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O08859

- TSG6_MOUSE

UniProt

O08859 - TSG6_MOUSE

Protein

Tumor necrosis factor-inducible gene 6 protein

Gene

Tnfaip6

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 112 (01 Oct 2014)
      Sequence version 1 (01 Jul 1997)
      Previous versions | rss
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    Functioni

    Possibly involved in cell-cell and cell-matrix interactions during inflammation and tumorigenesis.By similarity

    GO - Molecular functioni

    1. hyaluronic acid binding Source: InterPro

    GO - Biological processi

    1. cell adhesion Source: UniProtKB-KW

    Keywords - Biological processi

    Cell adhesion

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tumor necrosis factor-inducible gene 6 protein
    Alternative name(s):
    TNF-stimulated gene 6 protein
    Short name:
    TSG-6
    Tumor necrosis factor alpha-induced protein 6
    Short name:
    TNF alpha-induced protein 6
    Gene namesi
    Name:Tnfaip6
    Synonyms:Tnfip6, Tsg6
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 2

    Organism-specific databases

    MGIiMGI:1195266. Tnfaip6.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1717By similarityAdd
    BLAST
    Chaini18 – 275258Tumor necrosis factor-inducible gene 6 proteinPRO_0000026693Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi58 ↔ 127By similarity
    Disulfide bondi82 ↔ 103By similarity
    Glycosylationi118 – 1181N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi135 ↔ 161By similarity
    Disulfide bondi188 ↔ 210By similarity
    Glycosylationi258 – 2581N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiO08859.

    PTM databases

    PhosphoSiteiO08859.

    Expressioni

    Developmental stagei

    Expressed in cumulus cell-oocyte complexes during expansion in vivo.1 Publication

    Gene expression databases

    ArrayExpressiO08859.
    BgeeiO08859.
    CleanExiMM_TNFAIP6.
    GenevestigatoriO08859.

    Interactioni

    Subunit structurei

    Interacts with inter-alpha-inhibitor (I-alpha-I). Chondroitin sulfate may be required for the stability of the complex By similarity.By similarity

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000069231.

    Structurei

    3D structure databases

    ProteinModelPortaliO08859.
    SMRiO08859. Positions 36-249.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini36 – 12994LinkPROSITE-ProRule annotationAdd
    BLAST
    Domaini135 – 247113CUBPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 CUB domain.PROSITE-ProRule annotation
    Contains 1 Link domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG237473.
    HOGENOMiHOG000043074.
    HOVERGENiHBG006669.
    InParanoidiO08859.
    OMAiKECGGVF.
    OrthoDBiEOG7Q5HF0.
    PhylomeDBiO08859.
    TreeFamiTF334173.

    Family and domain databases

    Gene3Di2.60.120.290. 1 hit.
    3.10.100.10. 1 hit.
    InterProiIPR016186. C-type_lectin-like.
    IPR016187. C-type_lectin_fold.
    IPR000859. CUB_dom.
    IPR000538. Link.
    [Graphical view]
    PfamiPF00431. CUB. 1 hit.
    PF00193. Xlink. 1 hit.
    [Graphical view]
    PRINTSiPR01265. LINKMODULE.
    SMARTiSM00042. CUB. 1 hit.
    SM00445. LINK. 1 hit.
    [Graphical view]
    SUPFAMiSSF49854. SSF49854. 1 hit.
    SSF56436. SSF56436. 1 hit.
    PROSITEiPS01180. CUB. 1 hit.
    PS01241. LINK_1. 1 hit.
    PS50963. LINK_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O08859-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVVLLCLCVL LWEEAHGWGF KNGIFHNSIW LEQAAGVYHR EARAGRYKLT    50
    YAEAKAVCEF EGGRLATYKQ LEAARKIGFH VCAAGWMAKG RVGYPIVKPG 100
    PNCGFGKTGI IDYGIRLNRS ERWDAYCYNP HAKECGGVFT DPKRIFKSPG 150
    FPNEYDDNQV CYWHIRLKYG QRIHLSFLDF DLEHDPGCLA DYVEIYDSYD 200
    DVHGFVGRYC GDELPEDIIS TGNVMTLKFL SDASVTAGGF QIKYVTVDPA 250
    SKSSQAKNTS TTGNKKFLPG RFSHL 275
    Length:275
    Mass (Da):30,924
    Last modified:July 1, 1997 - v1
    Checksum:i1CD247228260B8F9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U83903 mRNA. Translation: AAC53527.1.
    BC021155 mRNA. Translation: AAH21155.1.
    CCDSiCCDS16032.1.
    PIRiJC6506.
    RefSeqiNP_033424.1. NM_009398.2.
    UniGeneiMm.3509.

    Genome annotation databases

    EnsembliENSMUST00000065927; ENSMUSP00000069231; ENSMUSG00000053475.
    GeneIDi21930.
    KEGGimmu:21930.
    UCSCiuc008jqp.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U83903 mRNA. Translation: AAC53527.1 .
    BC021155 mRNA. Translation: AAH21155.1 .
    CCDSi CCDS16032.1.
    PIRi JC6506.
    RefSeqi NP_033424.1. NM_009398.2.
    UniGenei Mm.3509.

    3D structure databases

    ProteinModelPortali O08859.
    SMRi O08859. Positions 36-249.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000069231.

    PTM databases

    PhosphoSitei O08859.

    Proteomic databases

    PRIDEi O08859.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000065927 ; ENSMUSP00000069231 ; ENSMUSG00000053475 .
    GeneIDi 21930.
    KEGGi mmu:21930.
    UCSCi uc008jqp.1. mouse.

    Organism-specific databases

    CTDi 7130.
    MGIi MGI:1195266. Tnfaip6.

    Phylogenomic databases

    eggNOGi NOG237473.
    HOGENOMi HOG000043074.
    HOVERGENi HBG006669.
    InParanoidi O08859.
    OMAi KECGGVF.
    OrthoDBi EOG7Q5HF0.
    PhylomeDBi O08859.
    TreeFami TF334173.

    Miscellaneous databases

    NextBioi 301524.
    PROi O08859.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O08859.
    Bgeei O08859.
    CleanExi MM_TNFAIP6.
    Genevestigatori O08859.

    Family and domain databases

    Gene3Di 2.60.120.290. 1 hit.
    3.10.100.10. 1 hit.
    InterProi IPR016186. C-type_lectin-like.
    IPR016187. C-type_lectin_fold.
    IPR000859. CUB_dom.
    IPR000538. Link.
    [Graphical view ]
    Pfami PF00431. CUB. 1 hit.
    PF00193. Xlink. 1 hit.
    [Graphical view ]
    PRINTSi PR01265. LINKMODULE.
    SMARTi SM00042. CUB. 1 hit.
    SM00445. LINK. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49854. SSF49854. 1 hit.
    SSF56436. SSF56436. 1 hit.
    PROSITEi PS01180. CUB. 1 hit.
    PS01241. LINK_1. 1 hit.
    PS50963. LINK_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Coding sequence, exon-intron structure and chromosomal localization of murine TNF-stimulated gene 6 that is specifically expressed by expanding cumulus cell-oocyte complexes."
      Fueloep C., Kamath R.V., Li Y., Otto J.M., Salustri A., Olsen B.R., Glant T.T., Hascall V.C.
      Gene 202:95-102(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], DEVELOPMENTAL STAGE.
      Strain: CD-1.
      Tissue: Embryo, Oocyte and Ovarian granulosa cell.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Colon.

    Entry informationi

    Entry nameiTSG6_MOUSE
    AccessioniPrimary (citable) accession number: O08859
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 26, 2001
    Last sequence update: July 1, 1997
    Last modified: October 1, 2014
    This is version 112 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3