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Protein

Flotillin-1

Gene

Flot1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles.

Miscellaneous

Expression increases at least 10-fold as 3T3-L1 cells differentiate into adipocytes.

GO - Molecular functioni

GO - Biological processi

  • axon guidance Source: MGI
  • axonogenesis Source: MGI
  • cellular response to exogenous dsRNA Source: MGI
  • dsRNA transport Source: MGI
  • endocytosis Source: MGI
  • extracellular matrix disassembly Source: MGI
  • membrane raft assembly Source: MGI
  • plasma membrane raft assembly Source: MGI
  • positive regulation of cell adhesion molecule production Source: MGI
  • positive regulation of cell-cell adhesion mediated by cadherin Source: UniProtKB
  • positive regulation of cell junction assembly Source: UniProtKB
  • positive regulation of cytokine production Source: MGI
  • positive regulation of endocytosis Source: UniProtKB
  • positive regulation of heterotypic cell-cell adhesion Source: MGI
  • positive regulation of interferon-beta production Source: MGI
  • positive regulation of myoblast fusion Source: UniProtKB
  • positive regulation of protein binding Source: UniProtKB
  • positive regulation of protein phosphorylation Source: MGI
  • positive regulation of skeletal muscle tissue development Source: UniProtKB
  • positive regulation of synaptic transmission, dopaminergic Source: UniProtKB
  • positive regulation of toll-like receptor 3 signaling pathway Source: MGI
  • protein homooligomerization Source: MGI
  • protein kinase C signaling Source: UniProtKB
  • protein localization to membrane raft Source: MGI
  • protein localization to plasma membrane Source: UniProtKB
  • protein stabilization Source: MGI
  • regulation of receptor internalization Source: UniProtKB
  • regulation of Rho protein signal transduction Source: MGI
  • response to endoplasmic reticulum stress Source: MGI

Enzyme and pathway databases

ReactomeiR-MMU-8849932 Synaptic adhesion-like molecules

Names & Taxonomyi

Protein namesi
Recommended name:
Flotillin-1
Gene namesi
Name:Flot1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:1100500 Flot1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Endosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000940451 – 428Flotillin-1Add BLAST428

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei19PhosphoserineBy similarity1
Modified residuei163PhosphoserineBy similarity1
Modified residuei385PhosphoserineBy similarity1
Modified residuei387PhosphothreonineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiO08917
PaxDbiO08917
PeptideAtlasiO08917
PRIDEiO08917

PTM databases

iPTMnetiO08917
PhosphoSitePlusiO08917
SwissPalmiO08917

Expressioni

Tissue specificityi

High expression in brain, white adipose tissue, heart muscle, skeletal muscle and lung. Low expression in spleen, liver and testis.

Gene expression databases

BgeeiENSMUSG00000059714
CleanExiMM_FLOT1
ExpressionAtlasiO08917 baseline and differential
GenevisibleiO08917 MM

Interactioni

Subunit structurei

Heterooligomeric complex of flotillin-1 and flotillin-2 and caveolin-1 and caveolin-2. Interacts with ECPAS (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi199704, 69 interactors
IntActiO08917, 63 interactors
MINTiO08917
STRINGi10090.ENSMUSP00000001569

Structurei

3D structure databases

ProteinModelPortaliO08917
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG2668 Eukaryota
COG2268 LUCA
GeneTreeiENSGT00560000077232
HOGENOMiHOG000240804
HOVERGENiHBG051628
InParanoidiO08917
KOiK07192
OMAiQYDSEVK
OrthoDBiEOG091G0D3R
PhylomeDBiO08917
TreeFamiTF324879

Family and domain databases

InterProiView protein in InterPro
IPR001107 Band_7
IPR036013 Band_7/SPFH_dom_sf
IPR031905 Flotillin_C
IPR027705 Flotillin_fam
PANTHERiPTHR13806 PTHR13806, 1 hit
PfamiView protein in Pfam
PF01145 Band_7, 1 hit
PF15975 Flot, 1 hit
SMARTiView protein in SMART
SM00244 PHB, 1 hit
SUPFAMiSSF117892 SSF117892, 1 hit

Sequencei

Sequence statusi: Complete.

O08917-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFFTCGPNEA MVVSGFCRSP PVMVAGGRVF VLPCIQQIQR ISLNTLTLNV
60 70 80 90 100
KSEKVYTRHG VPISVTGIAQ VKIQGQNKEM LAAACQMFLG KTEAEIAHIA
110 120 130 140 150
LETLEGHQRA IMAHMTVEEI YKDRQKFSEQ VFKVASSDLV NMGISVVSYT
160 170 180 190 200
LKDIHDDQDY LHSLGKARTA QVQKDARIGE AEAKRDAGIR EAKAKQEKVS
210 220 230 240 250
AQCLSEIEMA KAQRDYELKK ATYDIEVNTR RAQADLAYQL QVAKTKQQIE
260 270 280 290 300
EQRVQVQVVE RAQQVAVQEQ EIARREKELE ARVRKPAEAE RYRLERLAEA
310 320 330 340 350
EKAQLIMQAE AEAESVRMRG EAEAFAIGAR ARAEAEQMAK KAEAFQMYQE
360 370 380 390 400
AAQLDMLLEK LPQVAEEISG PLTSANKITL VSSGSGTMGA AKVTGEVLDI
410 420
LSRLPESVER LTGVSISQVN HNKPLRTA
Length:428
Mass (Da):47,513
Last modified:July 1, 1997 - v1
Checksum:i4B17C7EA1263F52C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U90435 mRNA Translation: AAB58583.1
AF145044 mRNA Translation: AAD33945.1
BC004647 mRNA Translation: AAH04647.1
CCDSiCCDS28705.1
RefSeqiNP_032053.1, NM_008027.2
XP_006523719.1, XM_006523656.3
UniGeneiMm.2931

Genome annotation databases

EnsembliENSMUST00000001569; ENSMUSP00000001569; ENSMUSG00000059714
GeneIDi14251
KEGGimmu:14251
UCSCiuc008cip.1 mouse

Similar proteinsi

Entry informationi

Entry nameiFLOT1_MOUSE
AccessioniPrimary (citable) accession number: O08917
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: July 1, 1997
Last modified: May 23, 2018
This is version 144 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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