Aip

Functionⁱ

May play a positive role in AHR-mediated (aromatic hydrocarbon receptor) signaling, possibly by influencing its receptivity for ligand and/or its nuclear targeting.

GO - Molecular functionⁱ

aryl hydrocarbon receptor binding
Source: MGI
Inferred from physical interactionⁱ
- 9083006
GAF domain binding Source: MGI
transcription cofactor activity
Source: MGI
Inferred from physical interactionⁱ
- 9083006
unfolded protein binding Source: HGNC

GO - Biological processⁱ

negative regulation of cyclic-nucleotide phosphodiesterase activity Source: Ensembl
protein maturation by protein folding Source: HGNC
protein targeting to mitochondrion Source: HGNC
regulation of protein kinase A signaling Source: Ensembl
xenobiotic metabolic process
Source: MGI
Inferred from physical interactionⁱ
- 9083006

Complete GO annotation...

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: AH receptor-interacting protein Short name: AIP Alternative name(s): Aryl-hydrocarbon receptor-interacting protein
Gene namesⁱ	Name:Aip
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 19

Organism-specific databases

MGIⁱ	MGI:109622. Aip.

Subcellular locationⁱ

Cytoplasm

GO - Cellular componentⁱ

aryl hydrocarbon receptor complex
Source: MGI
Inferred from direct assayⁱ
- 9083006
cytoplasm Source: MGI
cytosol
Source: MGI
Inferred from direct assayⁱ
- 17329248
- 9083006
membrane
Source: MGI
Inferred from direct assayⁱ
- 15082773
nucleoplasm Source: MGI
plasma membrane Source: Ensembl

Complete GO annotation...

Keywords - Cellular componentⁱ

Cytoplasm

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	Length	Description	Graphical view	Feature identifier	Actions
Chainⁱ	1 – 330	330	AH receptor-interacting protein		PRO_0000075340	Add BLAST

Amino acid modifications

Feature key	Position(s)	Length	Description	Graphical view	Feature identifier	Actions
Modified residueⁱ	43 – 43	1	PhosphoserineBy similarity Manual assertion inferred from sequence similarity toⁱ UniProtKB:O00170 (AIP_HUMAN)

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	O08915.
MaxQBⁱ	O08915.
PaxDbⁱ	O08915.
PeptideAtlasⁱ	O08915.
PRIDEⁱ	O08915.

2D gel databases

REPRODUCTION-2DPAGE	O08915.

REPRODUCTION-2DPAGE

O08915.

PTM databases

iPTMnetⁱ	O08915.
PhosphoSiteⁱ	O08915.

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000024847.
CleanExⁱ	MM_AIP.
ExpressionAtlasⁱ	O08915. baseline and differential.
Genevisibleⁱ	O08915. MM.

Interactionⁱ

Subunit structureⁱ

Interacts with RET in the pituitary gland; this interaction prevents the formation of the AIP-survivin complex.

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
Gna13	P27601	3	EBI-6935014,EBI-2255627
Gnaq	P21279	2	EBI-6935014,EBI-771975
Thrb	P37242	2	EBI-6935014,EBI-6935043

With

Entry

#Exp.

IntAct

Notes

Gna13

P27601

3

EBI-6935014,EBI-2255627

Gnaq

P21279

2

EBI-6935014,EBI-771975

Thrb

P37242

2

EBI-6935014,EBI-6935043

GO - Molecular functionⁱ

aryl hydrocarbon receptor binding
Source: MGI
Inferred from physical interactionⁱ
- 9083006
GAF domain binding Source: MGI
unfolded protein binding Source: HGNC

Protein-protein interaction databases

BioGridⁱ	198043. 1 interaction.
IntActⁱ	O08915. 4 interactions.
MINTⁱ	MINT-3374208.
STRINGⁱ	10090.ENSMUSP00000025767.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	O08915.
SMRⁱ	O08915. Positions 2-166, 173-325.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	Length	Description	Actions
Domainⁱ	31 – 121	91	PPIase FKBP-type	Add BLAST
Repeatⁱ	179 – 212	34	TPR 1	Add BLAST
Repeatⁱ	231 – 264	34	TPR 2	Add BLAST
Repeatⁱ	265 – 298	34	TPR 3	Add BLAST

Sequence similaritiesⁱ

Contains 1 PPIase FKBP-type domain.Curated

Contains 3 TPR repeats.PROSITE-ProRule annotation

Keywords - Domainⁱ

Repeat, TPR repeat

Phylogenomic databases

eggNOGⁱ	KOG0545. Eukaryota. ENOG410YGYV. LUCA.
GeneTreeⁱ	ENSGT00390000001289.
HOGENOMⁱ	HOG000007366.
HOVERGENⁱ	HBG004198.
InParanoidⁱ	O08915.
KOⁱ	K17767.
OMAⁱ	YEVIEHC.
OrthoDBⁱ	EOG091G0C69.
PhylomeDBⁱ	O08915.
TreeFamⁱ	TF314507.

Family and domain databases

Gene3Dⁱ	1.25.40.10. 1 hit.
InterProⁱ	IPR031208. AIP. IPR001179. PPIase_FKBP_dom. IPR013026. TPR-contain_dom. IPR011990. TPR-like_helical_dom. IPR019734. TPR_repeat. [Graphical view]
PANTHERⁱ	PTHR11242:SF3. PTHR11242:SF3. 1 hit.
Pfamⁱ	PF00254. FKBP_C. 1 hit. [Graphical view]
SUPFAMⁱ	SSF48452. SSF48452. 1 hit.
PROSITEⁱ	PS50005. TPR. 1 hit. PS50293. TPR_REGION. 1 hit. [Graphical view]

Sequenceⁱ

Sequence statusⁱ: Complete.

O08915-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MADLIARLRE DGIQKRVIQE GRGELPDFQD GTKATFHFRT LHSDNEGSVI 
        60         70         80         90        100
DDSRTRGKPM ELIVGKKFKL PVWETIVCTM REGEIAQFLC DIKHVVLYPL 
       110        120        130        140        150
VAKSLRNIAE GKDPLEGQRH CCGIAQMHEH SSLGHADLDA LQQNPQPLIF 
       160        170        180        190        200
HIEMLKVESP GTYQQDPWAM TDEEKAKAVP VIHQEGNRLY REGQVKEAAA 
       210        220        230        240        250
KYYDAIACLK NLQMKEQPGS PDWIQLDLQI TPLLLNYCQC KLVAQEYYEV 
       260        270        280        290        300
LDHCSSILNK YDDNVKAYFK RGKAHAAVWN AQEAQADFAK VLELDPALAP 
       310        320        330
VVSRELRALE TRIRQKDEED KARFRGIFSH

Length:330

Mass (Da):37,605

Last modified:July 1, 1997 - v1

Checksum:ⁱ25C61AB65F9064F2

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U85489 mRNA. Translation: AAB59009.1. AK146390 mRNA. Translation: BAE27133.1. BC075614 mRNA. Translation: AAH75614.1.
CCDSⁱ	CCDS29415.1.
RefSeqⁱ	NP_001263213.1. NM_001276284.1. NP_057875.1. NM_016666.3. XP_006531704.2. XM_006531641.2. XP_006531705.1. XM_006531642.2. XP_006531706.1. XM_006531643.1. XP_006544952.2. XM_006544889.2. XP_006544953.1. XM_006544890.1. XP_006544954.1. XM_006544891.1.
UniGeneⁱ	Mm.10433.

Genome annotation databases

Ensemblⁱ	ENSMUST00000025767; ENSMUSP00000025767; ENSMUSG00000024847. ENSMUST00000117831; ENSMUSP00000113807; ENSMUSG00000024847. ENSMUST00000180758; ENSMUSP00000137722; ENSMUSG00000097319. ENSMUST00000181243; ENSMUSP00000137847; ENSMUSG00000097319.
GeneIDⁱ	11632.
KEGGⁱ	mmu:11632.
UCSCⁱ	uc008fyp.2. mouse.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U85489 mRNA. Translation: AAB59009.1. AK146390 mRNA. Translation: BAE27133.1. BC075614 mRNA. Translation: AAH75614.1.
CCDSⁱ	CCDS29415.1.
RefSeqⁱ	NP_001263213.1. NM_001276284.1. NP_057875.1. NM_016666.3. XP_006531704.2. XM_006531641.2. XP_006531705.1. XM_006531642.2. XP_006531706.1. XM_006531643.1. XP_006544952.2. XM_006544889.2. XP_006544953.1. XM_006544890.1. XP_006544954.1. XM_006544891.1.
UniGeneⁱ	Mm.10433.

3D structure databases

ProteinModelPortalⁱ	O08915.
SMRⁱ	O08915. Positions 2-166, 173-325.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	198043. 1 interaction.
IntActⁱ	O08915. 4 interactions.
MINTⁱ	MINT-3374208.
STRINGⁱ	10090.ENSMUSP00000025767.

PTM databases

iPTMnetⁱ	O08915.
PhosphoSiteⁱ	O08915.

2D gel databases

REPRODUCTION-2DPAGE	O08915.

REPRODUCTION-2DPAGE

O08915.

Proteomic databases

EPDⁱ	O08915.
MaxQBⁱ	O08915.
PaxDbⁱ	O08915.
PeptideAtlasⁱ	O08915.
PRIDEⁱ	O08915.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000025767; ENSMUSP00000025767; ENSMUSG00000024847. ENSMUST00000117831; ENSMUSP00000113807; ENSMUSG00000024847. ENSMUST00000180758; ENSMUSP00000137722; ENSMUSG00000097319. ENSMUST00000181243; ENSMUSP00000137847; ENSMUSG00000097319.
GeneIDⁱ	11632.
KEGGⁱ	mmu:11632.
UCSCⁱ	uc008fyp.2. mouse.

Organism-specific databases

CTDⁱ	9049.
MGIⁱ	MGI:109622. Aip.

Phylogenomic databases

eggNOGⁱ	KOG0545. Eukaryota. ENOG410YGYV. LUCA.
GeneTreeⁱ	ENSGT00390000001289.
HOGENOMⁱ	HOG000007366.
HOVERGENⁱ	HBG004198.
InParanoidⁱ	O08915.
KOⁱ	K17767.
OMAⁱ	YEVIEHC.
OrthoDBⁱ	EOG091G0C69.
PhylomeDBⁱ	O08915.
TreeFamⁱ	TF314507.

Miscellaneous databases

ChiTaRSⁱ	Aip. mouse.
PROⁱ	O08915.
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000024847.
CleanExⁱ	MM_AIP.
ExpressionAtlasⁱ	O08915. baseline and differential.
Genevisibleⁱ	O08915. MM.

Family and domain databases

Gene3Dⁱ	1.25.40.10. 1 hit.
InterProⁱ	IPR031208. AIP. IPR001179. PPIase_FKBP_dom. IPR013026. TPR-contain_dom. IPR011990. TPR-like_helical_dom. IPR019734. TPR_repeat. [Graphical view]
PANTHERⁱ	PTHR11242:SF3. PTHR11242:SF3. 1 hit.
Pfamⁱ	PF00254. FKBP_C. 1 hit. [Graphical view]
SUPFAMⁱ	SSF48452. SSF48452. 1 hit.
PROSITEⁱ	PS50005. TPR. 1 hit. PS50293. TPR_REGION. 1 hit. [Graphical view]
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ

AIP_MOUSE

Accessionⁱ

Primary (citable) accession number: O08915
Secondary accession number(s): Q3UJM2

Entry historyⁱ

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	July 1, 1997
Last modified:	September 7, 2016
This is version 130 of the entry and version 1 of the sequence. [Complete history]

Entry statusⁱ

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Direct protein sequencing, Reference proteome

Documents

MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
SIMILARITY comments
Index of protein domains and families

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - O08915 (AIP_MOUSE)

UniProt

O08915 - AIP_MOUSE

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AH receptor-interacting protein

Select a section on the left to see content.

<p>Provides any useful information about the protein, mostly biological knowledge.</p><p><a href='../manual/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:</p><p><a href='../manual/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:</p><p><a href='../manual/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>Provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.</p><p><a href='../manual/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>Provides information on the location and the topology of the mature protein in the cell.</p><p><a href='../manual/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:</p><p><a href='../manual/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>Describes post-translational modifications (PTMs) and/or processing events.</p><p><a href='../manual/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

2D gel databases

PTM databases

<p>Provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.</p><p><a href='../manual/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>Provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.</p><p><a href='../manual/interaction_section' target='_top'>More...</a></p>Interactioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:</p><p><a href='../manual/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Protein-protein interaction databases

<p>Provides information on the tertiary and secondary structure of a protein.</p><p><a href='../manual/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>Provides information on sequence similarities with other proteins and the domain(s) present in a protein.</p><p><a href='../manual/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>Provides information about the sequence similarity with other proteins.</p><p><a href='../manual/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>Displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.</p><p><a href='../manual/sequences_section' target='_top'>More...</a></p>Sequencei

Sequence databases

Genome annotation databases

<p>Is used to point to information related to entries and found in data collections other than UniProtKB.</p><p><a href='../manual/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

2D gel databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>Provides general information on the entry.</p><p><a href='../manual/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>Contains any relevant information that doesn’t fit in any other defined sections</p><p><a href='../manual/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ