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O08875 (DCLK1_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 107. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Serine/threonine-protein kinase DCLK1

EC=2.7.11.1
Alternative name(s):
Calcium/calmodulin-dependent protein kinase type I-like CPG16
Doublecortin-like and CAM kinase-like 1
Doublecortin-like kinase 1
Gene names
Name:Dclk1
Synonyms:Cpg16, Dcamkl1
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length433 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Probable kinase that may be involved in a calcium-signaling pathway controlling neuronal migration in the developing brain. May also participate in functions of the mature nervous system By similarity.

Catalytic activity

ATP + a protein = ADP + a phosphoprotein.

Sequence similarities

Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.

Contains 1 protein kinase domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 433433Serine/threonine-protein kinase DCLK1
PRO_0000085921

Regions

Domain83 – 340258Protein kinase
Nucleotide binding89 – 979ATP By similarity
Compositional bias1 – 3333Pro/Ser-rich
Compositional bias391 – 3944Poly-Arg

Sites

Active site2041Proton acceptor By similarity
Binding site1121ATP By similarity

Amino acid modifications

Modified residue231Phosphoserine By similarity
Modified residue251Phosphoserine By similarity
Modified residue301Phosphoserine By similarity
Modified residue451Phosphoserine By similarity
Modified residue691Phosphoserine By similarity
Modified residue2131Phosphotyrosine By similarity

Sequences

Sequence LengthMass (Da)Tools
O08875 [UniParc].

Last modified July 1, 1997. Version 1.
Checksum: 0CE5E06E152A557D

FASTA43347,681
        10         20         30         40         50         60 
MLELIEVNGT PGSQLSTPRS GKSPSPSPTS PGSLRKQRIS QHGGSSTSLS STKVCSSMDE 

        70         80         90        100        110        120 
NDGPGEEESD EGFQIPATIT ERYKVGRTIG DGNFAVVKEC IERSTAREYA LKIIKKSKCR 

       130        140        150        160        170        180 
GKEHMIQNEV SILRRVKHPN IVLLIEEMDV PTELYLVMEL VKGGDLFDAI TSTSKYTERD 

       190        200        210        220        230        240 
ASGMLYNLAS AIKYLHSLNI VHRDIKPENL LVYEHQDGSK SLKLGDFGLA TIVDGPLYTV 

       250        260        270        280        290        300 
CGTPTYVAPE IIAETGYGLK VDIWAAGVIT YILLCGFPPF RGSGDDQEVL FDQILMGQVD 

       310        320        330        340        350        360 
FPSPYWDNVS DSAKELINMM LLVNVDQRFS AVQVLEHPWV NDDGLPENEH QLSVAGKIKK 

       370        380        390        400        410        420 
HFNTGPKPSS TAAGVSVIAT TALDKERQVF RRRRNQDVRG RYKAQPAPPE LNSESEDYSP 

       430 
SSSETVRSPN SPF 

« Hide

References

[1]"Hippocampal plasticity involves extensive gene induction and multiple cellular mechanisms."
Hevroni D., Rattner A., Bundman M., Lederfein D., Gabarah A., Mangelus M., Silverman M.A., Kedar H., Naor C., Kornuc M., Hanoch T., Seger R., Theill L.E., Nedivi E., Richter-Levin G., Citri Y.
J. Mol. Neurosci. 10:75-98(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Wistar.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U78857 mRNA. Translation: AAC99476.1.
RefSeqNP_445795.1. NM_053343.3.
UniGeneRn.155540.
Rn.80575.

3D structure databases

ProteinModelPortalO08875.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000049552.

PTM databases

PhosphoSiteO08875.

Proteomic databases

PRIDEO08875.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000019748; ENSRNOP00000019748; ENSRNOG00000032922.
GeneID83825.
KEGGrno:83825.
UCSCRGD:68437. rat.

Organism-specific databases

CTD9201.
RGD68437. Dclk1.

Phylogenomic databases

eggNOGCOG0515.
GeneTreeENSGT00680000099865.
HOGENOMHOG000230855.
HOVERGENHBG108055.
InParanoidO08875.
KOK08805.
OMAMVQLNSQ.
OrthoDBEOG7M98FQ.
PhylomeDBO08875.

Enzyme and pathway databases

BRENDA2.7.11.1. 5301.

Gene expression databases

ArrayExpressO08875.
GenevestigatorO08875.

Family and domain databases

InterProIPR020636. Ca/CaM-dep_Ca-dep_prot_Kinase.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PANTHERPTHR24347. PTHR24347. 1 hit.
PfamPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMSSF56112. SSF56112. 1 hit.
PROSITEPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio616446.

Entry information

Entry nameDCLK1_RAT
AccessionPrimary (citable) accession number: O08875
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: July 1, 1997
Last modified: April 16, 2014
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families