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Protein

RNA polymerase II elongation factor ELL

Gene

Ell

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Elongation factor component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. Specifically required for stimulating the elongation step of RNA polymerase II- and III-dependent snRNA gene transcription. ELL also plays an early role before its assembly into in the SEC complex by stabilizing RNA polymerase II recruitment/initiation and entry into the pause site. Required to stabilize the pre-initiation complex and early elongation. Specifically required for stimulating the elongation step of RNA polymerase II- and III-dependent snRNA gene transcription (By similarity). Elongation factor component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III (PubMed:22195968).By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-MMU-112382 Formation of RNA Pol II elongation complex
R-MMU-674695 RNA Polymerase II Pre-transcription Events
R-MMU-6796648 TP53 Regulates Transcription of DNA Repair Genes
R-MMU-6807505 RNA polymerase II transcribes snRNA genes
R-MMU-75955 RNA Polymerase II Transcription Elongation

Names & Taxonomyi

Protein namesi
Recommended name:
RNA polymerase II elongation factor ELL
Alternative name(s):
Eleven-nineteen lysine-rich leukemia protein
Gene namesi
Name:Ell
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:109377 Ell

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001467342 – 602RNA polymerase II elongation factor ELLAdd BLAST601

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei180PhosphothreonineBy similarity1
Modified residuei300PhosphoserineBy similarity1
Modified residuei542PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiO08856
MaxQBiO08856
PaxDbiO08856
PeptideAtlasiO08856
PRIDEiO08856

PTM databases

iPTMnetiO08856
PhosphoSitePlusiO08856

Expressioni

Gene expression databases

BgeeiENSMUSG00000070002
CleanExiMM_ELL
ExpressionAtlasiO08856 baseline and differential
GenevisibleiO08856 MM

Interactioni

Subunit structurei

Component of the super elongation complex (SEC), at least composed of EAF1, EAF2, CDK9, MLLT3/AF9, AFF (AFF1 or AFF4), the P-TEFb complex and ELL (ELL, ELL2 or ELL3). Component of the little elongation complex (LEC), at least composed of ELL (ELL, ELL2 or ELL3), ZC3H8, ICE1 and ICE2. Interacts with ICE1 (via N-terminus domain). Interacts with ICE2. Interacts with AFF4; the interaction is direct. Interacts with EAF1 and EAF2 (By similarity). Interacts with USPL1 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi199432, 3 interactors
IntActiO08856, 3 interactors
STRINGi10090.ENSMUSP00000091163

Structurei

3D structure databases

ProteinModelPortaliO08856
SMRiO08856
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ELL/occludin family.Curated

Phylogenomic databases

eggNOGiKOG4796 Eukaryota
ENOG410ZNGU LUCA
GeneTreeiENSGT00550000074378
HOGENOMiHOG000112356
HOVERGENiHBG005578
InParanoidiO08856
KOiK15183
OMAiCIQQYVS
OrthoDBiEOG091G043D
TreeFamiTF326161

Family and domain databases

InterProiView protein in InterPro
IPR031184 ELL
IPR031176 ELL/occludin
IPR019464 ELL_N
IPR010844 Occludin_ELL
IPR036390 WH_DNA-bd_sf
PANTHERiPTHR23288 PTHR23288, 1 hit
PTHR23288:SF9 PTHR23288:SF9, 1 hit
PfamiView protein in Pfam
PF10390 ELL, 1 hit
PF07303 Occludin_ELL, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O08856-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAALKEARSY GLSCGRVSDG SRVSVFHVKL TDSALKAFES YRAHQDSVSL
60 70 80 90 100
RPSIRFEGSQ GHISIPQPDC PEEVRAFSFY LSNIGRDSPQ GSFDCIQQYV
110 120 130 140 150
SSYGDVHLDC LGSIQDKVTV CATDDSYQKA RQSMAQAEEE TRSRSAIVIK
160 170 180 190 200
AGGRYMGKKV QFRKPAPGAA DAVPSRKRAT PINLASAIRK SSGSGASSVV
210 220 230 240 250
QRPFRDRVLH LLALRPYRKA ELLLRLQKDG LTQADKDTLD SLLQQVASVN
260 270 280 290 300
PKDGTCTLQD CMYKSLQKDW PGYSEGDRQL LKRMLMRKLC QPQNATTDSS
310 320 330 340 350
PPREHGRSAS PSQKRPTDFI DPLASKKPRI SHFTQRAQPT LNGKLGAPNG
360 370 380 390 400
HETLLPAPGP TPSDTLSSSH LPPRLEPPRT HDPLADVSND LGHSTQDYKH
410 420 430 440 450
QEATPAPAPH LGLPLLTDFP QAEQPTSSSH THSRPKKKSK KHKDKERPPE
460 470 480 490 500
ERPPAPQPDA PTAPALPPDA PGLNGACDNE PTSSSETPDY LLKYPAISSS
510 520 530 540 550
EQRQSYKNDF NAEYSEYRSL HARIEQITRR FTQLDAQLRQ LSQGSDEYET
560 570 580 590 600
TRGQILQEYR KIKKTNTNYS CEKRRCEYLH RKLAHIKRLI AEYDQRQLQA

WP
Length:602
Mass (Da):67,146
Last modified:July 27, 2011 - v2
Checksum:iDECAD56CF19ABF4B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti103Y → H in AAC53150 (PubMed:9037066).Curated1
Sequence conflicti103Y → H in AAH14816 (PubMed:15489334).Curated1
Sequence conflicti103Y → H in AAH24894 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U80227 mRNA Translation: AAC53150.1
AK159027 mRNA Translation: BAE34775.1
CH466569 Genomic DNA Translation: EDL28843.1
BC014816 mRNA Translation: AAH14816.1
BC024894 mRNA Translation: AAH24894.1
CCDSiCCDS22372.1
RefSeqiNP_031950.2, NM_007924.2
UniGeneiMm.271973

Genome annotation databases

EnsembliENSMUST00000093454; ENSMUSP00000091163; ENSMUSG00000070002
GeneIDi13716
KEGGimmu:13716
UCSCiuc009mau.1 mouse

Similar proteinsi

Entry informationi

Entry nameiELL_MOUSE
AccessioniPrimary (citable) accession number: O08856
Secondary accession number(s): Q3TXY9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: July 27, 2011
Last modified: March 28, 2018
This is version 122 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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