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Protein

Serine/threonine-protein kinase DCLK1

Gene

Dclk1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Probable kinase that may be involved in a calcium-signaling pathway controlling neuronal migration in the developing brain. May also participate in functions of the mature nervous system (By similarity).By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei112ATPPROSITE-ProRule annotation1
Active sitei204Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi89 – 97ATPPROSITE-ProRule annotation9

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • protein kinase activity Source: RGD
  • protein serine/threonine kinase activity Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, Kinase, Serine/threonine-protein kinase, Transferase
Biological processDifferentiation, Neurogenesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.11.1. 5301.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase DCLK1 (EC:2.7.11.1)
Alternative name(s):
Calcium/calmodulin-dependent protein kinase type I-like CPG16
Doublecortin-like and CAM kinase-like 1
Doublecortin-like kinase 1
Gene namesi
Name:Dclk1
Synonyms:Cpg16, Dcamkl1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 2

Organism-specific databases

RGDi68437. Dclk1.

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000859211 – 433Serine/threonine-protein kinase DCLK1Add BLAST433

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei23PhosphoserineBy similarity1
Modified residuei25PhosphoserineCombined sources1
Modified residuei27PhosphoserineBy similarity1
Modified residuei30PhosphoserineCombined sources1
Modified residuei40PhosphoserineBy similarity1
Modified residuei45PhosphoserineCombined sources1
Modified residuei46PhosphoserineCombined sources1
Modified residuei48PhosphoserineBy similarity1
Modified residuei57PhosphoserineBy similarity1
Modified residuei69PhosphoserineBy similarity1
Modified residuei213PhosphotyrosineBy similarity1
Modified residuei419PhosphoserineCombined sources1
Modified residuei428PhosphoserineBy similarity1
Modified residuei431PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiO08875.
PRIDEiO08875.

PTM databases

iPTMnetiO08875.
PhosphoSitePlusiO08875.

Expressioni

Gene expression databases

BgeeiENSRNOG00000032922.
ExpressionAtlasiO08875. baseline and differential.
GenevisibleiO08875. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000019748.

Structurei

3D structure databases

ProteinModelPortaliO08875.
SMRiO08875.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini83 – 340Protein kinasePROSITE-ProRule annotationAdd BLAST258

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi1 – 33Pro/Ser-richAdd BLAST33
Compositional biasi391 – 394Poly-Arg4

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0615. Eukaryota.
ENOG410YA63. LUCA.
GeneTreeiENSGT00840000129744.
HOGENOMiHOG000230855.
HOVERGENiHBG108055.
InParanoidiO08875.
KOiK08805.
PhylomeDBiO08875.

Family and domain databases

InterProiView protein in InterPro
IPR011009. Kinase-like_dom_sf.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
PfamiView protein in Pfam
PF00069. Pkinase. 1 hit.
SMARTiView protein in SMART
SM00220. S_TKc. 1 hit.
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiView protein in PROSITE
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.

Sequencei

Sequence statusi: Complete.

O08875-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLELIEVNGT PGSQLSTPRS GKSPSPSPTS PGSLRKQRIS QHGGSSTSLS
60 70 80 90 100
STKVCSSMDE NDGPGEEESD EGFQIPATIT ERYKVGRTIG DGNFAVVKEC
110 120 130 140 150
IERSTAREYA LKIIKKSKCR GKEHMIQNEV SILRRVKHPN IVLLIEEMDV
160 170 180 190 200
PTELYLVMEL VKGGDLFDAI TSTSKYTERD ASGMLYNLAS AIKYLHSLNI
210 220 230 240 250
VHRDIKPENL LVYEHQDGSK SLKLGDFGLA TIVDGPLYTV CGTPTYVAPE
260 270 280 290 300
IIAETGYGLK VDIWAAGVIT YILLCGFPPF RGSGDDQEVL FDQILMGQVD
310 320 330 340 350
FPSPYWDNVS DSAKELINMM LLVNVDQRFS AVQVLEHPWV NDDGLPENEH
360 370 380 390 400
QLSVAGKIKK HFNTGPKPSS TAAGVSVIAT TALDKERQVF RRRRNQDVRG
410 420 430
RYKAQPAPPE LNSESEDYSP SSSETVRSPN SPF
Length:433
Mass (Da):47,681
Last modified:July 1, 1997 - v1
Checksum:i0CE5E06E152A557D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U78857 mRNA. Translation: AAC99476.1.
RefSeqiNP_445795.1. NM_053343.3.
UniGeneiRn.155540.
Rn.80575.

Genome annotation databases

EnsembliENSRNOT00000019748; ENSRNOP00000019748; ENSRNOG00000032922.
GeneIDi83825.
KEGGirno:83825.
UCSCiRGD:68437. rat.

Similar proteinsi

Entry informationi

Entry nameiDCLK1_RAT
AccessioniPrimary (citable) accession number: O08875
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: July 1, 1997
Last modified: November 22, 2017
This is version 131 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families