Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

O08858

- SSR5_MOUSE

UniProt

O08858 - SSR5_MOUSE

Protein

Somatostatin receptor type 5

Gene

Sstr5

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 112 (01 Oct 2014)
      Sequence version 3 (27 Jul 2011)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Receptor for somatostatin-28. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. Increases cell growth inhibition activity of SSTR2 following heterodimerization.

    GO - Molecular functioni

    1. protein binding Source: MGI
    2. somatostatin receptor activity Source: InterPro

    GO - Biological processi

    1. glucose homeostasis Source: MGI
    2. regulation of insulin secretion Source: MGI

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Somatostatin receptor type 5
    Short name:
    SS-5-R
    Short name:
    SS5-R
    Short name:
    SS5R
    Gene namesi
    Name:Sstr5
    Synonyms:Smstr5
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 17

    Organism-specific databases

    MGIiMGI:894282. Sstr5.

    Subcellular locationi

    Cell membrane 1 Publication; Multi-pass membrane protein 1 Publication

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: MGI

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 362362Somatostatin receptor type 5PRO_0000070131Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi13 – 131N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi23 – 231N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi109 ↔ 184PROSITE-ProRule annotation
    Glycosylationi185 – 1851N-linked (GlcNAc...)Sequence Analysis
    Lipidationi319 – 3191S-palmitoyl cysteine; by ZDHHC51 Publication

    Post-translational modificationi

    Palmitoylated at Cys-319 by ZDHHC5, but not ZDHHC8. Palmitoylation creates an additional intracellular loop which is thought to be important for efficient coupling to G-proteins and may target the protein to lipid rafts.1 Publication

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

    Proteomic databases

    PRIDEiO08858.

    PTM databases

    PhosphoSiteiO08858.

    Expressioni

    Tissue specificityi

    Expressed in adult brain but not in liver, heart, spleen, or kidney.1 Publication

    Gene expression databases

    BgeeiO08858.
    CleanExiMM_SSTR5.
    GenevestigatoriO08858.

    Interactioni

    Subunit structurei

    Heterodimer with SSTR2. Heterodimerization with SSTR2 increases cell growth inhibition activity of SSTR2 By similarity.By similarity

    Protein-protein interaction databases

    IntActiO08858. 1 interaction.
    MINTiMINT-1489456.
    STRINGi10090.ENSMUSP00000051085.

    Structurei

    3D structure databases

    ProteinModelPortaliO08858.
    SMRiO08858. Positions 35-319.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3535ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini64 – 7310CytoplasmicSequence Analysis
    Topological domaini100 – 11011ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini133 – 15422CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini176 – 19520ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini221 – 24626CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini273 – 28210ExtracellularSequence Analysis
    Topological domaini308 – 36255CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei36 – 6328Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei74 – 9926Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei111 – 13222Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei155 – 17521Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei196 – 22025Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei247 – 27226Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei283 – 30725Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG274661.
    GeneTreeiENSGT00630000089736.
    HOVERGENiHBG106919.
    InParanoidiA6H6N8.
    KOiK04221.
    OMAiNAVSYWP.
    OrthoDBiEOG7BKCVQ.
    TreeFamiTF315737.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000586. Somatstn_rcpt.
    IPR001184. Somatstn_rcpt_5.
    [Graphical view]
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR00246. SOMATOSTATNR.
    PR00591. SOMATOSTTN5R.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O08858-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEPLSLTSTP SWNASAASSS SHNWSLVDPV SPMGARAVLV PVLYLLVCTV    50
    GLGGNTLVIY VVLRYAKMKT VTNVYILNLA VADVLFMLGL PFLATQNAVS 100
    YWPFGSFLCR LVMTLDGINQ FTSIFCLMVM SVDRYLAVVH PLRSARWRRP 150
    RVAKLASAAV WVFSLLMSLP LLVFADVQEG WGTCNLSWPE PVGLWGAAFI 200
    TYTSVLGFFG PLLVICLCYL LIVVKVKAAG MRVGSSRRRR SERKVTRMVV 250
    VVVLVFVGCW LPFFIVNIVN LAFTLPEEPT SAGLYFFVVV LSYANSCANP 300
    LLYGFLSDNF RQSFRKALCL RRGYGVEDAD AIEPRPDKSG RPQTTLPTRS 350
    CEANGLMQTS RL 362
    Length:362
    Mass (Da):40,008
    Last modified:July 27, 2011 - v3
    Checksum:iC069149B8A8141C4
    GO

    Sequence cautioni

    The sequence AAB88302.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti7 – 71T → A in AAC53353. (PubMed:9300821)Curated
    Sequence conflicti7 – 71T → A in AAB61418. 1 PublicationCurated
    Sequence conflicti7 – 71T → A in AAB86492. 1 PublicationCurated
    Sequence conflicti7 – 71T → A in AAB88302. 1 PublicationCurated
    Sequence conflicti7 – 71T → A in AAI45944. (PubMed:15489334)Curated
    Sequence conflicti7 – 71T → A in AAI50806. (PubMed:15489334)Curated
    Sequence conflicti20 – 201S → G in AAC53353. (PubMed:9300821)Curated
    Sequence conflicti20 – 201S → G in AAB61418. 1 PublicationCurated
    Sequence conflicti20 – 201S → G in AAB86492. 1 PublicationCurated
    Sequence conflicti20 – 201S → G in AAB88302. 1 PublicationCurated
    Sequence conflicti20 – 201S → G in AAI45944. (PubMed:15489334)Curated
    Sequence conflicti20 – 201S → G in AAI50806. (PubMed:15489334)Curated
    Sequence conflicti99 – 991V → VV in AAC53353. (PubMed:9300821)Curated
    Sequence conflicti303 – 3053YGF → LWL in AAB61418. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U82697 Genomic DNA. Translation: AAC53353.1.
    AF004740 Genomic DNA. Translation: AAB61418.1.
    AF030441 Genomic DNA. Translation: AAB86492.1.
    AF035777 Genomic DNA. Translation: AAB88302.1. Different initiation.
    AK133609 mRNA. Translation: BAE21747.1.
    AK133767 mRNA. Translation: BAE21829.1.
    AC131323 Genomic DNA. No translation available.
    BC145943 mRNA. Translation: AAI45944.1.
    BC150805 mRNA. Translation: AAI50806.1.
    CCDSiCCDS28520.1.
    RefSeqiNP_001177937.1. NM_001191008.1.
    NP_035555.1. NM_011425.3.
    XP_006524010.1. XM_006523947.1.
    UniGeneiMm.353282.
    Mm.489569.
    Mm.491029.

    Genome annotation databases

    EnsembliENSMUST00000051864; ENSMUSP00000051085; ENSMUSG00000050824.
    ENSMUST00000165183; ENSMUSP00000128787; ENSMUSG00000050824.
    GeneIDi20609.
    KEGGimmu:20609.
    UCSCiuc008bax.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U82697 Genomic DNA. Translation: AAC53353.1 .
    AF004740 Genomic DNA. Translation: AAB61418.1 .
    AF030441 Genomic DNA. Translation: AAB86492.1 .
    AF035777 Genomic DNA. Translation: AAB88302.1 . Different initiation.
    AK133609 mRNA. Translation: BAE21747.1 .
    AK133767 mRNA. Translation: BAE21829.1 .
    AC131323 Genomic DNA. No translation available.
    BC145943 mRNA. Translation: AAI45944.1 .
    BC150805 mRNA. Translation: AAI50806.1 .
    CCDSi CCDS28520.1.
    RefSeqi NP_001177937.1. NM_001191008.1.
    NP_035555.1. NM_011425.3.
    XP_006524010.1. XM_006523947.1.
    UniGenei Mm.353282.
    Mm.489569.
    Mm.491029.

    3D structure databases

    ProteinModelPortali O08858.
    SMRi O08858. Positions 35-319.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi O08858. 1 interaction.
    MINTi MINT-1489456.
    STRINGi 10090.ENSMUSP00000051085.

    Chemistry

    BindingDBi O08858.
    ChEMBLi CHEMBL2733.
    GuidetoPHARMACOLOGYi 359.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei O08858.

    Proteomic databases

    PRIDEi O08858.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000051864 ; ENSMUSP00000051085 ; ENSMUSG00000050824 .
    ENSMUST00000165183 ; ENSMUSP00000128787 ; ENSMUSG00000050824 .
    GeneIDi 20609.
    KEGGi mmu:20609.
    UCSCi uc008bax.2. mouse.

    Organism-specific databases

    CTDi 6755.
    MGIi MGI:894282. Sstr5.

    Phylogenomic databases

    eggNOGi NOG274661.
    GeneTreei ENSGT00630000089736.
    HOVERGENi HBG106919.
    InParanoidi A6H6N8.
    KOi K04221.
    OMAi NAVSYWP.
    OrthoDBi EOG7BKCVQ.
    TreeFami TF315737.

    Miscellaneous databases

    NextBioi 298963.
    PROi O08858.
    SOURCEi Search...

    Gene expression databases

    Bgeei O08858.
    CleanExi MM_SSTR5.
    Genevestigatori O08858.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000586. Somatstn_rcpt.
    IPR001184. Somatstn_rcpt_5.
    [Graphical view ]
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR00246. SOMATOSTATNR.
    PR00591. SOMATOSTTN5R.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation and characterization of the gene encoding the type 5 mouse (Mus musculus) somatostatin receptor (msst5)."
      Lublin A.L., Diehl N.L., Hochgeschwender U.
      Gene 195:63-66(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY.
      Strain: 129/SvJ.
      Tissue: Liver.
    2. Moldovan S., DeMayo F., Brunicardi F.C.
      Submitted (JUN-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 129/SvJ.
    3. Gordon D.F., Woodmansee W.W., Wood W.M., Knauf H., James R.A.
      Submitted (OCT-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: BALB/c.
      Tissue: Liver.
    4. Baumeister H., Roosterman D., Schafer J., Kreuzer O., Meyerhof W.
      Submitted (DEC-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 129/SvJ.
    5. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Pituitary.
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    8. "Somatostatin receptor 5 is palmitoylated by the interacting ZDHHC5 palmitoyltransferase."
      Kokkola T., Kruse C., Roy-Pogodzik E.M., Pekkinen J., Bauch C., Honck H.H., Hennemann H., Kreienkamp H.J.
      FEBS Lett. 585:2665-2670(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: TOPOLOGY, SUBCELLULAR LOCATION, PALMITOYLATION AT CYS-319.

    Entry informationi

    Entry nameiSSR5_MOUSE
    AccessioniPrimary (citable) accession number: O08858
    Secondary accession number(s): A6H6N8, O08998, Q3UZM7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 112 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3