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Protein

Flotillin-1

Gene

Flot1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles.

GO - Molecular functioni

GO - Biological processi

  • axon guidance Source: MGI
  • axonogenesis Source: MGI
  • cellular response to exogenous dsRNA Source: MGI
  • dsRNA transport Source: MGI
  • endocytosis Source: MGI
  • establishment of protein localization to plasma membrane Source: UniProtKB
  • extracellular matrix disassembly Source: MGI
  • membrane raft assembly Source: MGI
  • plasma membrane raft assembly Source: MGI
  • positive regulation of cell adhesion molecule production Source: MGI
  • positive regulation of cell-cell adhesion mediated by cadherin Source: UniProtKB
  • positive regulation of cell junction assembly Source: UniProtKB
  • positive regulation of cytokine production Source: MGI
  • positive regulation of endocytosis Source: UniProtKB
  • positive regulation of heterotypic cell-cell adhesion Source: MGI
  • positive regulation of interferon-beta production Source: MGI
  • positive regulation of myoblast fusion Source: UniProtKB
  • positive regulation of protein binding Source: UniProtKB
  • positive regulation of protein phosphorylation Source: MGI
  • positive regulation of skeletal muscle tissue development Source: UniProtKB
  • positive regulation of synaptic transmission, dopaminergic Source: UniProtKB
  • positive regulation of toll-like receptor 3 signaling pathway Source: MGI
  • protein homooligomerization Source: MGI
  • protein kinase C signaling Source: UniProtKB
  • protein localization to membrane raft Source: MGI
  • protein localization to plasma membrane Source: MGI
  • regulation of receptor internalization Source: UniProtKB
  • regulation of Rho protein signal transduction Source: MGI
  • response to endoplasmic reticulum stress Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Flotillin-1
Gene namesi
Name:Flot1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:1100500. Flot1.

Subcellular locationi

GO - Cellular componenti

  • basolateral plasma membrane Source: MGI
  • caveola Source: MGI
  • cell-cell adherens junction Source: MGI
  • cell-cell contact zone Source: MGI
  • centriolar satellite Source: MGI
  • COP9 signalosome Source: Ensembl
  • cortical actin cytoskeleton Source: Ensembl
  • cytoplasmic vesicle Source: MGI
  • early endosome Source: MGI
  • endosome Source: UniProtKB
  • extracellular exosome Source: MGI
  • flotillin complex Source: UniProtKB
  • focal adhesion Source: MGI
  • lamellipodium Source: MGI
  • lysosomal membrane Source: MGI
  • melanosome Source: UniProtKB-SubCell
  • membrane Source: MGI
  • membrane raft Source: MGI
  • microtubule organizing center Source: MGI
  • plasma membrane Source: MGI
  • plasma membrane raft Source: UniProtKB
  • sarcolemma Source: MGI
  • uropod Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Endosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 428428Flotillin-1PRO_0000094045Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei19 – 191PhosphoserineBy similarity
Modified residuei163 – 1631PhosphoserineBy similarity
Modified residuei385 – 3851PhosphoserineBy similarity
Modified residuei387 – 3871PhosphothreonineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiO08917.
PaxDbiO08917.
PeptideAtlasiO08917.
PRIDEiO08917.

PTM databases

iPTMnetiO08917.
PhosphoSiteiO08917.
SwissPalmiO08917.

Expressioni

Tissue specificityi

High expression in brain, white adipose tissue, heart muscle, skeletal muscle and lung. Low expression in spleen, liver and testis.

Gene expression databases

BgeeiENSMUSG00000059714.
CleanExiMM_FLOT1.
ExpressionAtlasiO08917. baseline and differential.
GenevisibleiO08917. MM.

Interactioni

Subunit structurei

Heterooligomeric complex of flotillin-1 and flotillin-2 and caveolin-1 and caveolin-2. Interacts with ECM29 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi199704. 69 interactions.
IntActiO08917. 64 interactions.
MINTiMINT-4095176.
STRINGi10090.ENSMUSP00000001569.

Structurei

3D structure databases

ProteinModelPortaliO08917.
SMRiO08917. Positions 39-170.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG2668. Eukaryota.
COG2268. LUCA.
HOGENOMiHOG000240804.
HOVERGENiHBG051628.
InParanoidiO08917.
KOiK07192.
OMAiGCCYSKP.
OrthoDBiEOG091G0D3R.
PhylomeDBiO08917.
TreeFamiTF324879.

Family and domain databases

InterProiIPR001107. Band_7.
IPR031905. Flotillin_C.
IPR027705. Flotillin_fam.
[Graphical view]
PANTHERiPTHR13806. PTHR13806. 1 hit.
PfamiPF01145. Band_7. 1 hit.
PF15975. Flot. 1 hit.
[Graphical view]
SMARTiSM00244. PHB. 1 hit.
[Graphical view]
SUPFAMiSSF117892. SSF117892. 1 hit.

Sequencei

Sequence statusi: Complete.

O08917-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFFTCGPNEA MVVSGFCRSP PVMVAGGRVF VLPCIQQIQR ISLNTLTLNV
60 70 80 90 100
KSEKVYTRHG VPISVTGIAQ VKIQGQNKEM LAAACQMFLG KTEAEIAHIA
110 120 130 140 150
LETLEGHQRA IMAHMTVEEI YKDRQKFSEQ VFKVASSDLV NMGISVVSYT
160 170 180 190 200
LKDIHDDQDY LHSLGKARTA QVQKDARIGE AEAKRDAGIR EAKAKQEKVS
210 220 230 240 250
AQCLSEIEMA KAQRDYELKK ATYDIEVNTR RAQADLAYQL QVAKTKQQIE
260 270 280 290 300
EQRVQVQVVE RAQQVAVQEQ EIARREKELE ARVRKPAEAE RYRLERLAEA
310 320 330 340 350
EKAQLIMQAE AEAESVRMRG EAEAFAIGAR ARAEAEQMAK KAEAFQMYQE
360 370 380 390 400
AAQLDMLLEK LPQVAEEISG PLTSANKITL VSSGSGTMGA AKVTGEVLDI
410 420
LSRLPESVER LTGVSISQVN HNKPLRTA
Length:428
Mass (Da):47,513
Last modified:July 1, 1997 - v1
Checksum:i4B17C7EA1263F52C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U90435 mRNA. Translation: AAB58583.1.
AF145044 mRNA. Translation: AAD33945.1.
BC004647 mRNA. Translation: AAH04647.1.
CCDSiCCDS28705.1.
RefSeqiNP_032053.1. NM_008027.2.
XP_006523719.1. XM_006523656.2.
XP_006536579.1. XM_006536516.2.
XP_006537312.1. XM_006537249.2.
UniGeneiMm.2931.

Genome annotation databases

EnsembliENSMUST00000001569; ENSMUSP00000001569; ENSMUSG00000059714.
GeneIDi14251.
KEGGimmu:14251.
UCSCiuc008cip.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U90435 mRNA. Translation: AAB58583.1.
AF145044 mRNA. Translation: AAD33945.1.
BC004647 mRNA. Translation: AAH04647.1.
CCDSiCCDS28705.1.
RefSeqiNP_032053.1. NM_008027.2.
XP_006523719.1. XM_006523656.2.
XP_006536579.1. XM_006536516.2.
XP_006537312.1. XM_006537249.2.
UniGeneiMm.2931.

3D structure databases

ProteinModelPortaliO08917.
SMRiO08917. Positions 39-170.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi199704. 69 interactions.
IntActiO08917. 64 interactions.
MINTiMINT-4095176.
STRINGi10090.ENSMUSP00000001569.

PTM databases

iPTMnetiO08917.
PhosphoSiteiO08917.
SwissPalmiO08917.

Proteomic databases

EPDiO08917.
PaxDbiO08917.
PeptideAtlasiO08917.
PRIDEiO08917.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000001569; ENSMUSP00000001569; ENSMUSG00000059714.
GeneIDi14251.
KEGGimmu:14251.
UCSCiuc008cip.1. mouse.

Organism-specific databases

CTDi10211.
MGIiMGI:1100500. Flot1.

Phylogenomic databases

eggNOGiKOG2668. Eukaryota.
COG2268. LUCA.
HOGENOMiHOG000240804.
HOVERGENiHBG051628.
InParanoidiO08917.
KOiK07192.
OMAiGCCYSKP.
OrthoDBiEOG091G0D3R.
PhylomeDBiO08917.
TreeFamiTF324879.

Miscellaneous databases

PROiO08917.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000059714.
CleanExiMM_FLOT1.
ExpressionAtlasiO08917. baseline and differential.
GenevisibleiO08917. MM.

Family and domain databases

InterProiIPR001107. Band_7.
IPR031905. Flotillin_C.
IPR027705. Flotillin_fam.
[Graphical view]
PANTHERiPTHR13806. PTHR13806. 1 hit.
PfamiPF01145. Band_7. 1 hit.
PF15975. Flot. 1 hit.
[Graphical view]
SMARTiSM00244. PHB. 1 hit.
[Graphical view]
SUPFAMiSSF117892. SSF117892. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiFLOT1_MOUSE
AccessioniPrimary (citable) accession number: O08917
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: July 1, 1997
Last modified: September 7, 2016
This is version 134 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Expression increases at least 10-fold as 3T3-L1 cells differentiate into adipocytes.

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.