Zinc finger protein Aiolos - Mus musculus (Mouse)

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O08900 (IKZF3_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 102. History...

Clusters with 100%, 90%, 50% identity |

Documents (2) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Zinc finger protein Aiolos

Alternative name(s):
Ikaros family zinc finger protein 3

Gene names

Name:	Ikzf3
Synonyms:	Zfpn1a3, Znfn1a3

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	507 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Transcription factor that plays an important role in the regulation of lymphocyte differentiation. Binds to GGGAA. Plays an essential role in regulation of B-cell differentiation, proliferation and maturation to an effector state. Involved in regulating BCL2 expression and controlling apoptosis in T-cells in an IL2-dependent manner. Ref.1 Ref.4
Subunit structure	Homodimer, and heterodimer with other IKAROS family members. Interacts with IKZF4 AND IKZF5. Interacts with HRAS. Interacts with FOXP3; this interaction may be required for silencing target genes and regulating the suppressive activity of FOXP3-positive regulatory T-cells (Treg). Interacts with BCL21L isoform Bcl-X(L); this interaction blocks the anti-apoptotic role of BCL21L. Associates with histone deacetylase complexes containing HDAC1, MTA2 and SIN3A By similarity. Interacts with IKZF1. Ref.1
Subcellular location	Nucleus. Cytoplasm Ref.1.
Tissue specificity	Expression is restricted to lymphoid tissues. Expressed at highest levels in spleen and at lower levels in the thymus and bone marrow. First detected in more committed lymphoid progenitors and strongly up-regulated as these differentiate into pre-T and pre-B cell precursors. Ref.1
Sequence similarities	Belongs to the Ikaros C2H2-type zinc-finger protein family. Contains 6 C2H2-type zinc fingers.

Ontologies

Keywords
Biological process	B-cell activation Transcription Transcription regulation
Cellular component	Cytoplasm Nucleus
Domain	Repeat Zinc-finger
Ligand	DNA-binding Metal-binding Zinc
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	B cell activation Inferred from electronic annotation. Source: UniProtKB-KW regulation of B cell differentiation Inferred from mutant phenotype Ref.4. Source: UniProtKB regulation of B cell proliferation Inferred from mutant phenotype Ref.4. Source: UniProtKB regulation of apoptotic process Inferred from sequence or structural similarity. Source: UniProtKB regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	cytoplasm Inferred from direct assay Ref.1. Source: UniProtKB nucleus Inferred from direct assay Ref.1. Source: UniProtKB plasma membrane Inferred from electronic annotation. Source: Compara
Molecular_function	protein homodimerization activity Inferred from sequence or structural similarity. Source: UniProtKB sequence-specific DNA binding Inferred from direct assay Ref.1. Source: UniProtKB zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 507

507

Zinc finger protein Aiolos

PRO_0000047091

Regions

Zinc finger

117 – 139

C2H2-type 1

Zinc finger

145 – 167

C2H2-type 2

Zinc finger

173 – 195

C2H2-type 3

Zinc finger

201 – 223

C2H2-type 4; atypical

Zinc finger

450 – 472

C2H2-type 5

Zinc finger

478 – 502

C2H2-type 6; atypical

Experimental info

Sequence conflict

114

G → S in AAB58795. Ref.1

Sequence conflict

319

L → F in AAB58795. Ref.1

Sequence conflict

352

N → M in AAB58795. Ref.1

Sequences

Sequence

Length

Mass (Da)

Tools

O08900 [UniParc].

Last modified July 27, 2011. Version 2.
Checksum: 103D46D0C6E236F7
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FASTA

507

57,967

        10         20         30         40         50         60 
MEDIQPTVEL KSTEEQPLPT ESPDALNDYS LPKPHEIENV DSREAPANED EDAGEDSMKV 

        70         80         90        100        110        120 
KDEYSDRDEN IMKPEPMGDA EESEMPYSYA REYSDYESIK LERHVPYDNS RPTGGKMNCD 

       130        140        150        160        170        180 
VCGLSCISFN VLMVHKRSHT GERPFQCNQC GASFTQKGNL LRHIKLHTGE KPFKCHLCNY 

       190        200        210        220        230        240 
ACQRRDALTG HLRTHSVEKP YKCEFCGRSY KQRSSLEEHK ERCRAFLQNP DLGDAASVEA 

       250        260        270        280        290        300 
RHIKAEMGSE RALVLDRLAS NVAKRKSSMP QKFIGEKRHC FDANYNPGYM YEKENEMMQT 

       310        320        330        340        350        360 
RMMDQAINNA ISYLGAEALR PLVQTPPAPT SEMVPVISSV YPIALTRADM PNGAPQEMEK 

       370        380        390        400        410        420 
KRILLPEKIL PSERGLSPNN SAQDSTDTDS NHEDRQHLYQ QSHVVLPQAR NGMPLLKEVP 

       430        440        450        460        470        480 
RSFELLKPPP ICLRDSIKVI NKEGEVMDVF RCDHCHVLFL DYVMFTIHMG CHGFRDPFEC 

       490        500 
NMCGYRSHDR YEFSSHIARG EHRAMLK

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Aiolos, a lymphoid restricted transcription factor that interacts with Ikaros to regulate lymphocyte differentiation." Morgan B., Sun L., Avitahl N., Andrikopoulos K., Ikeda T., Gonzales E., Wu P., Neben S., Georgopoulos K. EMBO J. 16:2004-2013(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INTERACTION WITH IKZF1, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
[2]	"Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. Ponting C.P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J.
[3]	Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"Aiolos regulates B cell activation and maturation to effector state." Wang J.H., Avitahl N., Cariappa A., Friedrich C., Ikeda T., Renold A., Andrikopoulos K., Liang L., Pillai S., Morgan B.A., Georgopoulos K. Immunity 9:543-553(1998) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF001293 mRNA. Translation: AAB58795.1. AL591390, AL591125 Genomic DNA. Translation: CAM22013.1. AL591125, AL591390 Genomic DNA. Translation: CAM24385.1. CH466556 Genomic DNA. Translation: EDL16146.1.
IPI	IPI00117144.
RefSeq	NP_035901.1. NM_011771.1.
UniGene	Mm.133367. Mm.459157.
3D structure databases
ProteinModelPortal	O08900.
SMR	O08900. Positions 109-220, 447-502.
ModBase	Search...
Protein-protein interaction databases
IntAct	O08900. 3 interactions.
PTM databases
PhosphoSite	O08900.
Proteomic databases
PaxDb	O08900.
PRIDE	O08900.
Protocols and materials databases
DNASU	22780.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000103141; ENSMUSP00000099430; ENSMUSG00000018168.
GeneID	22780.
KEGG	mmu:22780.
Organism-specific databases
CTD	22806.
MGI	MGI:1342542. Ikzf3.
Phylogenomic databases
eggNOG	NOG274203.
GeneTree	ENSGT00550000074392.
HOGENOM	HOG000049114.
HOVERGEN	HBG004752.
InParanoid	B1AQE6.
KO	K09220.
OMA	IQTRMMD.
OrthoDB	EOG4D52XF.
Gene expression databases
ArrayExpress	O08900.
Bgee	O08900.
CleanEx	MM_IKZF3.
Genevestigator	O08900.
GermOnline	ENSMUSG00000018168. Mus musculus.
Family and domain databases
Gene3D	3.30.160.60. 4 hits.
InterPro	IPR007087. Znf_C2H2. IPR015880. Znf_C2H2-like. IPR013087. Znf_C2H2/integrase_DNA-bd. [Graphical view]
SMART	SM00355. ZnF_C2H2. 6 hits. [Graphical view]
PROSITE	PS00028. ZINC_FINGER_C2H2_1. 4 hits. PS50157. ZINC_FINGER_C2H2_2. 4 hits. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	IKZF3. mouse.
NextBio	303343.
SOURCE	Search...

Entry information

Entry name

IKZF3_MOUSE

Accession

Primary (citable) accession number: O08900
Secondary accession number(s): B1AQE6

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 19, 2002
Last sequence update:	July 27, 2011
Last modified:	May 1, 2013
This is version 102 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents