Serine/threonine-protein kinase DCLK1 - Rattus norvegicus (Rat)

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O08875 (DCLK1_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 101. History...

Clusters with 100%, 90%, 50% identity |

Documents (1) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Serine/threonine-protein kinase DCLK1
EC=2.7.11.1

Alternative name(s):
Calcium/calmodulin-dependent protein kinase type I-like CPG16
Doublecortin-like and CAM kinase-like 1
Doublecortin-like kinase 1

Gene names

Name:	Dclk1
Synonyms:	Cpg16, Dcamkl1

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	433 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function

Probable kinase that may be involved in a calcium-signaling pathway controlling neuronal migration in the developing brain. May also participate in functions of the mature nervous system By similarity.

Catalytic activity

ATP + a protein = ADP + a phosphoprotein.

Sequence similarities

Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.

Contains 1 protein kinase domain.

Ontologies

Keywords
Biological process	Differentiation Neurogenesis
Ligand	ATP-binding Nucleotide-binding
Molecular function	Developmental protein Kinase Serine/threonine-protein kinase Transferase
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	axon extension Inferred from electronic annotation. Source: Compara central nervous system projection neuron axonogenesis Inferred from electronic annotation. Source: Compara dendrite morphogenesis Inferred from electronic annotation. Source: Compara forebrain development Inferred from electronic annotation. Source: Compara neuron migration Inferred from electronic annotation. Source: Compara response to virus Inferred from electronic annotation. Source: Compara
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW protein kinase activity Inferred from direct assay PubMed 12590608. Source: RGD protein serine/threonine kinase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 433

433

Serine/threonine-protein kinase DCLK1

PRO_0000085921

Regions

Domain

83 – 340

258

Protein kinase

Nucleotide binding

89 – 97

ATP By similarity

Compositional bias

1 – 33

Pro/Ser-rich

Compositional bias

391 – 394

Poly-Arg

Sites

Active site

204

Proton acceptor By similarity

Binding site

112

ATP By similarity

Amino acid modifications

Modified residue

Phosphoserine By similarity

Modified residue

Phosphoserine By similarity

Modified residue

Phosphothreonine By similarity

Modified residue

Phosphoserine By similarity

Modified residue

Phosphoserine By similarity

Modified residue

Phosphoserine By similarity

Modified residue

Phosphoserine By similarity

Modified residue

186

Phosphotyrosine By similarity

Modified residue

213

Phosphotyrosine By similarity

Modified residue

415

Phosphoserine By similarity

Modified residue

419

Phosphoserine By similarity

Sequences

Sequence

Length

Mass (Da)

Tools

O08875 [UniParc].

Last modified July 1, 1997. Version 1.
Checksum: 0CE5E06E152A557D
Show »

FASTA

433

47,681

        10         20         30         40         50         60 
MLELIEVNGT PGSQLSTPRS GKSPSPSPTS PGSLRKQRIS QHGGSSTSLS STKVCSSMDE 

        70         80         90        100        110        120 
NDGPGEEESD EGFQIPATIT ERYKVGRTIG DGNFAVVKEC IERSTAREYA LKIIKKSKCR 

       130        140        150        160        170        180 
GKEHMIQNEV SILRRVKHPN IVLLIEEMDV PTELYLVMEL VKGGDLFDAI TSTSKYTERD 

       190        200        210        220        230        240 
ASGMLYNLAS AIKYLHSLNI VHRDIKPENL LVYEHQDGSK SLKLGDFGLA TIVDGPLYTV 

       250        260        270        280        290        300 
CGTPTYVAPE IIAETGYGLK VDIWAAGVIT YILLCGFPPF RGSGDDQEVL FDQILMGQVD 

       310        320        330        340        350        360 
FPSPYWDNVS DSAKELINMM LLVNVDQRFS AVQVLEHPWV NDDGLPENEH QLSVAGKIKK 

       370        380        390        400        410        420 
HFNTGPKPSS TAAGVSVIAT TALDKERQVF RRRRNQDVRG RYKAQPAPPE LNSESEDYSP 

       430 
SSSETVRSPN SPF

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References

[1]

"Hippocampal plasticity involves extensive gene induction and multiple cellular mechanisms."
Hevroni D., Rattner A., Bundman M., Lederfein D., Gabarah A., Mangelus M., Silverman M.A., Kedar H., Naor C., Kornuc M., Hanoch T., Seger R., Theill L.E., Nedivi E., Richter-Levin G., Citri Y.
J. Mol. Neurosci. 10:75-98(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Wistar.

Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U78857 mRNA. Translation: AAC99476.1.
IPI	IPI00778626.
RefSeq	NP_445795.1. NM_053343.3.
UniGene	Rn.155540. Rn.80575.
3D structure databases
ProteinModelPortal	O08875.
ModBase	Search...
Protein-protein interaction databases
STRING	10116.ENSRNOP00000049552.
PTM databases
PhosphoSite	O08875.
Proteomic databases
PRIDE	O08875.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSRNOT00000019748; ENSRNOP00000019748; ENSRNOG00000032922.
GeneID	83825.
KEGG	rno:83825.
UCSC	RGD:68437. rat.
Organism-specific databases
CTD	9201.
RGD	68437. Dclk1.
Phylogenomic databases
eggNOG	COG0515.
GeneTree	ENSGT00680000099865.
HOGENOM	HOG000230855.
HOVERGEN	HBG108055.
InParanoid	O08875.
KO	K08805.
OrthoDB	EOG4H9XK1.
Enzyme and pathway databases
BRENDA	2.7.11.1. 5301.
Gene expression databases
ArrayExpress	O08875.
Genevestigator	O08875.
Family and domain databases
InterPro	IPR020636. Ca/CaM-dep_Ca-dep_prot_Kinase. IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_cat_dom. IPR017441. Protein_kinase_ATP_BS. IPR002290. Ser/Thr_dual-sp_kinase_dom. IPR008271. Ser/Thr_kinase_AS. [Graphical view]
PANTHER	PTHR24347. PTHR24347. 1 hit.
Pfam	PF00069. Pkinase. 1 hit. [Graphical view]
SMART	SM00220. S_TKc. 1 hit. [Graphical view]
SUPFAM	SSF56112. Kinase_like. 1 hit.
PROSITE	PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	616446.

Entry information

Entry name

DCLK1_RAT

Accession

Primary (citable) accession number: O08875

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	July 1, 1997
Last modified:	April 3, 2013
This is version 101 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Sites

Amino acid modifications

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents