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O08850

- RGS5_MOUSE

UniProt

O08850 - RGS5_MOUSE

Protein

Regulator of G-protein signaling 5

Gene

Rgs5

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 107 (01 Oct 2014)
      Sequence version 2 (14 Aug 2001)
      Previous versions | rss
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    Functioni

    Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G(i)-alpha and G(o)-alpha, but not to G(s)-alpha.

    GO - Molecular functioni

    1. GTPase activator activity Source: RefGenome

    GO - Biological processi

    1. G-protein coupled receptor signaling pathway Source: MGI
    2. positive regulation of GTPase activity Source: GOC
    3. termination of G-protein coupled receptor signaling pathway Source: InterPro

    Keywords - Molecular functioni

    Signal transduction inhibitor

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Regulator of G-protein signaling 5
    Short name:
    RGS5
    Gene namesi
    Name:Rgs5
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 1

    Organism-specific databases

    MGIiMGI:1098434. Rgs5.

    Subcellular locationi

    Cytoplasm By similarity. Membrane By similarity

    GO - Cellular componenti

    1. cytoplasm Source: RefGenome
    2. plasma membrane Source: RefGenome

    Keywords - Cellular componenti

    Cytoplasm, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 181181Regulator of G-protein signaling 5PRO_0000204189Add
    BLAST

    Proteomic databases

    PRIDEiO08850.

    PTM databases

    PhosphoSiteiO08850.

    Expressioni

    Tissue specificityi

    Expressed in heart and muscle.

    Gene expression databases

    BgeeiO08850.
    CleanExiMM_RGS5.
    GenevestigatoriO08850.

    Structurei

    3D structure databases

    ProteinModelPortaliO08850.
    SMRiO08850. Positions 44-180.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini64 – 180117RGSPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 RGS domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG285261.
    GeneTreeiENSGT00750000117600.
    HOGENOMiHOG000233512.
    HOVERGENiHBG013233.
    InParanoidiO08850.
    KOiK16449.
    OMAiWRDSLEK.
    OrthoDBiEOG7VHSZ5.
    PhylomeDBiO08850.
    TreeFamiTF315837.

    Family and domain databases

    Gene3Di1.10.196.10. 2 hits.
    InterProiIPR024066. Regulat_G_prot_signal_dom1.
    IPR016137. Regulat_G_prot_signal_superfam.
    IPR000342. RGS_dom.
    [Graphical view]
    PfamiPF00615. RGS. 1 hit.
    [Graphical view]
    PRINTSiPR01301. RGSPROTEIN.
    SMARTiSM00315. RGS. 1 hit.
    [Graphical view]
    SUPFAMiSSF48097. SSF48097. 1 hit.
    PROSITEiPS50132. RGS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O08850-1 [UniParc]FASTAAdd to Basket

    « Hide

    MCKGLAALPH SCLERAKEIK IKLGILLQKP DSAVDLVIPY NEKPEKPAKA    50
    HKPSLEEVLQ WRQSLDKLLQ NSYGFASFKS FLKSEFSEEN LEFWVACENY 100
    KKIKSPIKMA EKAKQIYEEF IQTEAPKEVN IDHFTKDITM KNLVEPSPRS 150
    FDLAQKRIYA LMEKDSLPRF VRSEFYKELI K 181
    Length:181
    Mass (Da):21,086
    Last modified:August 14, 2001 - v2
    Checksum:iB4B561CFE3DA9630
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti49 – 502KA → NG in AAB50618. (PubMed:9079700)Curated
    Sequence conflicti77 – 771S → T in AAB50618. (PubMed:9079700)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U67188 mRNA. Translation: AAB50618.1.
    AK004165 mRNA. Translation: BAB23201.1.
    AK044096 mRNA. Translation: BAC31773.1.
    AK054098 mRNA. Translation: BAC35655.1.
    BC037683 mRNA. Translation: AAH37683.1.
    CCDSiCCDS15464.1.
    RefSeqiNP_033089.2. NM_009063.3.
    UniGeneiMm.20954.

    Genome annotation databases

    EnsembliENSMUST00000027997; ENSMUSP00000027997; ENSMUSG00000026678.
    GeneIDi19737.
    KEGGimmu:19737.
    UCSCiuc007dlm.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U67188 mRNA. Translation: AAB50618.1 .
    AK004165 mRNA. Translation: BAB23201.1 .
    AK044096 mRNA. Translation: BAC31773.1 .
    AK054098 mRNA. Translation: BAC35655.1 .
    BC037683 mRNA. Translation: AAH37683.1 .
    CCDSi CCDS15464.1.
    RefSeqi NP_033089.2. NM_009063.3.
    UniGenei Mm.20954.

    3D structure databases

    ProteinModelPortali O08850.
    SMRi O08850. Positions 44-180.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei O08850.

    Proteomic databases

    PRIDEi O08850.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000027997 ; ENSMUSP00000027997 ; ENSMUSG00000026678 .
    GeneIDi 19737.
    KEGGi mmu:19737.
    UCSCi uc007dlm.1. mouse.

    Organism-specific databases

    CTDi 8490.
    MGIi MGI:1098434. Rgs5.

    Phylogenomic databases

    eggNOGi NOG285261.
    GeneTreei ENSGT00750000117600.
    HOGENOMi HOG000233512.
    HOVERGENi HBG013233.
    InParanoidi O08850.
    KOi K16449.
    OMAi WRDSLEK.
    OrthoDBi EOG7VHSZ5.
    PhylomeDBi O08850.
    TreeFami TF315837.

    Miscellaneous databases

    NextBioi 297180.
    PROi O08850.
    SOURCEi Search...

    Gene expression databases

    Bgeei O08850.
    CleanExi MM_RGS5.
    Genevestigatori O08850.

    Family and domain databases

    Gene3Di 1.10.196.10. 2 hits.
    InterProi IPR024066. Regulat_G_prot_signal_dom1.
    IPR016137. Regulat_G_prot_signal_superfam.
    IPR000342. RGS_dom.
    [Graphical view ]
    Pfami PF00615. RGS. 1 hit.
    [Graphical view ]
    PRINTSi PR01301. RGSPROTEIN.
    SMARTi SM00315. RGS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48097. SSF48097. 1 hit.
    PROSITEi PS50132. RGS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Characterization of a novel mammalian RGS protein that binds to Galpha proteins and inhibits pheromone signaling in yeast."
      Chen C., Zheng B., Han J., Lin S.-C.
      J. Biol. Chem. 272:8679-8685(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Brain cortex, Embryo and Oviduct.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Mammary gland.

    Entry informationi

    Entry nameiRGS5_MOUSE
    AccessioniPrimary (citable) accession number: O08850
    Secondary accession number(s): Q543B1, Q9D0Z2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: August 14, 2001
    Last modified: October 1, 2014
    This is version 107 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3