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O08900

- IKZF3_MOUSE

UniProt

O08900 - IKZF3_MOUSE

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Protein
Zinc finger protein Aiolos
Gene
Ikzf3, Zfpn1a3, Znfn1a3
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Transcription factor that plays an important role in the regulation of lymphocyte differentiation. Binds to GGGAA. Plays an essential role in regulation of B-cell differentiation, proliferation and maturation to an effector state. Involved in regulating BCL2 expression and controlling apoptosis in T-cells in an IL2-dependent manner.2 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri117 – 13923C2H2-type 1
Add
BLAST
Zinc fingeri145 – 16723C2H2-type 2
Add
BLAST
Zinc fingeri173 – 19523C2H2-type 3
Add
BLAST
Zinc fingeri201 – 22323C2H2-type 4; atypical
Add
BLAST
Zinc fingeri450 – 47223C2H2-type 5
Add
BLAST
Zinc fingeri478 – 50225C2H2-type 6; atypical
Add
BLAST

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. protein binding Source: UniProtKB
  3. protein heterodimerization activity Source: MGI
  4. protein homodimerization activity Source: UniProtKB
  5. sequence-specific DNA binding Source: UniProtKB

GO - Biological processi

  1. B cell activation Source: UniProtKB-KW
  2. regulation of B cell differentiation Source: UniProtKB
  3. regulation of B cell proliferation Source: UniProtKB
  4. regulation of apoptotic process Source: UniProtKB
  5. regulation of lymphocyte differentiation Source: UniProtKB
  6. regulation of transcription, DNA-templated Source: UniProtKB-KW
  7. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

B-cell activation, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein Aiolos
Alternative name(s):
Ikaros family zinc finger protein 3
Gene namesi
Name:Ikzf3
Synonyms:Zfpn1a3, Znfn1a3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:1342542. Ikzf3.

Subcellular locationi

Nucleus. Cytoplasm 1 Publication

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. nucleus Source: UniProtKB
  3. plasma membrane Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 507507Zinc finger protein Aiolos
PRO_0000047091Add
BLAST

Proteomic databases

PaxDbiO08900.
PRIDEiO08900.

PTM databases

PhosphoSiteiO08900.

Expressioni

Tissue specificityi

Expression is restricted to lymphoid tissues. Expressed at highest levels in spleen and at lower levels in the thymus and bone marrow. First detected in more committed lymphoid progenitors and strongly up-regulated as these differentiate into pre-T and pre-B cell precursors.1 Publication

Gene expression databases

ArrayExpressiO08900.
BgeeiO08900.
CleanExiMM_IKZF3.
GenevestigatoriO08900.

Interactioni

Subunit structurei

Homodimer, and heterodimer with other IKAROS family members. Interacts with IKZF4 AND IKZF5. Interacts with HRAS. Interacts with FOXP3; this interaction may be required for silencing target genes and regulating the suppressive activity of FOXP3-positive regulatory T-cells (Treg). Interacts with BCL21L isoform Bcl-X(L); this interaction blocks the anti-apoptotic role of BCL21L. Associates with histone deacetylase complexes containing HDAC1, MTA2 and SIN3A By similarity. Interacts with IKZF1.1 Publication

Protein-protein interaction databases

BioGridi204702. 4 interactions.
IntActiO08900. 3 interactions.

Structurei

3D structure databases

ProteinModelPortaliO08900.
SMRiO08900. Positions 85-220, 447-503.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiNOG274203.
GeneTreeiENSGT00550000074392.
HOGENOMiHOG000049114.
HOVERGENiHBG004752.
InParanoidiB1AQE6.
KOiK09220.
OMAiYPIALTR.
OrthoDBiEOG79GT61.
TreeFamiTF331189.

Family and domain databases

Gene3Di3.30.160.60. 4 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 6 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 4 hits.
PS50157. ZINC_FINGER_C2H2_2. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O08900-1 [UniParc]FASTAAdd to Basket

« Hide

MEDIQPTVEL KSTEEQPLPT ESPDALNDYS LPKPHEIENV DSREAPANED    50
EDAGEDSMKV KDEYSDRDEN IMKPEPMGDA EESEMPYSYA REYSDYESIK 100
LERHVPYDNS RPTGGKMNCD VCGLSCISFN VLMVHKRSHT GERPFQCNQC 150
GASFTQKGNL LRHIKLHTGE KPFKCHLCNY ACQRRDALTG HLRTHSVEKP 200
YKCEFCGRSY KQRSSLEEHK ERCRAFLQNP DLGDAASVEA RHIKAEMGSE 250
RALVLDRLAS NVAKRKSSMP QKFIGEKRHC FDANYNPGYM YEKENEMMQT 300
RMMDQAINNA ISYLGAEALR PLVQTPPAPT SEMVPVISSV YPIALTRADM 350
PNGAPQEMEK KRILLPEKIL PSERGLSPNN SAQDSTDTDS NHEDRQHLYQ 400
QSHVVLPQAR NGMPLLKEVP RSFELLKPPP ICLRDSIKVI NKEGEVMDVF 450
RCDHCHVLFL DYVMFTIHMG CHGFRDPFEC NMCGYRSHDR YEFSSHIARG 500
EHRAMLK 507
Length:507
Mass (Da):57,967
Last modified:July 27, 2011 - v2
Checksum:i103D46D0C6E236F7
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti114 – 1141G → S in AAB58795. 1 Publication
Sequence conflicti319 – 3191L → F in AAB58795. 1 Publication
Sequence conflicti352 – 3521N → M in AAB58795. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF001293 mRNA. Translation: AAB58795.1.
AL591390, AL591125 Genomic DNA. Translation: CAM22013.1.
AL591125, AL591390 Genomic DNA. Translation: CAM24385.1.
CH466556 Genomic DNA. Translation: EDL16146.1.
CCDSiCCDS25352.1.
RefSeqiNP_035901.1. NM_011771.1.
UniGeneiMm.133367.
Mm.459157.

Genome annotation databases

EnsembliENSMUST00000103141; ENSMUSP00000099430; ENSMUSG00000018168.
GeneIDi22780.
KEGGimmu:22780.
UCSCiuc007lgl.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF001293 mRNA. Translation: AAB58795.1 .
AL591390 , AL591125 Genomic DNA. Translation: CAM22013.1 .
AL591125 , AL591390 Genomic DNA. Translation: CAM24385.1 .
CH466556 Genomic DNA. Translation: EDL16146.1 .
CCDSi CCDS25352.1.
RefSeqi NP_035901.1. NM_011771.1.
UniGenei Mm.133367.
Mm.459157.

3D structure databases

ProteinModelPortali O08900.
SMRi O08900. Positions 85-220, 447-503.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 204702. 4 interactions.
IntActi O08900. 3 interactions.

PTM databases

PhosphoSitei O08900.

Proteomic databases

PaxDbi O08900.
PRIDEi O08900.

Protocols and materials databases

DNASUi 22780.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000103141 ; ENSMUSP00000099430 ; ENSMUSG00000018168 .
GeneIDi 22780.
KEGGi mmu:22780.
UCSCi uc007lgl.1. mouse.

Organism-specific databases

CTDi 22806.
MGIi MGI:1342542. Ikzf3.

Phylogenomic databases

eggNOGi NOG274203.
GeneTreei ENSGT00550000074392.
HOGENOMi HOG000049114.
HOVERGENi HBG004752.
InParanoidi B1AQE6.
KOi K09220.
OMAi YPIALTR.
OrthoDBi EOG79GT61.
TreeFami TF331189.

Miscellaneous databases

ChiTaRSi IKZF3. mouse.
NextBioi 303343.
PROi O08900.
SOURCEi Search...

Gene expression databases

ArrayExpressi O08900.
Bgeei O08900.
CleanExi MM_IKZF3.
Genevestigatori O08900.

Family and domain databases

Gene3Di 3.30.160.60. 4 hits.
InterProi IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view ]
SMARTi SM00355. ZnF_C2H2. 6 hits.
[Graphical view ]
PROSITEi PS00028. ZINC_FINGER_C2H2_1. 4 hits.
PS50157. ZINC_FINGER_C2H2_2. 4 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Aiolos, a lymphoid restricted transcription factor that interacts with Ikaros to regulate lymphocyte differentiation."
    Morgan B., Sun L., Avitahl N., Andrikopoulos K., Ikeda T., Gonzales E., Wu P., Neben S., Georgopoulos K.
    EMBO J. 16:2004-2013(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INTERACTION WITH IKZF1, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: FUNCTION.

Entry informationi

Entry nameiIKZF3_MOUSE
AccessioniPrimary (citable) accession number: O08900
Secondary accession number(s): B1AQE6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: July 27, 2011
Last modified: July 9, 2014
This is version 113 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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