UniProtKB - O08915 (AIP_MOUSE)
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Protein
AH receptor-interacting protein
Gene
Aip
Organism
Mus musculus (Mouse)
Status
Functioni
May play a positive role in AHR-mediated (aromatic hydrocarbon receptor) signaling, possibly by influencing its receptivity for ligand and/or its nuclear targeting.
GO - Molecular functioni
- aryl hydrocarbon receptor binding Source: MGI
- GAF domain binding Source: MGI
- transcription cofactor activity Source: MGI
- unfolded protein binding Source: HGNC
GO - Biological processi
- negative regulation of cyclic-nucleotide phosphodiesterase activity Source: Ensembl
- protein maturation by protein folding Source: HGNC
- protein targeting to mitochondrion Source: HGNC
- regulation of protein kinase A signaling Source: Ensembl
- xenobiotic metabolic process Source: MGI
Enzyme and pathway databases
Reactomei | R-MMU-8937144. Aryl hydrocarbon receptor signalling. |
Names & Taxonomyi
Protein namesi | Recommended name: AH receptor-interacting proteinShort name: AIP Alternative name(s): Aryl-hydrocarbon receptor-interacting protein |
Gene namesi | Name:Aip |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:109622. Aip. |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000075340 | 1 – 330 | AH receptor-interacting proteinAdd BLAST | 330 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 43 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | O08915. |
MaxQBi | O08915. |
PaxDbi | O08915. |
PeptideAtlasi | O08915. |
PRIDEi | O08915. |
2D gel databases
REPRODUCTION-2DPAGEi | O08915. |
PTM databases
iPTMneti | O08915. |
PhosphoSitePlusi | O08915. |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000024847. |
CleanExi | MM_AIP. |
ExpressionAtlasi | O08915. baseline and differential. |
Genevisiblei | O08915. MM. |
Interactioni
Subunit structurei
Interacts with RET in the pituitary gland; this interaction prevents the formation of the AIP-survivin complex.
Binary interactionsi
GO - Molecular functioni
- aryl hydrocarbon receptor binding Source: MGI
- GAF domain binding Source: MGI
- unfolded protein binding Source: HGNC
Protein-protein interaction databases
BioGridi | 198043. 2 interactors. |
CORUMi | O08915. |
IntActi | O08915. 4 interactors. |
MINTi | O08915. |
STRINGi | 10090.ENSMUSP00000025767. |
Structurei
3D structure databases
ProteinModelPortali | O08915. |
SMRi | O08915. |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 31 – 121 | PPIase FKBP-typeAdd BLAST | 91 | |
Repeati | 179 – 212 | TPR 1Add BLAST | 34 | |
Repeati | 231 – 264 | TPR 2Add BLAST | 34 | |
Repeati | 265 – 298 | TPR 3Add BLAST | 34 |
Keywords - Domaini
Repeat, TPR repeatPhylogenomic databases
eggNOGi | KOG0545. Eukaryota. ENOG410YGYV. LUCA. |
GeneTreei | ENSGT00390000001289. |
HOGENOMi | HOG000007366. |
HOVERGENi | HBG004198. |
InParanoidi | O08915. |
KOi | K17767. |
OMAi | YEVIEHC. |
OrthoDBi | EOG091G0C69. |
PhylomeDBi | O08915. |
TreeFami | TF314507. |
Family and domain databases
Gene3Di | 1.25.40.10. 1 hit. |
InterProi | View protein in InterPro IPR031208. AIP. IPR001179. PPIase_FKBP_dom. IPR013026. TPR-contain_dom. IPR011990. TPR-like_helical_dom_sf. IPR019734. TPR_repeat. |
PANTHERi | PTHR11242:SF3. PTHR11242:SF3. 1 hit. |
Pfami | View protein in Pfam PF00254. FKBP_C. 1 hit. |
SUPFAMi | SSF48452. SSF48452. 1 hit. |
PROSITEi | View protein in PROSITE PS50005. TPR. 1 hit. PS50293. TPR_REGION. 1 hit. |
i Sequence
Sequence statusi: Complete.
O08915-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MADLIARLRE DGIQKRVIQE GRGELPDFQD GTKATFHFRT LHSDNEGSVI
60 70 80 90 100
DDSRTRGKPM ELIVGKKFKL PVWETIVCTM REGEIAQFLC DIKHVVLYPL
110 120 130 140 150
VAKSLRNIAE GKDPLEGQRH CCGIAQMHEH SSLGHADLDA LQQNPQPLIF
160 170 180 190 200
HIEMLKVESP GTYQQDPWAM TDEEKAKAVP VIHQEGNRLY REGQVKEAAA
210 220 230 240 250
KYYDAIACLK NLQMKEQPGS PDWIQLDLQI TPLLLNYCQC KLVAQEYYEV
260 270 280 290 300
LDHCSSILNK YDDNVKAYFK RGKAHAAVWN AQEAQADFAK VLELDPALAP
310 320 330
VVSRELRALE TRIRQKDEED KARFRGIFSH
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U85489 mRNA. Translation: AAB59009.1. AK146390 mRNA. Translation: BAE27133.1. BC075614 mRNA. Translation: AAH75614.1. |
CCDSi | CCDS29415.1. |
RefSeqi | NP_001263213.1. NM_001276284.1. NP_057875.1. NM_016666.3. XP_006531704.2. XM_006531641.3. XP_006531705.1. XM_006531642.3. |
UniGenei | Mm.10433. |
Genome annotation databases
Similar proteinsi
Entry informationi
Entry namei | AIP_MOUSE | |
Accessioni | O08915Primary (citable) accession number: O08915 Secondary accession number(s): Q3UJM2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 30, 2000 |
Last sequence update: | July 1, 1997 | |
Last modified: | February 28, 2018 | |
This is version 140 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |