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O08859 (TSG6_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 111. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tumor necrosis factor-inducible gene 6 protein
Alternative name(s):
TNF-stimulated gene 6 protein
Short name=TSG-6
Tumor necrosis factor alpha-induced protein 6
Short name=TNF alpha-induced protein 6
Gene names
Name:Tnfaip6
Synonyms:Tnfip6, Tsg6
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length275 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Possibly involved in cell-cell and cell-matrix interactions during inflammation and tumorigenesis By similarity.

Subunit structure

Interacts with inter-alpha-inhibitor (I-alpha-I). Chondroitin sulfate may be required for the stability of the complex By similarity.

Developmental stage

Expressed in cumulus cell-oocyte complexes during expansion in vivo. Ref.1

Sequence similarities

Contains 1 CUB domain.

Contains 1 Link domain.

Ontologies

Keywords
   Biological processCell adhesion
   DomainSignal
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcell adhesion

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionhyaluronic acid binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1717 By similarity
Chain18 – 275258Tumor necrosis factor-inducible gene 6 protein
PRO_0000026693

Regions

Domain36 – 12994Link
Domain135 – 247113CUB

Amino acid modifications

Glycosylation1181N-linked (GlcNAc...) Potential
Glycosylation2581N-linked (GlcNAc...) Potential
Disulfide bond58 ↔ 127 By similarity
Disulfide bond82 ↔ 103 By similarity
Disulfide bond135 ↔ 161 By similarity
Disulfide bond188 ↔ 210 By similarity

Sequences

Sequence LengthMass (Da)Tools
O08859 [UniParc].

Last modified July 1, 1997. Version 1.
Checksum: 1CD247228260B8F9

FASTA27530,924
        10         20         30         40         50         60 
MVVLLCLCVL LWEEAHGWGF KNGIFHNSIW LEQAAGVYHR EARAGRYKLT YAEAKAVCEF 

        70         80         90        100        110        120 
EGGRLATYKQ LEAARKIGFH VCAAGWMAKG RVGYPIVKPG PNCGFGKTGI IDYGIRLNRS 

       130        140        150        160        170        180 
ERWDAYCYNP HAKECGGVFT DPKRIFKSPG FPNEYDDNQV CYWHIRLKYG QRIHLSFLDF 

       190        200        210        220        230        240 
DLEHDPGCLA DYVEIYDSYD DVHGFVGRYC GDELPEDIIS TGNVMTLKFL SDASVTAGGF 

       250        260        270 
QIKYVTVDPA SKSSQAKNTS TTGNKKFLPG RFSHL 

« Hide

References

« Hide 'large scale' references
[1]"Coding sequence, exon-intron structure and chromosomal localization of murine TNF-stimulated gene 6 that is specifically expressed by expanding cumulus cell-oocyte complexes."
Fueloep C., Kamath R.V., Li Y., Otto J.M., Salustri A., Olsen B.R., Glant T.T., Hascall V.C.
Gene 202:95-102(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], DEVELOPMENTAL STAGE.
Strain: CD-1.
Tissue: Embryo, Oocyte and Ovarian granulosa cell.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N.
Tissue: Colon.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U83903 mRNA. Translation: AAC53527.1.
BC021155 mRNA. Translation: AAH21155.1.
CCDSCCDS16032.1.
PIRJC6506.
RefSeqNP_033424.1. NM_009398.2.
UniGeneMm.3509.

3D structure databases

ProteinModelPortalO08859.
SMRO08859. Positions 36-249.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000069231.

PTM databases

PhosphoSiteO08859.

Proteomic databases

PRIDEO08859.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000065927; ENSMUSP00000069231; ENSMUSG00000053475.
GeneID21930.
KEGGmmu:21930.
UCSCuc008jqp.1. mouse.

Organism-specific databases

CTD7130.
MGIMGI:1195266. Tnfaip6.

Phylogenomic databases

eggNOGNOG237473.
HOGENOMHOG000043074.
HOVERGENHBG006669.
InParanoidO08859.
OMAKECGGVF.
OrthoDBEOG7Q5HF0.
PhylomeDBO08859.
TreeFamTF334173.

Gene expression databases

ArrayExpressO08859.
BgeeO08859.
CleanExMM_TNFAIP6.
GenevestigatorO08859.

Family and domain databases

Gene3D2.60.120.290. 1 hit.
3.10.100.10. 1 hit.
InterProIPR016186. C-type_lectin-like.
IPR016187. C-type_lectin_fold.
IPR000859. CUB_dom.
IPR000538. Link.
[Graphical view]
PfamPF00431. CUB. 1 hit.
PF00193. Xlink. 1 hit.
[Graphical view]
PRINTSPR01265. LINKMODULE.
SMARTSM00042. CUB. 1 hit.
SM00445. LINK. 1 hit.
[Graphical view]
SUPFAMSSF49854. SSF49854. 1 hit.
SSF56436. SSF56436. 1 hit.
PROSITEPS01180. CUB. 1 hit.
PS01241. LINK_1. 1 hit.
PS50963. LINK_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio301524.
PROO08859.
SOURCESearch...

Entry information

Entry nameTSG6_MOUSE
AccessionPrimary (citable) accession number: O08859
Entry history
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: July 1, 1997
Last modified: July 9, 2014
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot