Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Krueppel-like factor 10

Gene

Klf10

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Transcriptional repressor which binds to the consensus sequence 5'-GGTGTG-3'. Regulates the circadian expression of genes involved in lipogenesis, gluconeogenesis, and glycolysis in the liver. Represses the expression of PCK2, a rate-limiting step enzyme of gluconeogenesis. May play a role in the cell cycle regulation (By similarity). Plays a role in the regulation of the circadian clock; binds to the GC box sequence in the promoter of the core clock component ARTNL/BMAL1 and represses its transcriptional activity.By similarity1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri369 – 39325C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri399 – 42325C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri429 – 45123C2H2-type 3PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Biological rhythms, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Krueppel-like factor 10
Alternative name(s):
Transforming growth factor-beta-inducible early growth response protein 1
Short name:
TGFB-inducible early growth response protein 1
Short name:
TIEG-1
Zinc finger transcription factor homolog CPG20
Gene namesi
Name:Klf10
Synonyms:Cpg20, Tieg, Tieg1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 7

Organism-specific databases

RGDi621652. Klf10.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 480480Krueppel-like factor 10PRO_0000047179Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei183 – 1831PhosphoserineBy similarity
Modified residuei249 – 2491PhosphoserineBy similarity

Post-translational modificationi

Ubiquitinated; mediated by SIAH1 and leading to its subsequent proteasomal degradation.By similarity

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiO08876.
PRIDEiO08876.

Expressioni

Inductioni

Up-regulated in response to glucose.1 Publication

Gene expression databases

BgeeiENSRNOG00000006118.
ExpressionAtlasiO08876. baseline and differential.
GenevisibleiO08876. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000008350.

Structurei

3D structure databases

ProteinModelPortaliO08876.
SMRiO08876. Positions 353-451.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 3 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri369 – 39325C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri399 – 42325C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri429 – 45123C2H2-type 3PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000118984.
HOGENOMiHOG000059558.
HOVERGENiHBG052264.
InParanoidiO08876.
KOiK09209.
OMAiMEMISER.
OrthoDBiEOG091G1BN0.
PhylomeDBiO08876.
TreeFamiTF315506.

Family and domain databases

Gene3Di3.30.160.60. 3 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 3 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O08876-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLNFGASLQQ ASEGKMELIS EKSKEGAHPW DKAEQSDFEA VEALMSMSCD
60 70 80 90 100
WKSHFKKYLE NRPVTPVSDT SEEDSLLPGT PDLQTVPAFC LTPPYSPSDF
110 120 130 140 150
EPSQGSNLTA PAPPTGHFRS LSDAAKPPSI APFKEEEKSP LAAPPLPKAQ
160 170 180 190 200
ATSVIRHTAD AQLCNHQSCP VKAASILNYQ DNSFRRRTHI NVEATRKNIP
210 220 230 240 250
CAAVSPNRPK PEPSTAANGA EKAGTAPYDF AVPSSETVIC RSSQPAPTSP
260 270 280 290 300
VQKSVLMSSP TVSTGGVPPL PVICQMVPLP ANNSLVTTVV PSSPPSQPPA
310 320 330 340 350
VCSPVLFMGT QVPKGTVMFV VPQPVVQSPK PPVVSPNGTR LSPIAPAPGF
360 370 380 390 400
SPSAARVTPQ IDSSRVRSHI CSHPGCGKTY FKSSHLKAHV RTHTGEKPFS
410 420 430 440 450
CSWKGCERRF ARSDELSRHR RTHTGEKKFA CPMCDRRFMR SDHLTKHARR
460 470 480
HLSAKKLPNW QMEVSKLNDI ALPPATASAQ
Length:480
Mass (Da):51,829
Last modified:July 1, 1997 - v1
Checksum:iEE6880C27F255029
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U78875 mRNA. Translation: AAC99475.1.
BC097309 mRNA. Translation: AAH97309.1.
RefSeqiNP_112397.1. NM_031135.2.
UniGeneiRn.2398.

Genome annotation databases

EnsembliENSRNOT00000008350; ENSRNOP00000008350; ENSRNOG00000006118.
GeneIDi81813.
KEGGirno:81813.
UCSCiRGD:621652. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U78875 mRNA. Translation: AAC99475.1.
BC097309 mRNA. Translation: AAH97309.1.
RefSeqiNP_112397.1. NM_031135.2.
UniGeneiRn.2398.

3D structure databases

ProteinModelPortaliO08876.
SMRiO08876. Positions 353-451.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000008350.

Proteomic databases

PaxDbiO08876.
PRIDEiO08876.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000008350; ENSRNOP00000008350; ENSRNOG00000006118.
GeneIDi81813.
KEGGirno:81813.
UCSCiRGD:621652. rat.

Organism-specific databases

CTDi7071.
RGDi621652. Klf10.

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000118984.
HOGENOMiHOG000059558.
HOVERGENiHBG052264.
InParanoidiO08876.
KOiK09209.
OMAiMEMISER.
OrthoDBiEOG091G1BN0.
PhylomeDBiO08876.
TreeFamiTF315506.

Miscellaneous databases

PROiO08876.

Gene expression databases

BgeeiENSRNOG00000006118.
ExpressionAtlasiO08876. baseline and differential.
GenevisibleiO08876. RN.

Family and domain databases

Gene3Di3.30.160.60. 3 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 3 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKLF10_RAT
AccessioniPrimary (citable) accession number: O08876
Secondary accession number(s): Q4QRA4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: July 1, 1997
Last modified: September 7, 2016
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.