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O08875

- DCLK1_RAT

UniProt

O08875 - DCLK1_RAT

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Protein

Serine/threonine-protein kinase DCLK1

Gene

Dclk1

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Probable kinase that may be involved in a calcium-signaling pathway controlling neuronal migration in the developing brain. May also participate in functions of the mature nervous system (By similarity).By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei112 – 1121ATPPROSITE-ProRule annotation
Active sitei204 – 2041Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi89 – 979ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. protein kinase activity Source: RGD
  3. protein serine/threonine kinase activity Source: UniProtKB-KW

GO - Biological processi

  1. axon extension Source: Ensembl
  2. central nervous system projection neuron axonogenesis Source: Ensembl
  3. dendrite morphogenesis Source: Ensembl
  4. forebrain development Source: Ensembl
  5. neuron migration Source: Ensembl
  6. protein phosphorylation Source: RGD
  7. response to virus Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Biological processi

Differentiation, Neurogenesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.11.1. 5301.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase DCLK1 (EC:2.7.11.1)
Alternative name(s):
Calcium/calmodulin-dependent protein kinase type I-like CPG16
Doublecortin-like and CAM kinase-like 1
Doublecortin-like kinase 1
Gene namesi
Name:Dclk1
Synonyms:Cpg16, Dcamkl1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 2

Organism-specific databases

RGDi68437. Dclk1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 433433Serine/threonine-protein kinase DCLK1PRO_0000085921Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei23 – 231PhosphoserineBy similarity
Modified residuei25 – 251PhosphoserineBy similarity
Modified residuei30 – 301PhosphoserineBy similarity
Modified residuei45 – 451PhosphoserineBy similarity
Modified residuei69 – 691PhosphoserineBy similarity
Modified residuei213 – 2131PhosphotyrosineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiO08875.

PTM databases

PhosphoSiteiO08875.

Expressioni

Gene expression databases

ExpressionAtlasiO08875. baseline and differential.
GenevestigatoriO08875.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000049552.

Structurei

3D structure databases

ProteinModelPortaliO08875.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini83 – 340258Protein kinasePROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi1 – 3333Pro/Ser-richAdd
BLAST
Compositional biasi391 – 3944Poly-Arg

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00770000120480.
HOGENOMiHOG000230855.
HOVERGENiHBG108055.
InParanoidiO08875.
KOiK08805.
OMAiMVQLNSQ.
OrthoDBiEOG7M98FQ.
PhylomeDBiO08875.

Family and domain databases

InterProiIPR020636. Ca/CaM-dep_Ca-dep_prot_Kinase.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PANTHERiPTHR24347. PTHR24347. 1 hit.
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O08875-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLELIEVNGT PGSQLSTPRS GKSPSPSPTS PGSLRKQRIS QHGGSSTSLS
60 70 80 90 100
STKVCSSMDE NDGPGEEESD EGFQIPATIT ERYKVGRTIG DGNFAVVKEC
110 120 130 140 150
IERSTAREYA LKIIKKSKCR GKEHMIQNEV SILRRVKHPN IVLLIEEMDV
160 170 180 190 200
PTELYLVMEL VKGGDLFDAI TSTSKYTERD ASGMLYNLAS AIKYLHSLNI
210 220 230 240 250
VHRDIKPENL LVYEHQDGSK SLKLGDFGLA TIVDGPLYTV CGTPTYVAPE
260 270 280 290 300
IIAETGYGLK VDIWAAGVIT YILLCGFPPF RGSGDDQEVL FDQILMGQVD
310 320 330 340 350
FPSPYWDNVS DSAKELINMM LLVNVDQRFS AVQVLEHPWV NDDGLPENEH
360 370 380 390 400
QLSVAGKIKK HFNTGPKPSS TAAGVSVIAT TALDKERQVF RRRRNQDVRG
410 420 430
RYKAQPAPPE LNSESEDYSP SSSETVRSPN SPF
Length:433
Mass (Da):47,681
Last modified:July 1, 1997 - v1
Checksum:i0CE5E06E152A557D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U78857 mRNA. Translation: AAC99476.1.
RefSeqiNP_445795.1. NM_053343.3.
UniGeneiRn.155540.
Rn.80575.

Genome annotation databases

EnsembliENSRNOT00000019748; ENSRNOP00000019748; ENSRNOG00000032922.
GeneIDi83825.
KEGGirno:83825.
UCSCiRGD:68437. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U78857 mRNA. Translation: AAC99476.1 .
RefSeqi NP_445795.1. NM_053343.3.
UniGenei Rn.155540.
Rn.80575.

3D structure databases

ProteinModelPortali O08875.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000049552.

PTM databases

PhosphoSitei O08875.

Proteomic databases

PRIDEi O08875.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000019748 ; ENSRNOP00000019748 ; ENSRNOG00000032922 .
GeneIDi 83825.
KEGGi rno:83825.
UCSCi RGD:68437. rat.

Organism-specific databases

CTDi 9201.
RGDi 68437. Dclk1.

Phylogenomic databases

eggNOGi COG0515.
GeneTreei ENSGT00770000120480.
HOGENOMi HOG000230855.
HOVERGENi HBG108055.
InParanoidi O08875.
KOi K08805.
OMAi MVQLNSQ.
OrthoDBi EOG7M98FQ.
PhylomeDBi O08875.

Enzyme and pathway databases

BRENDAi 2.7.11.1. 5301.

Miscellaneous databases

NextBioi 616446.

Gene expression databases

ExpressionAtlasi O08875. baseline and differential.
Genevestigatori O08875.

Family and domain databases

InterProi IPR020636. Ca/CaM-dep_Ca-dep_prot_Kinase.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view ]
PANTHERi PTHR24347. PTHR24347. 1 hit.
Pfami PF00069. Pkinase. 1 hit.
[Graphical view ]
SMARTi SM00220. S_TKc. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Wistar.

Entry informationi

Entry nameiDCLK1_RAT
AccessioniPrimary (citable) accession number: O08875
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: July 1, 1997
Last modified: November 26, 2014
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3