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Protein

Somatostatin receptor type 5

Gene

Sstr5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for somatostatin-28. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. Increases cell growth inhibition activity of SSTR2 following heterodimerization.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-MMU-375276. Peptide ligand-binding receptors.
R-MMU-418594. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Somatostatin receptor type 5
Short name:
SS-5-R
Short name:
SS5-R
Short name:
SS5R
Gene namesi
Name:Sstr5
Synonyms:Smstr5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:894282. Sstr5.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 35ExtracellularSequence analysisAdd BLAST35
Transmembranei36 – 63Helical; Name=1Sequence analysisAdd BLAST28
Topological domaini64 – 73CytoplasmicSequence analysis10
Transmembranei74 – 99Helical; Name=2Sequence analysisAdd BLAST26
Topological domaini100 – 110ExtracellularSequence analysisAdd BLAST11
Transmembranei111 – 132Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini133 – 154CytoplasmicSequence analysisAdd BLAST22
Transmembranei155 – 175Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini176 – 195ExtracellularSequence analysisAdd BLAST20
Transmembranei196 – 220Helical; Name=5Sequence analysisAdd BLAST25
Topological domaini221 – 246CytoplasmicSequence analysisAdd BLAST26
Transmembranei247 – 272Helical; Name=6Sequence analysisAdd BLAST26
Topological domaini273 – 282ExtracellularSequence analysis10
Transmembranei283 – 307Helical; Name=7Sequence analysisAdd BLAST25
Topological domaini308 – 362CytoplasmicSequence analysisAdd BLAST55

GO - Cellular componenti

  • integral component of plasma membrane Source: GO_Central
  • neuron projection Source: GO_Central
  • nucleus Source: MGI
  • plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2733.
GuidetoPHARMACOLOGYi359.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000701311 – 362Somatostatin receptor type 5Add BLAST362

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi13N-linked (GlcNAc...)Sequence analysis1
Glycosylationi23N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi109 ↔ 184PROSITE-ProRule annotation
Glycosylationi185N-linked (GlcNAc...)Sequence analysis1
Lipidationi319S-palmitoyl cysteine; by ZDHHC51 Publication1

Post-translational modificationi

Palmitoylated at Cys-319 by ZDHHC5, but not ZDHHC8. Palmitoylation creates an additional intracellular loop which is thought to be important for efficient coupling to G-proteins and may target the protein to lipid rafts.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiO08858.
PRIDEiO08858.

PTM databases

PhosphoSitePlusiO08858.
SwissPalmiO08858.

Expressioni

Tissue specificityi

Expressed in adult brain but not in liver, heart, spleen, or kidney.1 Publication

Gene expression databases

BgeeiENSMUSG00000050824.
CleanExiMM_SSTR5.
GenevisibleiO08858. MM.

Interactioni

Subunit structurei

Heterodimer with SSTR2. Heterodimerization with SSTR2 increases cell growth inhibition activity of SSTR2 (By similarity).By similarity

Protein-protein interaction databases

IntActiO08858. 1 interactor.
MINTiMINT-1489456.
STRINGi10090.ENSMUSP00000051085.

Chemistry databases

BindingDBiO08858.

Structurei

3D structure databases

ProteinModelPortaliO08858.
SMRiO08858.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118797.
HOVERGENiHBG106919.
InParanoidiO08858.
KOiK04221.
OMAiQEGWDTC.
OrthoDBiEOG091G0HEN.
TreeFamiTF315737.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000586. Somatstn_rcpt.
IPR001184. Somatstn_rcpt_5.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00246. SOMATOSTATNR.
PR00591. SOMATOSTTN5R.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O08858-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEPLSLTSTP SWNASAASSS SHNWSLVDPV SPMGARAVLV PVLYLLVCTV
60 70 80 90 100
GLGGNTLVIY VVLRYAKMKT VTNVYILNLA VADVLFMLGL PFLATQNAVS
110 120 130 140 150
YWPFGSFLCR LVMTLDGINQ FTSIFCLMVM SVDRYLAVVH PLRSARWRRP
160 170 180 190 200
RVAKLASAAV WVFSLLMSLP LLVFADVQEG WGTCNLSWPE PVGLWGAAFI
210 220 230 240 250
TYTSVLGFFG PLLVICLCYL LIVVKVKAAG MRVGSSRRRR SERKVTRMVV
260 270 280 290 300
VVVLVFVGCW LPFFIVNIVN LAFTLPEEPT SAGLYFFVVV LSYANSCANP
310 320 330 340 350
LLYGFLSDNF RQSFRKALCL RRGYGVEDAD AIEPRPDKSG RPQTTLPTRS
360
CEANGLMQTS RL
Length:362
Mass (Da):40,008
Last modified:July 27, 2011 - v3
Checksum:iC069149B8A8141C4
GO

Sequence cautioni

The sequence AAB88302 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti7T → A in AAC53353 (PubMed:9300821).Curated1
Sequence conflicti7T → A in AAB61418 (Ref. 2) Curated1
Sequence conflicti7T → A in AAB86492 (Ref. 3) Curated1
Sequence conflicti7T → A in AAB88302 (Ref. 4) Curated1
Sequence conflicti7T → A in AAI45944 (PubMed:15489334).Curated1
Sequence conflicti7T → A in AAI50806 (PubMed:15489334).Curated1
Sequence conflicti20S → G in AAC53353 (PubMed:9300821).Curated1
Sequence conflicti20S → G in AAB61418 (Ref. 2) Curated1
Sequence conflicti20S → G in AAB86492 (Ref. 3) Curated1
Sequence conflicti20S → G in AAB88302 (Ref. 4) Curated1
Sequence conflicti20S → G in AAI45944 (PubMed:15489334).Curated1
Sequence conflicti20S → G in AAI50806 (PubMed:15489334).Curated1
Sequence conflicti99V → VV in AAC53353 (PubMed:9300821).Curated1
Sequence conflicti303 – 305YGF → LWL in AAB61418 (Ref. 2) Curated3

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U82697 Genomic DNA. Translation: AAC53353.1.
AF004740 Genomic DNA. Translation: AAB61418.1.
AF030441 Genomic DNA. Translation: AAB86492.1.
AF035777 Genomic DNA. Translation: AAB88302.1. Different initiation.
AK133609 mRNA. Translation: BAE21747.1.
AK133767 mRNA. Translation: BAE21829.1.
AC131323 Genomic DNA. No translation available.
BC145943 mRNA. Translation: AAI45944.1.
BC150805 mRNA. Translation: AAI50806.1.
CCDSiCCDS28520.1.
RefSeqiNP_001177937.1. NM_001191008.1.
NP_035555.1. NM_011425.3.
UniGeneiMm.353282.
Mm.489569.
Mm.491029.

Genome annotation databases

EnsembliENSMUST00000051864; ENSMUSP00000051085; ENSMUSG00000050824.
ENSMUST00000165183; ENSMUSP00000128787; ENSMUSG00000050824.
GeneIDi20609.
KEGGimmu:20609.
UCSCiuc008bax.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U82697 Genomic DNA. Translation: AAC53353.1.
AF004740 Genomic DNA. Translation: AAB61418.1.
AF030441 Genomic DNA. Translation: AAB86492.1.
AF035777 Genomic DNA. Translation: AAB88302.1. Different initiation.
AK133609 mRNA. Translation: BAE21747.1.
AK133767 mRNA. Translation: BAE21829.1.
AC131323 Genomic DNA. No translation available.
BC145943 mRNA. Translation: AAI45944.1.
BC150805 mRNA. Translation: AAI50806.1.
CCDSiCCDS28520.1.
RefSeqiNP_001177937.1. NM_001191008.1.
NP_035555.1. NM_011425.3.
UniGeneiMm.353282.
Mm.489569.
Mm.491029.

3D structure databases

ProteinModelPortaliO08858.
SMRiO08858.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiO08858. 1 interactor.
MINTiMINT-1489456.
STRINGi10090.ENSMUSP00000051085.

Chemistry databases

BindingDBiO08858.
ChEMBLiCHEMBL2733.
GuidetoPHARMACOLOGYi359.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSitePlusiO08858.
SwissPalmiO08858.

Proteomic databases

PaxDbiO08858.
PRIDEiO08858.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000051864; ENSMUSP00000051085; ENSMUSG00000050824.
ENSMUST00000165183; ENSMUSP00000128787; ENSMUSG00000050824.
GeneIDi20609.
KEGGimmu:20609.
UCSCiuc008bax.2. mouse.

Organism-specific databases

CTDi6755.
MGIiMGI:894282. Sstr5.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118797.
HOVERGENiHBG106919.
InParanoidiO08858.
KOiK04221.
OMAiQEGWDTC.
OrthoDBiEOG091G0HEN.
TreeFamiTF315737.

Enzyme and pathway databases

ReactomeiR-MMU-375276. Peptide ligand-binding receptors.
R-MMU-418594. G alpha (i) signalling events.

Miscellaneous databases

PROiO08858.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000050824.
CleanExiMM_SSTR5.
GenevisibleiO08858. MM.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000586. Somatstn_rcpt.
IPR001184. Somatstn_rcpt_5.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00246. SOMATOSTATNR.
PR00591. SOMATOSTTN5R.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSSR5_MOUSE
AccessioniPrimary (citable) accession number: O08858
Secondary accession number(s): A6H6N8, O08998, Q3UZM7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 27, 2011
Last modified: November 2, 2016
This is version 130 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.