O08850 (RGS5_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Regulator of G-protein signaling 5
Short name=RGS5

Gene names

Name:

Rgs5

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	181 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G(i)-alpha and G(o)-alpha, but not to G(s)-alpha.
Subcellular location	Cytoplasm By similarity. Membrane By similarity.
Tissue specificity	Expressed in heart and muscle.
Sequence similarities	Contains 1 RGS domain.

Ontologies

Keywords
Cellular component	Cytoplasm Membrane
Molecular function	Signal transduction inhibitor
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	G-protein coupled receptor signaling pathway Traceable author statement PubMed 11342430. Source: MGI termination of G-protein coupled receptor signaling pathway Inferred from electronic annotation. Source: InterPro
Cellular_component	cytoplasm Inferred from Biological aspect of Ancestor. Source: RefGenome plasma membrane Inferred from Biological aspect of Ancestor. Source: RefGenome
Molecular_function	GTPase activator activity Inferred from Biological aspect of Ancestor. Source: RefGenome
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 181	181	Regulator of G-protein signaling 5		PRO_0000204189
Regions
	Domain	64 – 180	117	RGS
Experimental info
	Sequence conflict	49 – 50	2	KA → NG in AAB50618. Ref.1
	Sequence conflict	77	1	S → T in AAB50618. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	O08850 [UniParc]. Last modified August 14, 2001. Version 2. Checksum: B4B561CFE3DA9630	FASTA	181	21,086
	10 20 30 40 50 60 MCKGLAALPH SCLERAKEIK IKLGILLQKP DSAVDLVIPY NEKPEKPAKA HKPSLEEVLQ 70 80 90 100 110 120 WRQSLDKLLQ NSYGFASFKS FLKSEFSEEN LEFWVACENY KKIKSPIKMA EKAKQIYEEF 130 140 150 160 170 180 IQTEAPKEVN IDHFTKDITM KNLVEPSPRS FDLAQKRIYA LMEKDSLPRF VRSEFYKELI K

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Characterization of a novel mammalian RGS protein that binds to Galpha proteins and inhibits pheromone signaling in yeast." Chen C., Zheng B., Han J., Lin S.-C. J. Biol. Chem. 272:8679-8685(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6J. Tissue: Brain cortex, Embryo and Oviduct.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: FVB/N. Tissue: Mammary gland.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U67188 mRNA. Translation: AAB50618.1. AK004165 mRNA. Translation: BAB23201.1. AK044096 mRNA. Translation: BAC31773.1. AK054098 mRNA. Translation: BAC35655.1. BC037683 mRNA. Translation: AAH37683.1.
IPI	IPI00116374.
RefSeq	NP_033089.2. NM_009063.3.
UniGene	Mm.20954.
3D structure databases
ProteinModelPortal	O08850.
SMR	O08850. Positions 44-180.
ModBase	Search...
PTM databases
PhosphoSite	O08850.
Proteomic databases
PRIDE	O08850.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000027997; ENSMUSP00000027997; ENSMUSG00000026678.
GeneID	19737.
KEGG	mmu:19737.
UCSC	uc007dlm.1. mouse.
Organism-specific databases
CTD	8490.
MGI	MGI:1098434. Rgs5.
Phylogenomic databases
eggNOG	NOG285261.
GeneTree	ENSGT00690000101738.
HOGENOM	HOG000233512.
HOVERGEN	HBG013233.
InParanoid	O08850.
KO	K16449.
OMA	HSCLERA.
OrthoDB	EOG41RPW5.
Gene expression databases
Bgee	O08850.
CleanEx	MM_RGS5.
Genevestigator	O08850.
GermOnline	ENSMUSG00000026678. Mus musculus.
Family and domain databases
Gene3D	1.10.196.10. 2 hits.
InterPro	IPR000342. Regulat_G_prot_signal. IPR024066. Regulat_G_prot_signal_dom1. IPR016137. Regulat_G_prot_signal_superfam. [Graphical view]
Pfam	PF00615. RGS. 1 hit. [Graphical view]
PRINTS	PR01301. RGSPROTEIN.
SMART	SM00315. RGS. 1 hit. [Graphical view]
SUPFAM	SSF48097. Regulat_G_prot_signal_superfam. 1 hit.
PROSITE	PS50132. RGS. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	297180.
SOURCE	Search...

Entry information

Entry name

RGS5_MOUSE

Accession

Primary (citable) accession number: O08850
Secondary accession number(s): Q543B1, Q9D0Z2

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	August 14, 2001
Last modified:	April 3, 2013
This is version 98 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program