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O08859

- TSG6_MOUSE

UniProt

O08859 - TSG6_MOUSE

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Protein

Tumor necrosis factor-inducible gene 6 protein

Gene

Tnfaip6

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Possibly involved in cell-cell and cell-matrix interactions during inflammation and tumorigenesis.By similarity

GO - Molecular functioni

  1. hyaluronic acid binding Source: InterPro

GO - Biological processi

  1. cell adhesion Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
Tumor necrosis factor-inducible gene 6 protein
Alternative name(s):
TNF-stimulated gene 6 protein
Short name:
TSG-6
Tumor necrosis factor alpha-induced protein 6
Short name:
TNF alpha-induced protein 6
Gene namesi
Name:Tnfaip6
Synonyms:Tnfip6, Tsg6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 2

Organism-specific databases

MGIiMGI:1195266. Tnfaip6.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717By similarityAdd
BLAST
Chaini18 – 275258Tumor necrosis factor-inducible gene 6 proteinPRO_0000026693Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi58 ↔ 127By similarity
Disulfide bondi82 ↔ 103By similarity
Glycosylationi118 – 1181N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi135 ↔ 161By similarity
Disulfide bondi188 ↔ 210By similarity
Glycosylationi258 – 2581N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiO08859.

PTM databases

PhosphoSiteiO08859.

Expressioni

Developmental stagei

Expressed in cumulus cell-oocyte complexes during expansion in vivo.1 Publication

Gene expression databases

BgeeiO08859.
CleanExiMM_TNFAIP6.
ExpressionAtlasiO08859. baseline and differential.
GenevestigatoriO08859.

Interactioni

Subunit structurei

Interacts with inter-alpha-inhibitor (I-alpha-I). Chondroitin sulfate may be required for the stability of the complex (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000069231.

Structurei

3D structure databases

ProteinModelPortaliO08859.
SMRiO08859. Positions 36-249.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini36 – 12994LinkPROSITE-ProRule annotationAdd
BLAST
Domaini135 – 247113CUBPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 CUB domain.PROSITE-ProRule annotation
Contains 1 Link domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG237473.
HOGENOMiHOG000043074.
HOVERGENiHBG006669.
InParanoidiO08859.
OMAiKECGGVF.
OrthoDBiEOG7Q5HF0.
PhylomeDBiO08859.
TreeFamiTF334173.

Family and domain databases

Gene3Di2.60.120.290. 1 hit.
3.10.100.10. 1 hit.
InterProiIPR016186. C-type_lectin-like.
IPR016187. C-type_lectin_fold.
IPR000859. CUB_dom.
IPR000538. Link.
[Graphical view]
PfamiPF00431. CUB. 1 hit.
PF00193. Xlink. 1 hit.
[Graphical view]
PRINTSiPR01265. LINKMODULE.
SMARTiSM00042. CUB. 1 hit.
SM00445. LINK. 1 hit.
[Graphical view]
SUPFAMiSSF49854. SSF49854. 1 hit.
SSF56436. SSF56436. 1 hit.
PROSITEiPS01180. CUB. 1 hit.
PS01241. LINK_1. 1 hit.
PS50963. LINK_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O08859-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVVLLCLCVL LWEEAHGWGF KNGIFHNSIW LEQAAGVYHR EARAGRYKLT
60 70 80 90 100
YAEAKAVCEF EGGRLATYKQ LEAARKIGFH VCAAGWMAKG RVGYPIVKPG
110 120 130 140 150
PNCGFGKTGI IDYGIRLNRS ERWDAYCYNP HAKECGGVFT DPKRIFKSPG
160 170 180 190 200
FPNEYDDNQV CYWHIRLKYG QRIHLSFLDF DLEHDPGCLA DYVEIYDSYD
210 220 230 240 250
DVHGFVGRYC GDELPEDIIS TGNVMTLKFL SDASVTAGGF QIKYVTVDPA
260 270
SKSSQAKNTS TTGNKKFLPG RFSHL
Length:275
Mass (Da):30,924
Last modified:July 1, 1997 - v1
Checksum:i1CD247228260B8F9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U83903 mRNA. Translation: AAC53527.1.
BC021155 mRNA. Translation: AAH21155.1.
CCDSiCCDS16032.1.
PIRiJC6506.
RefSeqiNP_033424.1. NM_009398.2.
UniGeneiMm.3509.

Genome annotation databases

EnsembliENSMUST00000065927; ENSMUSP00000069231; ENSMUSG00000053475.
GeneIDi21930.
KEGGimmu:21930.
UCSCiuc008jqp.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U83903 mRNA. Translation: AAC53527.1 .
BC021155 mRNA. Translation: AAH21155.1 .
CCDSi CCDS16032.1.
PIRi JC6506.
RefSeqi NP_033424.1. NM_009398.2.
UniGenei Mm.3509.

3D structure databases

ProteinModelPortali O08859.
SMRi O08859. Positions 36-249.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000069231.

PTM databases

PhosphoSitei O08859.

Proteomic databases

PRIDEi O08859.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000065927 ; ENSMUSP00000069231 ; ENSMUSG00000053475 .
GeneIDi 21930.
KEGGi mmu:21930.
UCSCi uc008jqp.1. mouse.

Organism-specific databases

CTDi 7130.
MGIi MGI:1195266. Tnfaip6.

Phylogenomic databases

eggNOGi NOG237473.
HOGENOMi HOG000043074.
HOVERGENi HBG006669.
InParanoidi O08859.
OMAi KECGGVF.
OrthoDBi EOG7Q5HF0.
PhylomeDBi O08859.
TreeFami TF334173.

Miscellaneous databases

NextBioi 301524.
PROi O08859.
SOURCEi Search...

Gene expression databases

Bgeei O08859.
CleanExi MM_TNFAIP6.
ExpressionAtlasi O08859. baseline and differential.
Genevestigatori O08859.

Family and domain databases

Gene3Di 2.60.120.290. 1 hit.
3.10.100.10. 1 hit.
InterProi IPR016186. C-type_lectin-like.
IPR016187. C-type_lectin_fold.
IPR000859. CUB_dom.
IPR000538. Link.
[Graphical view ]
Pfami PF00431. CUB. 1 hit.
PF00193. Xlink. 1 hit.
[Graphical view ]
PRINTSi PR01265. LINKMODULE.
SMARTi SM00042. CUB. 1 hit.
SM00445. LINK. 1 hit.
[Graphical view ]
SUPFAMi SSF49854. SSF49854. 1 hit.
SSF56436. SSF56436. 1 hit.
PROSITEi PS01180. CUB. 1 hit.
PS01241. LINK_1. 1 hit.
PS50963. LINK_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Coding sequence, exon-intron structure and chromosomal localization of murine TNF-stimulated gene 6 that is specifically expressed by expanding cumulus cell-oocyte complexes."
    Fueloep C., Kamath R.V., Li Y., Otto J.M., Salustri A., Olsen B.R., Glant T.T., Hascall V.C.
    Gene 202:95-102(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], DEVELOPMENTAL STAGE.
    Strain: CD-1.
    Tissue: Embryo, Oocyte and Ovarian granulosa cell.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Colon.

Entry informationi

Entry nameiTSG6_MOUSE
AccessioniPrimary (citable) accession number: O08859
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: July 1, 1997
Last modified: October 29, 2014
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3