O08859 (TSG6_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Tumor necrosis factor-inducible gene 6 protein

Alternative name(s):
TNF-stimulated gene 6 protein
Short name=TSG-6
Tumor necrosis factor alpha-induced protein 6
Short name=TNF alpha-induced protein 6

Gene names

Name:	Tnfaip6
Synonyms:	Tnfip6, Tsg6

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	275 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Possibly involved in cell-cell and cell-matrix interactions during inflammation and tumorigenesis By similarity.
Subunit structure	Interacts with inter-alpha-inhibitor (I-alpha-I). Chondroitin sulfate may be required for the stability of the complex By similarity.
Developmental stage	Expressed in cumulus cell-oocyte complexes during expansion in vivo. Ref.1
Sequence similarities	Contains 1 CUB domain. Contains 1 Link domain.

Ontologies

Keywords
Biological process	Cell adhesion
Domain	Signal
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell adhesion Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	hyaluronic acid binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 17	17	By similarity
	Chain	18 – 275	258	Tumor necrosis factor-inducible gene 6 protein		PRO_0000026693
Regions
	Domain	36 – 129	94	Link
	Domain	135 – 247	113	CUB
Amino acid modifications
	Glycosylation	118	1	N-linked (GlcNAc...) Potential
	Glycosylation	258	1	N-linked (GlcNAc...) Potential
	Disulfide bond	58 ↔ 127		By similarity
	Disulfide bond	82 ↔ 103		By similarity
	Disulfide bond	135 ↔ 161		By similarity
	Disulfide bond	188 ↔ 210		By similarity

Sequences

	Sequence		Length	Mass (Da)
	O08859 [UniParc]. Last modified July 1, 1997. Version 1. Checksum: 1CD247228260B8F9	FASTA	275	30,924
	10 20 30 40 50 60 MVVLLCLCVL LWEEAHGWGF KNGIFHNSIW LEQAAGVYHR EARAGRYKLT YAEAKAVCEF 70 80 90 100 110 120 EGGRLATYKQ LEAARKIGFH VCAAGWMAKG RVGYPIVKPG PNCGFGKTGI IDYGIRLNRS 130 140 150 160 170 180 ERWDAYCYNP HAKECGGVFT DPKRIFKSPG FPNEYDDNQV CYWHIRLKYG QRIHLSFLDF 190 200 210 220 230 240 DLEHDPGCLA DYVEIYDSYD DVHGFVGRYC GDELPEDIIS TGNVMTLKFL SDASVTAGGF 250 260 270 QIKYVTVDPA SKSSQAKNTS TTGNKKFLPG RFSHL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Coding sequence, exon-intron structure and chromosomal localization of murine TNF-stimulated gene 6 that is specifically expressed by expanding cumulus cell-oocyte complexes." Fueloep C., Kamath R.V., Li Y., Otto J.M., Salustri A., Olsen B.R., Glant T.T., Hascall V.C. Gene 202:95-102(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], DEVELOPMENTAL STAGE. Strain: CD-1. Tissue: Embryo, Oocyte and Ovarian granulosa cell.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: FVB/N. Tissue: Colon.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U83903 mRNA. Translation: AAC53527.1. BC021155 mRNA. Translation: AAH21155.1.
IPI	IPI00116388.
PIR	JC6506.
RefSeq	NP_033424.1. NM_009398.2.
UniGene	Mm.3509.
3D structure databases
ProteinModelPortal	O08859.
SMR	O08859. Positions 36-249.
ModBase	Search...
Protein-protein interaction databases
STRING	10090.ENSMUSP00000069231.
PTM databases
PhosphoSite	O08859.
Proteomic databases
PRIDE	O08859.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000065927; ENSMUSP00000069231; ENSMUSG00000053475.
GeneID	21930.
KEGG	mmu:21930.
Organism-specific databases
CTD	7130.
MGI	MGI:1195266. Tnfaip6.
Phylogenomic databases
eggNOG	NOG237473.
HOGENOM	HOG000043074.
HOVERGEN	HBG006669.
InParanoid	O08859.
OMA	PNEYDDN.
OrthoDB	EOG4WWRK3.
Gene expression databases
ArrayExpress	O08859.
Bgee	O08859.
CleanEx	MM_TNFAIP6.
Genevestigator	O08859.
GermOnline	ENSMUSG00000053475. Mus musculus.
Family and domain databases
Gene3D	2.60.120.290. 1 hit. 3.10.100.10. 1 hit.
InterPro	IPR016186. C-type_lectin-like. IPR016187. C-type_lectin_fold. IPR000859. CUB_dom. IPR000538. Link. [Graphical view]
Pfam	PF00431. CUB. 1 hit. PF00193. Xlink. 1 hit. [Graphical view]
PRINTS	PR01265. LINKMODULE.
SMART	SM00042. CUB. 1 hit. SM00445. LINK. 1 hit. [Graphical view]
SUPFAM	SSF56436. C-type_lectin_fold. 1 hit. SSF49854. CUB. 1 hit.
PROSITE	PS01180. CUB. 1 hit. PS01241. LINK_1. 1 hit. PS50963. LINK_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	301524.
SOURCE	Search...

Entry information

Entry name

TSG6_MOUSE

Accession

Primary (citable) accession number: O08859

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 26, 2001
Last sequence update:	July 1, 1997
Last modified:	April 3, 2013
This is version 103 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program