimary (citable) accession number: O08918
Secondary accession number(s): O35612
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: December 1, 2000
Last modified: November 2, 2016
This is version 117 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.