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Protein

Regulator of G-protein signaling 4

Gene

Rgs4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Activity on G(z)-alpha is inhibited by phosphorylation of the G-protein. Activity on G(z)-alpha and G(i)-alpha-1 is inhibited by palmitoylation of the G-protein (By similarity).By similarity

GO - Molecular functioni

  • GTPase activator activity Source: MGI

GO - Biological processi

  • G-protein coupled receptor signaling pathway Source: MGI
  • negative regulation of signal transduction Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Signal transduction inhibitor

Names & Taxonomyi

Protein namesi
Recommended name:
Regulator of G-protein signaling 4
Short name:
RGS4
Gene namesi
Name:Rgs4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:108409. Rgs4.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002041861 – 205Regulator of G-protein signaling 4Add BLAST205

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi2S-palmitoyl cysteineBy similarity1
Lipidationi12S-palmitoyl cysteineBy similarity1
Lipidationi95S-palmitoyl cysteineBy similarity1

Post-translational modificationi

Either Cys-2 or Cys-12 or both are palmitoylated.By similarity
Phosphorylated by cyclic GMP-dependent protein kinase.By similarity

Keywords - PTMi

Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

PaxDbiO08899.
PRIDEiO08899.

PTM databases

iPTMnetiO08899.
PhosphoSitePlusiO08899.

Expressioni

Tissue specificityi

Expressed at high levels in brain, moderately low levels in heart, and very low levels in lung, liver, and skeletal muscle.

Gene expression databases

CleanExiMM_RGS4.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000027991.

Structurei

3D structure databases

ProteinModelPortaliO08899.
SMRiO08899.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini62 – 178RGSPROSITE-ProRule annotationAdd BLAST117

Sequence similaritiesi

Contains 1 RGS domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3589. Eukaryota.
ENOG410YMJD. LUCA.
HOGENOMiHOG000233512.
HOVERGENiHBG013233.
InParanoidiO08899.
KOiK16449.
PhylomeDBiO08899.

Family and domain databases

Gene3Di1.10.196.10. 2 hits.
InterProiIPR016137. RGS.
IPR024066. RGS_subdom1.
[Graphical view]
PfamiPF00615. RGS. 1 hit.
[Graphical view]
PRINTSiPR01301. RGSPROTEIN.
SMARTiSM00315. RGS. 1 hit.
[Graphical view]
SUPFAMiSSF48097. SSF48097. 1 hit.
PROSITEiPS50132. RGS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O08899-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCKGLAGLPA SCLRSAKDMK HRLGFLLQKS DSCEHSSSHS KKDKVVTCQR
60 70 80 90 100
VSQEEVKKWA ESLENLIHHE CGLAAFKAFL KSEYSEENID FWISCEEYKK
110 120 130 140 150
IKSPSKLSPK AKKIYNEFIS VQATKEVNLD SCTREETSRN MLQPTITCFD
160 170 180 190 200
EAQKKIFNLM ERDSYRRFLK SRFYLDLTNP SSCGAEKQKG AKSSADCTSL

VSQCA
Length:205
Mass (Da):23,289
Last modified:July 1, 1997 - v1
Checksum:i5D79581711A1F67C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti162R → K in AAH03882 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB004315 mRNA. Translation: BAA20400.1.
BC003882 mRNA. Translation: AAH03882.1.
CCDSiCCDS15465.1.
RefSeqiNP_033088.2. NM_009062.3.
UniGeneiMm.41642.

Genome annotation databases

GeneIDi19736.
KEGGimmu:19736.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB004315 mRNA. Translation: BAA20400.1.
BC003882 mRNA. Translation: AAH03882.1.
CCDSiCCDS15465.1.
RefSeqiNP_033088.2. NM_009062.3.
UniGeneiMm.41642.

3D structure databases

ProteinModelPortaliO08899.
SMRiO08899.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000027991.

PTM databases

iPTMnetiO08899.
PhosphoSitePlusiO08899.

Proteomic databases

PaxDbiO08899.
PRIDEiO08899.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi19736.
KEGGimmu:19736.

Organism-specific databases

CTDi5999.
MGIiMGI:108409. Rgs4.

Phylogenomic databases

eggNOGiKOG3589. Eukaryota.
ENOG410YMJD. LUCA.
HOGENOMiHOG000233512.
HOVERGENiHBG013233.
InParanoidiO08899.
KOiK16449.
PhylomeDBiO08899.

Miscellaneous databases

ChiTaRSiRgs4. mouse.
PROiO08899.
SOURCEiSearch...

Gene expression databases

CleanExiMM_RGS4.

Family and domain databases

Gene3Di1.10.196.10. 2 hits.
InterProiIPR016137. RGS.
IPR024066. RGS_subdom1.
[Graphical view]
PfamiPF00615. RGS. 1 hit.
[Graphical view]
PRINTSiPR01301. RGSPROTEIN.
SMARTiSM00315. RGS. 1 hit.
[Graphical view]
SUPFAMiSSF48097. SSF48097. 1 hit.
PROSITEiPS50132. RGS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRGS4_MOUSE
AccessioniPrimary (citable) accession number: O08899
Secondary accession number(s): Q99L30
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 1, 1997
Last modified: November 2, 2016
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.