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Protein

Regulator of G-protein signaling 2

Gene

Rgs2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form (By similarity). It is involved in the negative regulation of the angiotensin-activated signaling pathway (By similarity). Plays a role in the regulation of blood pressure in response to signaling via G protein-coupled receptors and GNAQ. Plays a role in regulating the constriction and relaxation of vascular smooth muscle (PubMed:14608379). Binds EIF2B5 and blocks its activity, thereby inhibiting the translation of mRNA into protein (By similarity).By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

  • brown fat cell differentiation Source: MGI
  • cell cycle Source: UniProtKB-KW
  • G-protein coupled receptor signaling pathway Source: MGI
  • negative regulation of adenylate cyclase-inhibiting adrenergic receptor signaling pathway involved in heart process Source: BHF-UCL
  • negative regulation of cAMP-mediated signaling Source: MGI
  • negative regulation of cardiac muscle hypertrophy Source: BHF-UCL
  • negative regulation of G-protein coupled receptor protein signaling pathway Source: BHF-UCL
  • negative regulation of MAP kinase activity Source: BHF-UCL
  • negative regulation of phospholipase activity Source: BHF-UCL
  • positive regulation of cardiac muscle contraction Source: BHF-UCL
  • positive regulation of microtubule polymerization Source: Ensembl
  • regulation of G-protein coupled receptor protein signaling pathway Source: UniProtKB
  • regulation of translation Source: UniProtKB-KW
  • relaxation of cardiac muscle Source: BHF-UCL
  • relaxation of vascular smooth muscle Source: UniProtKB
  • spermatogenesis Source: BHF-UCL

Keywordsi

Molecular functionGTPase activation, Signal transduction inhibitor
Biological processCell cycle, Translation regulation

Enzyme and pathway databases

ReactomeiR-MMU-416476 G alpha (q) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
Regulator of G-protein signaling 2
Short name:
RGS2
Gene namesi
Name:Rgs2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1098271 Rgs2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane, Nucleus

Pathology & Biotechi

Disruption phenotypei

Mutant mice display increased blood pressure and impaired relaxation of vascular smooth muscle.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002041791 – 211Regulator of G-protein signaling 2Add BLAST211

Post-translational modificationi

Phosphorylated by protein kinase C. Phosphorylation by PRKG1 leads to activation of RGS2 activity.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO08849
PaxDbiO08849
PRIDEiO08849

PTM databases

iPTMnetiO08849
PhosphoSitePlusiO08849

Expressioni

Tissue specificityi

Expressed in a wide variety of tissues.1 Publication

Gene expression databases

BgeeiENSMUSG00000026360
CleanExiMM_RGS2
ExpressionAtlasiO08849 baseline and differential
GenevisibleiO08849 MM

Interactioni

Subunit structurei

Interacts with GNAQ. Does not interact with GNAI1 and GNAI3. Interacts with EIF2B5. Interacts with PRKG1 (isoform alpha).By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiO08849, 2 interactors
MINTiO08849
STRINGi10090.ENSMUSP00000115558

Structurei

3D structure databases

ProteinModelPortaliO08849
SMRiO08849
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini83 – 199RGSPROSITE-ProRule annotationAdd BLAST117

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni32 – 66Necessary for membrane associationBy similarityAdd BLAST35
Regioni79 – 116Necessary to inhibit protein synthesisBy similarityAdd BLAST38

Phylogenomic databases

eggNOGiKOG3589 Eukaryota
ENOG410YMJD LUCA
GeneTreeiENSGT00760000118903
HOGENOMiHOG000233512
HOVERGENiHBG013233
InParanoidiO08849
KOiK18154
OMAiAVQHDCV
OrthoDBiEOG091G0BDG
PhylomeDBiO08849
TreeFamiTF315837

Family and domain databases

Gene3Di1.10.196.10, 2 hits
InterProiView protein in InterPro
IPR016137 RGS
IPR034947 RGS2
IPR036305 RGS_sf
IPR024066 RGS_subdom1/3
PANTHERiPTHR10845:SF43 PTHR10845:SF43, 1 hit
PfamiView protein in Pfam
PF00615 RGS, 1 hit
PRINTSiPR01301 RGSPROTEIN
SMARTiView protein in SMART
SM00315 RGS, 1 hit
SUPFAMiSSF48097 SSF48097, 1 hit
PROSITEiView protein in PROSITE
PS50132 RGS, 1 hit

Sequencei

Sequence statusi: Complete.

O08849-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQSAMFLAVQ HDCVPMDKSA GNGPKVEEKR EKMKRTLLKD WKTRLSYFLQ
60 70 80 90 100
NSSAPGKPKT GKKSKQQTFI KPSPEEAQLW AEAFDELLAS KYGLAAFRAF
110 120 130 140 150
LKSEFCEENI EFWLACEDFK KTKSPQKLSS KARKIYTDFI EKEAPKEINI
160 170 180 190 200
DFQTKSLIAQ NIQEATSGCF TTAQKRVYSL MENNSYPRFL ESEFYQDLCK
210
KPQITTEPHA T
Length:211
Mass (Da):24,294
Last modified:August 14, 2001 - v2
Checksum:i5D6E255C2BC7E7FA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti39 – 40KD → NH in AAB50617 (PubMed:9079700).Curated2
Sequence conflicti78 – 79QL → DV in AAL28114 (Ref. 3) Curated2
Sequence conflicti78 – 79QL → HV in AAB50617 (PubMed:9079700).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U67187 mRNA Translation: AAB50617.1
AF215668 mRNA Translation: AAF34625.1
AF432916 mRNA Translation: AAL28114.1
AK031603 mRNA Translation: BAC27471.1
AK077922 mRNA Translation: BAC37065.1
AK162276 mRNA Translation: BAE36830.1
BC023001 mRNA Translation: AAH23001.1
CCDSiCCDS15347.1
RefSeqiNP_033087.2, NM_009061.4
UniGeneiMm.28262

Genome annotation databases

EnsembliENSMUST00000127206; ENSMUSP00000115558; ENSMUSG00000026360
GeneIDi19735
KEGGimmu:19735
UCSCiuc007cxg.2 mouse

Similar proteinsi

Entry informationi

Entry nameiRGS2_MOUSE
AccessioniPrimary (citable) accession number: O08849
Secondary accession number(s): Q544S7, Q91WX1, Q9JL24
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: August 14, 2001
Last modified: May 23, 2018
This is version 145 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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