Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

O08875

- DCLK1_RAT

UniProt

O08875 - DCLK1_RAT

Protein

Serine/threonine-protein kinase DCLK1

Gene

Dclk1

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 108 (01 Oct 2014)
      Sequence version 1 (01 Jul 1997)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Probable kinase that may be involved in a calcium-signaling pathway controlling neuronal migration in the developing brain. May also participate in functions of the mature nervous system By similarity.By similarity

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei112 – 1121ATPPROSITE-ProRule annotation
    Active sitei204 – 2041Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi89 – 979ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. protein kinase activity Source: RGD
    3. protein serine/threonine kinase activity Source: UniProtKB-KW

    GO - Biological processi

    1. axon extension Source: Ensembl
    2. central nervous system projection neuron axonogenesis Source: Ensembl
    3. dendrite morphogenesis Source: Ensembl
    4. forebrain development Source: Ensembl
    5. neuron migration Source: Ensembl
    6. protein phosphorylation Source: RGD
    7. response to virus Source: Ensembl

    Keywords - Molecular functioni

    Developmental protein, Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Biological processi

    Differentiation, Neurogenesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BRENDAi2.7.11.1. 5301.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Serine/threonine-protein kinase DCLK1 (EC:2.7.11.1)
    Alternative name(s):
    Calcium/calmodulin-dependent protein kinase type I-like CPG16
    Doublecortin-like and CAM kinase-like 1
    Doublecortin-like kinase 1
    Gene namesi
    Name:Dclk1
    Synonyms:Cpg16, Dcamkl1
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 2

    Organism-specific databases

    RGDi68437. Dclk1.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 433433Serine/threonine-protein kinase DCLK1PRO_0000085921Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei23 – 231PhosphoserineBy similarity
    Modified residuei25 – 251PhosphoserineBy similarity
    Modified residuei30 – 301PhosphoserineBy similarity
    Modified residuei45 – 451PhosphoserineBy similarity
    Modified residuei69 – 691PhosphoserineBy similarity
    Modified residuei213 – 2131PhosphotyrosineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PRIDEiO08875.

    PTM databases

    PhosphoSiteiO08875.

    Expressioni

    Gene expression databases

    ArrayExpressiO08875.
    GenevestigatoriO08875.

    Interactioni

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000049552.

    Structurei

    3D structure databases

    ProteinModelPortaliO08875.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini83 – 340258Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi1 – 3333Pro/Ser-richAdd
    BLAST
    Compositional biasi391 – 3944Poly-Arg

    Sequence similaritiesi

    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0515.
    GeneTreeiENSGT00680000099865.
    HOGENOMiHOG000230855.
    HOVERGENiHBG108055.
    InParanoidiO08875.
    KOiK08805.
    OMAiMVQLNSQ.
    OrthoDBiEOG7M98FQ.
    PhylomeDBiO08875.

    Family and domain databases

    InterProiIPR020636. Ca/CaM-dep_Ca-dep_prot_Kinase.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view]
    PANTHERiPTHR24347. PTHR24347. 1 hit.
    PfamiPF00069. Pkinase. 1 hit.
    [Graphical view]
    SMARTiSM00220. S_TKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O08875-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLELIEVNGT PGSQLSTPRS GKSPSPSPTS PGSLRKQRIS QHGGSSTSLS    50
    STKVCSSMDE NDGPGEEESD EGFQIPATIT ERYKVGRTIG DGNFAVVKEC 100
    IERSTAREYA LKIIKKSKCR GKEHMIQNEV SILRRVKHPN IVLLIEEMDV 150
    PTELYLVMEL VKGGDLFDAI TSTSKYTERD ASGMLYNLAS AIKYLHSLNI 200
    VHRDIKPENL LVYEHQDGSK SLKLGDFGLA TIVDGPLYTV CGTPTYVAPE 250
    IIAETGYGLK VDIWAAGVIT YILLCGFPPF RGSGDDQEVL FDQILMGQVD 300
    FPSPYWDNVS DSAKELINMM LLVNVDQRFS AVQVLEHPWV NDDGLPENEH 350
    QLSVAGKIKK HFNTGPKPSS TAAGVSVIAT TALDKERQVF RRRRNQDVRG 400
    RYKAQPAPPE LNSESEDYSP SSSETVRSPN SPF 433
    Length:433
    Mass (Da):47,681
    Last modified:July 1, 1997 - v1
    Checksum:i0CE5E06E152A557D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U78857 mRNA. Translation: AAC99476.1.
    RefSeqiNP_445795.1. NM_053343.3.
    UniGeneiRn.155540.
    Rn.80575.

    Genome annotation databases

    EnsembliENSRNOT00000019748; ENSRNOP00000019748; ENSRNOG00000032922.
    GeneIDi83825.
    KEGGirno:83825.
    UCSCiRGD:68437. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U78857 mRNA. Translation: AAC99476.1 .
    RefSeqi NP_445795.1. NM_053343.3.
    UniGenei Rn.155540.
    Rn.80575.

    3D structure databases

    ProteinModelPortali O08875.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000049552.

    PTM databases

    PhosphoSitei O08875.

    Proteomic databases

    PRIDEi O08875.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000019748 ; ENSRNOP00000019748 ; ENSRNOG00000032922 .
    GeneIDi 83825.
    KEGGi rno:83825.
    UCSCi RGD:68437. rat.

    Organism-specific databases

    CTDi 9201.
    RGDi 68437. Dclk1.

    Phylogenomic databases

    eggNOGi COG0515.
    GeneTreei ENSGT00680000099865.
    HOGENOMi HOG000230855.
    HOVERGENi HBG108055.
    InParanoidi O08875.
    KOi K08805.
    OMAi MVQLNSQ.
    OrthoDBi EOG7M98FQ.
    PhylomeDBi O08875.

    Enzyme and pathway databases

    BRENDAi 2.7.11.1. 5301.

    Miscellaneous databases

    NextBioi 616446.

    Gene expression databases

    ArrayExpressi O08875.
    Genevestigatori O08875.

    Family and domain databases

    InterProi IPR020636. Ca/CaM-dep_Ca-dep_prot_Kinase.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view ]
    PANTHERi PTHR24347. PTHR24347. 1 hit.
    Pfami PF00069. Pkinase. 1 hit.
    [Graphical view ]
    SMARTi SM00220. S_TKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Wistar.

    Entry informationi

    Entry nameiDCLK1_RAT
    AccessioniPrimary (citable) accession number: O08875
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: July 1, 1997
    Last modified: October 1, 2014
    This is version 108 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3