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O08900

- IKZF3_MOUSE

UniProt

O08900 - IKZF3_MOUSE

Protein

Zinc finger protein Aiolos

Gene

Ikzf3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 114 (01 Oct 2014)
      Sequence version 2 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    Transcription factor that plays an important role in the regulation of lymphocyte differentiation. Binds to GGGAA. Plays an essential role in regulation of B-cell differentiation, proliferation and maturation to an effector state. Involved in regulating BCL2 expression and controlling apoptosis in T-cells in an IL2-dependent manner.2 Publications

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri117 – 13923C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri145 – 16723C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri173 – 19523C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri201 – 22323C2H2-type 4; atypicalPROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri450 – 47223C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri478 – 50225C2H2-type 6; atypicalPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. protein binding Source: UniProtKB
    3. protein heterodimerization activity Source: MGI
    4. protein homodimerization activity Source: UniProtKB
    5. sequence-specific DNA binding Source: UniProtKB

    GO - Biological processi

    1. B cell activation Source: UniProtKB-KW
    2. regulation of apoptotic process Source: UniProtKB
    3. regulation of B cell differentiation Source: UniProtKB
    4. regulation of B cell proliferation Source: UniProtKB
    5. regulation of lymphocyte differentiation Source: UniProtKB
    6. regulation of transcription, DNA-templated Source: UniProtKB-KW
    7. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    B-cell activation, Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Zinc finger protein Aiolos
    Alternative name(s):
    Ikaros family zinc finger protein 3
    Gene namesi
    Name:Ikzf3
    Synonyms:Zfpn1a3, Znfn1a3
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 11

    Organism-specific databases

    MGIiMGI:1342542. Ikzf3.

    Subcellular locationi

    Nucleus 1 Publication. Cytoplasm 1 Publication

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. nucleus Source: UniProtKB
    3. plasma membrane Source: Ensembl

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 507507Zinc finger protein AiolosPRO_0000047091Add
    BLAST

    Proteomic databases

    PaxDbiO08900.
    PRIDEiO08900.

    PTM databases

    PhosphoSiteiO08900.

    Expressioni

    Tissue specificityi

    Expression is restricted to lymphoid tissues. Expressed at highest levels in spleen and at lower levels in the thymus and bone marrow. First detected in more committed lymphoid progenitors and strongly up-regulated as these differentiate into pre-T and pre-B cell precursors.1 Publication

    Gene expression databases

    ArrayExpressiO08900.
    BgeeiO08900.
    CleanExiMM_IKZF3.
    GenevestigatoriO08900.

    Interactioni

    Subunit structurei

    Homodimer, and heterodimer with other IKAROS family members. Interacts with IKZF4 AND IKZF5. Interacts with HRAS. Interacts with FOXP3; this interaction may be required for silencing target genes and regulating the suppressive activity of FOXP3-positive regulatory T-cells (Treg). Interacts with BCL21L isoform Bcl-X(L); this interaction blocks the anti-apoptotic role of BCL21L. Associates with histone deacetylase complexes containing HDAC1, MTA2 and SIN3A By similarity. Interacts with IKZF1.By similarity1 Publication

    Protein-protein interaction databases

    BioGridi204702. 4 interactions.
    IntActiO08900. 3 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliO08900.
    SMRiO08900. Positions 85-220, 447-503.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Contains 6 C2H2-type zinc fingers.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri117 – 13923C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri145 – 16723C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri173 – 19523C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri201 – 22323C2H2-type 4; atypicalPROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri450 – 47223C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri478 – 50225C2H2-type 6; atypicalPROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiNOG274203.
    GeneTreeiENSGT00550000074392.
    HOGENOMiHOG000049114.
    HOVERGENiHBG004752.
    InParanoidiB1AQE6.
    KOiK09220.
    OMAiYPIALTR.
    OrthoDBiEOG79GT61.
    TreeFamiTF331189.

    Family and domain databases

    Gene3Di3.30.160.60. 4 hits.
    InterProiIPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view]
    SMARTiSM00355. ZnF_C2H2. 6 hits.
    [Graphical view]
    PROSITEiPS00028. ZINC_FINGER_C2H2_1. 4 hits.
    PS50157. ZINC_FINGER_C2H2_2. 4 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O08900-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEDIQPTVEL KSTEEQPLPT ESPDALNDYS LPKPHEIENV DSREAPANED    50
    EDAGEDSMKV KDEYSDRDEN IMKPEPMGDA EESEMPYSYA REYSDYESIK 100
    LERHVPYDNS RPTGGKMNCD VCGLSCISFN VLMVHKRSHT GERPFQCNQC 150
    GASFTQKGNL LRHIKLHTGE KPFKCHLCNY ACQRRDALTG HLRTHSVEKP 200
    YKCEFCGRSY KQRSSLEEHK ERCRAFLQNP DLGDAASVEA RHIKAEMGSE 250
    RALVLDRLAS NVAKRKSSMP QKFIGEKRHC FDANYNPGYM YEKENEMMQT 300
    RMMDQAINNA ISYLGAEALR PLVQTPPAPT SEMVPVISSV YPIALTRADM 350
    PNGAPQEMEK KRILLPEKIL PSERGLSPNN SAQDSTDTDS NHEDRQHLYQ 400
    QSHVVLPQAR NGMPLLKEVP RSFELLKPPP ICLRDSIKVI NKEGEVMDVF 450
    RCDHCHVLFL DYVMFTIHMG CHGFRDPFEC NMCGYRSHDR YEFSSHIARG 500
    EHRAMLK 507
    Length:507
    Mass (Da):57,967
    Last modified:July 27, 2011 - v2
    Checksum:i103D46D0C6E236F7
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti114 – 1141G → S in AAB58795. (PubMed:9155026)Curated
    Sequence conflicti319 – 3191L → F in AAB58795. (PubMed:9155026)Curated
    Sequence conflicti352 – 3521N → M in AAB58795. (PubMed:9155026)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF001293 mRNA. Translation: AAB58795.1.
    AL591390, AL591125 Genomic DNA. Translation: CAM22013.1.
    AL591125, AL591390 Genomic DNA. Translation: CAM24385.1.
    CH466556 Genomic DNA. Translation: EDL16146.1.
    CCDSiCCDS25352.1.
    RefSeqiNP_035901.1. NM_011771.1.
    UniGeneiMm.133367.
    Mm.459157.

    Genome annotation databases

    EnsembliENSMUST00000103141; ENSMUSP00000099430; ENSMUSG00000018168.
    GeneIDi22780.
    KEGGimmu:22780.
    UCSCiuc007lgl.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF001293 mRNA. Translation: AAB58795.1 .
    AL591390 , AL591125 Genomic DNA. Translation: CAM22013.1 .
    AL591125 , AL591390 Genomic DNA. Translation: CAM24385.1 .
    CH466556 Genomic DNA. Translation: EDL16146.1 .
    CCDSi CCDS25352.1.
    RefSeqi NP_035901.1. NM_011771.1.
    UniGenei Mm.133367.
    Mm.459157.

    3D structure databases

    ProteinModelPortali O08900.
    SMRi O08900. Positions 85-220, 447-503.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 204702. 4 interactions.
    IntActi O08900. 3 interactions.

    PTM databases

    PhosphoSitei O08900.

    Proteomic databases

    PaxDbi O08900.
    PRIDEi O08900.

    Protocols and materials databases

    DNASUi 22780.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000103141 ; ENSMUSP00000099430 ; ENSMUSG00000018168 .
    GeneIDi 22780.
    KEGGi mmu:22780.
    UCSCi uc007lgl.1. mouse.

    Organism-specific databases

    CTDi 22806.
    MGIi MGI:1342542. Ikzf3.

    Phylogenomic databases

    eggNOGi NOG274203.
    GeneTreei ENSGT00550000074392.
    HOGENOMi HOG000049114.
    HOVERGENi HBG004752.
    InParanoidi B1AQE6.
    KOi K09220.
    OMAi YPIALTR.
    OrthoDBi EOG79GT61.
    TreeFami TF331189.

    Miscellaneous databases

    ChiTaRSi IKZF3. mouse.
    NextBioi 303343.
    PROi O08900.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O08900.
    Bgeei O08900.
    CleanExi MM_IKZF3.
    Genevestigatori O08900.

    Family and domain databases

    Gene3Di 3.30.160.60. 4 hits.
    InterProi IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view ]
    SMARTi SM00355. ZnF_C2H2. 6 hits.
    [Graphical view ]
    PROSITEi PS00028. ZINC_FINGER_C2H2_1. 4 hits.
    PS50157. ZINC_FINGER_C2H2_2. 4 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Aiolos, a lymphoid restricted transcription factor that interacts with Ikaros to regulate lymphocyte differentiation."
      Morgan B., Sun L., Avitahl N., Andrikopoulos K., Ikeda T., Gonzales E., Wu P., Neben S., Georgopoulos K.
      EMBO J. 16:2004-2013(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INTERACTION WITH IKZF1, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: FUNCTION.

    Entry informationi

    Entry nameiIKZF3_MOUSE
    AccessioniPrimary (citable) accession number: O08900
    Secondary accession number(s): B1AQE6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 19, 2002
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 114 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3