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Protein

AH receptor-interacting protein

Gene

Aip

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May play a positive role in AHR-mediated (aromatic hydrocarbon receptor) signaling, possibly by influencing its receptivity for ligand and/or its nuclear targeting.

GO - Molecular functioni

  • aryl hydrocarbon receptor binding Source: MGI
  • GAF domain binding Source: MGI
  • transcription cofactor activity Source: MGI
  • unfolded protein binding Source: HGNC

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
AH receptor-interacting protein
Short name:
AIP
Alternative name(s):
Aryl-hydrocarbon receptor-interacting protein
Gene namesi
Name:Aip
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:109622. Aip.

Subcellular locationi

GO - Cellular componenti

  • aryl hydrocarbon receptor complex Source: MGI
  • cytoplasm Source: MGI
  • cytosol Source: MGI
  • membrane Source: MGI
  • nucleoplasm Source: MGI
  • plasma membrane Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 330330AH receptor-interacting proteinPRO_0000075340Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei43 – 431PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiO08915.
MaxQBiO08915.
PaxDbiO08915.
PeptideAtlasiO08915.
PRIDEiO08915.

2D gel databases

REPRODUCTION-2DPAGEO08915.

PTM databases

iPTMnetiO08915.
PhosphoSiteiO08915.

Expressioni

Gene expression databases

BgeeiENSMUSG00000024847.
CleanExiMM_AIP.
ExpressionAtlasiO08915. baseline and differential.
GenevisibleiO08915. MM.

Interactioni

Subunit structurei

Interacts with RET in the pituitary gland; this interaction prevents the formation of the AIP-survivin complex.

Binary interactionsi

WithEntry#Exp.IntActNotes
Gna13P276013EBI-6935014,EBI-2255627
GnaqP212792EBI-6935014,EBI-771975
ThrbP372422EBI-6935014,EBI-6935043

GO - Molecular functioni

  • aryl hydrocarbon receptor binding Source: MGI
  • GAF domain binding Source: MGI
  • unfolded protein binding Source: HGNC

Protein-protein interaction databases

BioGridi198043. 1 interaction.
IntActiO08915. 4 interactions.
MINTiMINT-3374208.
STRINGi10090.ENSMUSP00000025767.

Structurei

3D structure databases

ProteinModelPortaliO08915.
SMRiO08915. Positions 2-166, 173-325.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini31 – 12191PPIase FKBP-typeAdd
BLAST
Repeati179 – 21234TPR 1Add
BLAST
Repeati231 – 26434TPR 2Add
BLAST
Repeati265 – 29834TPR 3Add
BLAST

Sequence similaritiesi

Contains 1 PPIase FKBP-type domain.Curated
Contains 3 TPR repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

eggNOGiKOG0545. Eukaryota.
ENOG410YGYV. LUCA.
GeneTreeiENSGT00390000001289.
HOGENOMiHOG000007366.
HOVERGENiHBG004198.
InParanoidiO08915.
KOiK17767.
OMAiYEVIEHC.
OrthoDBiEOG091G0C69.
PhylomeDBiO08915.
TreeFamiTF314507.

Family and domain databases

Gene3Di1.25.40.10. 1 hit.
InterProiIPR031208. AIP.
IPR001179. PPIase_FKBP_dom.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
[Graphical view]
PANTHERiPTHR11242:SF3. PTHR11242:SF3. 1 hit.
PfamiPF00254. FKBP_C. 1 hit.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 1 hit.
PROSITEiPS50005. TPR. 1 hit.
PS50293. TPR_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O08915-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADLIARLRE DGIQKRVIQE GRGELPDFQD GTKATFHFRT LHSDNEGSVI
60 70 80 90 100
DDSRTRGKPM ELIVGKKFKL PVWETIVCTM REGEIAQFLC DIKHVVLYPL
110 120 130 140 150
VAKSLRNIAE GKDPLEGQRH CCGIAQMHEH SSLGHADLDA LQQNPQPLIF
160 170 180 190 200
HIEMLKVESP GTYQQDPWAM TDEEKAKAVP VIHQEGNRLY REGQVKEAAA
210 220 230 240 250
KYYDAIACLK NLQMKEQPGS PDWIQLDLQI TPLLLNYCQC KLVAQEYYEV
260 270 280 290 300
LDHCSSILNK YDDNVKAYFK RGKAHAAVWN AQEAQADFAK VLELDPALAP
310 320 330
VVSRELRALE TRIRQKDEED KARFRGIFSH
Length:330
Mass (Da):37,605
Last modified:July 1, 1997 - v1
Checksum:i25C61AB65F9064F2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U85489 mRNA. Translation: AAB59009.1.
AK146390 mRNA. Translation: BAE27133.1.
BC075614 mRNA. Translation: AAH75614.1.
CCDSiCCDS29415.1.
RefSeqiNP_001263213.1. NM_001276284.1.
NP_057875.1. NM_016666.3.
XP_006531704.2. XM_006531641.2.
XP_006531705.1. XM_006531642.2.
XP_006531706.1. XM_006531643.1.
XP_006544952.2. XM_006544889.2.
XP_006544953.1. XM_006544890.1.
XP_006544954.1. XM_006544891.1.
UniGeneiMm.10433.

Genome annotation databases

EnsembliENSMUST00000025767; ENSMUSP00000025767; ENSMUSG00000024847.
ENSMUST00000117831; ENSMUSP00000113807; ENSMUSG00000024847.
ENSMUST00000180758; ENSMUSP00000137722; ENSMUSG00000097319.
ENSMUST00000181243; ENSMUSP00000137847; ENSMUSG00000097319.
GeneIDi11632.
KEGGimmu:11632.
UCSCiuc008fyp.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U85489 mRNA. Translation: AAB59009.1.
AK146390 mRNA. Translation: BAE27133.1.
BC075614 mRNA. Translation: AAH75614.1.
CCDSiCCDS29415.1.
RefSeqiNP_001263213.1. NM_001276284.1.
NP_057875.1. NM_016666.3.
XP_006531704.2. XM_006531641.2.
XP_006531705.1. XM_006531642.2.
XP_006531706.1. XM_006531643.1.
XP_006544952.2. XM_006544889.2.
XP_006544953.1. XM_006544890.1.
XP_006544954.1. XM_006544891.1.
UniGeneiMm.10433.

3D structure databases

ProteinModelPortaliO08915.
SMRiO08915. Positions 2-166, 173-325.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi198043. 1 interaction.
IntActiO08915. 4 interactions.
MINTiMINT-3374208.
STRINGi10090.ENSMUSP00000025767.

PTM databases

iPTMnetiO08915.
PhosphoSiteiO08915.

2D gel databases

REPRODUCTION-2DPAGEO08915.

Proteomic databases

EPDiO08915.
MaxQBiO08915.
PaxDbiO08915.
PeptideAtlasiO08915.
PRIDEiO08915.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000025767; ENSMUSP00000025767; ENSMUSG00000024847.
ENSMUST00000117831; ENSMUSP00000113807; ENSMUSG00000024847.
ENSMUST00000180758; ENSMUSP00000137722; ENSMUSG00000097319.
ENSMUST00000181243; ENSMUSP00000137847; ENSMUSG00000097319.
GeneIDi11632.
KEGGimmu:11632.
UCSCiuc008fyp.2. mouse.

Organism-specific databases

CTDi9049.
MGIiMGI:109622. Aip.

Phylogenomic databases

eggNOGiKOG0545. Eukaryota.
ENOG410YGYV. LUCA.
GeneTreeiENSGT00390000001289.
HOGENOMiHOG000007366.
HOVERGENiHBG004198.
InParanoidiO08915.
KOiK17767.
OMAiYEVIEHC.
OrthoDBiEOG091G0C69.
PhylomeDBiO08915.
TreeFamiTF314507.

Miscellaneous databases

ChiTaRSiAip. mouse.
PROiO08915.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000024847.
CleanExiMM_AIP.
ExpressionAtlasiO08915. baseline and differential.
GenevisibleiO08915. MM.

Family and domain databases

Gene3Di1.25.40.10. 1 hit.
InterProiIPR031208. AIP.
IPR001179. PPIase_FKBP_dom.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
[Graphical view]
PANTHERiPTHR11242:SF3. PTHR11242:SF3. 1 hit.
PfamiPF00254. FKBP_C. 1 hit.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 1 hit.
PROSITEiPS50005. TPR. 1 hit.
PS50293. TPR_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAIP_MOUSE
AccessioniPrimary (citable) accession number: O08915
Secondary accession number(s): Q3UJM2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: July 1, 1997
Last modified: September 7, 2016
This is version 130 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.