Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

O08849

- RGS2_MOUSE

UniProt

O08849 - RGS2_MOUSE

Protein

Regulator of G-protein signaling 2

Gene

Rgs2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 118 (01 Oct 2014)
      Sequence version 2 (14 Aug 2001)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. May play a role in leukemogenesis. Binds EIF2B5 and blocks its activity, thereby inhibiting the translation of mRNA into protein.

    GO - Molecular functioni

    1. GTPase activator activity Source: RefGenome
    2. protein binding Source: MGI

    GO - Biological processi

    1. brown fat cell differentiation Source: MGI
    2. cell cycle Source: UniProtKB-KW
    3. G-protein coupled receptor signaling pathway Source: MGI
    4. negative regulation of cAMP-mediated signaling Source: MGI
    5. negative regulation of cardiac muscle hypertrophy Source: BHF-UCL
    6. negative regulation of G-protein coupled receptor protein signaling pathway Source: BHF-UCL
    7. negative regulation of MAP kinase activity Source: BHF-UCL
    8. negative regulation of phospholipase activity Source: BHF-UCL
    9. positive regulation of cardiac muscle contraction Source: BHF-UCL
    10. positive regulation of microtubule polymerization Source: Ensembl
    11. regulation of adrenergic receptor signaling pathway Source: BHF-UCL
    12. regulation of translation Source: UniProtKB-KW
    13. relaxation of cardiac muscle Source: BHF-UCL
    14. relaxation of vascular smooth muscle Source: UniProtKB
    15. spermatogenesis Source: BHF-UCL
    16. termination of G-protein coupled receptor signaling pathway Source: InterPro

    Keywords - Molecular functioni

    Signal transduction inhibitor

    Keywords - Biological processi

    Cell cycle, Translation regulation

    Enzyme and pathway databases

    ReactomeiREACT_207651. G alpha (q) signalling events.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Regulator of G-protein signaling 2
    Short name:
    RGS2
    Gene namesi
    Name:Rgs2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 1

    Organism-specific databases

    MGIiMGI:1098271. Rgs2.

    Subcellular locationi

    Cell membrane By similarity. Cytoplasm By similarity. Nucleusnucleolus By similarity

    GO - Cellular componenti

    1. cytoplasm Source: RefGenome
    2. cytoplasmic side of plasma membrane Source: BHF-UCL
    3. cytosol Source: BHF-UCL
    4. neuron projection Source: Ensembl
    5. nucleolus Source: UniProtKB-SubCell
    6. nucleus Source: MGI
    7. plasma membrane Source: BHF-UCL

    Keywords - Cellular componenti

    Cell membrane, Cytoplasm, Membrane, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 211211Regulator of G-protein signaling 2PRO_0000204179Add
    BLAST

    Post-translational modificationi

    Phosphorylated by protein kinase C. Phosphorylation by PRKG1 leads to activation of RGS2 activity.By similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PRIDEiO08849.

    PTM databases

    PhosphoSiteiO08849.

    Expressioni

    Tissue specificityi

    Expressed in a wide variety of tissues.

    Gene expression databases

    BgeeiO08849.
    CleanExiMM_RGS2.
    GenevestigatoriO08849.

    Interactioni

    Subunit structurei

    Interacts with EIF2B5. Interacts with PRKG1 (isoform alpha).By similarity

    Protein-protein interaction databases

    IntActiO08849. 1 interaction.
    MINTiMINT-4953705.
    STRINGi10090.ENSMUSP00000115558.

    Structurei

    3D structure databases

    ProteinModelPortaliO08849.
    SMRiO08849. Positions 73-200.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini83 – 199117RGSPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni32 – 6635Necessary for membrane associationBy similarityAdd
    BLAST
    Regioni79 – 11638Necessary to inhibit protein synthesisBy similarityAdd
    BLAST

    Sequence similaritiesi

    Contains 1 RGS domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG252352.
    GeneTreeiENSGT00750000117382.
    HOGENOMiHOG000233512.
    HOVERGENiHBG013233.
    InParanoidiO08849.
    KOiK18154.
    OMAiQQAFIKP.
    OrthoDBiEOG7VHSZ5.
    PhylomeDBiO08849.
    TreeFamiTF315837.

    Family and domain databases

    Gene3Di1.10.196.10. 2 hits.
    InterProiIPR024066. Regulat_G_prot_signal_dom1.
    IPR016137. Regulat_G_prot_signal_superfam.
    IPR000342. RGS_dom.
    [Graphical view]
    PfamiPF00615. RGS. 1 hit.
    [Graphical view]
    PRINTSiPR01301. RGSPROTEIN.
    SMARTiSM00315. RGS. 1 hit.
    [Graphical view]
    SUPFAMiSSF48097. SSF48097. 1 hit.
    PROSITEiPS50132. RGS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O08849-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQSAMFLAVQ HDCVPMDKSA GNGPKVEEKR EKMKRTLLKD WKTRLSYFLQ    50
    NSSAPGKPKT GKKSKQQTFI KPSPEEAQLW AEAFDELLAS KYGLAAFRAF 100
    LKSEFCEENI EFWLACEDFK KTKSPQKLSS KARKIYTDFI EKEAPKEINI 150
    DFQTKSLIAQ NIQEATSGCF TTAQKRVYSL MENNSYPRFL ESEFYQDLCK 200
    KPQITTEPHA T 211
    Length:211
    Mass (Da):24,294
    Last modified:August 14, 2001 - v2
    Checksum:i5D6E255C2BC7E7FA
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti39 – 402KD → NH in AAB50617. (PubMed:9079700)Curated
    Sequence conflicti78 – 792QL → DV in AAL28114. 1 PublicationCurated
    Sequence conflicti78 – 792QL → HV in AAB50617. (PubMed:9079700)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U67187 mRNA. Translation: AAB50617.1.
    AF215668 mRNA. Translation: AAF34625.1.
    AF432916 mRNA. Translation: AAL28114.1.
    AK031603 mRNA. Translation: BAC27471.1.
    AK077922 mRNA. Translation: BAC37065.1.
    AK162276 mRNA. Translation: BAE36830.1.
    BC023001 mRNA. Translation: AAH23001.1.
    CCDSiCCDS15347.1.
    RefSeqiNP_033087.2. NM_009061.4.
    UniGeneiMm.28262.

    Genome annotation databases

    EnsembliENSMUST00000127206; ENSMUSP00000115558; ENSMUSG00000026360.
    GeneIDi19735.
    KEGGimmu:19735.
    UCSCiuc007cxg.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U67187 mRNA. Translation: AAB50617.1 .
    AF215668 mRNA. Translation: AAF34625.1 .
    AF432916 mRNA. Translation: AAL28114.1 .
    AK031603 mRNA. Translation: BAC27471.1 .
    AK077922 mRNA. Translation: BAC37065.1 .
    AK162276 mRNA. Translation: BAE36830.1 .
    BC023001 mRNA. Translation: AAH23001.1 .
    CCDSi CCDS15347.1.
    RefSeqi NP_033087.2. NM_009061.4.
    UniGenei Mm.28262.

    3D structure databases

    ProteinModelPortali O08849.
    SMRi O08849. Positions 73-200.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi O08849. 1 interaction.
    MINTi MINT-4953705.
    STRINGi 10090.ENSMUSP00000115558.

    PTM databases

    PhosphoSitei O08849.

    Proteomic databases

    PRIDEi O08849.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000127206 ; ENSMUSP00000115558 ; ENSMUSG00000026360 .
    GeneIDi 19735.
    KEGGi mmu:19735.
    UCSCi uc007cxg.2. mouse.

    Organism-specific databases

    CTDi 5997.
    MGIi MGI:1098271. Rgs2.

    Phylogenomic databases

    eggNOGi NOG252352.
    GeneTreei ENSGT00750000117382.
    HOGENOMi HOG000233512.
    HOVERGENi HBG013233.
    InParanoidi O08849.
    KOi K18154.
    OMAi QQAFIKP.
    OrthoDBi EOG7VHSZ5.
    PhylomeDBi O08849.
    TreeFami TF315837.

    Enzyme and pathway databases

    Reactomei REACT_207651. G alpha (q) signalling events.

    Miscellaneous databases

    NextBioi 297172.
    PROi O08849.
    SOURCEi Search...

    Gene expression databases

    Bgeei O08849.
    CleanExi MM_RGS2.
    Genevestigatori O08849.

    Family and domain databases

    Gene3Di 1.10.196.10. 2 hits.
    InterProi IPR024066. Regulat_G_prot_signal_dom1.
    IPR016137. Regulat_G_prot_signal_superfam.
    IPR000342. RGS_dom.
    [Graphical view ]
    Pfami PF00615. RGS. 1 hit.
    [Graphical view ]
    PRINTSi PR01301. RGSPROTEIN.
    SMARTi SM00315. RGS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48097. SSF48097. 1 hit.
    PROSITEi PS50132. RGS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Characterization of a novel mammalian RGS protein that binds to Galpha proteins and inhibits pheromone signaling in yeast."
      Chen C., Zheng B., Han J., Lin S.-C.
      J. Biol. Chem. 272:8679-8685(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "RGS molecule expression in murine B lymphocytes and ability to down-regulate chemotaxis to lymphoid chemokines."
      Reif K., Cyster J.G.
      J. Immunol. 164:4720-4729(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: C57BL/6J.
      Tissue: Embryo.
    3. "Identification of novel endometrial and embryonic factors involved in mouse embryo implantation."
      Shen Q.-X., Wang J., Huang Z.-P.
      Submitted (OCT-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: BALB/c.
    4. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Testis.
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6.
      Tissue: Retina.

    Entry informationi

    Entry nameiRGS2_MOUSE
    AccessioniPrimary (citable) accession number: O08849
    Secondary accession number(s): Q544S7, Q91WX1, Q9JL24
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: August 14, 2001
    Last modified: October 1, 2014
    This is version 118 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3