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Protein

Serine/threonine-protein kinase DCLK1

Gene

Dclk1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Probable kinase that may be involved in a calcium-signaling pathway controlling neuronal migration in the developing brain. May also participate in functions of the mature nervous system (By similarity).By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei112 – 1121ATPPROSITE-ProRule annotation
Active sitei204 – 2041Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi89 – 979ATPPROSITE-ProRule annotation

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • protein kinase activity Source: RGD
  • protein serine/threonine kinase activity Source: UniProtKB-KW

GO - Biological processi

  • cell differentiation Source: UniProtKB-KW
  • nervous system development Source: UniProtKB-KW
  • protein phosphorylation Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Biological processi

Differentiation, Neurogenesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.11.1. 5301.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase DCLK1 (EC:2.7.11.1)
Alternative name(s):
Calcium/calmodulin-dependent protein kinase type I-like CPG16
Doublecortin-like and CAM kinase-like 1
Doublecortin-like kinase 1
Gene namesi
Name:Dclk1
Synonyms:Cpg16, Dcamkl1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494 Componenti: Chromosome 2

Organism-specific databases

RGDi68437. Dclk1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 433433Serine/threonine-protein kinase DCLK1PRO_0000085921Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei23 – 231PhosphoserineBy similarity
Modified residuei25 – 251PhosphoserineBy similarity
Modified residuei30 – 301PhosphoserineBy similarity
Modified residuei45 – 451PhosphoserineBy similarity
Modified residuei69 – 691PhosphoserineBy similarity
Modified residuei213 – 2131PhosphotyrosineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiO08875.

PTM databases

PhosphoSiteiO08875.

Expressioni

Gene expression databases

ExpressionAtlasiO08875. baseline and differential.
GenevisibleiO08875. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000019748.

Structurei

3D structure databases

ProteinModelPortaliO08875.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini83 – 340258Protein kinasePROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi1 – 3333Pro/Ser-richAdd
BLAST
Compositional biasi391 – 3944Poly-Arg

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00780000121878.
HOGENOMiHOG000230855.
HOVERGENiHBG108055.
InParanoidiO08875.
OMAiMVQLNSQ.
OrthoDBiEOG7M98FQ.
PhylomeDBiO08875.

Family and domain databases

InterProiIPR020636. Ca/CaM-dep_Ca-dep_prot_Kinase.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PANTHERiPTHR24347. PTHR24347. 1 hit.
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O08875-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLELIEVNGT PGSQLSTPRS GKSPSPSPTS PGSLRKQRIS QHGGSSTSLS
60 70 80 90 100
STKVCSSMDE NDGPGEEESD EGFQIPATIT ERYKVGRTIG DGNFAVVKEC
110 120 130 140 150
IERSTAREYA LKIIKKSKCR GKEHMIQNEV SILRRVKHPN IVLLIEEMDV
160 170 180 190 200
PTELYLVMEL VKGGDLFDAI TSTSKYTERD ASGMLYNLAS AIKYLHSLNI
210 220 230 240 250
VHRDIKPENL LVYEHQDGSK SLKLGDFGLA TIVDGPLYTV CGTPTYVAPE
260 270 280 290 300
IIAETGYGLK VDIWAAGVIT YILLCGFPPF RGSGDDQEVL FDQILMGQVD
310 320 330 340 350
FPSPYWDNVS DSAKELINMM LLVNVDQRFS AVQVLEHPWV NDDGLPENEH
360 370 380 390 400
QLSVAGKIKK HFNTGPKPSS TAAGVSVIAT TALDKERQVF RRRRNQDVRG
410 420 430
RYKAQPAPPE LNSESEDYSP SSSETVRSPN SPF
Length:433
Mass (Da):47,681
Last modified:July 1, 1997 - v1
Checksum:i0CE5E06E152A557D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U78857 mRNA. Translation: AAC99476.1.
RefSeqiNP_445795.1. NM_053343.3.
UniGeneiRn.155540.
Rn.80575.

Genome annotation databases

EnsembliENSRNOT00000019748; ENSRNOP00000019748; ENSRNOG00000032922.
GeneIDi83825.
UCSCiRGD:68437. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U78857 mRNA. Translation: AAC99476.1.
RefSeqiNP_445795.1. NM_053343.3.
UniGeneiRn.155540.
Rn.80575.

3D structure databases

ProteinModelPortaliO08875.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000019748.

PTM databases

PhosphoSiteiO08875.

Proteomic databases

PRIDEiO08875.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000019748; ENSRNOP00000019748; ENSRNOG00000032922.
GeneIDi83825.
UCSCiRGD:68437. rat.

Organism-specific databases

CTDi9201.
RGDi68437. Dclk1.

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00780000121878.
HOGENOMiHOG000230855.
HOVERGENiHBG108055.
InParanoidiO08875.
OMAiMVQLNSQ.
OrthoDBiEOG7M98FQ.
PhylomeDBiO08875.

Enzyme and pathway databases

BRENDAi2.7.11.1. 5301.

Miscellaneous databases

NextBioi616446.
PROiO08875.

Gene expression databases

ExpressionAtlasiO08875. baseline and differential.
GenevisibleiO08875. RN.

Family and domain databases

InterProiIPR020636. Ca/CaM-dep_Ca-dep_prot_Kinase.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PANTHERiPTHR24347. PTHR24347. 1 hit.
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Wistar.

Entry informationi

Entry nameiDCLK1_RAT
AccessioniPrimary (citable) accession number: O08875
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: July 1, 1997
Last modified: July 22, 2015
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.